Daniel St Johnston
Affiliation: University of Cambridge
Fic W, Faria C, St Johnston D. Drosophila IMP regulates Kuzbanian to control the timing of Notch signalling in the follicle cells. Development. 2019;: pubmed publisher
..Thus, IMP regulates Notch signalling by controlling the localisation of Kuzbanian to the apical domain, where Notch cleavage occurs, revealing a novel regulatory step in the Notch pathway. ..
St Johnston D. Using mutants, knockdowns, and transgenesis to investigate gene function in Drosophila. Wiley Interdiscip Rev Dev Biol. 2013;2:587-613 pubmed publisher
Bergstralh D, St Johnston D. Spindle orientation: what if it goes wrong?. Semin Cell Dev Biol. 2014;34:140-5 pubmed publisher
..We speculate that one such mechanism involves a recently identified anaphase activity for two of the key players at metaphase: NuMA (Mud, LIN-5) and dynein. ..
St Johnston D, Ahringer J. Cell polarity in eggs and epithelia: parallels and diversity. Cell. 2010;141:757-74 pubmed publisher
..We also highlight the prospects for future studies on how cortical polarity interfaces with other cellular processes, such as morphogenesis, exocytosis, and lipid signaling, and how defects in polarity contribute to tumor formation. ..
St Johnston D, Sanson B. Epithelial polarity and morphogenesis. Curr Opin Cell Biol. 2011;23:540-6 pubmed publisher
Gardiol A, St Johnston D. Staufen targets coracle mRNA to Drosophila neuromuscular junctions and regulates GluRIIA synaptic accumulation and bouton number. Dev Biol. 2014;392:153-67 pubmed publisher
..Altogether, this suggests that this novel Staufen-dependent mRNA localisation and local translation pathway may play a role in the developmentally regulated growth of the NMJ. ..
Morais de Sá E, Mukherjee A, Lowe N, St Johnston D. Slmb antagonises the aPKC/Par-6 complex to control oocyte and epithelial polarity. Development. 2014;141:2984-92 pubmed publisher
..elegans axis formation, in which PAR-2 excludes the anterior PAR complex from the posterior cortex to induce polarity, but its function can be substituted by overexpressing Lgl. ..
Lowe N, Rees J, Roote J, Ryder E, Armean I, Johnson G, et al
. Analysis of the expression patterns, subcellular localisations and interaction partners of Drosophila proteins using a pigP protein trap library. Development. 2014;141:3994-4005 pubmed publisher
..Our resource substantially increases the number of available protein traps in Drosophila and identifies new markers for cellular organelles and structures. ..
Bergstralh D, Lovegrove H, Kujawiak I, Dawney N, Zhu J, Cooper S, et al
. Pins is not required for spindle orientation in the Drosophila wing disc. Development. 2016;143:2573-81 pubmed publisher
..Thus, Pins is not required in the wing disc because there are parallel mechanisms for Mud localization and hence spindle orientation, making it a more robust system than in other epithelia. ..