Research Topics
| Klaas Enno StephanSummaryAffiliation: University College London Country: UK Publications
| Collaborators
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Detail Information
Publications
Initial demonstration of in vivo tracing of axonal projections in the macaque brain and comparison with the human brain using diffusion tensor imaging and fast marching tractographyGeoffrey J M Parker
NMR Research Unit, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, United Kingdom
Neuroimage 15:797-809. 2002..Analogous human anatomical connectivity is also presented for the first time using the FMT method, and the results are compared. The current limitations of the methodology and possibilities available for further studies are discussed...
Comparing hemodynamic models with DCMKlaas Enno Stephan
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK, and Brain Dynamics Center, Westmead Millenium Institute, Westmead Hospital, NSW, Australia
Neuroimage 38:387-401. 2007..Using fMRI data from a group of twelve subjects, we demonstrate that the best model is a non-linear model with a revised form for the coefficients, in which epsilon is treated as a free parameter...- The Brain Connectivity Workshops: moving the frontiers of computational systems neuroscienceKlaas Enno Stephan
Wellcome Trust Centre for Neuroimaging, University College London, 12 Queen Square, London WC1N3BG, UK
Neuroimage 42:1-9. 2008..Finally, we outline some central challenges and research trajectories in computational systems neuroscience for the next years... - The functional anatomy of the MMN: a DCM study of the roving paradigmMarta I Garrido
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, UK
Neuroimage 42:936-44. 2008..Ilmoniemi, R.J., Levänen, S., Lin, F.H., May, P., Melcher, J., Stufflebeam, S., Tiitinen, H., Belliveau, J.W., 2004. Human posterior auditory cortex gates novel sounds to consciousness. Proc. Natl. Acad. Sci. U. S. A. 101, 6809-6814]... - A dual role for prediction error in associative learningHanneke E M den Ouden
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
Cereb Cortex 19:1175-85. 2009..These results posit a dual role for prediction-error in encoding surprise and driving associative plasticity... - Computational disease modeling - fact or fiction?Jesper N Tegnér
Computational Medicine group, Department of Medicine, Center for Molecular Medicine, Karolinska University Hospital, Solna, Stockholm, Sweden
BMC Syst Biol 3:56. 2009..On the other hand, the physics-inspired top-down modeling strategy identifies and selects features of (presumably) essential relevance to the phenomena of interest and combines available data in models of modest complexity... - Dynamic causal models of neural system dynamics:current state and future extensionsKlaas E Stephan
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
J Biosci 32:129-44. 2007..These extensions are guided by the long-term goal of using dynamic system models for pharmacological and clinical applications, particularly with regard to synaptic plasticity... - Interhemispheric integration of visual processing during task-driven lateralizationKlaas E Stephan
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
J Neurosci 27:3512-22. 2007.... - Mechanisms of hemispheric specialization: insights from analyses of connectivityKlaas Enno Stephan
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London, UK
Neuropsychologia 45:209-28. 2007..Adopting a model-based approach enables functional imaging to proceed from mere descriptions of asymmetric activation patterns to mechanistic accounts of how these asymmetries are caused... - Dysconnection in schizophrenia: from abnormal synaptic plasticity to failures of self-monitoringKlaas E Stephan
Schizophr Bull 35:509-27. 2009..Finally, we test the explanatory power of our theory against a list of empirical facts about schizophrenia... - Synaptic plasticity and dysconnection in schizophreniaKlaas E Stephan
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London, United Kingdom
Biol Psychiatry 59:929-39. 2006..Promising experimental paradigms include perceptual and reinforcement learning. We describe how theoretical and causal models of brain responses might contribute to a mechanistic understanding of synaptic plasticity in schizophrenia... - Nonlinear dynamic causal models for fMRIKlaas Enno Stephan
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
Neuroimage 42:649-62. 2008..In both practical examples, Bayesian model selection favoured the nonlinear models over corresponding bilinear ones... - Investigating the functional role of callosal connections with dynamic causal modelsKlaas E Stephan
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, United Kingdom
