Robert A Stockley

Summary

Affiliation: University of Birmingham
Country: UK

Publications

  1. pmc Predictors of mortality in alpha1-antitrypsin deficiency
    P A Dawkins
    Lung Investigation Unit, Queen Elizabeth Hospital, Birmingham, UK
    Thorax 58:1020-6. 2003
  2. pmc Relationship between airway inflammation and the frequency of exacerbations in patients with smoking related COPD
    S Gompertz
    Department of Respiratory Medicine, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
    Thorax 56:36-41. 2001
  3. ncbi request reprint Effect of expectoration on inflammation in induced sputum in alpha-1-antitrypsin deficiency
    Simon Gompertz
    Department of Respiratory Medicine, University Hospitals, Birmingham, England, UK
    Respir Med 100:1094-9. 2006
  4. ncbi request reprint Alpha-1-antitrypsin replacement therapy: current status
    Hatem Abusriwil
    Lung Investigation Unit, Nuffield House, Queen Elizabeth Hospital, University Hospital Birmingham NHS Trust, Birmingham, UK
    Curr Opin Pulm Med 12:125-31. 2006
  5. ncbi request reprint Reported and unreported exacerbations of COPD: analysis by diary cards
    Kesavaperumal Vijayasaratha
    Lung Investigations Unit, University Hospital Birmingham NHS Trust, Birmingham, UK
    Chest 133:34-41. 2008
  6. pmc Augmentation therapy for alpha-1 antitrypsin deficiency: towards a personalised approach
    Robert A Stockley
    Lung Investigation Unit, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham B15 2WB, UK
    Orphanet J Rare Dis 8:149. 2013
  7. pmc Wnt signalling in lung development and diseases
    Judit E Pongracz
    Department of Immunology and Biotechnology, University of Pecs, Pecs, Hungary
    Respir Res 7:15. 2006
  8. pmc Exploring the optimum approach to the use of CT densitometry in a randomised placebo-controlled study of augmentation therapy in alpha 1-antitrypsin deficiency
    David G Parr
    Department of Respiratory Medicine, University Hospitals of Coventry and Warwickshire, Clifford Bridge Road, Coventry CV22DX, UK
    Respir Res 10:75. 2009
  9. pmc Inflammation in sputum relates to progression of disease in subjects with COPD: a prospective descriptive study
    David G Parr
    Department of Respiratory Medicine, University Hospitals of Coventry and Warwickshire, Clifford Bridge Road, Coventry, CV2 2DX, UK
    Respir Res 7:136. 2006
  10. pmc Detection of emphysema progression in alpha 1-antitrypsin deficiency using CT densitometry; methodological advances
    David G Parr
    Department of Respiratory Medicine, University Hospitals of Coventry and Warwickshire, Clifford Bridge Road, Coventry, CV2 2DX, UK
    Respir Res 9:21. 2008

Collaborators

Detail Information

Publications97

  1. pmc Predictors of mortality in alpha1-antitrypsin deficiency
    P A Dawkins
    Lung Investigation Unit, Queen Elizabeth Hospital, Birmingham, UK
    Thorax 58:1020-6. 2003
    ..The aim of this study was to investigate the predictive potential of several parameters, including CT scanning, for mortality in patients with severe alpha(1)-antitrypsin deficiency...
  2. pmc Relationship between airway inflammation and the frequency of exacerbations in patients with smoking related COPD
    S Gompertz
    Department of Respiratory Medicine, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
    Thorax 56:36-41. 2001
    ....
  3. ncbi request reprint Effect of expectoration on inflammation in induced sputum in alpha-1-antitrypsin deficiency
    Simon Gompertz
    Department of Respiratory Medicine, University Hospitals, Birmingham, England, UK
    Respir Med 100:1094-9. 2006
    ..The presence of chronic expectoration in some patients will clearly complicate interpretation of studies employing sputum induction where this feature has not been identified...
  4. ncbi request reprint Alpha-1-antitrypsin replacement therapy: current status
    Hatem Abusriwil
    Lung Investigation Unit, Nuffield House, Queen Elizabeth Hospital, University Hospital Birmingham NHS Trust, Birmingham, UK
    Curr Opin Pulm Med 12:125-31. 2006
    ..We will comment briefly on the pathogenesis and epidemiology of the disease together with new therapeutic approaches currently under intense research...
  5. ncbi request reprint Reported and unreported exacerbations of COPD: analysis by diary cards
    Kesavaperumal Vijayasaratha
    Lung Investigations Unit, University Hospital Birmingham NHS Trust, Birmingham, UK
    Chest 133:34-41. 2008
    ..Exacerbations of COPD are a major cause of morbidity and mortality; however, it has been reported that nearly half of such episodes based on symptoms are classified as "unreported" (no change in treatment), although the reasons are unknown...
  6. pmc Augmentation therapy for alpha-1 antitrypsin deficiency: towards a personalised approach
    Robert A Stockley
    Lung Investigation Unit, Queen Elizabeth Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham B15 2WB, UK
    Orphanet J Rare Dis 8:149. 2013
    ....
