R Spiller

Summary

Affiliation: University of Nottingham
Country: UK

Publications

  1. ncbi Role of infection in irritable bowel syndrome
    Robin C Spiller
    Wolfson Digestive Diseases Centre, University Hospital, Nottingham, NG7 2UH, UK
    J Gastroenterol 42:41-7. 2007
  2. ncbi Irritable bowel syndrome: bacteria and inflammation--clinical relevance now
    Robin C Spiller
    Robin C Spiller, MB BChir, MSc, MD Wolfson Digestive Diseases Centre, University Hospital, Nottingham, NG7 2UH, England
    Curr Treat Options Gastroenterol 10:312-21. 2007
  3. pmc Irritable bowel syndrome, inflammatory bowel disease and the microbiome
    Giles Major
    Nottingham Digestive Diseases Biomedical Research Unit, University of Nottingham, Queen s Medical Centre, Nottingham, UK
    Curr Opin Endocrinol Diabetes Obes 21:15-21. 2014
  4. pmc Differential effects of FODMAPs (fermentable oligo-, di-, mono-saccharides and polyols) on small and large intestinal contents in healthy subjects shown by MRI
    Kathryn Murray
    Sir Peter Mansfield Magnetic Resonance Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK
    Am J Gastroenterol 109:110-9. 2014
  5. doi Fasting and postprandial volumes of the undisturbed colon: normal values and changes in diarrhea-predominant irritable bowel syndrome measured using serial MRI
    S E Pritchard
    Sir Peter Mansfield Magnetic Resonance Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK
    Neurogastroenterol Motil 26:124-30. 2014
  6. ncbi Effects of various food ingredients on gall bladder emptying
    L Marciani
    Nottingham Digestive Diseases Centre and NIHR Nottingham Digestive Diseases Biomedical Research Unit, University of Nottingham, Nottingham, UK
    Eur J Clin Nutr 67:1182-7. 2013
  7. ncbi Characterisation of faecal protease activity in irritable bowel syndrome with diarrhoea: origin and effect of gut transit
    David Tooth
    School of Biomedical Sciences, University of Nottingham, Nottingham, Nottinghamshire, UK
    Gut 63:753-60. 2014
  8. pmc Delayed gastric emptying and reduced postprandial small bowel water content of equicaloric whole meal bread versus rice meals in healthy subjects: novel MRI insights
    L Marciani
    University of Nottingham, Nottingham, UK
    Eur J Clin Nutr 67:754-8. 2013
  9. pmc An Update on Post-infectious Irritable Bowel Syndrome: Role of Genetics, Immune Activation, Serotonin and Altered Microbiome
    Robin Spiller
    NIHR Biomedical Research Unit in the Nottingham Digestive Diseases Centre, Nottingham, United Kingdom
    J Neurogastroenterol Motil 18:258-68. 2012
  10. pmc Efficacy and mode of action of mesalazine in the treatment of diarrhoea-predominant irritable bowel syndrome (IBS-D): study protocol for a randomised controlled trial
    Matthew P Leighton
    Nottingham Clinical Trials Unit, University of Nottingham, UK
    Trials 14:10. 2013

Collaborators

Detail Information

Publications71

  1. ncbi Role of infection in irritable bowel syndrome
    Robin C Spiller
    Wolfson Digestive Diseases Centre, University Hospital, Nottingham, NG7 2UH, UK
    J Gastroenterol 42:41-7. 2007
    ..The role of small-bowel bacterial overgrowth in IBS is controversial, but broad-spectrum antibiotics do have a temporary benefit in some patients. More acceptable long-term treatments altering gut flora are awaited with interest...
  2. ncbi Irritable bowel syndrome: bacteria and inflammation--clinical relevance now
    Robin C Spiller
    Robin C Spiller, MB BChir, MSc, MD Wolfson Digestive Diseases Centre, University Hospital, Nottingham, NG7 2UH, England
    Curr Treat Options Gastroenterol 10:312-21. 2007
    ..However, even in this group, preexisting psychological factors are as important as mucosal ones. Specific anti-inflammatory treatments have not been systematically evaluated, but there is no evidence of benefit currently...
