F A Stephenson

Summary

Affiliation: University of London
Country: UK

Publications

  1. ncbi Structure and trafficking of NMDA and GABAA receptors
    F A Stephenson
    School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Biochem Soc Trans 34:877-81. 2006
  2. ncbi Assembly and forward trafficking of NMDA receptors (Review)
    F Anne Stephenson
    School of Pharmacy, University of London, London, UK
    Mol Membr Biol 25:311-20. 2008
  3. ncbi Foreword: trafficking, assembly and regulation of neurotransmitter receptors and ion channels
    F Anne Stephenson
    School of Pharmacy, University of London, London, UK
    Mol Membr Biol 25:267-9. 2008
  4. ncbi Delineation of additional PSD-95 binding domains within NMDA receptor NR2 subunits reveals differences between NR2A/PSD-95 and NR2B/PSD-95 association
    S L Cousins
    School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Neuroscience 158:89-95. 2009
  5. ncbi The integrity of the glycine co-agonist binding site of N-methyl-D-aspartate receptors is a functional quality control checkpoint for cell surface delivery
    Anna V Kenny
    School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, United Kingdom
    J Biol Chem 284:324-33. 2009
  6. ncbi Subunit characterization of NMDA receptors
    F A Stephenson
    Department of Pharmaceutical and Biological Chemistry, School of Pharmacy, University of London, UK
    Curr Drug Targets 2:233-9. 2001
  7. ncbi Differential interaction of NMDA receptor subtypes with the post-synaptic density-95 family of membrane associated guanylate kinase proteins
    Sarah L Cousins
    School of Pharmacy, University of London, London, UK
    J Neurochem 104:903-13. 2008
  8. ncbi Biochemical evidence for the co-association of three N-methyl-D-aspartate (NMDA) R2 subunits in recombinant NMDA receptors
    L M Hawkins
    Department of Pharmaceutical and Biological Chemistry, School of Pharmacy, 29 39 Brunswick Square, London WC1N 1AX, United Kingdom
    J Biol Chem 274:27211-8. 1999
  9. ncbi Optimal expression of cloned NMDAR1/NMDAR2A heteromeric glutamate receptors: a biochemical characterization
    M Cik
    Department of Pharmaceutical Chemistry, School of Pharmacy, London, U K
    Biochem J 296:877-83. 1993
  10. ncbi Molecular characterization of N-methyl-D-aspartate receptors expressed in mammalian cells yields evidence for the coexistence of three subunit types within a discrete receptor molecule
    P L Chazot
    Department of Pharmaceutical Chemistry, School of Pharmacy, London, United Kingdom
    J Biol Chem 269:24403-9. 1994

Collaborators

  • C L Thompson
  • L Groc
  • David S Bredt
  • Paul Chazot
  • Masahiko Watanabe
  • Kate Prybylowski
  • Robert J Wenthold
  • Sarah L Cousins
  • Michalis Papadakis
  • Lynda M Hawkins
  • A Richard Rutter
  • Anna V Kenny
  • S L Cousins
  • Macarena Peran
  • Maria Isabel Aller
  • Marco Sassoè-Pognetto
  • Fumino Fujiyama
  • Leonor Pinho
  • A V Kenny
  • L M Hawkins
  • Kai Chang
  • Helen Hooper
  • Caroline Moussan
  • Ramiro Salas
  • Sharon L Rayner
  • Arsenio Fernandez-Lopez
  • Simon Pollard
  • Paola Camoletto
  • Miguel Angel Paniagua
  • Ole P Ottersen
  • Jo K Utvik
  • J Paul Bolam
  • Fiona M Freeman
  • M Cik

