David N Stephens

Summary

Affiliation: University of Sussex
Country: UK

Publications

  1. pmc Deletion of the gabra2 gene results in hypersensitivity to the acute effects of ethanol but does not alter ethanol self administration
    Claire I Dixon
    School of Psychology, University of Sussex, Brighton, United Kingdom
    PLoS ONE 7:e47135. 2012
  2. pmc Deletion of alpha-synuclein decreases impulsivity in mice
    Y Peña-Oliver
    School of Psychology, University of Sussex, Falmer, Brighton, UK
    Genes Brain Behav 11:137-46. 2012
  3. doi The challenge of studying parallel behaviors in humans and animal models
    David N Stephens
    School of Psychology, University of Sussex, Falmer, Brighton, BN1 9QG, UK
    Curr Top Behav Neurosci 13:611-45. 2013
  4. ncbi Role of GABAA alpha5-containing receptors in ethanol reward: the effects of targeted gene deletion, and a selective inverse agonist
    David N Stephens
    Department of Psychology, School of Life Sciences, University of Sussex, Brighton, BN1 9QG, UK
    Eur J Pharmacol 526:240-50. 2005
  5. ncbi Repeated ethanol exposure and withdrawal impairs human fear conditioning and depresses long-term potentiation in rat amygdala and hippocampus
    David N Stephens
    Department of Psychology, University of Sussex, Falmer, Brighton BN1 9QG, United Kingdom
    Biol Psychiatry 58:392-400. 2005
  6. ncbi Animal models/tests of drug addiction: a quest for the holy grail, or the pursuit of wild geese?
    David N Stephens
    Department of Psychology, University of Sussex, Brighton, UK
    Addict Biol 11:39-42. 2006
  7. pmc Review. Cognitive and emotional consequences of binge drinking: role of amygdala and prefrontal cortex
    David N Stephens
    Department of Psychology, University of Sussex, Falmer, Brighton, UK
    Philos Trans R Soc Lond B Biol Sci 363:3169-79. 2008
  8. ncbi Reward sensitivity: issues of measurement, and achieving consilience between human and animal phenotypes
    David N Stephens
    Department of Psychology, University of Sussex, Falmer, Brighton BN1 9QG, UK
    Addict Biol 15:145-68. 2010
  9. ncbi Effects of deletion of gria1 or gria2 genes encoding glutamatergic AMPA-receptor subunits on place preference conditioning in mice
    Andy N Mead
    Department of Psychology, School of Life Sciences, University of Sussex, BN1 9QG, UK
    Psychopharmacology (Berl) 179:164-71. 2005
  10. ncbi Involvement of AMPA receptor GluR2 subunits in stimulus-reward learning: evidence from glutamate receptor gria2 knock-out mice
    Andy N Mead
    Laboratory of Experimental Psychology, University of Sussex, Brighton BN1 9QG, United Kingdom
    J Neurosci 23:9500-7. 2003

Collaborators

Detail Information

Publications42

  1. pmc Deletion of the gabra2 gene results in hypersensitivity to the acute effects of ethanol but does not alter ethanol self administration
    Claire I Dixon
    School of Psychology, University of Sussex, Brighton, United Kingdom
    PLoS ONE 7:e47135. 2012
    ..However, no change was observed in ethanol self administration, suggesting the rewarding effects of ethanol remain unchanged...
  2. pmc Deletion of alpha-synuclein decreases impulsivity in mice
    Y Peña-Oliver
    School of Psychology, University of Sussex, Falmer, Brighton, UK
    Genes Brain Behav 11:137-46. 2012
    ..These findings suggest that alpha-synuclein may contribute to impulsivity and potentially, to ICDs which arise in some PD patients treated with dopaminergic medication...
  3. doi The challenge of studying parallel behaviors in humans and animal models
    David N Stephens
    School of Psychology, University of Sussex, Falmer, Brighton, BN1 9QG, UK
    Curr Top Behav Neurosci 13:611-45. 2013
    ..Examples of current weaknesses and suggestions for more limited approaches that may allow better homology between the test animal and human condition are made...