  3. pmc Irritable bowel syndrome, inflammatory bowel disease and the microbiome
    Giles Major
    Nottingham Digestive Diseases Biomedical Research Unit, University of Nottingham, Queen s Medical Centre, Nottingham, UK
    Curr Opin Endocrinol Diabetes Obes 21:15-21. 2014
    ..It will also consider current efforts to modulate the microbiota for therapeutic effect...
  4. pmc Differential effects of FODMAPs (fermentable oligo-, di-, mono-saccharides and polyols) on small and large intestinal contents in healthy subjects shown by MRI
    Kathryn Murray
    Sir Peter Mansfield Magnetic Resonance Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK
    Am J Gastroenterol 109:110-9. 2014
    ..The aim was to better understand the origin of these symptoms by magnetic resonance imaging (MRI) of the gut...
  5. doi Fasting and postprandial volumes of the undisturbed colon: normal values and changes in diarrhea-predominant irritable bowel syndrome measured using serial MRI
    S E Pritchard
    Sir Peter Mansfield Magnetic Resonance Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK
    Neurogastroenterol Motil 26:124-30. 2014
    ..We aimed to measure regional volumes of the undisturbed colon in healthy volunteers (HV) and patients with diarrhea-predominant irritable bowel syndrome (IBS-D)...
  6. ncbi Effects of various food ingredients on gall bladder emptying
    L Marciani
    Nottingham Digestive Diseases Centre and NIHR Nottingham Digestive Diseases Biomedical Research Unit, University of Nottingham, Nottingham, UK
    Eur J Clin Nutr 67:1182-7. 2013
    ..To investigate this we designed two randomized, investigator-blind, cross-over studies in healthy subjects using magnetic resonance imaging (MRI) to measure gall bladder volumes serially and non-invasively...
  7. ncbi Characterisation of faecal protease activity in irritable bowel syndrome with diarrhoea: origin and effect of gut transit
    David Tooth
    School of Biomedical Sciences, University of Nottingham, Nottingham, Nottinghamshire, UK
    Gut 63:753-60. 2014
    ..Faecal serine proteases (FSPs) may play a role in irritable bowel syndrome with diarrhoea (IBS-D), but their origin is unclear. We aimed to structurally characterise them and define the impact of colonic cleansing and transit time...
  8. pmc Delayed gastric emptying and reduced postprandial small bowel water content of equicaloric whole meal bread versus rice meals in healthy subjects: novel MRI insights
    L Marciani
    University of Nottingham, Nottingham, UK
    Eur J Clin Nutr 67:754-8. 2013
    ..Whole meal bread (WMB) often aggravates such symptoms though the mechanisms are unclear. We used magnetic resonance imaging (MRI) to monitor the intragastric fate of a WMB meal (11% bran) compared with a rice pudding (RP) meal...
  9. pmc An Update on Post-infectious Irritable Bowel Syndrome: Role of Genetics, Immune Activation, Serotonin and Altered Microbiome
    Robin Spiller
    NIHR Biomedical Research Unit in the Nottingham Digestive Diseases Centre, Nottingham, United Kingdom
    J Neurogastroenterol Motil 18:258-68. 2012
    ..Future therapies aimed at correcting underlying mechanisms including immune activation and serotonin excess are currently being explored and may provide better treatments in the future...
  10. pmc Efficacy and mode of action of mesalazine in the treatment of diarrhoea-predominant irritable bowel syndrome (IBS-D): study protocol for a randomised controlled trial
    Matthew P Leighton
    Nottingham Clinical Trials Unit, University of Nottingham, UK
    Trials 14:10. 2013
    ..The current study aims to test the effectiveness of mesalazine to reduce symptoms in diarrhoea-predominant IBS patients. The study will also investigate the mode of action of the drug, especially its impact on mast cell activation...
  11. doi Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and TNF╬▒
    Caroline Swan
    Division of Therapeutics and Molecular Medicine, University of Nottingham, Nottingham, UK
    Gut 62:985-94. 2013
    ..The authors hypothesised that polymorphisms in genes whose expression were altered by gastroenteritis might be linked to IBS with diarrhoea (IBS-D) which closely resembles PI-IBS...
  12. doi Is it diverticular disease or is it irritable bowel syndrome?
