Research Topics
Genomes and Genes | David N StephensSummaryAffiliation: University of Sussex Country: UK Publications
| Collaborators
|
Detail Information
Publications
The challenge of studying parallel behaviors in humans and animal modelsDavid N Stephens
School of Psychology, University of Sussex, Falmer, Brighton, BN1 9QG, UK
Curr Top Behav Neurosci 13:611-45. 2013..Examples of current weaknesses and suggestions for more limited approaches that may allow better homology between the test animal and human condition are made...
Animal models/tests of drug addiction: a quest for the holy grail, or the pursuit of wild geese?David N Stephens
Department of Psychology, University of Sussex, Brighton, UK
Addict Biol 11:39-42. 2006- Role of GABAA alpha5-containing receptors in ethanol reward: the effects of targeted gene deletion, and a selective inverse agonistDavid N Stephens
Department of Psychology, School of Life Sciences, University of Sussex, Brighton, BN1 9QG, UK
Eur J Pharmacol 526:240-50. 2005..Although inverse agonists acting at alpha5-containing receptors reduce ethanol self-administration, alpha5 subunits may not be essential to signaling ethanol reward... - Repeated ethanol exposure and withdrawal impairs human fear conditioning and depresses long-term potentiation in rat amygdala and hippocampusDavid N Stephens
Department of Psychology, University of Sussex, Falmer, Brighton BN1 9QG, United Kingdom
Biol Psychiatry 58:392-400. 2005..In rats, repeated episodes of alcohol consumption and withdrawal (RWD) impair fear conditioning to discrete cues... 
Review. Cognitive and emotional consequences of binge drinking: role of amygdala and prefrontal cortexDavid N Stephens
Department of Psychology, University of Sussex, Falmer, Brighton, UK
Philos Trans R Soc Lond B Biol Sci 363:3169-79. 2008..We propose that repeated episodes of withdrawal from alcohol induce aberrant neuronal plasticity that results in altered cognitive and emotional competences...- Effects of deletion of gria1 or gria2 genes encoding glutamatergic AMPA-receptor subunits on place preference conditioning in miceAndy N Mead
Department of Psychology, School of Life Sciences, University of Sussex, BN1 9QG, UK
Psychopharmacology (Berl) 179:164-71. 2005..Critically, this classical conditioning procedure requires the formation of associations between a rewarding stimulus and environmental cues, and the ability of these cues to direct subsequent behaviour... - Reward sensitivity: issues of measurement, and achieving consilience between human and animal phenotypesDavid N Stephens
Department of Psychology, University of Sussex, Falmer, Brighton BN1 9QG, UK
Addict Biol 15:145-68. 2010.... - Involvement of AMPA receptor GluR2 subunits in stimulus-reward learning: evidence from glutamate receptor gria2 knock-out miceAndy N Mead
Laboratory of Experimental Psychology, University of Sussex, Brighton BN1 9QG, United Kingdom
J Neurosci 23:9500-7. 2003.... - Aversive conditioning following repeated withdrawal from ethanol and epileptic kindlingTamzin L Ripley
Sussex Centre for Research in Alcohol, Alcoholism and Drug Dependence, Department of Psychology, School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
Eur J Neurosci 17:1664-70. 2003..These results suggest that, despite evidence suggesting a common neuronal mechanism underlying seizure sensitivity following these types of kindling, they differ in their effects on fear conditioning... - AMPA-receptor GluR1 subunits are involved in the control over behavior by cocaine-paired cuesAndy N Mead
Department of Psychology, School of Life Sciences, University of Sussex, Falmer, Brighton, UK
Neuropsychopharmacology 32:343-53. 2007.... - Selective disruption of stimulus-reward learning in glutamate receptor gria1 knock-out miceAndy N Mead
Laboratory of Experimental Psychology, University of Sussex, Brighton BN1 9QG, United Kingdom
J Neurosci 23:1041-8. 2003..Immunostaining for GluR2/3 subunits revealed changes in GluR2/3 expression in the gria1 KOs in the BLA but not the central nucleus of the amygdala (CA), consistent with the behavioral correlates of BLA but not CA function... - The mGluR5 antagonist MTEP dissociates the acquisition of predictive and incentive motivational properties of reward-paired stimuli in miceEoin C O'Connor
School of Psychology, University of Sussex, Brighton, Falmer, UK
Neuropsychopharmacology 35:1807-17. 2010..Thus, mGluR5 has a critical role in the acquisition of incentive properties by a CS, but is not required for the expression of incentive learning, or for the CS to acquire predictive properties that signal reward availability... - Repeated withdrawal from ethanol spares contextual fear conditioning and spatial learning but impairs negative patterning and induces over-responding: evidence for effect on frontal cortical but not hippocampal function?Gilyana G Borlikova
Department of Psychology, School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UK
Eur J Neurosci 24:205-16. 2006..The deficit seen after repeated withdrawal in the negative patterning discrimination and over-responding in the fixed-interval paradigm might be related to the changes in the functioning of the cortex after withdrawal... - Ethanol effects on impulsivity in two mouse strains: similarities to diazepam and ketamineYolanda Peña Oliver
