Tara L Spires
Affiliation: University of Oxford
- Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanismTara L Spires
University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, United Kingdom
J Neurosci 24:2270-6. 2004..These results suggest that environmental enrichment benefits animals at early stages of the disease by rescuing protein deficits, possibly through rescuing transcription or protein transport problems...
- Activity-dependent regulation of synapse and dendritic spine morphology in developing barrel cortex requires phospholipase C-beta1 signallingTara L Spires
University Laboratory of Physiology, University of Oxford, Parks Road, Oxford, UK
Cereb Cortex 15:385-93. 2005..Interrupting this regulation leads to changes in synapse and dendritic spine morphology, possibly altering post-synaptic integration of signal...
- Dendritic spine pathology and deficits in experience-dependent dendritic plasticity in R6/1 Huntington's disease transgenic miceTara L Spires
University Laboratory of Physiology, University of Oxford, Parks Road, Oxford, OX1 3PT, UK
Eur J Neurosci 19:2799-807. 2004..Furthermore, we demonstrate that Huntington's disease pathology interferes with the normal plastic response of dendritic spines to environmental enrichment...
- Wheel running from a juvenile age delays onset of specific motor deficits but does not alter protein aggregate density in a mouse model of Huntington's diseaseAnton van Dellen
Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK
BMC Neurosci 9:34. 2008..Furthermore, wheel running initiated in adulthood ameliorates the rear-paw clasping motor sign, but not an accelerating rotarod deficit...
- Nature, nurture and neurology: gene-environment interactions in neurodegenerative disease. FEBS Anniversary Prize Lecture delivered on 27 June 2004 at the 29th FEBS Congress in WarsawTara L Spires
MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA
FEBS J 272:2347-61. 2005..Here, we review the studies of environmental enrichment relevant to some major neurodegenerative diseases and discuss their research and clinical implications...
- Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopyTara L Spires
Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
J Neurosci 25:7278-87. 2005..Decreased spine density will likely contribute to altered neural system function and behavioral impairments observed in Tg2576 mice...
- Region-specific dissociation of neuronal loss and neurofibrillary pathology in a mouse model of tauopathyTara L Spires
Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown 02129, USA
Am J Pathol 168:1598-607. 2006..Together, these results imply that neurofibrillary tangles do not necessarily lead to neuronal death...
- Neuronal structure is altered by amyloid plaquesTara L Spires
Department of Neurology, Alzheimer s Disease Research Laboratory, Massachusetts General Hospital, Charlestown, MA 02129, USA
Rev Neurosci 15:267-78. 2004....
- Spine tingling polymorphisms--is apolipoprotein E involved in dendritic shape and plasticity?Tara L Spires
MassGeneral Institute for Neurodegenerative Disease Harvard Medical School, Charlestown, MA, United States
Neurobiol Aging 28:687-8; discussion 704-6. 2007
- Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivoTudor A Fulga
Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Harvard New Research Building Room 652, 77 Louis Pasteur Avenue, Boston, MA 02115, USA
Nat Cell Biol 9:139-48. 2007..These findings raise the possibility that a direct interaction between tau and actin may be a critical mediator of tau-induced neurotoxicity in Alzheimer's disease and related disorders...
- Molecular mechanisms mediating pathological plasticity in Huntington's disease and Alzheimer's diseaseTara L Spires
MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, MA, USA
J Neurochem 100:874-82. 2007..This review will present evidence for altered plasticity in Huntington's and Alzheimer's diseases, relate these findings to symptomatology, and review possible causes and commonalities...
- Transgenic models of Alzheimer's disease: learning from animalsTara L Spires
Harvard Medical School, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
NeuroRx 2:423-37. 2005..This chapter reviews animal models of AD and their contributions to developing therapeutic approaches for AD...