    Robin Spiller
    NIHR Biomedical Research Unit, Nottingham Digestive Diseases Centre, Nottingham, UK
    Dig Dis 30:64-9. 2012
    ..For them, abnormalities of the gut are probably more important than cerebral factors, while for IBS the reverse is true. Treatments should be directed at the predominant abnormality which will vary in every patient...
  13. pmc Guidelines on the irritable bowel syndrome: mechanisms and practical management
    R Spiller
    Wolfson Digestive Diseases Centre, University of Nottingham, Nottingham, UK
    Gut 56:1770-98. 2007
    ..IBS affects 5-11% of the population of most countries. Prevalence peaks in the third and fourth decades, with a female predominance...
  14. ncbi Clinical update: irritable bowel syndrome
    Robin Spiller
    Wolfson Digestive Diseases Centre, University Hospital, Nottingham NG7 2UH, UK
    Lancet 369:1586-8. 2007
  15. ncbi Recent advances in understanding the role of serotonin in gastrointestinal motility in functional bowel disorders: alterations in 5-HT signalling and metabolism in human disease
    R Spiller
    Professor of Gastroenterology, Wolfson Digestive Diseases Centre, Nottingham, UK
    Neurogastroenterol Motil 19:25-31. 2007
    ..While IBS-D is associated with increased 5-HT postprandially, IBS with constipation (IBS-C) is associated with impaired 5-HT response and responds to 5-HT(4) agonists such as Prucalopride and 5-HT(4) partial agonists such as Tegaserod...
  16. ncbi Is IBS caused by infectious diarrhea?
    Robin C Spiller
    Wolfson Digestive Diseases Centre, University Hospital, Nottingham, UK
    Nat Clin Pract Gastroenterol Hepatol 4:642-3. 2007
  17. pmc Gut in 2007
    R Spiller
    Division of Gastroenterology, University Hospital Nottingham, Nottingham NG7 2UH, UK
    Gut 56:1645. 2007
  18. pmc Chronic diarrhoea
    R Spiller
    Division of Gastroenterology, University Hospital Nottingham, Nottingham NG7 2UH, UK
    Gut 56:1756-7. 2007
  19. doi Serotonin, inflammation, and IBS: fitting the jigsaw together?
    Robin Spiller
    Department of Gastroenterology, Wolfson Digestive Diseases Centre, Nottingham, UK
    J Pediatr Gastroenterol Nutr 45:S115-9. 2007
    ..However, reliable markers of low-grade inflammation that may predict response to serotonin antagonists or other anti-inflammatory agents remain a goal for future research...
  20. doi Serotonergic agents and the irritable bowel syndrome: what goes wrong?
    Robin Spiller
    Wolfson Digestive Diseases Centre, University Hospital, Nottingham, UK
    Curr Opin Pharmacol 8:709-14. 2008
    ....
  21. doi Serotonin and GI clinical disorders
    Robin Spiller
    Wolfson Digestive Diseases Centre, C Floor South Block, University Hospital, Clifton Boulevard, Nottingham, NG7 2UH, United Kingdom
    Neuropharmacology 55:1072-80. 2008
    ..Other conditions including IBS-C and constipation may have inadequate 5-HT release and benefit from both 5-HT(3) and 5-HT(4) receptor agonists...
  22. doi Postinfectious irritable bowel syndrome
    Robin Spiller
    Nottingham Digestive Diseases Centre Biomedical Research Unit, University Hospital, Nottingham, England
    Gastroenterology 136:1979-88. 2009
    ..There are no specific treatments for PI-IBS; these should be tailored to the predominant bowel disturbance, which is most frequently diarrhea...
  23. doi Infection, inflammation, and the irritable bowel syndrome
    R Spiller
    Nottingham Digestive Diseases Centre Biomedical Research Unit, University Hospital, Nottingham, United Kingdom
    Dig Liver Dis 41:844-9. 2009
    ..As yet there are no proven specific treatments, though 5HT(3) receptor antagonists, anti-inflammatory agents and probiotics are all logical treatments which should be examined in large well-designed randomised placebo controlled trials...
  24. doi Overlap between irritable bowel syndrome and inflammatory bowel disease
    Robin C Spiller
    Nottingham Digestive Diseases Centre, Biomedical Research Unit, University Hospital, Nottingham, UK
    Dig Dis 27:48-54. 2009
    ..Demonstration of the importance of the low-grade inflammation observed awaits definitive large scale trials of agents designed to specifically reverse these changes...
