J J Strain

Summary

Affiliation: University of Ulster
Country: UK

Publications

  1. ncbi request reprint B-vitamins, homocysteine metabolism and CVD
    J J Strain
    Northern Ireland Centre for Food and Health NICHE, University of Ulster, Coleraine BT52 1SA, UK
    Proc Nutr Soc 63:597-603. 2004
  2. pmc Choline status and neurodevelopmental outcomes at 5 years of age in the Seychelles Child Development Nutrition Study
    J J Strain
    Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland, BT52 1SA, UK
    Br J Nutr 110:330-6. 2013
  3. pmc Associations of maternal long-chain polyunsaturated fatty acids, methyl mercury, and infant development in the Seychelles Child Development Nutrition Study
    J J Strain
    Northern Ireland Centre for Food and Health NICHE, Centre for Molecular Biosciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland, United Kingdom
    Neurotoxicology 29:776-82. 2008
  4. ncbi request reprint Choline supplementation and measures of choline and betaine status: a randomised, controlled trial in postmenopausal women
    Julie M W Wallace
    Northern Ireland Centre for Food and Health NICHE, University of Ulster, Coleraine, County Londonderry, UK
    Br J Nutr 108:1264-71. 2012
  5. pmc Intakes and adequacy of potentially important nutrients for cognitive development among 5-year-old children in the Seychelles Child Development and Nutrition Study
    Alison J McAfee
    Northern Ireland Centre for Food and Health NICHE, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, UK
    Public Health Nutr 15:1670-7. 2012
  6. doi request reprint Effect of adiposity on vitamin D status and the 25-hydroxycholecalciferol response to supplementation in healthy young and older Irish adults
    L Kirsty Forsythe
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine BT52 1SA, UK
    Br J Nutr 107:126-34. 2012
  7. ncbi request reprint Effect of zinc supplementation on the immune status of healthy older individuals aged 55-70 years: the ZENITH Study
    Clare F Hodkinson
    Northern Ireland Centre for Food and Health NICHE, University of Ulster, Coleraine, Northern Ireland
    J Gerontol A Biol Sci Med Sci 62:598-608. 2007
  8. ncbi request reprint Low-dose vitamin B-6 effectively lowers fasting plasma homocysteine in healthy elderly persons who are folate and riboflavin replete
    M C McKinley
    Northern Ireland Centre for Diet and Health, University of Ulster, Coleraine, United Kingdom
    Am J Clin Nutr 73:759-64. 2001
  9. doi request reprint Low colonocyte folate is associated with uracil misincorporation and global DNA hypomethylation in human colorectum
    Angela P McGlynn
    Centre for Molecular Biosciences, University of Ulster, Coleraine, Northern Ireland
    J Nutr 143:27-33. 2013
  10. ncbi request reprint The rate of intestinal absorption of natural food folates is not related to the extent of folate conjugation
    Derek J McKillop
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, United Kingdom
    Am J Clin Nutr 84:167-73. 2006

Detail Information

Publications100

  1. ncbi request reprint B-vitamins, homocysteine metabolism and CVD
    J J Strain
    Northern Ireland Centre for Food and Health NICHE, University of Ulster, Coleraine BT52 1SA, UK
    Proc Nutr Soc 63:597-603. 2004
    ..Individuals with the MTHFR 677TT genotype are genetically predisposed to elevated plasma homocysteine, and in most populations have a markedly higher risk of CVD...
  2. pmc Choline status and neurodevelopmental outcomes at 5 years of age in the Seychelles Child Development Nutrition Study
    J J Strain
    Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland, BT52 1SA, UK
    Br J Nutr 110:330-6. 2013
    ..As there is considerable animal evidence suggesting that choline status during development is associated with cognitive outcome, the issue deserves further study in other cohorts...
  3. pmc Associations of maternal long-chain polyunsaturated fatty acids, methyl mercury, and infant development in the Seychelles Child Development Nutrition Study
    J J Strain
    Northern Ireland Centre for Food and Health NICHE, Centre for Molecular Biosciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland, United Kingdom
    Neurotoxicology 29:776-82. 2008
    ..Furthermore, they indicate that the beneficial effects of LCPUFA can obscure the determination of adverse effects of prenatal MeHg exposure in longitudinal observational studies...
  4. ncbi request reprint Choline supplementation and measures of choline and betaine status: a randomised, controlled trial in postmenopausal women
    Julie M W Wallace
    Northern Ireland Centre for Food and Health NICHE, University of Ulster, Coleraine, County Londonderry, UK
    Br J Nutr 108:1264-71. 2012
    ....
  5. pmc Intakes and adequacy of potentially important nutrients for cognitive development among 5-year-old children in the Seychelles Child Development and Nutrition Study
    Alison J McAfee
    Northern Ireland Centre for Food and Health NICHE, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, UK
    Public Health Nutr 15:1670-7. 2012
    ..To assess the nutritional adequacy of Seychellois children in relation to nutrients reported to be important for cognitive development...
  6. doi request reprint Effect of adiposity on vitamin D status and the 25-hydroxycholecalciferol response to supplementation in healthy young and older Irish adults
    L Kirsty Forsythe
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine BT52 1SA, UK
    Br J Nutr 107:126-34. 2012
    ..Results suggest that adiposity may need to be taken into account when determining an adequate wintertime dietary vitamin D intake for healthy older adults residing at higher latitudes...