Department of Psychology, University of Sussex, Falmer, Brighton, BN1 9QG, UK
Psychopharmacology (Berl) 204:679-92. 2009..The effects of ethanol on attention and impulsivity have been contradictory... - Consequences of amygdala kindling and repeated withdrawal from ethanol on amphetamine-induced behavioursTamzin L Ripley
Sussex Centre for Research in Alcohol, Alcoholism and Drug Dependence, School of Biological Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UK
Eur J Neurosci 16:1129-38. 2002..Behavioural changes following amygdala kindling differed from those following repeated ethanol withdrawal, suggesting that withdrawal kindling from a mild ethanol treatment differs in its effects from amygdala kindling... - Measuring impulsivity in mice: the five-choice serial reaction time taskSandra Sanchez-Roige
School of Psychology, University of Sussex, Falmer, Brighton, BN1 9QG, UK
Psychopharmacology (Berl) 219:253-70. 2012..The five-choice serial reaction time task (5CSRTT) paradigm has been well established in rats, but its transferability to mice is less well documented... - Learning not to be impulsive: disruption by experience of alcohol withdrawalSophie E Walker
School of Psychology, University of Sussex, Falmer, Brighton, BN1 9QG, UK
Psychopharmacology (Berl) 217:433-42. 2011..There is extensive evidence that alcoholism and impulsivity are related, but the direction of causality is unclear... - Food-induced behavioral sensitization, its cross-sensitization to cocaine and morphine, pharmacological blockade, and effect on food intakeJulie Le Merrer
Department of Psychology, University of Sussex, Falmer, Brighton BN1 9QG, United Kingdom
J Neurosci 26:7163-71. 2006..Thus, many of the features of behavioral sensitization to drugs can be demonstrated using food reward and may contribute to excessive eating... - Cocaine effects on mouse incentive-learning and human addiction are linked to alpha2 subunit-containing GABAA receptorsClaire I Dixon
Department of Psychology, University of Sussex, Brighton BN1 9QG, United Kingdom
Proc Natl Acad Sci U S A 107:2289-94. 2010..Consistent with a role of these receptors in addiction, we found specific markers and haplotypes of the GABRA2 gene to be associated with human cocaine addiction... - Effects of alcohol and lorazepam during extinction of alcohol self-administration in ratsAnne Jackson
Department of Pharmacology, School of Pharmacy and Biomolecular Sciences, University of Brighton, Moulsecoomb, Brighton, UK
J Psychopharmacol 17:293-9. 2003..By contrast, the pattern of results suggested that, in this model, they 'satiated' or substituted for alcohol, resulting in a reduced motivation to respond... - Ethanol modifies the effect of handling stress on gene expression: problems in the analysis of two-way gene expression studies in mouse brainStuart L Rulten
Trafford Centre for Medical Research, University of Sussex, Falmer, Brighton, UK
Brain Res 1102:39-43. 2006..In addition to demonstrating the complexity of gene expression in response to physical and environmental stress, this work raises questions on the interpretation and validity of studies relying on pairwise comparisons... - Deletion of the gabra2 gene results in hypersensitivity to the acute effects of ethanol but does not alter ethanol self administrationClaire I Dixon
School of Psychology, University of Sussex, Brighton, United Kingdom
PLoS ONE 7:e47135. 2012..However, no change was observed in ethanol self administration, suggesting the rewarding effects of ethanol remain unchanged... - Experimental medicine in drug addiction: towards behavioral, cognitive and neurobiological biomarkersTheodora Duka
Behavioral and Clinical Neuroscience Research Group, School of Psychology, University of Sussex, Brighton, UK
J Psychopharmacol 25:1235-55. 2011..In evaluating these psychological and/or behavioral processes and their relationship to addiction we make reference to putative underlying brain structures identified by basic animal studies and/or imaging studies with humans... - Lack of self-administration and behavioural sensitisation to morphine, but not cocaine, in mice lacking NK1 receptorsTamzin L Ripley
Laboratory of Experimental Psychology, University of Sussex, Falmer, BN1 9QG, Brighton, UK
Neuropharmacology 43:1258-68. 2002..It is postulated that substance P and the NK1 receptor may be necessary for the development of opiate, but not cocaine addiction... - Impairment in cognitive functions after multiple detoxifications in alcoholic inpatientsTheodora Duka
Laboratory of Experimental Psychology, Unviersity of Sussex, Falmer, Brighton, United Kingdom
Alcohol Clin Exp Res 27:1563-72. 2003..The aim of this study was to determine whether repeated withdrawals affect cognitive function... - Unique brain areas associated with abstinence control are damaged in multiply detoxified alcoholicsTheodora Duka
School of Psychology, University of Sussex, Brighton, United Kingdom