  25. doi The Patient Health Questionnaire 12 Somatic Symptom scale as a predictor of symptom severity and consulting behaviour in patients with irritable bowel syndrome and symptomatic diverticular disease
    R C Spiller
    Nottingham Digestive Diseases Centre, University Hospital, UK
    Aliment Pharmacol Ther 32:811-20. 2010
    ..We modified the Patient Health Questionnaire 15 (PHQ-15) by excluding three gastrointestinal items to create the PHQ-12 Somatic Symptom (PHQ-12 SS) scale...
  26. doi Potential biomarkers
    Robin C Spiller
    NIHR Biomedical Research Unit, Nottingham Digestive Diseases Centre, E Floor West Block, University Hospital, Nottingham, NG7 2UH, UK
    Gastroenterol Clin North Am 40:121-39. 2011
    ..However radio-isotope tests are expensive and of limited availability so the search for other more convenient markers including blood and stool tests is still an important goal for the future...
  27. doi Targeting the 5-HT(3) receptor in the treatment of irritable bowel syndrome
    Robin C Spiller
    NIHR Biomedical Research Unit, Nottingham Digestive Diseases Centre, University Hospital, Nottingham NG7 2UH, United Kingdom
    Curr Opin Pharmacol 11:68-74. 2011
    ..5-HT(3) receptor agonists stimulate intestinal motility, shorten transit times and in a pilot trial accelerated transit in patients with IBS-C...
  28. doi Irritable bowel syndrome: gender, infection, lifestyle or what else?
    Robin C Spiller
    University Hospital, Queen s Medical Centre, Nottingham Digestive Diseases Centre, NIHR Biomedical Research Unit, Nottingham, UK
    Dig Dis 29:215-21. 2011
    ..Host factors include gender, age and psychological characteristics, while environmental factors include psychosocial stressors, gastrointestinal infections, antibiotics and food...
  29. ncbi Role of motility in chronic diarrhoea
    R Spiller
    Wolfson Digestive Diseases Centre, University Hospital, Nottingham, UK
    Neurogastroenterol Motil 18:1045-55. 2006
    ..There are also treatments aimed primarily at altering motility directly including opiates, 5HT3 receptor antagonists and amitriptyline...
  30. pmc Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome
    R C Spiller
    Division of Gastroenterology, University Hospital Nottingham, Nottingham, UK
    Gut 47:804-11. 2000
    ..Post-dysenteric irritable bowel syndrome (PD-IBS) develops in up to 25% of patients following Campylobacter enteritis. Our aim was to define the pathological basis of this subgroup of IBS...
  31. ncbi Irritable bowel syndrome
    Robin C Spiller
    Wolfson Digestive Diseases Centre, University Hospital, Nottingham, NG7 2UH, UK
    Br Med Bull 72:15-29. 2004
    ..Low-dose tricyclic antidepressants are also helpful in alleviating pain and anxiety, even in those without obvious psychiatric disorders. If diagnostic criteria are met, then once diagnosed, new diagnoses rarely appear...
  32. ncbi Inflammation as a basis for functional GI disorders
    R C Spiller
    Division of Gastroenterology, The Wolfson Digestive Disease Centre, University Hospital, Nottingham NG7 2UH, UK
    Best Pract Res Clin Gastroenterol 18:641-61. 2004
    ..There are isolated anecdotal reports of symptom response to anti-inflammatory treatments but larger controlled trials are needed...
  33. ncbi Post-infectious irritable bowel syndrome
    Robin Spiller
    Wolfson Digestive Diseases Centre, University Hospital, Nottingham, UK
    Curr Opin Gastroenterol 22:13-7. 2006
    ..The peripheral component is prominent in irritable bowel syndrome developing after infection (post-infectious irritable bowel syndrome) and this has proved a profitable area of research...
  34. ncbi Infection, immune function, and functional gut disorders
    Robin C Spiller
    Wolfson Digestive Diseases Centre, University Hospital, Nottingham, United Kingdom
    Clin Gastroenterol Hepatol 2:445-55. 2004
  35. ncbi Is there any difference in Helicobacter pylori eradication rates in patients with active peptic ulcer, inactive peptic ulcer and functional dyspepsia?