  7. pmc Wnt signalling in lung development and diseases
    Judit E Pongracz
    Department of Immunology and Biotechnology, University of Pecs, Pecs, Hungary
    Respir Res 7:15. 2006
    ..In this review, we will present a synopsis of current Wnt research with particular attention paid to the role of Wnt signals in lung development and in pulmonary diseases...
  8. pmc Exploring the optimum approach to the use of CT densitometry in a randomised placebo-controlled study of augmentation therapy in alpha 1-antitrypsin deficiency
    David G Parr
    Department of Respiratory Medicine, University Hospitals of Coventry and Warwickshire, Clifford Bridge Road, Coventry CV22DX, UK
    Respir Res 10:75. 2009
    ....
  9. pmc Inflammation in sputum relates to progression of disease in subjects with COPD: a prospective descriptive study
    David G Parr
    Department of Respiratory Medicine, University Hospitals of Coventry and Warwickshire, Clifford Bridge Road, Coventry, CV2 2DX, UK
    Respir Res 7:136. 2006
    ..We performed a prospective longitudinal study of subjects with COPD that related markers of sputum inflammation at baseline to subsequent disease progression...
  10. pmc Detection of emphysema progression in alpha 1-antitrypsin deficiency using CT densitometry; methodological advances
    David G Parr
    Department of Respiratory Medicine, University Hospitals of Coventry and Warwickshire, Clifford Bridge Road, Coventry, CV2 2DX, UK
    Respir Res 9:21. 2008
    ..However, emphysema is frequently localised to sub-regions of the lung and targeted densitometric sampling may be more informative than whole lung assessment...
  11. pmc Addition of salmeterol to existing treatment in patients with COPD: a 12 month study
    R A Stockley
    Department of Medicine, Queen Elizabeth Hospital, Birmingham B15 2HT, UK
    Thorax 61:122-8. 2006
    ..This study investigated the addition of salmeterol to existing treatment for exacerbations in patients with poorly reversible chronic obstructive pulmonary disease (COPD)...
  12. ncbi request reprint Ongoing research in Europe: Alpha One International Registry (AIR) objectives and development
    R A Stockley
    Dept of Medicine, University Hospital Birmingham, Edgbaston, Birmingham, B15 2TH, UK
    Eur Respir J 29:582-6. 2007
    ..The success related to the convergence of national registries into a common database creating a unique registry beyond geographic boundaries and encompassing alpha1-antitrypsin deficiency from various ethnic groups...
  13. pmc Therapeutic efficacy of α-1 antitrypsin augmentation therapy on the loss of lung tissue: an integrated analysis of 2 randomised clinical trials using computed tomography densitometry
    Robert A Stockley
    Lung Investigation Unit, University Hospitals of Birmingham, Edgbaston, Birmingham B15 2TH, UK
    Respir Res 11:136. 2010
    ..Two randomised, double-blind, placebo-controlled trials have investigated the efficacy of IV alpha-1 antitrypsin (AAT) augmentation therapy on emphysema progression using CT densitometry...
  14. pmc Improved outcomes in patients with chronic obstructive pulmonary disease treated with salmeterol compared with placebo/usual therapy: results of a meta-analysis
    Robert A Stockley
    Queen Elizabeth Hospital, Birmingham, UK
    Respir Res 7:147. 2006
    ....
  15. ncbi request reprint The effect of augmentation therapy on bronchial inflammation in alpha1-antitrypsin deficiency
    Robert A Stockley
    Department of Medicine, Queen Elizabeth Hospital, Edgbaston, Birmingham, United Kingdom
    Am J Respir Crit Care Med 165:1494-8. 2002
    ..In summary, short-term therapy with AAT increased lung secretion concentrations and was associated with a fall in leukotriene B(4), which is thought to be central to the airway inflammation of AAT deficiency...
  16. ncbi request reprint Progression of chronic obstructive pulmonary disease: impact of inflammation, comorbidities and therapeutic intervention
    Robert A Stockley
    University Hospital Birmingham NHS Foundation Trust, Birmingham, UK
    Curr Med Res Opin 25:1235-45. 2009
    ..This review examines evidence linking inflammation, disease progression and comorbidities in COPD, and the potential role of anti-inflammatory therapies...
  17. ncbi request reprint Neutrophils and the pathogenesis of COPD
    Robert A Stockley
    Lung Resource Center, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK
    Chest 121:151S-155S. 2002
  18. pmc Assessment of airway neutrophils by sputum colour: correlation with airways inflammation
    R A Stockley
    Department of Medicine, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK
    Thorax 56:366-72. 2001
    ..We hypothesised that gradations of sputum colour would correlate directly with the myeloperoxidase content of sputum and with various other indicators of the activity and consequences of bronchial diseases...
  19. pmc The TNFalpha gene relates to clinical phenotype in alpha-1-antitrypsin deficiency
    Alice M Wood
    Division of Medical Sciences, The Medical School, University of Birmingham, Birmingham, B15 2TT, UK
    Respir Res 9:52. 2008
    ..This study investigated subjects with AATD to determine the relationship between specific phenotypes and TNFalpha polymorphisms...
