Klaas Enno Stephan

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Initial demonstration of in vivo tracing of axonal projections in the macaque brain and comparison with the human brain using diffusion tensor imaging and fast marching tractography
    Geoffrey J M Parker
    NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom
    Neuroimage 15:797-809. 2002
  2. pmc Comparing hemodynamic models with DCM
    Klaas Enno Stephan
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK, and Brain Dynamics Center, Westmead Millenium Institute, Westmead Hospital, NSW, Australia
    Neuroimage 38:387-401. 2007
  3. pmc The Brain Connectivity Workshops: moving the frontiers of computational systems neuroscience
    Klaas Enno Stephan
    Wellcome Trust Centre for Neuroimaging, University College London, 12 Queen Square, London WC1N3BG, UK
    Neuroimage 42:1-9. 2008
  4. pmc The functional anatomy of the MMN: a DCM study of the roving paradigm
    Marta I Garrido
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, UK
    Neuroimage 42:936-44. 2008
  5. pmc A dual role for prediction error in associative learning
    Hanneke E M den Ouden
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Cereb Cortex 19:1175-85. 2009
  6. pmc Computational disease modeling - fact or fiction?
    Jesper N Tegnér
    Computational Medicine group, Department of Medicine, Center for Molecular Medicine, Karolinska University Hospital, Solna, Stockholm, Sweden
    BMC Syst Biol 3:56. 2009
  7. pmc Dysconnection in schizophrenia: from abnormal synaptic plasticity to failures of self-monitoring
    Klaas E Stephan
    Schizophr Bull 35:509-27. 2009
  8. ncbi request reprint Synaptic plasticity and dysconnection in schizophrenia
    Klaas E Stephan
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, United Kingdom
    Biol Psychiatry 59:929-39. 2006
  9. pmc Nonlinear dynamic causal models for fMRI
    Klaas Enno Stephan
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Neuroimage 42:649-62. 2008
  10. pmc Investigating the functional role of callosal connections with dynamic causal models
    Klaas E Stephan
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, United Kingdom
    Ann N Y Acad Sci 1064:16-36. 2005

Detail Information

Publications44

  1. ncbi request reprint Initial demonstration of in vivo tracing of axonal projections in the macaque brain and comparison with the human brain using diffusion tensor imaging and fast marching tractography
    Geoffrey J M Parker
    NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom
    Neuroimage 15:797-809. 2002
    ..Analogous human anatomical connectivity is also presented for the first time using the FMT method, and the results are compared. The current limitations of the methodology and possibilities available for further studies are discussed...
  2. pmc Comparing hemodynamic models with DCM
    Klaas Enno Stephan
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK, and Brain Dynamics Center, Westmead Millenium Institute, Westmead Hospital, NSW, Australia
    Neuroimage 38:387-401. 2007
    ..Using fMRI data from a group of twelve subjects, we demonstrate that the best model is a non-linear model with a revised form for the coefficients, in which epsilon is treated as a free parameter...
  3. pmc The Brain Connectivity Workshops: moving the frontiers of computational systems neuroscience
    Klaas Enno Stephan
    Wellcome Trust Centre for Neuroimaging, University College London, 12 Queen Square, London WC1N3BG, UK
    Neuroimage 42:1-9. 2008
    ..Finally, we outline some central challenges and research trajectories in computational systems neuroscience for the next years...
  4. pmc The functional anatomy of the MMN: a DCM study of the roving paradigm
    Marta I Garrido
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, UK
    Neuroimage 42:936-44. 2008
    ..Ilmoniemi, R.J., Levänen, S., Lin, F.H., May, P., Melcher, J., Stufflebeam, S., Tiitinen, H., Belliveau, J.W., 2004. Human posterior auditory cortex gates novel sounds to consciousness. Proc. Natl. Acad. Sci. U. S. A. 101, 6809-6814]...
  5. pmc A dual role for prediction error in associative learning
    Hanneke E M den Ouden
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Cereb Cortex 19:1175-85. 2009
    ..These results posit a dual role for prediction-error in encoding surprise and driving associative plasticity...
  6. pmc Computational disease modeling - fact or fiction?