Ann N Y Acad Sci 1064:16-36. 2005..We first review the theoretical foundations of DCM and BMS before demonstrating the application of these techniques to empirical data from a single subject... - Bayesian model selection for group studiesKlaas Enno Stephan
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK
Neuroimage 46:1004-17. 2009..g. comparing different source reconstruction methods for EEG/MEG or selecting among competing computational models of learning and decision-making... - Biophysical models of fMRI responsesKlaas E Stephan
The Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
Curr Opin Neurobiol 14:629-35. 2004..Forward models with parameters at the neural level, such as dynamic causal modelling, combine both approaches, modelling the whole causal chain from external stimuli, via induced neural dynamics, to observed BOLD responses... - On the role of general system theory for functional neuroimagingKlaas Enno Stephan
The Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, UK
J Anat 205:443-70. 2004.... - Striatal prediction error modulates cortical couplingHanneke E M den Ouden
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, United Kingdom
J Neurosci 30:3210-9. 2010..This finding substantially advances our understanding of striatal function and provides direct empirical evidence for formal learning theories that posit a central role for prediction error-dependent plasticity... - Repetition suppression and plasticity in the human brainMarta I Garrido
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, UK
Neuroimage 48:269-79. 2009..It is remarkable that distinct changes in intrinsic and extrinsic connections could be quantified so reliably and non-invasively using EEG... - Integrated Bayesian models of learning and decision making for saccadic eye movementsKay H Brodersen
Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
Neural Netw 21:1247-60. 2008.... - The mismatch negativity: a review of underlying mechanismsMarta I Garrido
Wellcome Trust Centre for Neuroimaging, University College London, UK
Clin Neurophysiol 120:453-63. 2009..This paper presents a review of studies that focus on neuronal mechanisms underlying the MMN generation, discusses the two major explanatory hypotheses, and proposes predictive coding as a general framework that attempts to unify both... - Anterolateral prefrontal cortex mediates the analgesic effect of expected and perceived control over painKatja Wiech
Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG, United Kingdom
J Neurosci 26:11501-9. 2006..Failure to activate right alPFC may explain the maladaptive effects of strong general control beliefs during uncontrollable pain... - Dopamine, affordance and active inferenceKarl J Friston
The Wellcome Trust Centre for Neuroimaging, University College London, Queen Square, London, United Kingdom
PLoS Comput Biol 8:e1002327. 2012..We use these simulations to demonstrate how a single functional role for dopamine at the synaptic level can manifest in different ways at the behavioural level... 
Fronto-temporal interactions during overt verbal initiation and suppressionPaul Allen
Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, London, UK
J Cogn Neurosci 20:1656-69. 2008....- Context-dependent human extinction memory is mediated by a ventromedial prefrontal and hippocampal networkRaffael Kalisch
Wellcome Department of Imaging Neuroscience, Functional Imaging Laboratory, Institute of Neurology, University College London, London, WC1N 3BG, United Kingdom
J Neurosci 26:9503-11. 2006..Thus, a VMPFC-hippocampal network provides for context-dependent recall of human extinction memory, consistent with a view that hippocampus confers context dependence on VMPFC... - Attention to action in Parkinson's disease: impaired effective connectivity among frontal cortical regionsJames Rowe
Wellcome Department of Cognitive Neurology, Institute of Neurology, Queen Square, London, UK
Brain 125:276-89. 2002..This deficit indicates a context-specific functional disconnection between the prefrontal cortex and the supplementary and premotor cortex in Parkinson's disease... - Cingulate activity and fronto-temporal connectivity in people with prodromal signs of psychosisPaul Allen
Division of Psychological Medicine, Institute of Psychiatry, King s College, De Crespigny Park 16, London, UK
Neuroimage 49:947-55. 2010..Although task related fronto-temporal integration in the ARMS was intact, this may depend on increased engagement of the ACC which was not observed in healthy control subjects... - Task and content modulate amygdala-hippocampal connectivity in emotional retrievalAdam P R Smith
Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London WC1N 6BT, United Kingdom
Neuron 49:631-8. 2006..Our findings demonstrate that both memory content and behavioral context impact upon large scale neuronal dynamics underlying emotional retrieval... - Comparing families of dynamic causal modelsWill D Penny