  20. doi request reprint Phenotypic differences in alpha 1 antitrypsin-deficient sibling pairs may relate to genetic variation
    Alice M Wood
    Department of Medical Sciences, University of Birmingham, Birmingham, UK
    COPD 5:353-9. 2008
    ..01). Our results show that clinical differences in families with alpha-1-antitrypsin deficiency are not solely explained by smoking or ascertainment bias and may be due to variation within genes involved in inflammatory pathways...
  21. pmc Relationship between frequency, length, and treatment outcome of exacerbations to baseline lung function and lung density in alpha-1 antitrypsin-deficient COPD
    Kesavaperumal Vijayasaratha
    Lung Investigation Unit, University Hospital Birmingham NHS Trust, UK
    Int J Chron Obstruct Pulmon Dis 7:789-96. 2012
    ..This study investigated factors that influence the features of exacerbations in patients with alpha-1 antitrypsin (AAT) deficiency (PiZ phenotype) and COPD...
  22. doi request reprint Studies of gamma-glutamyl transferase in alpha-1 antitrypsin deficiency
    Jayne Holme
    Lung Investigation Unit, 1st floor Nuffield House, Queen Elizabeth Hospital, University Hospital Birmingham NHS Foundation Trust, Birmingham, UK
    COPD 7:126-32. 2010
    ..Further studies are needed to establish the role of GGT in oxidative lung injury, and its use as a potential biomarker in chronic inflammatory lung disease...
  23. ncbi request reprint Alpha one antitrypsin deficiency: from gene to treatment
    Alice M Wood
    Department of Medical Sciences, University of Birmingham, Birmingham, UK
    Respiration 74:481-92. 2007
    ..Specific treatments for the disorder based on this knowledge will be reviewed, including alpha1-antitrypsin replacement, gene therapy and possible future therapies, such as those based on stem cells...
  24. doi request reprint Behavioral and structural differences in migrating peripheral neutrophils from patients with chronic obstructive pulmonary disease
    Elizabeth Sapey
    Department of Clinical and Experimental Medicine, First Floor, Nuffield House, University of Birmingham, Edgbaston, Birmingham B15 2TH, UK
    Am J Respir Crit Care Med 183:1176-86. 2011
    ..This is critical, because inaccurate or excessive neutrophil chemotaxis could drive pathological accumulation and tissue damage...
  25. ncbi request reprint Radiologic and clinical features of COPD patients with discordant pulmonary physiology: lessons from alpha1-antitrypsin deficiency
    Jayne Holme
    University Hospital Birmingham, Birmingham, UK
    Chest 132:909-15. 2007
    ..We investigated differences in emphysema distribution and health status in alpha(1)-antitrypsin deficient subjects (PiZ) with discordant lung function...
  26. ncbi request reprint CT scan appearance, densitometry, and health status in protease inhibitor SZ alpha1-antitrypsin deficiency
    Jayne Holme
    University Hospital Birmingham NHS Foundation Trust, The University of Birmingham, Birmingham, UK
    Chest 136:1284-90. 2009
    ....
  27. ncbi request reprint The relationship of chronic sputum expectoration to physiologic, radiologic, and health status characteristics in alpha(1)-antitrypsin deficiency (PiZ)
    Lee J Dowson
    Lung Investigation Unit, Nuffield House, Queen Elizabeth University Hospital, Birmingham B15 2TH, UK
    Chest 122:1247-55. 2002
    ..Second, to use multivariate analysis to determine how these factors influence health status...
  28. ncbi request reprint Longitudinal changes in physiological, radiological, and health status measurements in alpha(1)-antitrypsin deficiency and factors associated with decline
    L J Dowson
    Lung Investigation Unit, Nuffield House, Queen Elizabeth Hospital, Birmingham, United Kingdom
    Am J Respir Crit Care Med 164:1805-9. 2001
    ..002). Progression of emphysema in alpha(1)-ATD is dependent on baseline physiology and exacerbation frequency and may be detected by several different measurements of which HRCT density mask analysis and DL(CO) appear most sensitive...
  29. doi request reprint Proteinase 3 activity in sputum from subjects with alpha-1-antitrypsin deficiency and COPD
    Nicola J Sinden
    Centre for Translational Inflammation Research, University of Birmingham Research Laboratories, Queen Elizabeth Hospital, Birmingham, UK
    Eur Respir J 41:1042-50. 2013
    ..The regular identification of PR3 activity in sputum from stable subjects with A1AT deficiency or usual COPD suggests it may play a greater role in the pathophysiology than previously thought...
  30. ncbi request reprint Influence of calibration on densitometric studies of emphysema progression using computed tomography
    David G Parr
    Lung Investigation Unit, First Floor, Nuffield House, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
    Am J Respir Crit Care Med 170:883-90. 2004
    ..Internal air calibration is therefore critical in longitudinal and multicenter lung densitometry studies of emphysema and incorporation of a correction factor is essential for quantitative image analysis...
  31. doi request reprint The fibrinogen cleavage product Aα-Val360, a specific marker of neutrophil elastase activity in vivo
    Richard I Carter
    Lung Function and Sleep Department, ADAPT Office Office 4, Queen Elizabeth Hospital, Birmingham B15 2WB, UK
    Thorax 66:686-91. 2011
    ....