  7. ncbi request reprint Effect of zinc supplementation on the immune status of healthy older individuals aged 55-70 years: the ZENITH Study
    Clare F Hodkinson
    Northern Ireland Centre for Food and Health NICHE, University of Ulster, Coleraine, Northern Ireland
    J Gerontol A Biol Sci Med Sci 62:598-608. 2007
    ..Overall, these findings suggest that total Zn intake (diet plus supplementation) of up to 40 mg Zn/d do not have significant long-term effects on immune status in apparently healthy persons aged 55-70 years...
  8. ncbi request reprint Low-dose vitamin B-6 effectively lowers fasting plasma homocysteine in healthy elderly persons who are folate and riboflavin replete
    M C McKinley
    Northern Ireland Centre for Diet and Health, University of Ulster, Coleraine, United Kingdom
    Am J Clin Nutr 73:759-64. 2001
    ..This suggests that any program aimed at the treatment or prevention of hyperhomocysteinemia should include vitamin B-6 supplementation...
  9. doi request reprint Low colonocyte folate is associated with uracil misincorporation and global DNA hypomethylation in human colorectum
    Angela P McGlynn
    Centre for Molecular Biosciences, University of Ulster, Coleraine, Northern Ireland
    J Nutr 143:27-33. 2013
    ..Folate supplementation trials aimed at colon cancer prevention should target individuals with suboptimal folate status...
  10. ncbi request reprint The rate of intestinal absorption of natural food folates is not related to the extent of folate conjugation
    Derek J McKillop
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, United Kingdom
    Am J Clin Nutr 84:167-73. 2006
    ..Evidence is conflicting as to whether the bioavailability of food folates is influenced by the extent of their conjugation...
  11. pmc Contribution of fish to intakes of micronutrients important for fetal development: a dietary survey of pregnant women in the Republic of Seychelles
    Maxine P Bonham
    Northern Ireland Centre for Food and Health, Department of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, UK
    Public Health Nutr 12:1312-20. 2009
    ..To characterise the diets of pregnant women in the Republic of Seychelles and to determine the contribution of fish to intakes of nutrients important for fetal and neonatal development...
  12. ncbi request reprint Zinc status and age-related changes in peripheral blood leukocyte subpopulations in healthy men and women aged 55-70 y: the ZENITH study
    C F Hodkinson
    Northern Ireland Centre for Food and Health NICHE, University of Ulster, Coleraine, Northern Ireland, UK
    Eur J Clin Nutr 59:S63-7. 2005
    ..To determine zinc status and age-related changes in the immune function of healthy late-middle-aged men and women (aged 55-70 y)...
  13. doi request reprint Predictors of taste acuity in healthy older Europeans
    Ellen E A Simpson
    School of Psychology, University of Ulster, Cromore Road, Coleraine, County Londonderry BT52 1SA, Ireland
    Appetite 58:188-95. 2012
    ..These data suggest that socio-demographic and cultural factors should be taken into account when considering taste acuity in older people...
  14. doi request reprint Blood pressure in treated hypertensive individuals with the MTHFR 677TT genotype is responsive to intervention with riboflavin: findings of a targeted randomized trial
    Carol P Wilson
    Northern Ireland Centre for Food and Health, University of Ulster, Cromore Rd, Coleraine, BT52 1SA, Northern Ireland
    Hypertension 61:1302-8. 2013
    ..Clinical Trial Registration- URL: http://www.clinicaltrials.gov. Unique identifier: ISRCTN23620802...
  15. ncbi request reprint The short-term bioavailabilities of [6S]-5-methyltetrahydrofolate and folic acid are equivalent in men
    Kristina Pentieva
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland BT52 1SA
    J Nutr 134:580-5. 2004
    ..Supplementation with the natural folate derivative could have all the beneficial effects associated with FA, but without the potential disadvantage of masking the anemia of vitamin B-12 deficiency...
  16. doi request reprint Riboflavin offers a targeted strategy for managing hypertension in patients with the MTHFR 677TT genotype: a 4-y follow-up
    Carol P Wilson
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland, United Kingdom
    Am J Clin Nutr 95:766-72. 2012
    ....
  17. ncbi request reprint Tracking of nutrient intakes in adolescence: the experiences of the Young Hearts Project, Northern Ireland
    P J Robson
    Northern Ireland Centre for Diet and Health NICHE, University of Ulster, UK
    Br J Nutr 84:541-8. 2000
    ..09) in the girls' diets. In conclusion, the poor to fair tracking observed in this cohort suggests that individual dietary patterns exhibited at 12 years of age are unlikely to be predictive of energy and nutrient intake at age 15 years...
  18. doi request reprint Evaluation of the effect of wheat aleurone-rich foods on markers of antioxidant status, inflammation and endothelial function in apparently healthy men and women
    Ruth K Price
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, UK
    Br J Nutr 108:1644-51. 2012
    ..However, it is unclear whether this effect is owing to a specific component, or a combination of components in wheat aleurone...
  19. doi request reprint Postgraduate Symposium: The MTHFR C677T polymorphism, B-vitamins and blood pressure
    C P Wilson
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine BT52 1SA, UK
    Proc Nutr Soc 69:156-65. 2010
    ..The present review will investigate the evidence linking the MTHFR C677T polymorphism to BP and the potential modulating role of B-vitamins...
