Adam Stevens

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. ncbi request reprint Dissociation of steroid receptor coactivator 1 and nuclear receptor corepressor recruitment to the human glucocorticoid receptor by modification of the ligand-receptor interface: the role of tyrosine 735
    Adam Stevens
    Endocrine Sciences Research Group, Faculty of Medicine, University of Manchester, United Kingdom
    Mol Endocrinol 17:845-59. 2003
  2. ncbi request reprint Glucocorticoid sensitivity is determined by a specific glucocorticoid receptor haplotype
    Adam Stevens
    Endocrine Sciences Research Group and Centre for Molecular Medicine, Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester M13 9PT, United Kingdom
    J Clin Endocrinol Metab 89:892-7. 2004
  3. ncbi request reprint Glucocorticoid ligands specify different interactions with NF-kappaB by allosteric effects on the glucocorticoid receptor DNA binding domain
    Helen Garside
    Centre for Molecular Medicine and Endocrine Sciences Research Group, Stopford Building, Faculty of Medicine, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom
    J Biol Chem 279:50050-9. 2004
  4. ncbi request reprint Regulation of glucocorticoid receptor gamma (GRgamma) by glucocorticoid receptor haplotype and glucocorticoid
    Adam Stevens
    Endocrine Sciences Research Group, Faculty of Medicine, University of Manchester, Manchester, UK
    Clin Endocrinol (Oxf) 61:327-31. 2004
  5. pmc Identification and functional analysis of SKA2 interaction with the glucocorticoid receptor
    Lisa Rice
    Faculty of Medical and Human Sciences, School of Medicine, University of Manchester, Manchester M13 9PT, UK
    J Endocrinol 198:499-509. 2008
  6. ncbi request reprint Mutation screening of the macrophage migration inhibitory factor gene: positive association of a functional polymorphism of macrophage migration inhibitory factor with juvenile idiopathic arthritis
    Rachelle Donn
    Epidemiology Unit, Arthritis Research Campaign, University of Manchester, Manchester, UK
    Arthritis Rheum 46:2402-9. 2002
  7. ncbi request reprint Haplotype analysis of the polymorphic human vascular endothelial growth factor gene promoter
    Adam Stevens
    Endocrine Sciences Research Group, University of Manchester, Manchester M13 9PT, United Kingdom
    Cancer Res 63:812-6. 2003
  8. doi request reprint Epigenetic changes in the hypothalamic proopiomelanocortin and glucocorticoid receptor genes in the ovine fetus after periconceptional undernutrition
    Adam Stevens
    Faculties of Life Sciences and Medical and Human Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester M13 9PT, UK
    Endocrinology 151:3652-64. 2010
  9. doi request reprint Glucocorticoid receptor-mediated apoptosis: mechanisms of resistance in cancer cells
    George Schlossmacher
    Endocrinology and Diabetes, Faculty of Life Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester M13 9PT, UK
    J Endocrinol 211:17-25. 2011
  10. ncbi request reprint Use of gene expression profiling to identify a novel glucocorticoid sensitivity determining gene, BMPRII
    Rachelle Donn
    Centre for Molecular Medicine, University of Manchester, Oxford Rd, Manchester, M13 9PT, UK
    FASEB J 21:402-14. 2007

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Dissociation of steroid receptor coactivator 1 and nuclear receptor corepressor recruitment to the human glucocorticoid receptor by modification of the ligand-receptor interface: the role of tyrosine 735
    Adam Stevens
    Endocrine Sciences Research Group, Faculty of Medicine, University of Manchester, United Kingdom
    Mol Endocrinol 17:845-59. 2003
    ..As both SRC1 and NCoR are predicted to recognize a common hydrophobic cleft in the GR, it seems that changes favorable to one interaction are detrimental to the other, thus identifying a molecular switch...
  2. ncbi request reprint Glucocorticoid sensitivity is determined by a specific glucocorticoid receptor haplotype
    Adam Stevens
    Endocrine Sciences Research Group and Centre for Molecular Medicine, Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester M13 9PT, United Kingdom
    J Clin Endocrinol Metab 89:892-7. 2004
    ..This haplotype may help predetermine variation in clinical response to GC therapy and also assist the understanding of diseases related to GC production...
  3. ncbi request reprint Glucocorticoid ligands specify different interactions with NF-kappaB by allosteric effects on the glucocorticoid receptor DNA binding domain
    Helen Garside
    Centre for Molecular Medicine and Endocrine Sciences Research Group, Stopford Building, Faculty of Medicine, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom
    J Biol Chem 279:50050-9. 2004
    ..This has implications for understanding ligand-dependent interdomain communication...
  4. ncbi request reprint Regulation of glucocorticoid receptor gamma (GRgamma) by glucocorticoid receptor haplotype and glucocorticoid
    Adam Stevens
    Endocrine Sciences Research Group, Faculty of Medicine, University of Manchester, Manchester, UK
    Clin Endocrinol (Oxf) 61:327-31. 2004
    ..Therefore we proposed that the GR haplotype affects glucocorticoid sensitivity either by influencing GRgamma expression basally, or in response to Gc exposure...
  5. pmc Identification and functional analysis of SKA2 interaction with the glucocorticoid receptor
    Lisa Rice
    Faculty of Medical and Human Sciences, School of Medicine, University of Manchester, Manchester M13 9PT, UK
    J Endocrinol 198:499-509. 2008
    ..Our new data show involvement in cell proliferation and GC signalling, with implications for understanding how GCs impact on cell fate...
  6. ncbi request reprint Mutation screening of the macrophage migration inhibitory factor gene: positive association of a functional polymorphism of macrophage migration inhibitory factor with juvenile idiopathic arthritis
    Rachelle Donn
    Epidemiology Unit, Arthritis Research Campaign, University of Manchester, Manchester, UK
    Arthritis Rheum 46:2402-9. 2002
    ..To determine if polymorphisms of the macrophage migration inhibitory factor (MIF) gene are associated with juvenile idiopathic arthritis (JIA)...
  7. ncbi request reprint Haplotype analysis of the polymorphic human vascular endothelial growth factor gene promoter
    Adam Stevens
    Endocrine Sciences Research Group, University of Manchester, Manchester M13 9PT, United Kingdom
    Cancer Res 63:812-6. 2003
    ..Therefore, carriage of the -460/+405 polymorphism significantly alters VEGF promoter activity and responsiveness. This has implications for the inherited susceptibility of common diseases...
  8. doi request reprint Epigenetic changes in the hypothalamic proopiomelanocortin and glucocorticoid receptor genes in the ovine fetus after periconceptional undernutrition
    Adam Stevens
    Faculties of Life Sciences and Medical and Human Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester M13 9PT, UK
    Endocrinology 151:3652-64. 2010
    ..These epigenetic changes in GR and POMC in the hypothalamus may also predispose the offspring to altered regulation of food intake, energy expenditure, and glucose homeostasis later in life...
  9. doi request reprint Glucocorticoid receptor-mediated apoptosis: mechanisms of resistance in cancer cells
    George Schlossmacher
    Endocrinology and Diabetes, Faculty of Life Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester M13 9PT, UK
    J Endocrinol 211:17-25. 2011
    ....
  10. ncbi request reprint Use of gene expression profiling to identify a novel glucocorticoid sensitivity determining gene, BMPRII
    Rachelle Donn
    Centre for Molecular Medicine, University of Manchester, Oxford Rd, Manchester, M13 9PT, UK
    FASEB J 21:402-14. 2007
    ..Furthermore, this combined gene profiling, and functional analysis approach has identified BMPRII as a modulator of Gc signaling...