  32. ncbi request reprint Pattern of emphysema distribution in alpha1-antitrypsin deficiency influences lung function impairment
    David G Parr
    Lung Investigation Unit, First Floor, Nuffield House, Queen Elizabeth Hospital, Birmingham, UK B15 2TH
    Am J Respir Crit Care Med 170:1172-8. 2004
    ..409, p < 0.001). The use of single physiologic parameters as a surrogate measure of emphysema severity may introduce systematic bias in the staging of subjects with emphysema...
  33. ncbi request reprint Inter-relationships between inflammatory markers in patients with stable COPD with bronchitis: intra-patient and inter-patient variability
    E Sapey
    Department of Respiratory Medicine, First Floor, Nuffield House, University Hospital Birmingham, Edgbaston, Birmingham B15 2TH, UK
    Thorax 63:493-9. 2008
    ..A study was undertaken to examine the intra- and inter-patient variability in spontaneous sputum samples from patients in the stable state and to describe the relationship between biomarkers, cell counts and markers of disease...
  34. pmc Effect of sputum processing with dithiothreitol on the detection of inflammatory mediators in chronic bronchitis and bronchiectasis
    I S Woolhouse
    Department of Medicine, Queen Elizabeth Hospital, Birmingham, UK
    Thorax 57:667-71. 2002
    ..However, it is not known whether dithiothreitol (DTT), a reducing mucolytic agent regularly used to homogenise sputum, affects the detection of inflammatory mediators in the sputum soluble phase from such patients...
  35. doi request reprint Aα-Val360: a marker of neutrophil elastase and COPD disease activity
    Richard I Carter
    University of Birmingham Research Laboratories, Queen Elizabeth Hospital Birmingham, Birmingham, UK
    Eur Respir J 41:31-8. 2013
    ..This study therefore reports the first in vivo data to support the pathophysiological role of NE in COPD...
  36. ncbi request reprint Variability of sputum inflammatory mediators in COPD and α1-antitrypsin deficiency
    Helen Stone
    School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, B15 2TT, UK
    Eur Respir J 40:561-9. 2012
    ..This can be utilised to perform power calculations for future proof of concept studies; averaging three sequential samples appears optimum...
  37. doi request reprint Matrix metalloprotease polymorphisms are associated with gas transfer in alpha 1 antitrypsin deficiency
    Christopher J McAloon
    Lung Investigation Unit, University Hospital Birmingham, Birmingham, UK
    Ther Adv Respir Dis 3:23-30. 2009
    ..Matrix metalloproteinases [MMPs] are believed to be important in the pathophysiology of COPD, and may therefore confer susceptibility to this phenotype in patients with AATD...
  38. doi request reprint Recent advances in α-1-antitrypsin deficiency-related lung disease
    Judith A Brebner
    The ADAPT Project, Lung Function and Sleep Department, University Hospital Birmingham, Mindelsohn Way, Edgbaston, Birmingham, B15 2WB, UK
    Expert Rev Respir Med 7:213-29; quiz 230. 2013
    ..In this article, the authors review the recent advances in this field and outline potential future directions of research in A1ATD...
  39. pmc Chronic Obstructive Pulmonary Disease, inflammation and co-morbidity--a common inflammatory phenotype?
    Martin J Sevenoaks
    Department of Medicine, Queen Elizabeth Hospital Birmingham, UK
    Respir Res 7:70. 2006
    ..This article describes the mechanisms involved and proposes a common inflammatory TNF-alpha phenotype that may, in part, account for the associations...
  40. ncbi request reprint Outdoor air pollution is associated with rapid decline of lung function in alpha-1-antitrypsin deficiency
    Alice M Wood
    School of Medicine and Dental Sciences, University of Birmingham, Birmingham, UK
    Occup Environ Med 67:556-61. 2010
    ..Patients with alpha-1-antitrypsin deficiency (AATD) typically exhibit faster decline of lung function than subjects with usual COPD and thus represent a group in whom studies of factors influencing decline may be more easily clarified...
  41. ncbi request reprint Imbalances between interleukin-1 and tumor necrosis factor agonists and antagonists in stable COPD
    Elizabeth Sapey
    Department of Medicine, University of Birmingham, Birmingham, UK
    J Clin Immunol 29:508-16. 2009
    ..It is unclear if concentrations relate to disease severity. The study aimed to investigate these relationships and to assess the potential activity of each cytokine in the context of their antagonists...
  42. ncbi request reprint Early donor management increases the retrieval rate of lungs for transplantation
    Rajamiyer V Venkateswaran
    Department of Cardiothoracic Surgery Heart and Lung Transplantation Unit, University Hospital Birmingham NHS Foundation Trust, Birmingham, United Kingdom
    Ann Thorac Surg 85:278-86; discussion 286. 2008
    ..Lung transplantation activity is frustrated by donor lung availability. We sought to examine the effect of active donor management and hormone administration on pulmonary function and yield in cadaveric heart-beating potential lung donors...
  43. ncbi request reprint Exacerbations in {alpha}1-antitrypsin deficiency
    M Needham
    Respiratory Medicine, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
    Eur Respir J 25:992-1000. 2005
    ..Despite lung function decline, patients do not show a progressive loss in health status...
