J Douglas Steele
Affiliation: University of Aberdeen
- Prefrontal cortical functional abnormality in major depressive disorder: a stereotactic meta-analysisJ Douglas Steele
Department of Mental Health, University of Aberdeen, UK
J Affect Disord 101:1-11. 2007..Second, the objective was to determine whether such regions are reported typically to be either over or under-active...
- Anterior cingulotomy for major depression: clinical outcome and relationship to lesion characteristicsJ Douglas Steele
Department of Mental Health, University of Aberdeen, Royal Cornhill Hospital, Aberdeen, United Kingdom
Biol Psychiatry 63:670-7. 2008..Although a long-established therapeutic intervention, the optimal location and volume of lesions are not known, but it is generally believed that efficacious lesions interrupt the fibers of the cingulum bundle...
- Blunted response to feedback information in depressive illnessJ D Steele
Department of Mental Health, University of Aberdeen, Royal Cornhill Hospital, Aberdeen AB25 2ZH, UK
Brain 130:2367-74. 2007..Our results suggest a direct link between the core subjective symptom of anhedonia, replicated neuropsychological deficits, electrophysiological and imaging abnormalities, and hypothesized dysfunction of the error correction system...
- Frontal operculum temporal difference signals and social motor response learningPoornima Kumar
Department of Mental Health, University of Aberdeen, Aberdeen, Scotland, United Kingdom
Hum Brain Mapp 30:1421-30. 2009..Dysfunction of such a mechanism might be associated with abnormal affective responses and incorrect social predictions, as occur in psychiatric disorders...
- Expected value and prediction error abnormalities in depression and schizophreniaVictoria B Gradin
Centre for Neuroscience, Department of Psychiatry, University of Dundee, Mail Box 5, Level 5, Ninewells Hospital and Medical School, Dundee DD1 9SY, UK
Brain 134:1751-64. 2011....
- Abnormal temporal difference reward-learning signals in major depressionP Kumar
Department of Mental Health, University of Aberdeen, Aberdeen AB25 2ZH, UK
Brain 131:2084-93. 2008....
- Possible structural abnormality of the brainstem in unipolar depressive illness: a transcranial ultrasound and diffusion tensor magnetic resonance imaging studyJ D Steele
Department of Mental Health, University of Aberdeen, Royal Cornhill Hospital, UK
J Neurol Neurosurg Psychiatry 76:1510-5. 2005..This may be consistent with disruption of white matter tracts, including the medial forebrain bundle, and it has been suggested that the effect of such disruption could be reversed by antidepressants...
- Neural predictive error signal correlates with depressive illness severity in a game paradigmJ D Steele
Department of Mental Health, University of Aberdeen, Aberdeen, AB25 2ZH, UK
Neuroimage 23:269-80. 2004..Again, differences were found that in some cases correlated with illness severity. These results are discussed in the context of quantitative theories of brain function, clinical features of depressive illness and treatments...
- Functional specialization within rostral prefrontal cortex (area 10): a meta-analysisSam J Gilbert
University College London, UK
J Cogn Neurosci 18:932-48. 2006..These results point to considerable functional segregation within rostral prefrontal cortex...
- Statistical parametric mapping of (99m)Tc-HMPAO-SPECT images for the diagnosis of Alzheimer's disease: normalizing to cerebellar tracer uptakeDarius Soonawala
Department of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, United Kingdom
Neuroimage 17:1193-202. 2002..We also investigated whether cerebellar normalization increases the sensitivity and specificity of SPM analysis of ATD patients compared with global normalization...
- Recent developments and current controversies in depressionKlaus P Ebmeier
Division of Psychiatry, University of Edinburgh, Kennedy Tower, Morningside Park, Edinburgh, UK
Lancet 367:153-67. 2006..We will try to describe the considerable effort that has gone into collecting evidence to enlighten this debate...
- Capsulotomy for obsessive-compulsive disorder: long-term follow-up of 25 patientsChristian Ruck
Section of Psychiatry M57, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
Arch Gen Psychiatry 65:914-21. 2008..Capsulotomy is sometimes used as a treatment of last resort in severe and treatment-refractory cases of obsessive-compulsive disorder (OCD)...
- Left dorso-lateral repetitive transcranial magnetic stimulation affects cortical excitability and functional connectivity, but does not impair cognition in major depressionPolash M Shajahan
MRC Brain Metabolism Unit, University of Edinburgh, Edinburgh, UK
Prog Neuropsychopharmacol Biol Psychiatry 26:945-54. 2002..This study was designed to explore the effects of differential treatment parameters, such as stimulation frequency. In addition, the data were examined to determine whether a change in connectivity occurred following TMS...