  20. ncbi request reprint Plasma homocysteine is not subject to seasonal variation
    M C McKinley
    Northern Ireland Centre for Diet and Health, University of Ulster, Coleraine BT52 1SA, Northern Ireland
    Clin Chem 47:1430-6. 2001
    ..This, however, needs to be confirmed in different subgroups of the population...
  21. ncbi request reprint Tracking of energy and nutrient intakes from adolescence to young adulthood: the experiences of the Young Hearts Project, Northern Ireland
    A M Gallagher
    Northern Ireland Centre for Food and Health NICHE, University of Ulster, Coleraine, UK
    Public Health Nutr 9:1027-34. 2006
    ..To assess tracking of energy and nutrient intakes between adolescence and young adulthood...
  22. doi request reprint EURRECA-Estimating folate requirements for deriving dietary reference values
    Leane Hoey
    Northern Ireland Centre for Food and Health NICHE, School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland, United Kingdom
    Crit Rev Food Sci Nutr 53:1041-50. 2013
    ..This review summarizes the available evidence and the issues to consider in the setting of dietary reference values for folate...
  23. doi request reprint Supplemented zinc does not alter mood in healthy older European adults--a randomised placebo-controlled trial: the Zenith study
    Barbara J Stewart-Knox
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, BT521SA, Northern Ireland, UK
    Public Health Nutr 14:882-8. 2011
    ..This randomised, placebo-controlled, double-blind intervention study aimed to investigate the effect of oral zinc gluconate supplementation (15 mg/d; 30 mg/d; and placebo) on subjective mood (affect) in older Europeans...
  24. ncbi request reprint Zinc supplementation has no effect on lipoprotein metabolism, hemostasis, and putative indices of copper status in healthy men
    Maxine Bonham
    Northern Ireland Centre for Diet and Health NICHE, University of Ulster at Coleraine, BT52 1SA, Northern Ireland
    Biol Trace Elem Res 93:75-86. 2003
    ..These results indicate that short-term low-level zinc supplementation (total intake 40 mg/d) is not detrimental to health...
  25. doi request reprint C(1) metabolism and CVD outcomes in older adults
    Helene McNulty
    Northern Ireland Centre for Food and Health, University of Ulster, Cromore Road, Coleraine BT52 1SA, UK
    Proc Nutr Soc 71:213-21. 2012
    ..This novel gene-nutrient interaction may provide insights as to the mechanism that links C(1) metabolism with CVD outcomes...
  26. ncbi request reprint Biomarker responses to folic acid intervention in healthy adults: a meta-analysis of randomized controlled trials
    Maresa E Duffy
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland MED, L Hoey, CFH, JJS, AR, and HM the Division of Human Nutrition, Wageningen University and Research Centre, Wageningen, Netherlands OWS and CD and Norwich Medical School, University of East Anglia, Norfolk, United Kingdom RC and L Hooper
    Am J Clin Nutr 99:96-106. 2014
    ..The task of revising dietary folate recommendations for optimal health is complicated by a lack of data quantifying the biomarker response that reliably reflects a given folate intake...
  27. ncbi request reprint Whole blood analysis of phagocytosis, apoptosis, cytokine production, and leukocyte subsets in healthy older men and women: the ZENITH study
    Clare F Hodkinson
    Northern Ireland Centre for Food and Health NICHE, University of Ulster, Coleraine, Northern Ireland, BT52 1SA
    J Gerontol A Biol Sci Med Sci 61:907-17. 2006
    ..The study further highlights the need for sex-specific reference ranges for such markers...
  28. ncbi request reprint Effect of supplemental methionine on plasma homocysteine concentrations in healthy men: a preliminary study
    M Ward
    Northern Ireland Centre for Diet and Health (NICHE, School of Biomedical Sciences, University of Ulster, Coleraine, BT52 1SA
    Int J Vitam Nutr Res 71:82-6. 2001
    ..Because it is very unlikely that such levels could be achieved through dietary means alone we conclude that plasma homocysteine is unlikely to be affected by longer-term changes in food methionine intake...
  29. doi request reprint Consumption of wheat aleurone-rich foods increases fasting plasma betaine and modestly decreases fasting homocysteine and LDL-cholesterol in adults
    Ruth K Price
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, UK
    J Nutr 140:2153-7. 2010
    ..Although this supports a role for betaine in the protective effects of whole grains, concomitant decreases in LDL suggest more than one component or mechanism may be responsible...
  30. ncbi request reprint Determining bioavailability of food folates in a controlled intervention study
    Mary P Hannon-Fletcher
    Northern Ireland Centre for Food and Health and the School of Hotel, Leisure, and Tourism, University of Ulster, Coleraine, United Kingdom
    Am J Clin Nutr 80:911-8. 2004
    ..However, many published reports on folate bioavailability are problematic because of several confounding factors...
  31. doi request reprint Studies of biomarker responses to intervention with riboflavin: a systematic review
    Leane Hoey
    Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland, United Kingdom
    Am J Clin Nutr 89:1960S-1980S. 2009
    ..In addition, the effectiveness of different biomarkers of riboflavin status has not been critically evaluated...
  32. pmc Iron status in pregnant women in the Republic of Seychelles
    Emeir M Duffy
    Northern Ireland Centre for Food and Health NICHE, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, UK
    Public Health Nutr 13:331-7. 2010
    ..To establish the Fe status of pregnant women and their neonates in the Republic of Seychelles...