  44. pmc Sputum chemotactic activity in chronic obstructive pulmonary disease: effect of alpha(1)-antitrypsin deficiency and the role of leukotriene B(4) and interleukin 8
    I S Woolhouse
    Department of Medicine, Queen Elizabeth Hospital, Birmingham, UK
    Thorax 57:709-14. 2002
    ..However, the chemoattractant nature of secretions from these patients has yet to be clarified...
  45. ncbi request reprint Exercise capacity predicts health status in alpha(1)-antitrypsin deficiency
    L J Dowson
    Lung Investigation Unit, Nuffield House, Queen Elizabeth University Hospital, Birmingham, United Kingdom
    Am J Respir Crit Care Med 163:936-41. 2001
    ..Although both HRCT and lung function relate to health status, exercise capacity is the best predictor of patients disability in these patients with predominantly lower zone emphysema...
  46. pmc COPD exacerbations . 2: aetiology
    E Sapey
    Lung Investigation Unit, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
    Thorax 61:250-8. 2006
    ..Important aetiologies, with their potential underlying mechanisms, are discussed and the significance of each aetiology is considered...
  47. pmc Validation of computed tomographic lung densitometry for monitoring emphysema in alpha1-antitrypsin deficiency
    D G Parr
    Lung Investigation Unit, First Floor, Nuffield House, Queen Elizabeth Hospital, Birmingham B15 2TH, UK, and Department of Radiology, Leiden University Medical Centre, The Netherlands
    Thorax 61:485-90. 2006
    ..We related progression of densitometry (15th percentile point and voxel index, threshold -950 Hounsfield units) to disease stage and FEV1 decline in two studies of subjects with alpha1-antitrypsin deficiency (PiZ)...
  48. ncbi request reprint Exacerbations of COPD diagnosed in primary care: changes in spirometry and relationship to symptoms
    Andrew J White
    Department of Respiratory Medicine, Queen Elizabeth Hospital, Edgbaston, Birmingham, B15 2TH, United Kingdom
    COPD 2:419-25. 2005
    ..However, exacerbations characterized by increased breathlessness are associated with increases in airflow obstruction that may be influenced by sputum characteristics and/or changes in airway reactivity...
  49. ncbi request reprint Alpha1-antitrypsin review
    Robert A Stockley
    ADAPT Project, Lung Function and Sleep Department, Queen Elizabeth Hospital Birmingham, Ground Floor, Out patients Area 3, Mindelsohn Way, Edgbaston, Birmingham B15 2WB, UK Electronic address
    Clin Chest Med 35:39-50. 2014
    ..Early detection and modification of lifestyle remains crucial to the management of AAT deficiency. ..
  50. ncbi request reprint Myeloid related protein-8/14 stimulates interleukin-8 production in airway epithelial cells
    Ali Ahmad
    Respiratory Research Laboratory, Department of Medicine, University of Birmingham, Birmingham B15 2TT, UK
    Am J Respir Cell Mol Biol 29:523-30. 2003
    ....
  51. doi request reprint Systemic inflammation and comorbidity in COPD: a result of 'overspill' of inflammatory mediators from the lungs? Review of the evidence
    Nicola J Sinden
    Lung Investigation Unit, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK
    Thorax 65:930-6. 2010
    ..This paper considers the concept of 'overspill' in depth, reviews the current evidence and highlights problems in generating direct evidence to support or refute this concept...
  52. ncbi request reprint Modification of gene expression and increase in alpha1-antitrypsin (alpha1-AT) secretion after homologous recombination in alpha1-AT-deficient monocytes
    Gillian L McNab
    Department of Respiratory Medicine, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Hum Gene Ther 18:1171-7. 2007
    ..The development of this methodology to repair the gene defect in hepatocytes should have beneficial effects on secretion, thereby protecting both the lung and liver...
  53. doi request reprint Gamma-glutamyl transferase: the silent partner?
    Dippica Mistry
    University of Birmingham, UK
    COPD 7:285-90. 2010
    ..Future studies of systemic and local GGT function and genotypes in well characterised patients may lead to a better understanding of the processes involved and hence the development of new treatment strategies...
  54. ncbi request reprint IgA1 protease
    Dippica Mistry
    Respiratory Research Laboratory, Department of Medicine, University of Birmingham, Birmingham B15 2TT, UK
    Int J Biochem Cell Biol 38:1244-8. 2006
    ..The development of strategies to inactivate these IgA1 proteases has become the subject of recent research, as this has the potential to reduce bacterial colonisation at mucosal surfaces...
  55. ncbi request reprint Outdoor air pollution is associated with disease severity in alpha1-antitrypsin deficiency
    A M Wood
    Division of Medical Sciences, University Hospitals Birmingham, Birmingham, UK
    Eur Respir J 34:346-53. 2009
    ..Higher exposures to ozone may be associated with worse respiratory status in alpha(1)-antitrypsin deficiency, identifying a group susceptible to ambient air pollution...
  56. ncbi request reprint High-resolution computed tomography scanning in alpha1-antitrypsin deficiency: relationship to lung function and health status
    L J Dowson
    Lung Investigation Unit, Queen Elizabeth Hospital, Birmingham, UK
    Eur Respir J 17:1097-104. 2001
    ....