    Jesper N Tegnér
    Computational Medicine group, Department of Medicine, Center for Molecular Medicine, Karolinska University Hospital, Solna, Stockholm, Sweden
    BMC Syst Biol 3:56. 2009
    ..On the other hand, the physics-inspired top-down modeling strategy identifies and selects features of (presumably) essential relevance to the phenomena of interest and combines available data in models of modest complexity...
  7. pmc Dysconnection in schizophrenia: from abnormal synaptic plasticity to failures of self-monitoring
    Klaas E Stephan
    Schizophr Bull 35:509-27. 2009
    ..Finally, we test the explanatory power of our theory against a list of empirical facts about schizophrenia...
  8. ncbi request reprint Synaptic plasticity and dysconnection in schizophrenia
    Klaas E Stephan
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, United Kingdom
    Biol Psychiatry 59:929-39. 2006
    ..Promising experimental paradigms include perceptual and reinforcement learning. We describe how theoretical and causal models of brain responses might contribute to a mechanistic understanding of synaptic plasticity in schizophrenia...
  9. pmc Nonlinear dynamic causal models for fMRI
    Klaas Enno Stephan
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Neuroimage 42:649-62. 2008
    ..In both practical examples, Bayesian model selection favoured the nonlinear models over corresponding bilinear ones...
  10. pmc Investigating the functional role of callosal connections with dynamic causal models
    Klaas E Stephan
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, United Kingdom
    Ann N Y Acad Sci 1064:16-36. 2005
    ..We first review the theoretical foundations of DCM and BMS before demonstrating the application of these techniques to empirical data from a single subject...
  11. pmc Bayesian model selection for group studies
    Klaas Enno Stephan
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK
    Neuroimage 46:1004-17. 2009
    ..g. comparing different source reconstruction methods for EEG/MEG or selecting among competing computational models of learning and decision-making...
  12. pmc On the role of general system theory for functional neuroimaging
    Klaas Enno Stephan
    The Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, UK
    J Anat 205:443-70. 2004
    ....
  13. ncbi request reprint Biophysical models of fMRI responses
    Klaas E Stephan
    The Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Curr Opin Neurobiol 14:629-35. 2004
    ..Forward models with parameters at the neural level, such as dynamic causal modelling, combine both approaches, modelling the whole causal chain from external stimuli, via induced neural dynamics, to observed BOLD responses...
  14. pmc Interhemispheric integration of visual processing during task-driven lateralization
    Klaas E Stephan
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 27:3512-22. 2007
    ....
  15. pmc Dynamic causal models of neural system dynamics:current state and future extensions
    Klaas E Stephan
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    J Biosci 32:129-44. 2007
    ..These extensions are guided by the long-term goal of using dynamic system models for pharmacological and clinical applications, particularly with regard to synaptic plasticity...
  16. pmc Mechanisms of hemispheric specialization: insights from analyses of connectivity
    Klaas Enno Stephan
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London, UK
    Neuropsychologia 45:209-28. 2007
    ..Adopting a model-based approach enables functional imaging to proceed from mere descriptions of asymmetric activation patterns to mechanistic accounts of how these asymmetries are caused...
  17. pmc Striatal prediction error modulates cortical coupling
    Hanneke E M den Ouden
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, United Kingdom
    J Neurosci 30:3210-9. 2010
    ..This finding substantially advances our understanding of striatal function and provides direct empirical evidence for formal learning theories that posit a central role for prediction error-dependent plasticity...
  18. pmc Integrated Bayesian models of learning and decision making for saccadic eye movements
    Kay H Brodersen
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    Neural Netw 21:1247-60. 2008
    ....
  19. pmc Repetition suppression and plasticity in the human brain
    Marta I Garrido
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, UK
    Neuroimage 48:269-79. 2009
    ..It is remarkable that distinct changes in intrinsic and extrinsic connections could be quantified so reliably and non-invasively using EEG...
  20. pmc The mismatch negativity: a review of underlying mechanisms
    Marta I Garrido
    Wellcome Trust Centre for Neuroimaging, University College London, UK
    Clin Neurophysiol 120:453-63. 2009
    ..This paper presents a review of studies that focus on neuronal mechanisms underlying the MMN generation, discusses the two major explanatory hypotheses, and proposes predictive coding as a general framework that attempts to unify both...