  4. ncbi Role of GABAA alpha5-containing receptors in ethanol reward: the effects of targeted gene deletion, and a selective inverse agonist
    David N Stephens
    Department of Psychology, School of Life Sciences, University of Sussex, Brighton, BN1 9QG, UK
    Eur J Pharmacol 526:240-50. 2005
    ..Although inverse agonists acting at alpha5-containing receptors reduce ethanol self-administration, alpha5 subunits may not be essential to signaling ethanol reward...
  5. ncbi Repeated ethanol exposure and withdrawal impairs human fear conditioning and depresses long-term potentiation in rat amygdala and hippocampus
    David N Stephens
    Department of Psychology, University of Sussex, Falmer, Brighton BN1 9QG, United Kingdom
    Biol Psychiatry 58:392-400. 2005
    ..In rats, repeated episodes of alcohol consumption and withdrawal (RWD) impair fear conditioning to discrete cues...
  6. ncbi Animal models/tests of drug addiction: a quest for the holy grail, or the pursuit of wild geese?
    David N Stephens
    Department of Psychology, University of Sussex, Brighton, UK
    Addict Biol 11:39-42. 2006
  7. pmc Review. Cognitive and emotional consequences of binge drinking: role of amygdala and prefrontal cortex
    David N Stephens
    Department of Psychology, University of Sussex, Falmer, Brighton, UK
    Philos Trans R Soc Lond B Biol Sci 363:3169-79. 2008
    ..We propose that repeated episodes of withdrawal from alcohol induce aberrant neuronal plasticity that results in altered cognitive and emotional competences...
  8. ncbi Reward sensitivity: issues of measurement, and achieving consilience between human and animal phenotypes
    David N Stephens
    Department of Psychology, University of Sussex, Falmer, Brighton BN1 9QG, UK
    Addict Biol 15:145-68. 2010
    ....
  9. ncbi Effects of deletion of gria1 or gria2 genes encoding glutamatergic AMPA-receptor subunits on place preference conditioning in mice
    Andy N Mead
    Department of Psychology, School of Life Sciences, University of Sussex, BN1 9QG, UK
    Psychopharmacology (Berl) 179:164-71. 2005
    ..Critically, this classical conditioning procedure requires the formation of associations between a rewarding stimulus and environmental cues, and the ability of these cues to direct subsequent behaviour...
  10. ncbi Involvement of AMPA receptor GluR2 subunits in stimulus-reward learning: evidence from glutamate receptor gria2 knock-out mice
    Andy N Mead
    Laboratory of Experimental Psychology, University of Sussex, Brighton BN1 9QG, United Kingdom
    J Neurosci 23:9500-7. 2003
    ....
  11. ncbi AMPA-receptor GluR1 subunits are involved in the control over behavior by cocaine-paired cues
    Andy N Mead
    Department of Psychology, School of Life Sciences, University of Sussex, Falmer, Brighton, UK
    Neuropsychopharmacology 32:343-53. 2007
    ....
  12. ncbi Aversive conditioning following repeated withdrawal from ethanol and epileptic kindling
    Tamzin L Ripley
    Sussex Centre for Research in Alcohol, Alcoholism and Drug Dependence, Department of Psychology, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    Eur J Neurosci 17:1664-70. 2003
    ..These results suggest that, despite evidence suggesting a common neuronal mechanism underlying seizure sensitivity following these types of kindling, they differ in their effects on fear conditioning...
  13. ncbi Selective disruption of stimulus-reward learning in glutamate receptor gria1 knock-out mice
    Andy N Mead
    Laboratory of Experimental Psychology, University of Sussex, Brighton BN1 9QG, United Kingdom
    J Neurosci 23:1041-8. 2003
    ..Immunostaining for GluR2/3 subunits revealed changes in GluR2/3 expression in the gria1 KOs in the BLA but not the central nucleus of the amygdala (CA), consistent with the behavioral correlates of BLA but not CA function...