  33. doi request reprint Preliminary evidence of immune function modulation by thyroid hormones in healthy men and women aged 55-70 years
    Clare F Hodkinson
    Northern Ireland Centre for Food and Health NICHE School of Psychology, University of Ulster, Coleraine, Northern Ireland
    J Endocrinol 202:55-63. 2009
    ..In conclusion, these findings highlight the potential implications of altered thyroid function in older individuals and the importance of future research examining thyroid-immune interactions...
  34. pmc Maternal PUFA status but not prenatal methylmercury exposure is associated with children's language functions at age five years in the Seychelles
    J J Strain
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, UK
    J Nutr 142:1943-9. 2012
    ....
  35. pmc Vitamin D and bone health: potential mechanisms
    Eamon Laird
    School of Biomedical Sciences, University of Ulster, Coleraine, UK
    Nutrients 2:693-724. 2010
    ..The immunoregulatory mechanisms of vitamin D may thus modulate the effect of these cytokines on bone health and subsequent fracture risk. Vitamin D, therefore, may influence fracture risk via a number of different mechanisms...
  36. doi request reprint Maintenance of wintertime vitamin D status with cholecalciferol supplementation is not associated with alterations in serum cytokine concentrations among apparently healthy younger or older adults
    Maria S Barnes
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, BT52 1SA, Republic of Ireland
    J Nutr 141:476-81. 2011
    ..05). The long-term effects of low vitamin D status remain to be elucidated and optimization of vitamin D status in otherwise healthy individuals may potentially have lasting beneficial effects on the immune system...
  37. doi request reprint B-vitamins, methylenetetrahydrofolate reductase (MTHFR) and hypertension
    Mary Ward
    Nothern Ireland Centre for Food and Health, University of Ulster, Coleraine BT52 1SA, UK
    Int J Vitam Nutr Res 81:240-4. 2011
    ....
  38. doi request reprint The relationship between gender and age with monocyte tissue factor expression
    P Scully
    Northern Ireland Centre for Diet and Health NICHE, University of Ulster, Northern Ireland, UK
    J Thromb Thrombolysis 28:156-65. 2009
    ..However, very few studies have examined the relationship between age and gender on TF expression...
  39. ncbi request reprint Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C->T polymorphism
    Helene McNulty
    Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland
    Circulation 113:74-80. 2006
    ....
  40. ncbi request reprint Effect of cholesterol feeding on DNA damage in male and female Syrian hamsters
    E Turley
    Northern Ireland Centre for Diet and Health, University of Ulster, Coleraine, Northern Ireland, UK
    Ann Nutr Metab 43:47-51. 1999
    ..Heart cells from cholesterol-fed hamsters, however, showed a significant decrease in tail DNA (p = 0.050) indicating decreased damage compared with controls and a possible protective effect of cholesterol against DNA damage...
  41. doi request reprint Riboflavin lowers blood pressure in cardiovascular disease patients homozygous for the 677C-->T polymorphism in MTHFR
    Geraldine Horigan
    Northern Ireland Centre for Food and Health NICHE, School of Biomedical Sciences, University of Ulster, Coleraine, Ireland
    J Hypertens 28:478-86. 2010
    ..The purpose was to examine the effect of intervention with riboflavin (a cofactor for MTHFR) on blood pressure in patients homozygous (TT genotype) for the common 677C-->T polymorphism in MTHFR...
  42. doi request reprint Studies of biomarker responses to intervention with vitamin B-12: a systematic review of randomized controlled trials
    Leane Hoey
    Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland, United Kingdom
    Am J Clin Nutr 89:1981S-1996S. 2009
    ..Furthermore, different biomarkers of vitamin B-12 status have not been systematically reviewed...
  43. ncbi request reprint Vitamin D deficiency is associated with inflammation in older Irish adults
    E Laird
    Institute of Molecular Medicine E L, A M M, School of Medicine, Trinity College, Dublin, Ireland Northern Ireland Centre for Food and Health H M, M W, L H, E M, J M W W, E C, J J S, University of Ulster, Coleraine, Londonderry BT52 1SA, Northern Ireland Department of Clinical Biochemistry M H, St James s Hospital, Dublin, Ireland and The Mercers Institute for Research on Ageing M C C, C C, St James s Hospital, Dublin, Ireland
    J Clin Endocrinol Metab 99:1807-15. 2014
    ..Few studies have investigated the relationship between vitamin D status and age-related immune dysfunction in humans...
  44. doi request reprint Supplementation with calcium and short-chain fructo-oligosaccharides affects markers of bone turnover but not bone mineral density in postmenopausal women
    Mary M Slevin
    Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland
    J Nutr 144:297-304. 2014
    ..This trial was registered at www.controlled-trials.com as ISRCTN63118444. ..
  45. ncbi request reprint Frequency of fruit and vegetable consumption and blood antioxidants in the Caerphilly cohort of older men
    J J Strain
    Northern Ireland Centre for Diet and Health NICHE, University of Ulster, Coleraine, Co Londonderry, UK
    Eur J Clin Nutr 54:828-33. 2000
    ....
  46. ncbi request reprint The effect of low-dose fish oil supplementation on serum growth factors in healthy humans
    J M Wallace
    Northern Ireland Centre for Diet and Health NICHE, University of Ulster, Coleraine, Northern Ireland, UK
    Eur J Clin Nutr 54:690-4. 2000
    ....