  21. pmc Anterolateral prefrontal cortex mediates the analgesic effect of expected and perceived control over pain
    Katja Wiech
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG, United Kingdom
    J Neurosci 26:11501-9. 2006
    ..Failure to activate right alPFC may explain the maladaptive effects of strong general control beliefs during uncontrollable pain...
  22. pmc Dopamine, affordance and active inference
    Karl J Friston
    The Wellcome Trust Centre for Neuroimaging, University College London, Queen Square, London, United Kingdom
    PLoS Comput Biol 8:e1002327. 2012
    ..We use these simulations to demonstrate how a single functional role for dopamine at the synaptic level can manifest in different ways at the behavioural level...
  23. pmc Context-dependent human extinction memory is mediated by a ventromedial prefrontal and hippocampal network
    Raffael Kalisch
    Wellcome Department of Imaging Neuroscience, Functional Imaging Laboratory, Institute of Neurology, University College London, London, WC1N 3BG, United Kingdom
    J Neurosci 26:9503-11. 2006
    ..Thus, a VMPFC-hippocampal network provides for context-dependent recall of human extinction memory, consistent with a view that hippocampus confers context dependence on VMPFC...
  24. ncbi request reprint Fronto-temporal interactions during overt verbal initiation and suppression
    Paul Allen
    Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, London, UK
    J Cogn Neurosci 20:1656-69. 2008
    ....
  25. ncbi request reprint Attention to action in Parkinson's disease: impaired effective connectivity among frontal cortical regions
    James Rowe
    Wellcome Department of Cognitive Neurology, Institute of Neurology, Queen Square, London, UK
    Brain 125:276-89. 2002
    ..This deficit indicates a context-specific functional disconnection between the prefrontal cortex and the supplementary and premotor cortex in Parkinson's disease...
  26. pmc Cingulate activity and fronto-temporal connectivity in people with prodromal signs of psychosis
    Paul Allen
    Division of Psychological Medicine, Institute of Psychiatry, King s College, De Crespigny Park 16, London, UK
    Neuroimage 49:947-55. 2010
    ..Although task related fronto-temporal integration in the ARMS was intact, this may depend on increased engagement of the ACC which was not observed in healthy control subjects...
  27. pmc Contextual novelty changes reward representations in the striatum
    Marc Guitart-Masip
    Institute of Cognitive Neuroscience, University College London, London WC1N 3AR, United Kingdom
    J Neurosci 30:1721-6. 2010
    ..These findings support a view that contextual novelty enhances neural responses underlying reward representation in the striatum and concur with the effects of novelty processing as predicted by the model of Lisman and Grace (2005)...
  28. pmc Comparing families of dynamic causal models
    Will D Penny
    Wellcome Trust Centre for Neuroimaging, University College, London, United Kingdom
    PLoS Comput Biol 6:e1000709. 2010
    ..We illustrate the methods using Dynamic Causal Models of brain imaging data...
  29. pmc Observing the observer (I): meta-bayesian models of learning and decision-making
    Jean Daunizeau
    Wellcome Trust Centre for Neuroimaging, University College of London, London, United Kingdom
    PLoS ONE 5:e15554. 2010
    ....
  30. pmc Observing the observer (II): deciding when to decide
    Jean Daunizeau
    Wellcome Trust Centre for Neuroimaging, University College of London, London, United Kingdom
    PLoS ONE 5:e15555. 2010
    ..Finally, we illustrate how our approach can be used to quantify subjective beliefs and preferences that underlie inter-individual differences in behaviour...
  31. pmc Adaptive and aberrant reward prediction signals in the human brain
    Jonathan P Roiser
    Institute of Cognitive Neuroscience, University College London, London, UK
    Neuroimage 50:657-64. 2010
    ..The results are discussed in terms of their implications for different theories of associative learning...
  32. pmc Repetitive transcranial magnetic stimulation-induced changes in sensorimotor coupling parallel improvements of somatosensation in humans
    Burkhard Pleger
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG, United Kingdom
    J Neurosci 26:1945-52. 2006
    ..Thus, our data demonstrate that rTMS can temporarily induce behaviorally relevant reorganization within a complex cortical network underlying human somatosensory experience...
