Leigh A Stephens

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. ncbi Phenotypic characterization of regulatory CD4+CD25+ T cells in rats
    Leigh A Stephens
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    Int Immunol 16:365-75. 2004
  2. ncbi CD4+CD25+ regulatory T cells limit the risk of autoimmune disease arising from T cell receptor crossreactivity
    Leigh A Stephens
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, UK
    Proc Natl Acad Sci U S A 102:17418-23. 2005
  3. ncbi Death, adaptation and regulation: the three pillars of immune tolerance restrict the risk of autoimmune disease caused by molecular mimicry
    Kelli R Ryan
    University of Edinburgh, Institute of Immunology and Infection Research, School of Biological Sciences, Kings Buildings, West Mains Road, Edinburgh, EH9 3JT, UK
    J Autoimmun 29:262-71. 2007
  4. ncbi Antigen-based therapy and immune-regulation in experimental autoimmune encephalomyelitis
    Mandy J McGeachy
    Institute of Immunology and Infection Research, Iniversity of Edinburgh, UK
    Methods Mol Biol 380:313-26. 2007
  5. ncbi Curing CNS autoimmune disease with myelin-reactive Foxp3+ Treg
    Leigh A Stephens
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, Edinburgh, UK
    Eur J Immunol 39:1108-17. 2009
  6. ncbi Natural recovery and protection from autoimmune encephalomyelitis: contribution of CD4+CD25+ regulatory cells within the central nervous system
    Mandy J McGeachy
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    J Immunol 175:3025-32. 2005
  7. ncbi Comment on "Cutting edge: anti-CD25 monoclonal antibody injection results in the functional inactivation, not depletion, of CD4+CD25+ T regulatory cells"
    Leigh A Stephens
    J Immunol 177:2036; author reply 2037-8. 2006

Detail Information

Publications7

  1. ncbi Phenotypic characterization of regulatory CD4+CD25+ T cells in rats
    Leigh A Stephens
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    Int Immunol 16:365-75. 2004
    ..Our studies indicate that, at present, CD25 remains the most useful marker to enrich for regulatory CD4(+) T cells in rats and no further subdivision of the regulatory component of CD4(+)CD25(-)CD45RC(low) T cells has yet been achieved...
  2. ncbi CD4+CD25+ regulatory T cells limit the risk of autoimmune disease arising from T cell receptor crossreactivity
    Leigh A Stephens
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, UK
    Proc Natl Acad Sci U S A 102:17418-23. 2005
    ..These data demonstrate the importance of Treg in raising the threshold of triggering of autoreactive T cell responses, thus limiting the risk of autoimmune disease due to molecular mimicry...
  3. ncbi Death, adaptation and regulation: the three pillars of immune tolerance restrict the risk of autoimmune disease caused by molecular mimicry
    Kelli R Ryan
    University of Edinburgh, Institute of Immunology and Infection Research, School of Biological Sciences, Kings Buildings, West Mains Road, Edinburgh, EH9 3JT, UK
    J Autoimmun 29:262-71. 2007
    ..We show that each of the three pillars of immune tolerance (death, anergy/adaptation and regulation) has a role in limiting the risk of molecular mimicry by maintaining a threshold for harm...
  4. ncbi Antigen-based therapy and immune-regulation in experimental autoimmune encephalomyelitis
    Mandy J McGeachy
    Institute of Immunology and Infection Research, Iniversity of Edinburgh, UK
    Methods Mol Biol 380:313-26. 2007
    ..Sampling of the lymphoid cell infiltrate within the central nervous system has identified the accumulation of regulatory T cells in the target organ during this period of resolution...
  5. ncbi Curing CNS autoimmune disease with myelin-reactive Foxp3+ Treg
    Leigh A Stephens
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, Edinburgh, UK
    Eur J Immunol 39:1108-17. 2009
    ....
  6. ncbi Natural recovery and protection from autoimmune encephalomyelitis: contribution of CD4+CD25+ regulatory cells within the central nervous system
    Mandy J McGeachy
    Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
    J Immunol 175:3025-32. 2005
    ..These are the first data demonstrating the direct involvement of CD4+CD25+ regulatory T cells in the natural resolution of autoimmune disease within the target organ...
  7. ncbi Comment on "Cutting edge: anti-CD25 monoclonal antibody injection results in the functional inactivation, not depletion, of CD4+CD25+ T regulatory cells"
    Leigh A Stephens
    J Immunol 177:2036; author reply 2037-8. 2006