  57. ncbi request reprint Changes in bronchial inflammation during acute exacerbations of chronic bronchitis
    S Gompertz
    Dept of Respiratory Medicine, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK
    Eur Respir J 17:1112-9. 2001
    ..Purulent exacerbations are related to bacterial infection, and are associated with increased neutrophilic inflammation and increased leukotriene B4 concentrations...
  58. ncbi request reprint Pulmonary infection in Wegener granulomatosis and idiopathic pulmonary fibrosis
    A G Richter
    Lung Investigation Unit, 1st floor Nuffield House, Birmingham, UK
    Thorax 64:692-7. 2009
    ..Wegener granulomatosis (WG) has previously been associated with increased nasal carriage of Staphylococcus aureus, but no studies have investigated the occurrence of pathogen growth in the lower airways...
  59. doi request reprint Vitamin D-binding protein contributes to COPD by activation of alveolar macrophages
    A M Wood
    School of Clinical and Experimental Medicine, University of Birmingham, Birmingham B15 2TT, UK
    Thorax 66:205-10. 2011
    ..DBP has an indirect role in macrophage activation; thus it was hypothesised that DBP is present in the airway and contributes to lung disease by this mechanism...
  60. ncbi request reprint Chronic obstructive pulmonary disease, neutrophils and bacteria: from science to integrated care pathways
    R A Stockley
    Queen Elizabeth Hospital, Edgbaston, Birmingham
    Clin Med 4:567-72. 2004
    ..This simple clinical observation enables decision making about the need for antibiotic therapy to be as much a part of patient self-management as physician directed management in the integrated care pathway for COPD...
  61. doi request reprint Smoke exposure as a determinant of autoantibody titre in α₁-antitrypsin deficiency and COPD
    A M Wood
    College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    Eur Respir J 37:32-8. 2011
    ..Smoke exposure is the main determinant of anti-elastin antibody levels, which fall after 10 pack-yrs. Local antibody complexes may be a better measure of elastin directed autoimmunity than circulating levels...
  62. doi request reprint Rate of progression of lung function impairment in alpha1-antitrypsin deficiency
    P A Dawkins
    Lung Investigation Unit, UniversityHospital Birmingham and University of Birmingham, Birmingham, UK
    Eur Respir J 33:1338-44. 2009
    ..In PiZ alpha(1)-AT-deficient patients, FEV(1) decline was greatest in moderate disease, unlike K(CO) decline, which was greatest in severe disease. The FEV(1) decline showed associations with BDR, BMI, sex and exacerbation rate...
  63. doi request reprint Alpha-1 antitrypsin deficiency: the European experience
    Robert A Stockley
    Lung Investigation Unit, University Hospital Birmingham NHS Trust, Birmingham, United Kingdom
    COPD 10:50-3. 2013
    ..The establishment of a worldwide registry remains central to the future of understanding and managing AATD...
  64. pmc Neutrophil elastase reduces secretion of secretory leukoproteinase inhibitor (SLPI) by lung epithelial cells: role of charge of the proteinase-inhibitor complex
    Anita L Sullivan
    Department of Respiratory Medicine, University Hospitals Birmingham, Birmingham, UK
    Respir Res 9:60. 2008
    ..A fall in SLPI concentration is also seen in culture supernatants of respiratory cells exposed to NE, for unknown reasons. We investigated the hypothesis that SLPI complexed with NE associates with cell membranes in vitro...
  65. ncbi request reprint Emerging drugs for alpha-1-antitrypsin deficiency
    Robert A Stockley
    University of Birmingham, Queen Elizabeth Hospital, Department of Medical Sciences, Edgbaston, Birmingham, B15 2TH, UK
    Expert Opin Emerg Drugs 15:685-94. 2010
    ..These strategies may have benefits beyond A1AT deficiency...
  66. pmc Exercise training and inspiratory muscle training in patients with bronchiectasis
    C Newall
    Department of Respiratory Medicine, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
    Thorax 60:943-8. 2005
    ..The role of pulmonary rehabilitation (PR) and inspiratory muscle training (IMT) has not been investigated in this group of patients...
  67. ncbi request reprint Validation of assays for inflammatory mediators in exhaled breath condensate
    D L Bayley
    Dept of Medicine, University of Birmingham, Edgbaston, Birmingham, B15 2TH, UK
    Eur Respir J 31:943-8. 2008
    ....
  68. doi request reprint Bronchiectasis in older patients with chronic obstructive pulmonary disease : prevalence, diagnosis and therapeutic management
    Deborah Whitters
    Department of Lung Function and Sleep, University Hospitals Birmingham NHS Foundation Trust, Queen Elizabeth Hospital, Mindelsohn Way, Edgbaston, Birmingham, B15 2WB, UK
    Drugs Aging 30:215-25. 2013
    ..Here, we review the factors associated with bronchiectasis in older patients with COPD and the evidence for many of the therapies currently used in the treatment of patients, providing a rational approach to their management...
