Francis B Stephens

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. doi request reprint Lipid-induced insulin resistance is associated with an impaired skeletal muscle protein synthetic response to amino Acid ingestion in healthy young men
    Francis B Stephens
    Medical Research Council Arthritis Research UK Centre for Musculoskeletal Ageing Research, School of Life Sciences, University of Nottingham, Nottingham, U K
    Diabetes 64:1615-20. 2015
  2. doi request reprint Vegetarians have a reduced skeletal muscle carnitine transport capacity
    Francis B Stephens
    Metabolic Physiology Research Group, School of Biomedical Sciences, Nottingham University Medical School, Queens Medical Centre, United Kingdom
    Am J Clin Nutr 94:938-44. 2011
  3. ncbi request reprint Post-exercise ingestion of a unique, high molecular weight glucose polymer solution improves performance during a subsequent bout of cycling exercise
    Francis B Stephens
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    J Sports Sci 26:149-54. 2008
  4. pmc New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle
    Francis B Stephens
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    J Physiol 581:431-44. 2007
  5. ncbi request reprint Carbohydrate ingestion augments L-carnitine retention in humans
    Francis B Stephens
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK
    J Appl Physiol (1985) 102:1065-70. 2007
  6. ncbi request reprint A threshold exists for the stimulatory effect of insulin on plasma L-carnitine clearance in humans
    Francis B Stephens
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    Am J Physiol Endocrinol Metab 292:E637-41. 2007
  7. ncbi request reprint An acute increase in skeletal muscle carnitine content alters fuel metabolism in resting human skeletal muscle
    Francis B Stephens
    Centre for Integrated Systems Biology and Medicine, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, United Kingdom
    J Clin Endocrinol Metab 91:5013-8. 2006
  8. pmc Skeletal muscle carnitine loading increases energy expenditure, modulates fuel metabolism gene networks and prevents body fat accumulation in humans
    Francis B Stephens
    Professor P Greenhaff MRC Arthritis Research UK Centre for Musculoskeletal Ageing Research, School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, UK
    J Physiol 591:4655-66. 2013
  9. ncbi request reprint Insulin stimulates L-carnitine accumulation in human skeletal muscle
    Francis B Stephens
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, NG7 2UH, UK
    FASEB J 20:377-9. 2006
  10. doi request reprint Acute pantothenic acid and cysteine supplementation does not affect muscle coenzyme A content, fuel selection, or exercise performance in healthy humans
    Benjamin T Wall
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, United Kingdom
    J Appl Physiol (1985) 112:272-8. 2012