  47. pmc Habitual fish consumption does not prevent a decrease in LCPUFA status in pregnant women (the Seychelles Child Development Nutrition Study)
    M P Bonham
    Northern Ireland Centre for Food and Health NICHE, Department of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, Northern Ireland, UK
    Prostaglandins Leukot Essent Fatty Acids 78:343-50. 2008
    ..Overall the data suggest that high exposure to LCPUFAs from habitual fish consumption does not prevent the documented decrease in LCPUFA status in pregnancy that occurs as a result of foetal accretion in the third trimester of pregnancy...
  48. doi request reprint Salivary cortisol, stress and mood in healthy older adults: the Zenith study
    Ellen E A Simpson
    Psychology Research Institute and School of Psychology, University of Ulster, Northern Ireland, United Kingdom
    Biol Psychol 78:1-9. 2008
    ..Further, more extensive research is required to better understand the apparent interplay between these variables and ageing...
  49. ncbi request reprint Effect of vitamin D supplementation on vitamin D status and bone turnover markers in young adults
    M S Barnes
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland, UK
    Eur J Clin Nutr 60:727-33. 2006
    ..To assess the vitamin D status of healthy young people living in Northern Ireland and the effect of vitamin D supplementation on vitamin D status and bone turnover...
  50. ncbi request reprint Protocol for the production of concentrated extracts of food folate for use in human bioavailability studies
    Derek J McKillop
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland BT52 1SA
    J Agric Food Chem 51:4382-8. 2003
    ..Neither the mono- to polyglutamate ratio nor the distribution of the main folate derivatives was altered during processing, making these extracts suitable for use in human bioavailability studies...
  51. doi request reprint Obesity, whole blood serotonin and sex differences in healthy volunteers
    Stephanie Hodge
    Northern Ireland Centre for Food and Health NICHE, Carshalton, UK
    Obes Facts 5:399-407. 2012
    ..Reduced circulating serotonin may contribute to the development of obesity. This study aimed to explore associations between whole blood (WB) serotonin concentrations and anthropometric measures...
  52. ncbi request reprint Fitness, fatness, and coronary heart disease risk in adolescents: the Northern Ireland Young Hearts Project
    C Boreham
    Sport and Exercise Science Sports Studies, Faculty of Business and Management, University of Ulster, United Kingdom
    Med Sci Sports Exerc 33:270-4. 2001
    ..The purpose of this study was to examine the independence and relative strengths of association between coronary heart disease (CHD) risk status and both body fatness and cardiorespiratory (C-R) fitness in 12- and 15-yr-old adolescents...
  53. ncbi request reprint Total homocysteine is not a determinant of arterial pulse wave velocity in young healthy adults
    J V Woodside
    School of Medicine, Queen s University, Mulhouse Building, Grosvenor Road, Belfast BT126BJ, Northern Ireland, UK
    Atherosclerosis 177:337-44. 2004
    ..The aim of this study was to examine the association between total homocysteine (tHcy) concentrations, the biochemical and genetic determinants of tHcy and PWV in healthy young adults...
  54. doi request reprint Red meat from animals offered a grass diet increases plasma and platelet n-3 PUFA in healthy consumers
    A J McAfee
    School of Biomedical Sciences, Northern Ireland Centre for Food and Health, University of Ulster, Cromore Road, Coleraine BT52 1SA, Northern Ireland
    Br J Nutr 105:80-9. 2011
    ..As a result, red meat from grass-fed animals may contribute to dietary intakes of LC n-3 PUFA in populations where red meat is habitually consumed...
  55. ncbi request reprint Copper supplementation has no effect on markers of DNA damage and liver function in healthy adults (FOODCUE project)
    J M O'Connor
    Northern Ireland Centre for Food and Health NICHE, Department of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland
    Ann Nutr Metab 47:201-6. 2003
    ..The aim of this study was to provide data on how increased intake of copper affected mononuclear leukocyte DNA damage and liver function in healthy young free-living men and women...
  56. ncbi request reprint Nonalcoholic red wine extract and quercetin inhibit LDL oxidation without affecting plasma antioxidant vitamin and carotenoid concentrations
    M Chopra
    Northern Ireland Center for Diet and Health NICHE, University of Ulster, Coleraine BT52 1SA, Northern Ireland
    Clin Chem 46:1162-70. 2000
    ....
  57. ncbi request reprint Taste acuity in response to zinc supplementation in older Europeans
    Barbara J Stewart-Knox
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine BT52 1SA, UK
    Br J Nutr 99:129-36. 2008
    ..Supplemented Zn may have potential to enhance salt taste acuity in those over the age of 70 years. Further research is required to determine if enhanced salt taste acuity is reflected in the eating experiences of older individuals...
  58. ncbi request reprint Assessment of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D3 concentrations in male and female multiple sclerosis patients and control volunteers
    M S Barnes
    Northern Ireland Centre for Food and Health NICHE, University of Ulster, Coleraine BT52 1SA, Northern Ireland, UK
    Mult Scler 13:670-2. 2007
    ..677, P=0.001). Significant sex differences in vitamin D metabolism were observed and were most marked in individuals with MS, suggesting that vitamin D requirements may differ between the sexes, as well as by underlying disease state...
  59. ncbi request reprint Insulin-like growth factor-I (IGF-I) and its association with lymphocyte homeostasis in the ageing cat
    D J Campbell
    Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine, BT52 1SA, UK
    Mech Ageing Dev 125:497-505. 2004
    ..We propose that the observed association is not a direct effect of IGF-I on PBL, but may be mediated through an effect of IGF-I on the thymus...