Detail Information

Publications23

  1. ncbi Structure and trafficking of NMDA and GABAA receptors
    F A Stephenson
    School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Biochem Soc Trans 34:877-81. 2006
    ..In the present paper, processes regulating the trafficking, assembly and molecular organization of both NMDA receptors and GABAA receptors will be discussed...
  2. ncbi Assembly and forward trafficking of NMDA receptors (Review)
    F Anne Stephenson
    School of Pharmacy, University of London, London, UK
    Mol Membr Biol 25:311-20. 2008
    ....
  3. ncbi Foreword: trafficking, assembly and regulation of neurotransmitter receptors and ion channels
    F Anne Stephenson
    School of Pharmacy, University of London, London, UK
    Mol Membr Biol 25:267-9. 2008
  4. ncbi Delineation of additional PSD-95 binding domains within NMDA receptor NR2 subunits reveals differences between NR2A/PSD-95 and NR2B/PSD-95 association
    S L Cousins
    School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    Neuroscience 158:89-95. 2009
    ..These results suggest that NR2A and NR2B may associate with PSD-95 but with different affinities. This may be important in the determination of the lateral mobility of NMDA receptor subtypes in post-synaptic membranes...
  5. ncbi The integrity of the glycine co-agonist binding site of N-methyl-D-aspartate receptors is a functional quality control checkpoint for cell surface delivery
    Anna V Kenny
    School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, United Kingdom
    J Biol Chem 284:324-33. 2009
    ..These findings demonstrate that integrity of the glycine co-agonist binding site is a functional checkpoint requisite for efficient cell surface trafficking of assembled NMDA receptors...
  6. ncbi Subunit characterization of NMDA receptors
    F A Stephenson
    Department of Pharmaceutical and Biological Chemistry, School of Pharmacy, University of London, UK
    Curr Drug Targets 2:233-9. 2001
    ..This article summarizes knowledge on the subunit compositions of NMDA receptors based on these approaches together with the current status of NMDA receptor subunit stoichiometry and hence quaternary structure. of native NMDA receptors...
  7. ncbi Differential interaction of NMDA receptor subtypes with the post-synaptic density-95 family of membrane associated guanylate kinase proteins
    Sarah L Cousins
    School of Pharmacy, University of London, London, UK
    J Neurochem 104:903-13. 2008
    ..This has implications for the stabilisation, turnover and compartmentalisation of NMDA receptor subtypes in neurones during development and in the mature brain...
  8. ncbi Biochemical evidence for the co-association of three N-methyl-D-aspartate (NMDA) R2 subunits in recombinant NMDA receptors
    L M Hawkins
    Department of Pharmaceutical and Biological Chemistry, School of Pharmacy, 29 39 Brunswick Square, London WC1N 1AX, United Kingdom
    J Biol Chem 274:27211-8. 1999
    ..These results, taken together with those previously described that showed two NR1 subunits/oligomer, suggest that the NMDA receptor is at least pentameric...
  9. ncbi Optimal expression of cloned NMDAR1/NMDAR2A heteromeric glutamate receptors: a biochemical characterization
    M Cik
    Department of Pharmaceutical Chemistry, School of Pharmacy, London, U K
    Biochem J 296:877-83. 1993
    ..Furthermore, the conditions reported for maximal transient expression provide a basis for further structure-activity studies...
  10. ncbi Molecular characterization of N-methyl-D-aspartate receptors expressed in mammalian cells yields evidence for the coexistence of three subunit types within a discrete receptor molecule
    P L Chazot
    Department of Pharmaceutical Chemistry, School of Pharmacy, London, United Kingdom
    J Biol Chem 269:24403-9. 1994
    ..These results show that the three NMDA receptor subunit types can co-assemble following their co-expression in mammalian cells with a pharmacological profile that is similar to that found for adult cerebellar NMDA receptors...
  11. ncbi Biochemical evidence for the existence of a pool of unassembled C2 exon-containing NR1 subunits of the mammalian forebrain NMDA receptor
    P L Chazot
    Department of Pharmaceutical and Biological Chemistry, School of Pharmacy, London, England
    J Neurochem 68:507-16. 1997
    ..These results are consistent with the identification of a pool of unassembled C2 exon-containing NR1 subunits, i.e., NR1-1a, NR1-1b, NR1-2a, and NR1-2b, selectively solubilised by 1% Triton X-100/1 M NaCl...
  12. ncbi Decreased expression of GABAA receptor alpha6 and beta3 subunits in stargazer mutant mice: a possible role for brain-derived neurotrophic factor in the regulation of cerebellar GABAA receptor expression?
    C L Thompson
    Department of Pharmaceutical and Biological Chemistry, School of Pharmacy, University of London, 29 39 Brunswick Square, London, WC1N 1AX, UK
    Brain Res Mol Brain Res 60:282-90. 1998