  14. pmc The mGluR5 antagonist MTEP dissociates the acquisition of predictive and incentive motivational properties of reward-paired stimuli in mice
    Eoin C O'Connor
    School of Psychology, University of Sussex, Brighton, Falmer, UK
    Neuropsychopharmacology 35:1807-17. 2010
    ..Thus, mGluR5 has a critical role in the acquisition of incentive properties by a CS, but is not required for the expression of incentive learning, or for the CS to acquire predictive properties that signal reward availability...
  15. doi Learning not to be impulsive: disruption by experience of alcohol withdrawal
    Sophie E Walker
    School of Psychology, University of Sussex, Falmer, Brighton, BN1 9QG, UK
    Psychopharmacology (Berl) 217:433-42. 2011
    ..There is extensive evidence that alcoholism and impulsivity are related, but the direction of causality is unclear...
  16. pmc Cocaine effects on mouse incentive-learning and human addiction are linked to alpha2 subunit-containing GABAA receptors
    Claire I Dixon
    Department of Psychology, University of Sussex, Brighton BN1 9QG, United Kingdom
    Proc Natl Acad Sci U S A 107:2289-94. 2010
    ..Consistent with a role of these receptors in addiction, we found specific markers and haplotypes of the GABRA2 gene to be associated with human cocaine addiction...
  17. ncbi Repeated withdrawal from ethanol spares contextual fear conditioning and spatial learning but impairs negative patterning and induces over-responding: evidence for effect on frontal cortical but not hippocampal function?
    Gilyana G Borlikova
    Department of Psychology, School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UK
    Eur J Neurosci 24:205-16. 2006
    ..The deficit seen after repeated withdrawal in the negative patterning discrimination and over-responding in the fixed-interval paradigm might be related to the changes in the functioning of the cortex after withdrawal...
  18. ncbi Ethanol effects on impulsivity in two mouse strains: similarities to diazepam and ketamine
    Yolanda Peña Oliver
    Department of Psychology, University of Sussex, Falmer, Brighton, BN1 9QG, UK
    Psychopharmacology (Berl) 204:679-92. 2009
    ..The effects of ethanol on attention and impulsivity have been contradictory...
  19. ncbi Consequences of amygdala kindling and repeated withdrawal from ethanol on amphetamine-induced behaviours
    Tamzin L Ripley
    Sussex Centre for Research in Alcohol, Alcoholism and Drug Dependence, School of Biological Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UK
    Eur J Neurosci 16:1129-38. 2002
    ..Behavioural changes following amygdala kindling differed from those following repeated ethanol withdrawal, suggesting that withdrawal kindling from a mild ethanol treatment differs in its effects from amygdala kindling...
  20. doi Measuring impulsivity in mice: the five-choice serial reaction time task
    Sandra Sanchez-Roige
    School of Psychology, University of Sussex, Falmer, Brighton, BN1 9QG, UK
    Psychopharmacology (Berl) 219:253-70. 2012
    ..The five-choice serial reaction time task (5CSRTT) paradigm has been well established in rats, but its transferability to mice is less well documented...
  21. ncbi Food-induced behavioral sensitization, its cross-sensitization to cocaine and morphine, pharmacological blockade, and effect on food intake
    Julie Le Merrer
    Department of Psychology, University of Sussex, Falmer, Brighton BN1 9QG, United Kingdom
    J Neurosci 26:7163-71. 2006
    ..Thus, many of the features of behavioral sensitization to drugs can be demonstrated using food reward and may contribute to excessive eating...
  22. ncbi Ethanol modifies the effect of handling stress on gene expression: problems in the analysis of two-way gene expression studies in mouse brain
    Stuart L Rulten
    Trafford Centre for Medical Research, University of Sussex, Falmer, Brighton, UK
    Brain Res 1102:39-43. 2006
    ..In addition to demonstrating the complexity of gene expression in response to physical and environmental stress, this work raises questions on the interpretation and validity of studies relying on pairwise comparisons...
