Genomes and Genes
H A F Stephens
Affiliation: University College London
- Immunogenetic surveillance of HIV/AIDSHenry A F Stephens
UCL Centre for Nephrology and the Anthony Nolan Laboratories, Royal Free Hospital, Rowland Hill Street, London NW3 2PF, UK
Infect Genet Evol 12:1481-91. 2012....
- HIV-1 diversity versus HLA class I polymorphismHenry A F Stephens
Institute of Urology and Nephrology, University College London, The Middlesex Hospital, Mortimer Street, London, UK
Trends Immunol 26:41-7. 2005..HLA-A11 displays unique peptide-binding properties and is recognized by natural killer cells utilizing the inhibitory killer Ig-like receptor 3DL2 in a peptide-dependent manner...
- MHC haplotypes, MICA genes and the 'wonderland' of NK receptor polymorphismHenry A F Stephens
Institute of Urology and Nephrology, University College London, The Middlesex Hospital, 48 Riding House Street, London, UK
Trends Immunol 23:385-6. 2002
- HLA-A and -B allele associations with secondary dengue virus infections correlate with disease severity and the infecting viral serotype in ethnic ThaisH A F Stephens
Institute of Urology and Nephrology, University College, London, UK
Tissue Antigens 60:309-18. 2002..These results confirm that classical HLA class I alleles are associated with the clinical outcome of exposure to dengue virus, in previously exposed and immunologically primed individuals...
- MICA and MICB genes: can the enigma of their polymorphism be resolved?H A Stephens
Institute of Urology and Nephrology, University College London, The Middlesex Hospital, 48 Riding House Street, London, UK, W1W 7EY
Trends Immunol 22:378-85. 2001..MICA molecules appear to be highly flexible and polymorphic, although the functional relevance and implications of their polymorphism have yet to be fully discerned...
- A comparison of molecular HLA-DR and DQ allele profiles forming DR51-, DR52-, and DR53-related haplotypes in five ethnic Thai populations from mainland southeast AsiaH A Stephens
Department of Transfusion Medicine, Siriraj Hospital and Medical School, Mahidol University, Bangkok, Thailand
Hum Immunol 61:1039-47. 2000....
- HLA and other gene associations with dengue disease severityH A F Stephens
Centre for Nephrology and The Anthony Nolan Trust, University College London, The Royal Free Hospital Campus, Rowland Hill Street, London, NW3 2PF, UK
Curr Top Microbiol Immunol 338:99-114. 2010..Further analysis of the genetic basis of severe DENV disease in different at risk populations may contribute to the development of new preventative and therapeutic interventions...
- Associations of HLA class II alleles with pulmonary tuberculosis in ThaisS Vejbaesya
Department of Transfusion Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
Eur J Immunogenet 29:431-4. 2002..02 and P = 0.01, respectively). Our results suggest that HLA-DQB1*0502 may be involved in the development of pulmonary tuberculosis, whereas HLA-DQA1*0601 and DQB1*0301 may be associated with protection against tuberculosis...
- Distribution of natural killer cell immunoglobulin-like receptor sequences in three ethnic groupsP J Norman
South Thames Tissue Typing, Guy s Hospital, London, UK
Immunogenetics 52:195-205. 2001..The A haplotype was always the most prevalent, but the ratio of A to B varied between populations. The frequency of B haplotype was highest in the Palestinians and lowest in the Thais (Pc<0.0001)...
- Natural killer cell immunoglobulin-like receptor (KIR) locus profiles in African and South Asian populationsP J Norman
South Thames Tissue Typing, Guy s Hospital, London, UK
Genes Immun 3:86-95. 2002..0001 to < 0.004). Furthermore, gene frequency independent deviances in the linkage disequilibrium were apparent between populations...
- Does the polymorphism of MHC class II promoters matter?N A Mitchison
Department of Immunology, Windeyer Institute of Medical Science, 46 Cleveland Street, London W1T 4JF, UK
Cell Immunol 233:162-5. 2005....
- Two novel MICA alleles, MICA*054 and MICA*056S T Cox
The Anthony Nolan Research Institute and Trust, The Royal Free Hospital, London, UK
Tissue Antigens 73:85-7. 2009..MICA*056 has a nucleotide substitution at position 758 of G to C resulting in the substitution of tryptophan for serine at codon 230, also in the alpha-3 domain...
- HLA-DR and -DQ associations with melioidosisT Dharakul
Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
Hum Immunol 59:580-6. 1998..In contrast, no HLA association was observed in localized melioidosis or melioidosis with diabetes mellitus. These findings provide the suggestive evidence of an immunogenetic basis of certain aspects of melioidosis...
- Towards a molecular phototyping system for allelic variants of MICA, encoded by polymorphisms in exons 2, 3 and 4 of MHC class I chain-related genesH A Stephens
South Thames Tissue Typing Laboratory, Guys Hospital, Institute of Urology and Nephrology, University College London Medical School, UK
Tissue Antigens 53:167-74. 1999....
- SNP haplotypes and allele frequencies show evidence for disruptive and balancing selection in the human leukocyte receptor complexPaul J Norman
Clinical Transplantation Laboratory, Guy s Hospital, 3rd Floor New Guy s House, St Thomas Street, London, SE1 9RT, UK
Immunogenetics 56:225-37. 2004..The different natural selection pressures acting on each locus may have contributed to a lack of linkage disequilibrium between them...
- High resolution molecular phototyping of MICA and MICB alleles using sequence specific primersRobert W M Collins
South Thames Tissue Typing, Guy s Hospital, London, United Kingdom
Hum Immunol 63:783-94. 2002....
- Unusual selection on the KIR3DL1/S1 natural killer cell receptor in AfricansPaul J Norman
Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305, USA
Nat Genet 39:1092-9. 2007..Natural killer cells express the dominant KIR3DL1 at a high frequency and with high surface density, providing strong responses to cells perturbed in Bw4 expression...
- A comparison of HLA-DR and -DQ allele and haplotype frequencies in Trinidadian populations of African, South Asian, and mixed ancestryChristine V F Carrington
Department of Pre Clinical Sciences, Faculty of Medical Sciences, University of the West Indies, St Augustine, Trinidad
Hum Immunol 63:1045-54. 2002..Trinidad South Asians displayed similar allele frequencies and associations to other populations from Northern India...
- Molecular typing of the MHC class I chain-related gene locusR W M Collins
Guy's and St. Thomas's Hospitals, London, United Kingdom
Methods Mol Biol 210:305-21. 2003
- DNA sequence variation and molecular genotyping of natural killer leukocyte immunoglobulin-like receptor, LILRA3Paul J Norman
Clinical Transplantation Laboratory, Guy s Hospital, 3rd Floor New Guy s House, St Thomas Street, SE1 9RT, London, UK
Immunogenetics 55:165-71. 2003..Six alleles were present in this group but they were unevenly distributed, as three alleles accounted for 88% of the studied chromosomes...
- T cell responses to an HLA-B*07-restricted epitope on the dengue NS3 protein correlate with disease severityIva Zivna
Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Immunol 168:5959-65. 2002..These findings support the hypothesis that activation of DV-specific CD8(+) T cells plays an important role in the pathogenesis of DHF...