Research Topics
| Francis B StephensSummaryAffiliation: University of Nottingham Country: UK Publications
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Detail Information
Publications
An acute increase in skeletal muscle carnitine content alters fuel metabolism in resting human skeletal muscleFrancis B Stephens
Centre for Integrated Systems Biology and Medicine, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, United Kingdom
J Clin Endocrinol Metab 91:5013-8. 2006..Carnitine plays an essential role in the integration of fat and carbohydrate oxidation in skeletal muscle, which is impaired in obesity and type 2 diabetes...- A threshold exists for the stimulatory effect of insulin on plasma L-carnitine clearance in humansFrancis B Stephens
School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham, NG7 2UH, UK
Am J Physiol Endocrinol Metab 292:E637-41. 2007..This is of relevance to athletes, and the treatment of obesity and type 2 diabetes, where increasing skeletal muscle carnitine content may be used as tool to modify skeletal muscle energy metabolism... - Carbohydrate ingestion augments L-carnitine retention in humansFrancis B Stephens
School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK
J Appl Physiol 102:1065-70. 2007..001). The difference in plasma TC concentration in study A and 24-h urinary TC excretion in both studies suggests that insulin augmented the retention of carnitine in the CHO trials... 
New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscleFrancis B Stephens
Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
J Physiol 581:431-44. 2007..The demonstration that its availability can be readily manipulated in humans, and impacts on physiological function, will result in renewed business and scientific interest in this compound...- Post-exercise ingestion of a unique, high molecular weight glucose polymer solution improves performance during a subsequent bout of cycling exerciseFrancis B Stephens
Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham, UK
J Sports Sci 26:149-54. 2008..05) solutions. These findings could be of practical importance for athletes wishing to optimize performance by facilitating rapid re-synthesis of the muscle glycogen store during recovery following prolonged sub-maximal exercise... 
Vegetarians have a reduced skeletal muscle carnitine transport capacityFrancis B Stephens
Metabolic Physiology Research Group, School of Biomedical Sciences, Nottingham University Medical School, Queens Medical Centre, United Kingdom
Am J Clin Nutr 94:938-44. 2011..Ninety-five percent of the body carnitine pool resides in skeletal muscle where it plays a vital role in fuel metabolism. However, vegetarians obtain negligible amounts of carnitine from their diet...- Insulin stimulates L-carnitine accumulation in human skeletal muscleFrancis B Stephens
Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, Queen's Medical Centre, University of Nottingham, NG7 2UH, UK
FASEB J 20:377-9. 2006..These novel findings may be of importance to the regulation of muscle fat oxidation during exercise, particularly in obesity and type 2 diabetes where it is known to be impaired... - Acute pantothenic acid and cysteine supplementation does not affect muscle coenzyme A content, fuel selection, or exercise performance in healthy humansBenjamin T Wall
School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, United Kingdom
J Appl Physiol 112:272-8. 2012..Acute feeding with pantothenic acid and cysteine does not alter muscle CoASH content and consequently does not impact on muscle fuel metabolism or performance during exercise in humans...