Rebecca Stewart

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi request reprint Mechanisms of self-renewal in human embryonic stem cells
    Rebecca Stewart
    Centre for Stem Cell Biology and Developmental Genetics, Institute of Human Genetics, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK
    Eur J Cancer 42:1257-72. 2006
  2. ncbi request reprint An autogeneic feeder cell system that efficiently supports growth of undifferentiated human embryonic stem cells
    Petra Stojkovic
    Centre for Stem Cell Biology and Developmental Genetics, University of Newcastle, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK
    Stem Cells 23:306-14. 2005
  3. ncbi request reprint Human-serum matrix supports undifferentiated growth of human embryonic stem cells
    Petra Stojkovic
    Centre for Stem Cell Biology and Developmental Genetics, Institute of Human Genetics, University of Newcastle, Newcastle upon Tyne, UK
    Stem Cells 23:895-902. 2005
  4. ncbi request reprint The role of PI3K/AKT, MAPK/ERK and NFkappabeta signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis
    Lyle Armstrong
    Centre for Stem Cell Biology and Developmental Genetics, Institute of Human Genetics, University of Newcastle, Central Parkways, Newcastle upon Tyne, UK
    Hum Mol Genet 15:1894-913. 2006
  5. ncbi request reprint Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells
    Gabriele Saretzki
    Crucible Lab, Institute of Human Genetics, Central Parkway, Newcastle upon Tyne NE1 3BZ, United Kingdom
    Stem Cells 26:455-64. 2008
  6. ncbi request reprint Derivation of human embryonic stem cells from day-8 blastocysts recovered after three-step in vitro culture
    Miodrag Stojkovic
    Institute of Human Genetics, University of Newcastle, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK
    Stem Cells 22:790-7. 2004
  7. ncbi request reprint Differentiation of human embryonic stem cells into corneal epithelial-like cells by in vitro replication of the corneal epithelial stem cell niche
    Sajjad Ahmad
    Centre for Stem Cell Biology and Developmental Genetics, University of Newcastle, Newcastle upon Tyne, United Kingdom
    Stem Cells 25:1145-55. 2007
  8. ncbi request reprint Non-neural adult stem cells: tools for brain repair?
    Rebecca Stewart
    School of Biological and Biomedical Science, University of Durham, UK
    Bioessays 24:708-13. 2002
  9. ncbi request reprint Manipulation of human pluripotent embryonal carcinoma stem cells and the development of neural subtypes
    Rebecca Stewart
    School of Biological and Biomedical Sciences, University of Durham, Durham, United Kingdom
    Stem Cells 21:248-56. 2003
  10. ncbi request reprint Formation of neurospheres from human embryonal carcinoma stem cells
    Grace M Horrocks
    School of Biological and Biomedical Sciences, University of Durham, South Road, Durham, DH1 3LE, UK
    Biochem Biophys Res Commun 304:411-6. 2003

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Mechanisms of self-renewal in human embryonic stem cells
    Rebecca Stewart
    Centre for Stem Cell Biology and Developmental Genetics, Institute of Human Genetics, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK
    Eur J Cancer 42:1257-72. 2006
    ..In this review, we discuss the intrinsic and extrinsic factors associated with self-renewal process, together with possible signalling pathway interactions and mechanisms of regulation...
  2. ncbi request reprint An autogeneic feeder cell system that efficiently supports growth of undifferentiated human embryonic stem cells
    Petra Stojkovic
    Centre for Stem Cell Biology and Developmental Genetics, University of Newcastle, Central Parkway, Newcastle upon Tyne NE1 3BZ, UK
    Stem Cells 23:306-14. 2005
    ..Feeder cells derived from hESCs offers a potentially more secure autogeneic and genotypically homogenous system for the growth of undifferentiated hESCs...
  3. ncbi request reprint Human-serum matrix supports undifferentiated growth of human embryonic stem cells
    Petra Stojkovic
    Centre for Stem Cell Biology and Developmental Genetics, Institute of Human Genetics, University of Newcastle, Newcastle upon Tyne, UK
    Stem Cells 23:895-902. 2005
    ....
