Steven H Spoel
Affiliation: University of Edinburgh
Mata Pérez C, Spoel S. Thioredoxin-mediated redox signalling in plant immunity. Plant Sci. 2019;279:27-33 pubmed publisher
..In this review we discuss these questions by examining evidence showing TRX enzymes exhibit novel activities that play important roles in diverse aspects of plant immune signalling. ..
Kneeshaw S, Spoel S. Thioredoxin-Dependent Decomposition of Protein S-Nitrosothiols. Methods Mol Biol. 2018;1747:281-297 pubmed publisher
..We show that this methodology identifies both global and specific protein-SNO targets of TRX in plant cell extracts. ..
Skelly M, Frungillo L, Spoel S. Transcriptional regulation by complex interplay between post-translational modifications. Curr Opin Plant Biol. 2016;33:126-132 pubmed publisher
..Complex interplay between these different post-translational modifications may provide robust control mechanisms to fine tune developmental and stress-responsive transcriptional programs. ..
Dussart F, Douglas R, SjÃ¶kvist E, Hoebe P, Spoel S, McGrann G. Genome-based discovery of polyketide-derived secondary metabolism pathways in the barley pathogen Ramularia collo-cygni. Mol Plant Microbe Interact. 2018;: pubmed publisher
Kneeshaw S, Gelineau S, Tada Y, Loake G, Spoel S. Selective protein denitrosylation activity of Thioredoxin-h5 modulates plant Immunity. Mol Cell. 2014;56:153-62 pubmed publisher
..Our data indicate that TRXh5 discriminates between protein-SNO substrates to provide previously unrecognized specificity and reversibility to protein-SNO signaling in plant immunity. ..
Kneeshaw S, Keyani R, Delorme Hinoux V, Imrie L, Loake G, Le Bihan T, et al
. Nucleoredoxin guards against oxidative stress by protecting antioxidant enzymes. Proc Natl Acad Sci U S A. 2017;: pubmed publisher
..These data suggest that unexpectedly H2O2-scavenging enzymes experience oxidative distress in ROS-rich environments and require reductive protection from NRX1 for optimal activity. ..
Frungillo L, Spoel S. Modulating the Modulator: Regulation of Protein Methylation by Nitric Oxide. Mol Cell. 2017;67:535-537 pubmed publisher
..Hu et al. (2017) demonstrate in this issue of Molecular Cell that S-nitrosylation selectively modulates enzymatic activity of a protein arginine methyltransferase vital to abiotic stress tolerance. ..