    ..Thus, we have identified an abnormality in the GABAA receptor profile of stg/stg mutant mice that might underpin its irregular phenotype...
  13. ncbi Further characterization of the molecular interaction between PSD-95 and NMDA receptors: the effect of the NR1 splice variant and evidence for modulation of channel gating
    A Richard Rutter
    Department of Pharmaceutical and Biological Chemistry, School of Pharmacy, University of London, London, UK
    J Neurochem 81:1298-307. 2002
    ..It is suggested that PSD-95(c-Myc) has a dual effect on NMDA receptors expressed in mammalian cells, a reduction in channel gating and an enhanced expression of NMDA receptor subunits containing C-terminal E(T/S)XV PSD-95 binding motifs...
  14. ncbi Appropriate NR1-NR1 disulfide-linked homodimer formation is requisite for efficient expression of functional, cell surface N-methyl-D-aspartate NR1/NR2 receptors
    Michalis Papadakis
    Department of Pharmaceutical and Biological Chemistry, School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, United Kingdom
    J Biol Chem 279:14703-12. 2004
    ..They suggest that disulfide bridging and structural integrity within the NR1 N-terminal domain is requisite for cell surface N-methyl-D-aspartate receptor expression...
  15. ncbi NMDA receptor surface mobility depends on NR2A-2B subunits
    Laurent Groc
    Physiologie Cellulaire de la Synapse, Unité Mixte de Recherche UMR 5091, Centre National de la Recherche Scientifique CNRS, Universite Bordeaux 2, 33077 Bordeaux, France
    Proc Natl Acad Sci U S A 103:18769-74. 2006
    ..This suggests that the switch in synaptic NMDAR subtypes depends on the regulation of the receptor surface trafficking...
  16. ncbi NMDA receptor surface trafficking and synaptic subunit composition are developmentally regulated by the extracellular matrix protein Reelin
    Laurent Groc
    Physiologie Cellulaire de la Synapse, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5091, 33077 Bordeaux, France
    J Neurosci 27:10165-75. 2007
    ..Our data reveal a new mode of control of synaptic NMDAR assembly at postnatal hippocampal synapses and an unprecedented role of ECM proteins in regulating glutamate receptor surface diffusion...
  17. ncbi Export from the endoplasmic reticulum of assembled N-methyl-d-aspartic acid receptors is controlled by a motif in the c terminus of the NR2 subunit
    Lynda M Hawkins
    Laboratory of Neurochemistry, NIDCD, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:28903-10. 2004
    ..These results are consistent with HLFY functioning as a signal that is necessary for the release of the assembled functional NMDA receptor complex from the ER...
  18. ncbi Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors
    Laurent Groc
    , Bordeaux 33077, France
    Nat Neurosci 7:695-6. 2004
    ..Differences in mobility were mainly detected for extrasynaptic AMPARs, suggesting that receptor diffusion between synaptic and extrasynaptic domains is involved in plasticity processes...
  19. ncbi The GABA(A) receptor complex in the chicken brain: immunocytochemical distribution of alpha 1- and gamma 2-subunits and autoradiographic distribution of BZ1 and BZ2 binding sites
    Maria Isabel Aller
    , , , Spain
    J Chem Neuroanat 25:1-18. 2003
    ....
  20. ncbi Immunohistochemical localization of N-methyl-D-aspartate receptor subunits in the adult murine hippocampal formation: evidence for a unique role of the NR2D subunit
    Christopher L Thompson
    School of Biological and Biomedical Sciences, University of Durham, Science Research Laboratories, South Road, Durham, UK
    Brain Res Mol Brain Res 102:55-61. 2002
    ..Less intense staining was also observed in the internal third of the molecular layer of the dentate gyrus...
  21. ncbi GABAA receptor alpha1 and alpha6 subunits mediate cell surface anchoring in cultured cells
    Macarena Peran
    Departamento de Bioquimica, Facultad de Medicina, Universidad de Malaga, Campus de Teatinos, Malaga 29080, Spain
    Neurosci Lett 364:67-70. 2004
    ..We show that the alpha1 and alpha6 subunits immobilize recombinant GABAAR in transfected cells. This is consistent with the immobility of native receptors in CG cells, which express alpha1 and alpha6...
  22. ncbi Organization of postsynaptic density proteins and glutamate receptors in axodendritic and dendrodendritic synapses of the rat olfactory bulb
    Marco Sassoè-Pognetto
    Department of Anatomy, Pharmacology, and Forensic Medicine, University of Turin, I 10126 Torino, Italy
    J Comp Neurol 463:237-48. 2003
    ..The latter molecules appear to be expressed in an all-or-none fashion and may form a standard lattice common to different types of glutamatergic synapse...
  23. ncbi Synaptic localization of GABA(A) receptor subunits in the substantia nigra of the rat: effects of quinolinic acid lesions of the striatum
    Fumino Fujiyama
    MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, Oxford, OX1 3TH, UK
    Eur J Neurosci 15:1961-75. 2002
    ....