Wellcome Trust Centre for Neuroimaging, University College, London, United Kingdom
PLoS Comput Biol 6:e1000709. 2010..We illustrate the methods using Dynamic Causal Models of brain imaging data... - Observing the observer (I): meta-bayesian models of learning and decision-makingJean Daunizeau
Wellcome Trust Centre for Neuroimaging, University College of London, London, United Kingdom
PLoS ONE 5:e15554. 2010.... - Observing the observer (II): deciding when to decideJean Daunizeau
Wellcome Trust Centre for Neuroimaging, University College of London, London, United Kingdom
PLoS ONE 5:e15555. 2010..Finally, we illustrate how our approach can be used to quantify subjective beliefs and preferences that underlie inter-individual differences in behaviour... - Contextual novelty changes reward representations in the striatumMarc Guitart-Masip
Institute of Cognitive Neuroscience, University College London, London WC1N 3AR, United Kingdom
J Neurosci 30:1721-6. 2010..These findings support a view that contextual novelty enhances neural responses underlying reward representation in the striatum and concur with the effects of novelty processing as predicted by the model of Lisman and Grace (2005)... - Adaptive and aberrant reward prediction signals in the human brainJonathan P Roiser
Institute of Cognitive Neuroscience, University College London, London, UK
Neuroimage 50:657-64. 2010..The results are discussed in terms of their implications for different theories of associative learning... - The prefrontal cortex shows context-specific changes in effective connectivity to motor or visual cortex during the selection of action or colourJames B Rowe
Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG, UK
Cereb Cortex 15:85-95. 2005.... - Nicotinic modulation of human auditory sensory memory: Evidence from mismatch negativity potentialsTorsten Baldeweg
Institute of Child Health and Great Ormond Street Hospital, 30 Guilford Street, London WC1N 1EH, UK
Int J Psychophysiol 59:49-58. 2006..These results have potential implications for schizophrenia by suggesting that nicotinic agonists could ameliorate patients' MMN deficits by improving stimulus encoding and sensory memory trace formation... - Empathic neural responses are modulated by the perceived fairness of othersTania Singer
Wellcome Department of Imaging Neuroscience, University College of London, London WC1N 3AR, UK
Nature 439:466-9. 2006.... - Repetitive transcranial magnetic stimulation-induced changes in sensorimotor coupling parallel improvements of somatosensation in humansBurkhard Pleger
Wellcome Department of Imaging Neuroscience, Institute of Neurology, London WC1N 3BG, United Kingdom
J Neurosci 26:1945-52. 2006..Thus, our data demonstrate that rTMS can temporarily induce behaviorally relevant reorganization within a complex cortical network underlying human somatosensory experience... - Acute changes in frontoparietal activity after repetitive transcranial magnetic stimulation over the dorsolateral prefrontal cortex in a cued reaction time taskElisabeth Rounis
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom
J Neurosci 26:9629-38. 2006.... - Neural coding of tactile decisions in the human prefrontal cortexBurkhard Pleger
Wellcome Center of Neuroimaging, University College London, London WC1N 3AR, United Kingdom
J Neurosci 26:12596-601. 2006..Our findings suggest that activity in the left DLPFC encodes stimulus representations that underlie veridical tactile decisions in humans... - Dynamic causal modelling of evoked potentials: a reproducibility studyMarta I Garrido
The Wellcome Dept of Imaging Neuroscience, University College London, Queen Square, London, WC1N 3BG, UK
Neuroimage 36:571-80. 2007..At the group level the FB-model supervened. We discuss these findings in terms of the validity and usefulness of DCM in characterising EEG/MEG data and its ability to model ERPs in a mechanistic fashion... - Modulation of pain processing in hyperalgesia by cognitive demandKatja Wiech
Wellcome Department of Imaging Neuroscience, Institute of Neurology, UCL, 12 Queen Square, London WC1N 3BG, UK
Neuroimage 27:59-69. 2005..Within the limitations of an experimental model of pain, we suggest that the findings are relevant to understanding both the neurobiology and pathophysiology of chronic pain and its amelioration by cognitive strategies... - Approaches to the cortical analysis of auditory objectsTimothy D Griffiths
Auditory Group, Medical School, Framlington Place, University of Newcastle, Newcastle upon Tyne, UK
Hear Res 229:46-53. 2007..The subjects have lesions of the normal network described above with normal perception of pitch strength but abnormal perception of the analysis of spectral envelope change...