  4. ncbi request reprint The role of PI3K/AKT, MAPK/ERK and NFkappabeta signalling in the maintenance of human embryonic stem cell pluripotency and viability highlighted by transcriptional profiling and functional analysis
    Lyle Armstrong
    Centre for Stem Cell Biology and Developmental Genetics, Institute of Human Genetics, University of Newcastle, Central Parkways, Newcastle upon Tyne, UK
    Hum Mol Genet 15:1894-913. 2006
    ..Disruption of these pathways in isolation using specific inhibitors resulted in loss of pluripotency and/or loss of viability suggesting the importance of such signalling pathways in embryonic stem cell maintenance...
  5. ncbi request reprint Downregulation of multiple stress defense mechanisms during differentiation of human embryonic stem cells
    Gabriele Saretzki
    Crucible Lab, Institute of Human Genetics, Central Parkway, Newcastle upon Tyne NE1 3BZ, United Kingdom
    Stem Cells 26:455-64. 2008
    ..These results confirm earlier data obtained during mouse embryonic stem cell differentiation and are in accordance with evolutionary predictions...
  6. ncbi request reprint Derivation of human embryonic stem cells from day-8 blastocysts recovered after three-step in vitro culture
    Miodrag Stojkovic
    Institute of Human Genetics, University of Newcastle, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK
    Stem Cells 22:790-7. 2004
    ..The pluripotency of the cell line was confirmed by the formation of teratomas after injection into severely combined immunodeficient mice and spontaneous differentiation under in vitro conditions...
  7. ncbi request reprint Differentiation of human embryonic stem cells into corneal epithelial-like cells by in vitro replication of the corneal epithelial stem cell niche
    Sajjad Ahmad
    Centre for Stem Cell Biology and Developmental Genetics, University of Newcastle, Newcastle upon Tyne, United Kingdom
    Stem Cells 25:1145-55. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  8. ncbi request reprint Non-neural adult stem cells: tools for brain repair?
    Rebecca Stewart
    School of Biological and Biomedical Science, University of Durham, UK
    Bioessays 24:708-13. 2002
    ....
  9. ncbi request reprint Manipulation of human pluripotent embryonal carcinoma stem cells and the development of neural subtypes
    Rebecca Stewart
    School of Biological and Biomedical Sciences, University of Durham, Durham, United Kingdom
    Stem Cells 21:248-56. 2003
    ..These experiments demonstrate that cultured human EC stem cells provide a robust model cell system capable of reproducibly forming neural subtypes for research purposes...
  10. ncbi request reprint Formation of neurospheres from human embryonal carcinoma stem cells
    Grace M Horrocks
    School of Biological and Biomedical Sciences, University of Durham, South Road, Durham, DH1 3LE, UK
    Biochem Biophys Res Commun 304:411-6. 2003
    ..In this study, we describe the development of novel procedures to enhance neuronal productivity with dramatically increased efficiency, which will be of value for research purposes and drug discovery programmes...
  11. ncbi request reprint Ontogeny of Xenopus NK cells in the absence of MHC class I antigens
    Trudy L Horton
    School of Biological and Biomedical Sciences, University of Durham, Durham DH1 3LE, UK
    Dev Comp Immunol 27:715-26. 2003
    ....
  12. doi request reprint A key role for telomerase reverse transcriptase unit in modulating human embryonic stem cell proliferation, cell cycle dynamics, and in vitro differentiation
    Chunbo Yang
    North East Institute for Stem Cell Research, Newcastle upon Tyne NE1 3BZ, United Kingdom
    Stem Cells 26:850-63. 2008
    ..Our results indicate for the first time an important role for TERT in the maintenance of human ESC pluripotency, cell cycle regulation, and in vitro differentiation capacity...
  13. doi request reprint Epigenetic marking prepares the human HOXA cluster for activation during differentiation of pluripotent cells
    Stuart P Atkinson
    North East Institute for Stem Cell Research, University of Newcastle upon Tyne, International Centre for Life, Newcastle upon Tyne, United Kingdom
    Stem Cells 26:1174-85. 2008
    ..The precise locations of such modified histones may be involved in controlling the colinear expression of genes from the cluster...
  14. doi request reprint Silencing of the expression of pluripotent driven-reporter genes stably transfected into human pluripotent cells
    Rebecca Stewart
    North East Institute for Stem Cell Research, Newcastle University International Centre for Life, Newcastle NE13BZ, UK
    Regen Med 3:505-22. 2008
    ..Our aim was to use core promoter regions from such pluripotent genes to drive expression of reporter genes that would be suitable for human ES cell selection amongst differentiated cells...