Biol Psychiatry 70:545-52. 2011..The ability to abstain from drinking, despite incentives to imbibe, is essential to recovery from alcoholism... - Previous experience of ethanol withdrawal increases withdrawal-induced c-fos expression in limbic areas, but not withdrawal-induced anxiety and prevents withdrawal-induced elevations in plasma corticosteroneGilyana G Borlikova
Department of Psychology, School of Life Sciences, University of Sussex, Falmer, Brighton, BN1 9QG, UK
Psychopharmacology (Berl) 185:188-200. 2006..We suggest parallels between the consequences of repeated ethanol withdrawal and repeated exposure to stress, and discuss implications of withdrawal for brain plasticity... - Evidence for disrupted NMDA receptor function in tissue plasminogen activator knockout miceJennifer M Horwood
Laboratory of Experimental Psychology, University of Sussex, Falmer, Brighton BN1 9QG, UK
Behav Brain Res 150:127-38. 2004..This supports a role for tPA in modification of the NMDA receptor, although absence of tPA does not have consequences for all forms of NMDA-dependent mediated learning... - Lack of involvement of alpha-synuclein in unconditioned anxiety in miceYolanda Peña-Oliver
Department of Psychology, University of Sussex, Falmer, Brighton BN1 9QG, UK
Behav Brain Res 209:234-40. 2010..Alpha-synuclein knock out mice and wild type controls displayed consistently similar emotionality profiles in all the tests, suggesting a lack of involvement of alpha-synuclein in unconditioned anxiety in mice... - Critical thoughts on current rodent models for evaluating potential treatments of alcohol addiction and withdrawalTamzin L Ripley
School of Psychology, University of Sussex, Falmer, Brighton, UK
Br J Pharmacol 164:1335-56. 2011.... - Modeling appetitive Pavlovian-instrumental interactions in miceEoin C O'Connor
Behavioral and Clinical Neuroscience Research Group, School of Psychology, The University of Sussex, Brighton, East Sussex, United Kingdom
Curr Protoc Neurosci . 2010.... - Lorazepam substitutes for the alcohol stimulus in social drinkersAnne Jackson
Department of Experimental Psychology, School of Biological Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
Psychopharmacology (Berl) 166:181-7. 2003..The alcohol discriminative stimulus has been extensively studied in animals and demonstrated to be pharmacologically complex. In contrast, however, the alcohol stimulus has been less frequently studied in humans... - Kindling of withdrawal: a study of craving and anxiety after multiple detoxifications in alcoholic inpatientsTheodora Duka
Laboratory of Experimental Psychology, University of Sussex, Falmer, Brighton, United Kingdom
Alcohol Clin Exp Res 26:785-95. 2002..Thus, we predicted that patients who had undergone multiple detoxifications would show greater desire for alcohol and might experience more anxiety compared with patients with fewer detoxifications or compared with social drinkers... - Effect of CGP39551 administration on the kindling of ethanol-withdrawal seizuresTamzin L Ripley
Sussex Centre for Research in Alcohol, Alcoholism and Drug Dependence, School of Biological Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
Psychopharmacology (Berl) 163:157-65. 2002..CONCLUSIONS: Treatment with an NMDA receptor-competitive antagonist potentiated the ethanol-withdrawal syndrome in animals with previous experience of ethanol withdrawal... - Per1(Brdm1) mice self-administer cocaine and reinstate cocaine-seeking behaviour following extinctionBriac Halbout
Department of Psychopharmacology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany
Behav Pharmacol 22:76-80. 2011..This study adds one further example to the notion that various behavioural tests usually used in addiction research rely on different neurobiological substrates... - Provision of cues to signal a withdrawal US prevents the US pre-exposure effect in a diazepam-withdrawal conditioned taste aversionSarah J Dunworth
Laboratory of Experimental Psychology, University of Sussex, Falmer, Brighton BN1 9QG, UK
Psychopharmacology (Berl) 160:245-52. 2002..An explanation in terms of the nature of US predictability following repeated withdrawal from diazepam is consistent both with the current data and our previous findings... - What role do GluR1 subunits play in drug abuse?David N Stephens
Trends Neurosci 26:181-2; author reply 182-3. 2003 - Alcohol withdrawal and conditioningHilary J Little
Department of Pharmacology, George s Hospital Medical School, Cranmer Terrace, London, SW17 ORE, UK
Alcohol Clin Exp Res 29:453-64. 2005..Finally, Dr. C. Cunningham provided a summary of the concepts involved in the presentations and discussed the conditioning processes that affect behavior during and after alcohol withdrawal... - Lack of evidence for appetitive effects of Delta 9-tetrahydrocannabinol in the intracranial self-stimulation and conditioned place preference procedures in rodentsStyliani Vlachou
Laboratory of Behavioral Neuroscience, Department of Psychology, School of Social Sciences, University of Crete, Rethymnon, Crete, Greece
Behav Pharmacol 18:311-9. 2007..These findings indicate that Delta 9-THC, in contrast to other drugs of abuse, does not facilitate ICSS or support CPP under the present experimental conditions, but rather has a dose-dependent inhibitory influence on ICSS...