    R C Spiller
    Division of Gastroenterology, University Hospital, Queen s Medical Centre, Nottingham, UK
    Eur J Gastroenterol Hepatol 11:S25-8; discussion S43-5. 1999
    ..Alternatively, inflammation may be a marker for more aggressive H. pylori subtypes, which are also more vulnerable to antibiotic therapy...
  36. pmc Pharmacotherapy: non-serotonergic mechanisms
    R Spiller
    Division of Gastroenterology, University Hospital, Notttingham, UK
    Gut 51:i87-90. 2002
    ..As knowledge increases, there are undoubtedly many other possible targets, and new drugs currently undergoing development may provide future benefit in patients with IBS...
  37. ncbi Review article: probiotics and prebiotics in irritable bowel syndrome
    R Spiller
    Wolfson Digestive Diseases Centre, University Hospital, University of Nottingham, Nottinghamshire, UK
    Aliment Pharmacol Ther 28:385-96. 2008
    ..Recent studies suggest a disturbance of this relationship in irritable bowel syndrome (IBS) and the potential to correct this using prebiotics and probiotics...
  38. pmc Role of nerves in enteric infection
    R C Spiller
    Division of Gastroenterology, University Hospital, Nottingham, UK
    Gut 51:759-62. 2002
    ..As our understanding of the role of nerves increases, exciting new targets for therapeutic intervention will emerge in both acute and chronic disorders induced by enteric infection...
  39. pmc Serotonergic modulating drugs for functional gastrointestinal diseases
    Robin Spiller
    Division of Gastroenterology, University Hospital, Nottingham, UK
    Br J Clin Pharmacol 54:11-20. 2002
    ..The drugs so far described are by and large devoid of CNS effects. It remains possible therefore that a drug which combines both peripheral and central effects would likely to be beneficial...
  40. doi The shifting interface between IBS and IBD
    Robin Spiller
    NIHR Biomedical Research Unit, Nottingham Digestive Diseases Centre, University Hospital, Nottingham NG7 2UH, United Kingdom
    Curr Opin Pharmacol 11:586-92. 2011
    ..Inconsistent changes have also been described in IBS but studies controlling for antibiotic use and differences in diet and bowel habit are needed before definitive conclusions can be made...
  41. ncbi Enterochromaffin cell hyperplasia and decreased serotonin transporter in a mouse model of postinfectious bowel dysfunction
    J Wheatcroft
    Wolfson Digestive Diseases Centre, University Hospital, Nottingham, UK
    Neurogastroenterol Motil 17:863-70. 2005
    ..Thus infection induced inflammation increases EC numbers, as has been reported in PI-IBS, and reduces SERT. This may increase mucosal 5HT availability and contribute to the clinical presentation of PI-IBS...
  42. ncbi Esophageal transit and in vivo disintegration of branded risedronate sodium tablets and two generic formulations of alendronic acid tablets: a single-center, single-blind, six-period crossover study in healthy female subjects
    Alan C Perkins
    Academic Medical Physics and Wolfson Digestive Diseases Centre, University Hospital, Nottingham, United Kingdom
    Clin Ther 30:834-44. 2008
    ....
  43. doi Concurrent drug use and the risk of perforated colonic diverticular disease: a population-based case-control study
    David J Humes
    Nottingham Digestive Disease Centre and Biomedical Research Unit, Department of Surgery, QMC Campus, E Floor, West Block, Nottingham University Hospital NHS Trust, Derby Road, Nottingham NG72UH, UK
    Gut 60:219-24. 2011
    ..To determine the risk of diverticular perforation associated with current and ever use of corticosteroids, opiate analgesics, non-steroidal anti-inflammatory drugs, aspirin, cyclo-oxygenase-2 inhibitors, statins and calcium antagonists...
  44. doi A population-based study of perforated diverticular disease incidence and associated mortality
    David J Humes
    Wolfson Digestive Disease Centre, Nottingham University Hospital NHS Trust, and Division of Epidemiology and Public Health, University of Nottingham, Nottingham, UK
    Gastroenterology 136:1198-205. 2009
    ..We aimed to determine the incidence and mortality associated with diverticular perforation and the influence of comorbidity...