  60. ncbi request reprint Birthweight and aerobic fitness in adolescents: the Northern Ireland Young Hearts Project
    C A Boreham
    Sports Studies, Faculty of Science, University of Ulster, Newtownabbey, Co Antrim, Northern Ireland, UK
    Public Health 115:373-9. 2001
    ..We are currently re-examining this cohort to see if, as with blood pressure, the association with fitness re-emerges at an older age...
  61. ncbi request reprint Impaired functioning of thermolabile methylenetetrahydrofolate reductase is dependent on riboflavin status: implications for riboflavin requirements
    Helene McNulty
    Northern Ireland Centre for Diet and Health, University of Ulster, Coleraine, United Kingdom
    Am J Clin Nutr 76:436-41. 2002
    ..A reduction in MTHFR activity, as occurs in the homozygous state for the 677C-->T (so-called thermolabile) enzyme variant (TT genotype), is associated with an increase in plasma total homocysteine (tHcy)...
  62. ncbi request reprint Zinc status and taste acuity in older Europeans: the ZENITH study
    B J Stewart-Knox
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland
    Eur J Clin Nutr 59:S31-6. 2005
    ..Age-related decline in taste acuity may be both a cause and an effect of depleted zinc and/or increased zinc requirement...
  63. ncbi request reprint Effect of riboflavin supplementation on plasma homocysteine in elderly people with low riboflavin status
    M C McKinley
    Northern Ireland Centre for Food and Health NICHE, University of Ulster, Coleraine, Northern Ireland
    Eur J Clin Nutr 56:850-6. 2002
    ..To investigate the effect of riboflavin supplementation on plasma homocysteine (tHcy) concentrations in healthy elderly people with sub-optimal riboflavin status...
  64. ncbi request reprint Assessment of ex vivo responses to T-cell mitogens and oxidative stress in lymphocytes from healthy adult and senior cats
    David J Campbell
    Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, Northern Ireland
    J Nutr 136:2084S-2086S. 2006
  65. ncbi request reprint An evaluation of the sensitivity and specificity of energy expenditure measured by heart rate and the Goldberg cut-off for energy intake: basal metabolic rate for identifying mis-reporting of energy intake by adults and children: a retrospective analysis
    M B E Livingstone
    Northern Ireland Centre for Diet and Health, University of Ulster, Coleraine, Co Londonderry, Northern Ireland, UK
    Eur J Clin Nutr 57:455-63. 2003
    ....
  66. ncbi request reprint Bioavailability of n-3 polyunsaturated fatty acids (PUFA) in foods enriched with microencapsulated fish oil
    J M Wallace
    Northern Ireland Centre for Diet and Health NICHE, University of Ulster, Coleraine, UK
    Ann Nutr Metab 44:157-62. 2000
    ..The aim of the present study was to evaluate the bioavailability of n-3 PUFA in microencapsulated fish-oil-enriched foods compared with an equal amount of n-3 PUFAs contained in fish oil capsules...
  67. ncbi request reprint Global DNA and p53 region-specific hypomethylation in human colonic cells is induced by folate depletion and reversed by folate supplementation
    Gillian R Wasson
    Centre for Molecular Biosciences, University of Ulster, Coleraine, Northern Ireland
    J Nutr 136:2748-53. 2006
    ..This study also introduces 2 novel functional biomarkers of DNA hypomethylation and demonstrates their suitability to detect folate depletion-induced molecular changes...
  68. ncbi request reprint Age-related differences in parameters of feline immune status
    D J Campbell
    Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, Northern Ireland
    Vet Immunol Immunopathol 100:73-80. 2004
    ..Our findings suggest that age-related changes to parameters of immune status in the feline model are likely to follow a similar pattern to those observed in other long-lived mammalian species...
  69. ncbi request reprint Zinc supplementation has no effect on circulating levels of peripheral blood leucocytes and lymphocyte subsets in healthy adult men
    Maxine Bonham
    Department of Biomedical Sciences, University of Ulster, Northern Ireland Centre for Food and Health NICHE, Coleraine BT52 1SA, Northern Ireland, UK
    Br J Nutr 89:695-703. 2003
    ..The seasonal variations observed in lymphocyte subsets in the group as a whole could have implications for seasonal variability in the incidence of infectious diseases...
  70. doi request reprint In vitro antioxidant activity and antigenotoxic effects of avenanthramides and related compounds
    Alison M Lee-Manion
    Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, United Kingdom
    J Agric Food Chem 57:10619-24. 2009
    ..Overall, results show that avenanthramides exert antioxidant and antigenotoxic activities that are comparable to those of ascorbic acid and which have the potential to exert beneficial physiological effects...
  71. ncbi request reprint The effect of nutrient intake on bone mineral status in young adults: the Northern Ireland young hearts project
    C E Neville
    School of Applied Medical Sciences and Sports Studies, University of Ulster, Jordanstown, Northern Ireland
    Calcif Tissue Int 70:89-98. 2002
    ..Intakes of Ca reported by adolescent males also had a strong negative effect on lumbar spine BMD measured at young adulthood...
  72. pmc Milk consumption, stroke, and heart attack risk: evidence from the Caerphilly cohort of older men
    P C Elwood
    University of Ulster, Coleraine, Northern Ireland
    J Epidemiol Community Health 59:502-5. 2005
    ..To examine associations between milk consumption and incident heart disease and stroke...