  23. ncbi Effects of alcohol and lorazepam during extinction of alcohol self-administration in rats
    Anne Jackson
    Department of Pharmacology, School of Pharmacy and Biomolecular Sciences, University of Brighton, Moulsecoomb, Brighton, UK
    J Psychopharmacol 17:293-9. 2003
    ..By contrast, the pattern of results suggested that, in this model, they 'satiated' or substituted for alcohol, resulting in a reduced motivation to respond...
  24. doi Experimental medicine in drug addiction: towards behavioral, cognitive and neurobiological biomarkers
    Theodora Duka
    Behavioral and Clinical Neuroscience Research Group, School of Psychology, University of Sussex, Brighton, UK
    J Psychopharmacol 25:1235-55. 2011
    ..In evaluating these psychological and/or behavioral processes and their relationship to addiction we make reference to putative underlying brain structures identified by basic animal studies and/or imaging studies with humans...
  25. ncbi Lack of self-administration and behavioural sensitisation to morphine, but not cocaine, in mice lacking NK1 receptors
    Tamzin L Ripley
    Laboratory of Experimental Psychology, University of Sussex, Falmer, BN1 9QG, Brighton, UK
    Neuropharmacology 43:1258-68. 2002
    ..It is postulated that substance P and the NK1 receptor may be necessary for the development of opiate, but not cocaine addiction...
  26. ncbi Impairment in cognitive functions after multiple detoxifications in alcoholic inpatients
    Theodora Duka
    Laboratory of Experimental Psychology, Unviersity of Sussex, Falmer, Brighton, United Kingdom
    Alcohol Clin Exp Res 27:1563-72. 2003
    ..The aim of this study was to determine whether repeated withdrawals affect cognitive function...
  27. pmc Lack of involvement of alpha-synuclein in unconditioned anxiety in mice
    Yolanda Peña-Oliver
    Department of Psychology, University of Sussex, Falmer, Brighton BN1 9QG, UK
    Behav Brain Res 209:234-40. 2010
    ..Alpha-synuclein knock out mice and wild type controls displayed consistently similar emotionality profiles in all the tests, suggesting a lack of involvement of alpha-synuclein in unconditioned anxiety in mice...
  28. pmc Unique brain areas associated with abstinence control are damaged in multiply detoxified alcoholics
    Theodora Duka
    School of Psychology, University of Sussex, Brighton, United Kingdom
    Biol Psychiatry 70:545-52. 2011
    ..The ability to abstain from drinking, despite incentives to imbibe, is essential to recovery from alcoholism...
  29. ncbi Evidence for disrupted NMDA receptor function in tissue plasminogen activator knockout mice
    Jennifer M Horwood
    Laboratory of Experimental Psychology, University of Sussex, Falmer, Brighton BN1 9QG, UK
    Behav Brain Res 150:127-38. 2004
    ..This supports a role for tPA in modification of the NMDA receptor, although absence of tPA does not have consequences for all forms of NMDA-dependent mediated learning...
  30. ncbi Previous experience of ethanol withdrawal increases withdrawal-induced c-fos expression in limbic areas, but not withdrawal-induced anxiety and prevents withdrawal-induced elevations in plasma corticosterone
    Gilyana G Borlikova
    Department of Psychology, School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UK
    Psychopharmacology (Berl) 185:188-200. 2006
    ..Increased anxiety is a characteristic of the acute ethanol withdrawal syndrome. Repeated exposure of rats to withdrawal from chronic ethanol increases sensitivity to seizures...
  31. pmc Critical thoughts on current rodent models for evaluating potential treatments of alcohol addiction and withdrawal
    Tamzin L Ripley
    School of Psychology, University of Sussex, Falmer, Brighton, UK
    Br J Pharmacol 164:1335-56. 2011
    ....
  32. doi Modeling appetitive Pavlovian-instrumental interactions in mice
    Eoin C O'Connor
    Behavioral and Clinical Neuroscience Research Group, School of Psychology, The University of Sussex, Brighton, East Sussex, United Kingdom
    Curr Protoc Neurosci . 2010
    ....