Detail Information

Publications12

  1. doi request reprint Lipid-induced insulin resistance is associated with an impaired skeletal muscle protein synthetic response to amino Acid ingestion in healthy young men
    Francis B Stephens
    Medical Research Council Arthritis Research UK Centre for Musculoskeletal Ageing Research, School of Life Sciences, University of Nottingham, Nottingham, U K
    Diabetes 64:1615-20. 2015
    ..We propose that increased muscle lipid availability may contribute to anabolic resistance in insulin-resistant conditions by impairing translation initiation. ..
  2. doi request reprint Vegetarians have a reduced skeletal muscle carnitine transport capacity
    Francis B Stephens
    Metabolic Physiology Research Group, School of Biomedical Sciences, Nottingham University Medical School, Queens Medical Centre, United Kingdom
    Am J Clin Nutr 94:938-44. 2011
    ..Ninety-five percent of the body carnitine pool resides in skeletal muscle where it plays a vital role in fuel metabolism. However, vegetarians obtain negligible amounts of carnitine from their diet...
  3. ncbi request reprint Post-exercise ingestion of a unique, high molecular weight glucose polymer solution improves performance during a subsequent bout of cycling exercise
    Francis B Stephens
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham, UK
    J Sports Sci 26:149-54. 2008
    ..05) solutions. These findings could be of practical importance for athletes wishing to optimize performance by facilitating rapid re-synthesis of the muscle glycogen store during recovery following prolonged sub-maximal exercise...
  4. pmc New insights concerning the role of carnitine in the regulation of fuel metabolism in skeletal muscle
    Francis B Stephens
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK
    J Physiol 581:431-44. 2007
    ..The demonstration that its availability can be readily manipulated in humans, and impacts on physiological function, will result in renewed business and scientific interest in this compound...
  5. ncbi request reprint Carbohydrate ingestion augments L-carnitine retention in humans
    Francis B Stephens
    School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, Nottingham, NG7 2UH, UK
    J Appl Physiol (1985) 102:1065-70. 2007
    ..001). The difference in plasma TC concentration in study A and 24-h urinary TC excretion in both studies suggests that insulin augmented the retention of carnitine in the CHO trials...
  6. ncbi request reprint A threshold exists for the stimulatory effect of insulin on plasma L-carnitine clearance in humans
    Francis B Stephens
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham, NG7 2UH, UK
    Am J Physiol Endocrinol Metab 292:E637-41. 2007
    ..This is of relevance to athletes, and the treatment of obesity and type 2 diabetes, where increasing skeletal muscle carnitine content may be used as tool to modify skeletal muscle energy metabolism...
  7. ncbi request reprint An acute increase in skeletal muscle carnitine content alters fuel metabolism in resting human skeletal muscle
    Francis B Stephens
    Centre for Integrated Systems Biology and Medicine, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, United Kingdom
    J Clin Endocrinol Metab 91:5013-8. 2006
    ..Carnitine plays an essential role in the integration of fat and carbohydrate oxidation in skeletal muscle, which is impaired in obesity and type 2 diabetes...
  8. pmc Skeletal muscle carnitine loading increases energy expenditure, modulates fuel metabolism gene networks and prevents body fat accumulation in humans
    Francis B Stephens
    Professor P Greenhaff MRC Arthritis Research UK Centre for Musculoskeletal Ageing Research, School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, UK
    J Physiol 591:4655-66. 2013
    ..Implications to health warrant further investigation, particularly in obese individuals who have a reduced reliance on muscle fat oxidation during low-intensity exercise...
  9. ncbi request reprint Insulin stimulates L-carnitine accumulation in human skeletal muscle
    Francis B Stephens
    Centre for Integrated Systems Biology and Medicine, School of Biomedical Sciences, Queen s Medical Centre, University of Nottingham, NG7 2UH, UK
    FASEB J 20:377-9. 2006
    ..These novel findings may be of importance to the regulation of muscle fat oxidation during exercise, particularly in obesity and type 2 diabetes where it is known to be impaired...
  10. doi request reprint Acute pantothenic acid and cysteine supplementation does not affect muscle coenzyme A content, fuel selection, or exercise performance in healthy humans
    Benjamin T Wall
    School of Biomedical Sciences, University of Nottingham Medical School, Queen s Medical Centre, Nottingham NG7 2UH, United Kingdom
    J Appl Physiol (1985) 112:272-8. 2012
    ..Acute feeding with pantothenic acid and cysteine does not alter muscle CoASH content and consequently does not impact on muscle fuel metabolism or performance during exercise in humans...
  11. doi request reprint Fish oil omega-3 fatty acids partially prevent lipid-induced insulin resistance in human skeletal muscle without limiting acylcarnitine accumulation
    Francis B Stephens
    MRC ARUK Centre for Musculoskeletal Ageing, School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, U K
    Clin Sci (Lond) 127:315-22. 2014
    ....
  12. doi request reprint Carnitine and fat oxidation
    Francis B Stephens
    MRC Arthritis Research UK Centre for Musculoskeletal Ageing Research, University of Nottingham Medical School, Queen s Medical Centre, Nottingham, UK
    Nestle Nutr Inst Workshop Ser 76:13-23. 2013
    ....