  73. ncbi request reprint The relationship between whole-blood serotonin and subjective mood in apparently healthy postmenopausal women
    Maresa E Duffy
    The Northern Ireland Centre for Food and Health NICHE, University of Ulster, Coleraine, Northern Ireland, UK
    Biol Psychol 73:165-8. 2006
    ..03). No association was apparent for negative affect. These findings indicate that WB 5-HT and positive affect are related in postmenopausal women...
  74. doi request reprint Attitudes toward genetic testing and personalised nutrition in a representative sample of European consumers
    Barbara J Stewart-Knox
    Northern Ireland Centre for Food, Health, University of Ulster, Coleraine, County Londonderry, UK
    Br J Nutr 101:982-9. 2009
    ..These findings are encouraging for the future application of personalised nutrition provided that policies are put in place to address public concern about how genetic information is used and held...
  75. ncbi request reprint A longitudinal study through adolescence to adulthood: the Young Hearts Project, Northern Ireland
    A M Gallagher
    Northern Ireland Centre for Diet and Health NICHE, School of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, UK
    Public Health 116:332-40. 2002
    ....
  76. ncbi request reprint Boron supplementation and activated factor VII in healthy men
    J M W Wallace
    Northern Ireland Centre for Diet and Health, University of Ulster, Coleraine, Northern Ireland, UK
    Eur J Clin Nutr 56:1102-7. 2002
    ..The aim of the present study was to determine whether postprandial concentrations of the active component of serine protease coagulation factor VII (VIIa) were lowered by acute boron supplementation in vivo...
  77. ncbi request reprint The effect of different cooking methods on folate retention in various foods that are amongst the major contributors to folate intake in the UK diet
    Derek J McKillop
    Northern Ireland Centre for Food and Health NICHE, University of Ulster, Coleraine, BT52 1SA, Northern Ireland, UK
    Br J Nutr 88:681-8. 2002
    ..Thus, public health efforts to increase folate intake in order to improve folate status should incorporate practical advice on cooking...
  78. pmc Detection of replicative integrity in small colonic biopsies using the BrdUrd comet assay
    A P McGlynn
    Cancer and Ageing Research Group, School of Biomedical Sciences, University of Ulster, Coleraine, County Londonderry, Northern Ireland, UK
    Br J Cancer 88:895-901. 2003
    ..Thus, the BrdUrd comet assay has the potential to facilitate trial investigations of diet- or environment-related factors that may affect replicative integrity in the colon and provides a novel biomarker for colon carcinogenesis...
  79. ncbi request reprint Inter-relationships between DNA damage, ascorbic acid and glycaemic control in Type 2 diabetes mellitus
    S W Choi
    Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Kowloon, Hong Kong
    Diabet Med 22:1347-53. 2005
    ....
  80. ncbi request reprint Importance of both folic acid and vitamin B12 in reduction of risk of vascular disease
    E P Quinlivan
    Lancet 359:227-8. 2002
    ....
  81. ncbi request reprint Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults
    Leo A J Kluijtmans
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Blood 101:2483-8. 2003
    ..These data underscore the potential benefits that may be gained by improving the dietary status of young adults, and provide support for the implementation of folate/B-vitamin food fortification programs...
  82. ncbi request reprint Socio-economic position and coronary heart disease risk factors in youth. Findings from the Young Hearts Project in Northern Ireland
    F J van Lenthe
    Department of Public Health, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands
    Eur J Public Health 11:43-50. 2001
    ..CONCLUSION: Differences in lifestyle by socio-economic position seem to become established in adolescence. These differences however, are not (yet) reflected in differences in biological risk factors by socio-economic position...
  83. ncbi request reprint Riboflavin, flavin mononucleotide, and flavin adenine dinucleotide in human plasma and erythrocytes at baseline and after low-dose riboflavin supplementation
    Steinar Hustad
    LOCUS for Homocysteine and Related Vitamins, University of Bergen, Armauer Hansens Hus, N 5021 Bergen, Norway
    Clin Chem 48:1571-7. 2002
    ..We investigated the relationships of EGRAC and plasma and erythrocyte concentrations of riboflavin, FMN, and FAD in elderly volunteers and their responses to riboflavin administration...
  84. ncbi request reprint Genetic evidence that nitric oxide modulates homocysteine: the NOS3 894TT genotype is a risk factor for hyperhomocystenemia
    Karen S Brown
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Arterioscler Thromb Vasc Biol 23:1014-20. 2003
    ..Nitric oxide may also modulate plasma homocysteine (tHcy) concentrations, either by direct inhibition of methionine synthase or via an indirect effect on folate catabolism...
  85. ncbi request reprint Association between the NAT1 1095C > A polymorphism and homocysteine concentration
    Anna Stanisławska-Sachadyn
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6084, USA
    Am J Med Genet A 140:2374-7. 2006
  86. ncbi request reprint Nutrient and methyl mercury exposure from consuming fish
    Gary J Myers
    Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Nutr 137:2805-8. 2007
    ..Preliminary findings from this study suggest that the beneficial influence of nutrients from fish may counter any adverse effects of MeHg on the developing nervous system...