  33. ncbi Alpha-synuclein deletion decreases motor impulsivity but does not affect risky decision making in a mouse Gambling Task
    Yolanda Peña-Oliver
    School of Psychology, University of Sussex, Falmer, Brighton, BN1 9QG, UK
    Psychopharmacology (Berl) 231:2493-506. 2014
    ..There is evidence to support the role of alpha-synuclein in motor impulsivity, but the extrapolation of this finding to other types of impulsivity remains to be elucidated...
  34. pmc Tonic inhibition of accumbal spiny neurons by extrasynaptic α4βδ GABAA receptors modulates the actions of psychostimulants
    Edward P Maguire
    Division of Neuroscience, Medical Research Institute, Ninewells Hospital and Medical School, Ninewells Hospital, Dundee University, Dundee, DD19SY, United Kingdom, School of Psychology, University of Sussex, Falmer, Brighton, BN1 9QG, United Kingdom, and Institute for Biomedical and Biomolecular Sciences, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth PO1 2DT, United Kingdom
    J Neurosci 34:823-38. 2014
    ..Therefore, α4βδ GABAARs may represent a viable target for the development of novel therapeutics to better understand and influence addictive behaviors. ..
  35. ncbi Lorazepam substitutes for the alcohol stimulus in social drinkers
    Anne Jackson
    Department of Experimental Psychology, School of Biological Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    Psychopharmacology (Berl) 166:181-7. 2003
    ..The alcohol discriminative stimulus has been extensively studied in animals and demonstrated to be pharmacologically complex. In contrast, however, the alcohol stimulus has been less frequently studied in humans...
  36. ncbi Kindling of withdrawal: a study of craving and anxiety after multiple detoxifications in alcoholic inpatients
    Theodora Duka
    Laboratory of Experimental Psychology, University of Sussex, Falmer, Brighton, United Kingdom
    Alcohol Clin Exp Res 26:785-95. 2002
    ..Thus, we predicted that patients who had undergone multiple detoxifications would show greater desire for alcohol and might experience more anxiety compared with patients with fewer detoxifications or compared with social drinkers...
  37. ncbi Effect of CGP39551 administration on the kindling of ethanol-withdrawal seizures
    Tamzin L Ripley
    Sussex Centre for Research in Alcohol, Alcoholism and Drug Dependence, School of Biological Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    Psychopharmacology (Berl) 163:157-65. 2002
    ....
  38. doi Per1(Brdm1) mice self-administer cocaine and reinstate cocaine-seeking behaviour following extinction
    Briac Halbout
    Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
    Behav Pharmacol 22:76-80. 2011
    ..This study adds one further example to the notion that various behavioural tests usually used in addiction research rely on different neurobiological substrates...
  39. ncbi Provision of cues to signal a withdrawal US prevents the US pre-exposure effect in a diazepam-withdrawal conditioned taste aversion
    Sarah J Dunworth
    Laboratory of Experimental Psychology, University of Sussex, Falmer, Brighton BN1 9QG, UK
    Psychopharmacology (Berl) 160:245-52. 2002
    ....
  40. ncbi Alcohol withdrawal and conditioning
    Hilary J Little
    Department of Pharmacology, George s Hospital Medical School, Cranmer Terrace, London, SW17 ORE, UK
    Alcohol Clin Exp Res 29:453-64. 2005
    ..Finally, Dr. C. Cunningham provided a summary of the concepts involved in the presentations and discussed the conditioning processes that affect behavior during and after alcohol withdrawal...
  41. ncbi What role do GluR1 subunits play in drug abuse?
    David N Stephens
    Trends Neurosci 26:181-2; author reply 182-3. 2003
  42. ncbi Lack of evidence for appetitive effects of Delta 9-tetrahydrocannabinol in the intracranial self-stimulation and conditioned place preference procedures in rodents
    Styliani Vlachou
    Laboratory of Behavioral Neuroscience, Department of Psychology, School of Social Sciences, University of Crete, Rethymnon, Crete, Greece
    Behav Pharmacol 18:311-9. 2007
    ..These findings indicate that Delta 9-THC, in contrast to other drugs of abuse, does not facilitate ICSS or support CPP under the present experimental conditions, but rather has a dose-dependent inhibitory influence on ICSS...