  33. ncbi request reprint Nicotinic modulation of human auditory sensory memory: Evidence from mismatch negativity potentials
    Torsten Baldeweg
    Institute of Child Health and Great Ormond Street Hospital, 30 Guilford Street, London WC1N 1EH, UK
    Int J Psychophysiol 59:49-58. 2006
    ..These results have potential implications for schizophrenia by suggesting that nicotinic agonists could ameliorate patients' MMN deficits by improving stimulus encoding and sensory memory trace formation...
  34. ncbi request reprint The prefrontal cortex shows context-specific changes in effective connectivity to motor or visual cortex during the selection of action or colour
    James B Rowe
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG, UK
    Cereb Cortex 15:85-95. 2005
    ....
  35. ncbi request reprint Acute changes in frontoparietal activity after repetitive transcranial magnetic stimulation over the dorsolateral prefrontal cortex in a cued reaction time task
    Elisabeth Rounis
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
    J Neurosci 26:9629-38. 2006
    ....
  36. pmc Neural coding of tactile decisions in the human prefrontal cortex
    Burkhard Pleger
    Wellcome Center of Neuroimaging, University College London, London WC1N 3AR, United Kingdom
    J Neurosci 26:12596-601. 2006
    ..Our findings suggest that activity in the left DLPFC encodes stimulus representations that underlie veridical tactile decisions in humans...
  37. pmc Dynamic causal modelling of evoked potentials: a reproducibility study
    Marta I Garrido
    The Wellcome Dept of Imaging Neuroscience, University College London, Queen Square, London, WC1N 3BG, UK
    Neuroimage 36:571-80. 2007
    ..At the group level the FB-model supervened. We discuss these findings in terms of the validity and usefulness of DCM in characterising EEG/MEG data and its ability to model ERPs in a mechanistic fashion...
  38. ncbi request reprint Task and content modulate amygdala-hippocampal connectivity in emotional retrieval
    Adam P R Smith
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London WC1N 6BT, United Kingdom
    Neuron 49:631-8. 2006
    ..Our findings demonstrate that both memory content and behavioral context impact upon large scale neuronal dynamics underlying emotional retrieval...
  39. pmc Empathic neural responses are modulated by the perceived fairness of others
    Tania Singer
    Wellcome Department of Imaging Neuroscience, University College of London, London WC1N 3AR, UK
    Nature 439:466-9. 2006
    ....
  40. ncbi request reprint On nodes and modes in resting state fMRI
    Karl J Friston
    The Wellcome Trust Centre for Neuroimaging, University College London, Queen Square, London WC1N 3BG, UK Electronic address
    Neuroimage 99:533-47. 2014
    ..Here, we focus on conceptual issues with simulated fMRI data and provide an illustrative application using an empirical multi-region timeseries. ..
  41. pmc The computational anatomy of psychosis
    Rick A Adams
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK
    Front Psychiatry 4:47. 2013
    ....
  42. ncbi request reprint Model selection and gobbledygook: response to Lohmann et al
    Karl Friston
    The Wellcome Trust Centre for Neuroimaging, University College London, Queen Square, London WC1N 3BG, UK
    Neuroimage 75:275-8; discussion 279-81. 2013
    ..2010). In this response, we unpack their misconceptions and try to answer their questions...
  43. ncbi request reprint Modulation of pain processing in hyperalgesia by cognitive demand
    Katja Wiech
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, UCL, 12 Queen Square, London WC1N 3BG, UK
    Neuroimage 27:59-69. 2005
    ..Within the limitations of an experimental model of pain, we suggest that the findings are relevant to understanding both the neurobiology and pathophysiology of chronic pain and its amelioration by cognitive strategies...
  44. ncbi request reprint Approaches to the cortical analysis of auditory objects
    Timothy D Griffiths
    Auditory Group, Medical School, Framlington Place, University of Newcastle, Newcastle upon Tyne, UK
    Hear Res 229:46-53. 2007
    ..The subjects have lesions of the normal network described above with normal perception of pitch strength but abnormal perception of the analysis of spectral envelope change...