  87. doi request reprint Evidence for sex differences in the determinants of homocysteine concentrations
    Anna Stanisławska-Sachadyn
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Mol Genet Metab 93:355-62. 2008
    ..Among females, smokers (regardless of MTHFR genotype) appear to be at the highest risk, and to be the most vulnerable to a single factor (i.e. RBC folate) that is associated with homocysteine raising effects...
  88. doi request reprint An insertion/deletion polymorphism of the dihydrofolate reductase (DHFR) gene is associated with serum and red blood cell folate concentrations in women
    Anna Stanisławska-Sachadyn
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA, 19104 6084, USA
    Hum Genet 123:289-95. 2008
    ....
  89. ncbi request reprint Effect of copper supplementation on indices of copper status and certain CVD risk markers in young healthy women
    Susanne Bugel
    Department of Human Nutrition and Centre for Advanced Food Studies, Royal Veterinary and Agricultural University, Rolighedsvej 30, DK 1958 Frederiksberg C, Denmark
    Br J Nutr 94:231-6. 2005
    ..The results indicate that supplementation with 3 or 6 mg Cu/d may improve Cu status in these healthy young women. Increased Cu intake could reduce the risk of CVD and atherosclerosis in man by promoting improved fibrinolytic capacity...
  90. ncbi request reprint A common insertion/deletion polymorphism of the thymidylate synthase (TYMS) gene is a determinant of red blood cell folate and homocysteine concentrations
    Carmel Kealey
    Department of Pharmacology, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Hum Genet 116:347-53. 2005
    ....
  91. ncbi request reprint Vitamins C and E: acute interactive effects on biomarkers of antioxidant defence and oxidative stress
    S W Choi
    Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Kowloon, Hong Kong
    Mutat Res 551:109-17. 2004
    ....
  92. ncbi request reprint The thymidylate synthase tandem repeat polymorphism is not associated with homocysteine concentrations in healthy young subjects
    Karen S Brown
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Hum Genet 114:182-5. 2004
    ..Our findings indicate that the TYMS 3R3R genotype is not a determinant of homocysteine in this sample of healthy young Caucasian adults from Northern Ireland...
  93. ncbi request reprint Effect of high-dose iron supplements on fractional zinc absorption and status in pregnant women
    Linda J Harvey
    Institute of Food Research, Norwich Research Park, Colney, Norwich, United Kingdom
    Am J Clin Nutr 85:131-6. 2007
    ..Iron supplements are commonly advocated as a prophylactic treatment and are generally taken with meals to reduce side effects, but iron can interfere with the absorption of zinc...
  94. ncbi request reprint The 5,10-methylenetetrahydrofolate reductase C677T polymorphism interacts with smoking to increase homocysteine
    Karen S Brown
    Department of Pharmacology and Center for Pharmacogenetics, University of Pennsylvania School of Medicine, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Atherosclerosis 174:315-22. 2004
    ..We propose that hyperhomocysteinemia in MTHFR 677TT homozygote smokers is the consequence of mild intracellular folate deficiency caused by a smoking-related reduction of NOS3 activity that is exacerbated when serum folate is low...
  95. ncbi request reprint Long-term high copper intake: effects on indexes of copper status, antioxidant status, and immune function in young men
    Judith R Turnlund
    US Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, University of California, Davis 95616, USA
    Am J Clin Nutr 79:1037-44. 2004
    ..Short-term high copper intake does not appear to affect indexes of copper status or functions related to copper status, but the effects of long-term high copper intake are unknown...
  96. ncbi request reprint The immune system as a physiological indicator of marginal copper status?
    Maxine Bonham
    Northern Ireland Centre for Diet and Health NICHE, University of Ulster at Coleraine BT52 1SA, UK
    Br J Nutr 87:393-403. 2002
    ..The indices of immune function reviewed are neutrophil function, interleukin 2 production, blastogenic response to mitogens and lymphocyte subset phenotyping...
  97. doi request reprint Acute hyperglycemia and oxidative stress: direct cause and effect?
    Siu Wai Choi
    Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Kowloon, Hong Kong
    Free Radic Biol Med 44:1217-31. 2008
    ....
  98. ncbi request reprint Determination of an acute no-observed-adverse-effect level (NOAEL) for copper in water
    M Araya
    Institute of Nutrition and Food Technology (INTA, University of Chile, Macul 5540, Casilla 138 11, Santiago 11, Chile
    Regul Toxicol Pharmacol 34:137-45. 2001
    ..Therefore, an acute NOAEL and lowest-observed-adverse-effect level of 4 and 6 mg Cu/L (0.8 and 1.2 mg Cu), respectively, were determined in drinking water for a combined international human population...
  99. ncbi request reprint Nutritional factors may modify the toxic action of methyl mercury in fish-eating populations
    Thomas W Clarkson
    Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    J Nutr 133:1539S-43S. 2003
    ..This article discusses the potential role of micronutrients in fish as a plausible explanation for these findings...
  100. ncbi request reprint Confirmation of an acute no-observed-adverse-effect and low-observed-adverse-effect level for copper in bottled drinking water in a multi-site international study
    Magdalena Araya
    Institute of Nutrition and Food Technology INTA, University of Chile, Macul 5540, Casilla 13811, Santiago, 11, Chile
    Regul Toxicol Pharmacol 38:389-99. 2003
    ..8mg Cu (4mg Cu/L) for adult females. These data confirm a previously determined human acute NOAEL for Cu added to distilled water, and provide additional, controlled human data for determining safe concentrations of Cu in drinking water...