Leigh A Stephens
Affiliation: University of Edinburgh
- Phenotypic characterization of regulatory CD4+CD25+ T cells in ratsLeigh A Stephens
Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
Int Immunol 16:365-75. 2004..Our studies indicate that, at present, CD25 remains the most useful marker to enrich for regulatory CD4(+) T cells in rats and no further subdivision of the regulatory component of CD4(+)CD25(-)CD45RC(low) T cells has yet been achieved...
- CD4+CD25+ regulatory T cells limit the risk of autoimmune disease arising from T cell receptor crossreactivityLeigh A Stephens
Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, UK
Proc Natl Acad Sci U S A 102:17418-23. 2005..These data demonstrate the importance of Treg in raising the threshold of triggering of autoreactive T cell responses, thus limiting the risk of autoimmune disease due to molecular mimicry...
- Death, adaptation and regulation: the three pillars of immune tolerance restrict the risk of autoimmune disease caused by molecular mimicryKelli R Ryan
University of Edinburgh, Institute of Immunology and Infection Research, School of Biological Sciences, Kings Buildings, West Mains Road, Edinburgh, EH9 3JT, UK
J Autoimmun 29:262-71. 2007..We show that each of the three pillars of immune tolerance (death, anergy/adaptation and regulation) has a role in limiting the risk of molecular mimicry by maintaining a threshold for harm...
- Antigen-based therapy and immune-regulation in experimental autoimmune encephalomyelitisMandy J McGeachy
Institute of Immunology and Infection Research, Iniversity of Edinburgh, UK
Methods Mol Biol 380:313-26. 2007..Sampling of the lymphoid cell infiltrate within the central nervous system has identified the accumulation of regulatory T cells in the target organ during this period of resolution...
- Curing CNS autoimmune disease with myelin-reactive Foxp3+ TregLeigh A Stephens
Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Ashworth Laboratories, Edinburgh, UK
Eur J Immunol 39:1108-17. 2009....
- Natural recovery and protection from autoimmune encephalomyelitis: contribution of CD4+CD25+ regulatory cells within the central nervous systemMandy J McGeachy
Institute of Immunology and Infection Research, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom
J Immunol 175:3025-32. 2005..These are the first data demonstrating the direct involvement of CD4+CD25+ regulatory T cells in the natural resolution of autoimmune disease within the target organ...
- Comment on "Cutting edge: anti-CD25 monoclonal antibody injection results in the functional inactivation, not depletion, of CD4+CD25+ T regulatory cells"Leigh A Stephens
J Immunol 177:2036; author reply 2037-8. 2006