  69. ncbi request reprint A randomized, placebo-controlled trial of a leukotriene synthesis inhibitor in patients with COPD
    Simon Gompertz
    Department of Respiratory Medicine, Queen Elizabeth Hospital, Birmingham, UK
    Chest 122:289-94. 2002
    ..A small phase II trial was conducted to assess the effects of a leukotriene synthesis inhibitor on bronchial inflammation in patients with stable COPD...
  70. doi request reprint Burden and pathogenesis of chronic obstructive pulmonary disease
    Robert A Stockley
    University Hospital Birmingham NHS Foundation Trust, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK
    Proc Am Thorac Soc 6:524-6. 2009
    ..Molecular studies provide new insights that may lead to specific therapies to halt progression...
  71. ncbi request reprint The interaction of host and pathogen factors in chronic obstructive pulmonary disease exacerbations and their role in tissue damage
    Hatem Abusriwil
    The University of Birmingham and University Hospital Birmingham Foundation Trust, Birmingham, United Kingdom
    Proc Am Thorac Soc 4:611-7. 2007
    ..Finally, controlled clinical trials will be required to demonstrate that modifying inflammation influences long-term progression...
  72. ncbi request reprint Leukotriene B4
    S W Crooks
    Department of Medicine, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK
    Int J Biochem Cell Biol 30:173-8. 1998
    ....
  73. pmc Symptom resolution assessed using a patient directed diary card during treatment of acute exacerbations of chronic bronchitis
    I S Woolhouse
    Department of Medicine, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
    Thorax 56:947-53. 2001
    ..Larger numbers may be required to demonstrate a statistically (if not clinically) significant difference...
  74. ncbi request reprint The link between chronic periodontitis and COPD: a common role for the neutrophil?
    Adam K H Usher
    Lung Investigation Unit, Queen Elizabeth Hospital, Mindelsohn Way, Edgbaston, Birmingham B15 2WB, UK
    BMC Med 11:241. 2013
    ..However, the nature of any relationship between them is unclear, but if pathophysiologically established may have wide-reaching implications for targeted treatments to improve outcomes and prognosis...
  75. ncbi request reprint Disease 'Activity', 'Severity' and 'Impact': Interrelationships in COPD; Is a Measure of Disease 'Activity' the Holy Grail for COPD, or a Variable Impossible to Quantify?
    Richard I Carter
    1Centre for Translational Inflammation Research, University of Birmingham Research Laboratories, Birmingham, United Kingdom
    COPD 11:363-7. 2014
    ....
  76. pmc Chronic obstructive pulmonary disease: an update of treatment related to frequently associated comorbidities
    Nicola J Sinden
    Nicola J Sinden, MBChB Honours, MRCP UK University Hospital Birmingham NHS Foundation Trust Respiratory Medicine, Birmingham, UK
    Ther Adv Chronic Dis 1:43-57. 2010
    ..In this review we explore the concepts of systemic inflammation in COPD and current evidence for treatment of its related comorbidities...
  77. doi request reprint A novel model and molecular therapy for Z alpha-1 antitrypsin deficiency
    Gillian L McNab
    Department of Respiratory Medicine, Centre for Translational Inflammation, University of Birmingham Research Laboratories, Queen Elizabeth Hospital, Mindelsohn Way, Birmingham, B15 2WB, UK
    Mamm Genome 23:241-9. 2012
    ..2 ± 0.01) to that of "M" (20.2 ± 0.02). The data support the concept that the murine "Z" gene is a potential model for the study of α(1)ATD and that mice expressing this gene would be relevant for testing treatments in vivo...
  78. pmc The genetics of chronic obstructive pulmonary disease
    Alice M Wood
    Department of Medical Sciences, University of Birmingham, Birmingham, UK
    Respir Res 7:130. 2006
    ..The main methods of genomic research for complex disease traits are described, together with the genes implicated in COPD thus far, their roles in disease causation and the future for this area of investigation...
  79. doi request reprint An evaluation of measured and calculated serum free cortisol in a group of patients with known adrenal suppression
    Nicola L Barlow
    Regional Endocrine Laboratory, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK
    Ann Clin Biochem 47:200-4. 2010
    ..However, measurement of SFC is technically difficult and calculated SFC may offer a more practical alternative...
  80. ncbi request reprint The cleavage specificity of an IgA1 protease from Haemophilus influenzae
    Dippica V Mistry
    Respiratory Research, Cardiovascular and Respiratory Sciences, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK
    Virulence 2:103-10. 2011
    ..Further work will be required in order to design specific inhibitors to this important class of proteolytic enzymes...
  81. pmc Resolution of bronchial inflammation is related to bacterial eradication following treatment of exacerbations of chronic bronchitis
    A J White
    Department of Respiratory Medicine, Queen Elizabeth Hospital, Birmingham B15 2TH, UK
    Thorax 58:680-5. 2003
    ..Changes in bronchial inflammation in response to the success or failure of bacterial eradication following AECB were therefore studied...
  82. pmc Chronic obstructive pulmonary disease . 6: The aetiology of exacerbations of chronic obstructive pulmonary disease
    A J White
    Department of Respiratory Medicine, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK
    Thorax 58:73-80. 2003
    ..Future studies need to define populations clearly, stratify for known confounding factors, and should aim to identify clinical correlates so that clinical practice can be modified appropriately...
  83. pmc Alpha 1-antitrypsin deficiency. 3: Clinical manifestations and natural history
    M Needham
    Department of Respiratory Medicine, Queen Elizabeth Hospital, Birmingham, UK
    Thorax 59:441-5. 2004
    ..A review of the clinical manifestations of alpha(1)-antitrypsin (AAT) deficiency, including lung disease and liver disease, and risk factors affecting the rate of decline in lung function in AAT deficient patients...
  84. ncbi request reprint Effect of storage and postage on recovery and quantitation of bacteria in sputum samples
    A Pye
    Respiratory Research Laboratory, Department of Medicine, Queen Elizabeth Hospital, and The University of Birmingham, Edgbaston, Birmingham B15 2TH, UK
    J Clin Pathol 61:352-4. 2008
    ..The aims of the study were to compare bacterial recovery following storage of sputum samples at 20 degrees C room temperature and 4 degrees C (refrigerated) for 24 h, and to determine the effect of postage on viable bacterial numbers...
  85. ncbi request reprint Endothelial interactions of neutrophils under flow in chronic obstructive pulmonary disease
    I S Woolhouse
    Dept of Respiratory Medicine, University Hospital Birmingham, Birmingham B29 6JD, UK
    Eur Respir J 25:612-7. 2005
    ....
  86. ncbi request reprint Proteases and antiproteases
    R A Stockley
    Department of Medicine, Queen Elizabeth Hospital, Edgbaston, Birmingham B15 2TH, UK
    Novartis Found Symp 234:189-99; discussion 199-204. 2001
    ..The migration into and activation of neutrophils in the lung is likely to be a major determinant of the development of COPD. Understanding the processes has important implications for the design of new therapeutic strategies...
  87. doi request reprint Adrenal suppression in bronchiectasis and the impact of inhaled corticosteroids
    J Holme
    Dept of Endocrinology, Division of Medical Sciences, University of Birmingham, Birmingham, UK
    Eur Respir J 32:1047-52. 2008
    ..Impairment of the cortisol response to stimulation is associated with poorer health status...
  88. doi request reprint The vitamin D axis in the lung: a key role for vitamin D-binding protein
    L Chishimba
    Lung Investigation Unit, University Hospitals Birmingham, Birmingham B15 2TH, UK
    Thorax 65:456-62. 2010
    ..This article reviews the evidence of the role VDBP and its gene (GC) in a range of lung diseases, including asthma, COPD and tuberculosis...
  89. ncbi request reprint Panniculitis secondary to extravasation of clarithromycin in a patient with alpha 1-antitrypsin deficiency (phenotype PiZ)
    D G Parr
    Department of Pulmonology, University Hospital Birmingham, Birmingham, UK
    Br J Dermatol 149:410-3. 2003
    ..Resolution occurred with conservative management. The histopathology and management of this unusual condition are discussed, with a review of the literature...
  90. ncbi request reprint Alpha-1-antitrypsin genotyping with mouthwash specimens
    R A Stockley
    Dept. of Medicine, Queen Elizabeth Hospital, Birmingham, UK
    Eur Respir J 17:356-9. 2001
    ..The results raise the possibility that other deficiency alleles are more common than has previously been suspected...
  91. ncbi request reprint Inflammatory markers in bacterial exacerbations of COPD
    Timothy F Murphy
    Am J Respir Crit Care Med 165:132. 2002
  92. ncbi request reprint The prevention of chronic obstructive pulmonary disease exacerbations by salmeterol/fluticasone propionate or tiotropium bromide
    Jadwiga A Wedzicha
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, University College London, London, UK
    Am J Respir Crit Care Med 177:19-26. 2008
    ..Exacerbations are key drivers of morbidity and mortality in chronic obstructive pulmonary disease (COPD)...
  93. ncbi request reprint Bacterial load and exacerbations of COPD
    Hatem Abusriwil
    Am J Respir Crit Care Med 177:1048-9; author reply 1049. 2008
  94. ncbi request reprint Variability in densitometric assessment of pulmonary emphysema with computed tomography
    M Els Bakker
    Division of Image Processing, Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands, and the Department of Respiratory Medicine, Gentofte Hospital, Hellerup, Denmark
    Invest Radiol 40:777-83. 2005
    ....
  95. ncbi request reprint Progression parameters for emphysema: a clinical investigation
    Jan Stolk
    Department of Pulmonology, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    Respir Med 101:1924-30. 2007
    ..5-fold more sensitive using lung densitometry than by using currently recommended lung function parameters. Our results support CT scan as an efficacious test for novel drugs for emphysema...
  96. ncbi request reprint "Knock-out" mouse: down but not out
    Robert A Stockley
    Am J Respir Crit Care Med 168:145-6. 2003
  97. ncbi request reprint Prevalence and impact of bronchiectasis in alpha1-antitrypsin deficiency
    David G Parr
    Department of Respiratory Medicine, University Hospitals of Coventry and Warwickshire, Coventry CV2 2DX, UK
    Am J Respir Crit Care Med 176:1215-21. 2007
    ..alpha(1)-Antitrypsin (AAT) deficiency is associated with increased risk of chronic obstructive pulmonary disease (COPD), in particular emphysema, but airway disease is less well described...