  45. doi Gastric emptying of three liquid oral preoperative metabolic preconditioning regimens measured by magnetic resonance imaging in healthy adult volunteers: a randomised double-blind, crossover study
    Dileep N Lobo
    Division of Gastrointestinal Surgery, Nottingham Digestive Diseases Centre Biomedical Research Unit, Nottingham University Hospitals, Queen s Medical Centre, Nottingham, UK
    Clin Nutr 28:636-41. 2009
    ..We compared the gastric emptying of two types of preoperative metabolic preconditioning drinks [Oral Nutritional Supplement (ONS) (Fresenius Kabi, Germany) and preOp (Nutricia Clinical Care, UK)] in healthy volunteers...
  46. ncbi Improved methods for fMRI studies of combined taste and aroma stimuli
    Luca Marciani
    Wolfson Digestive Diseases Centre, University Hospital, University of Nottingham, Nottingham NG7 2UH, UK
    J Neurosci Methods 158:186-94. 2006
    ....
  47. ncbi Potential future therapies for irritable bowel syndrome: will disease modifying therapy as opposed to symptomatic control become a reality?
    Robin C Spiller
    Wolfson Digestive Diseases Centre, University Hospital, C Floor South Bank, Nottingham NG7 2UH, United Kingdom
    Gastroenterol Clin North Am 34:337-54. 2005
    ..Hypnotherapy has been shown to be effective in randomized placebo controlled trials and has a sustained effect...
  48. ncbi Esophageal transit of the weekly film-coated risedronate (Actonel) placebo tablet in subjects with Kyphosis
    Alan C Perkins
    University Hospital, Medical School, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Int J Pharm 311:20-5. 2006
    ....
  49. ncbi Abnormalities of GI transit in bloated irritable bowel syndrome: effect of bran on transit and symptoms
    John M Hebden
    Department of Gastroenterology, University Hospital Nottingham, United Kingdom
    Am J Gastroenterol 97:2315-20. 2002
    ..The aim of our study was to determine whether IBS patients with bloating responded to bran differently from healthy controls...
  50. ncbi Abnormal intestinal permeability in subgroups of diarrhea-predominant irritable bowel syndromes
    Simon P Dunlop
    Wolfson Digestive Diseases Centre and Division of Medical Physics, University Hospital, Nottingham, United Kingdom
    Am J Gastroenterol 101:1288-94. 2006
    ..Our aim was to compare small and large intestinal permeability in various subtypes of IBS to healthy controls...
  51. ncbi Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome
    Simon P Dunlop
    Division of Gastroenterology, University Hospital, Nottingham NG7 2UH, UK
    Clin Gastroenterol Hepatol 3:349-57. 2005
    ..Mucosal 5-HT-containing enterochromaffin cells (EC) are increased in postinfectious IBS (PI-IBS). Our aim was to define the postprandial release of 5-HT in PI-IBS and C-IBS patients and to relate this to mucosal 5-HT turnover...
  52. ncbi Postinfectious irritable bowel syndrome
    Robin C Spiller
    Division of Gastroenterology, University Hospital, Nottingham, United Kingdom
    Gastroenterology 124:1662-71. 2003
    ..Treatment with Loperamide, low-fiber diets, and bile salt- binding therapy may help some patients. Serotonin antagonists are logical treatments but have yet to be evaluated...
  53. doi Postprandial changes in small bowel water content in healthy subjects and patients with irritable bowel syndrome
    Luca Marciani
    Nottingham Digestive Diseases Centre NIHR Biomedical Research Unit, Queen s Medical Centre Campus, Nottingham University Hospitals NHS Trust, University of Nottingham, Nottingham, United Kingdom
    Gastroenterology 138:469-77, 477.e1. 2010
    ..We studied postprandial changes in distribution of water in the upper gastrointestinal tract of healthy volunteers (HVs) and patients with IBS-D after contrasting meals...
  54. ncbi Estimating the importance of infection in IBS
    Robin C Spiller
    Am J Gastroenterol 98:238-41. 2003
  55. ncbi Distinctive clinical, psychological, and histological features of postinfective irritable bowel syndrome
    Simon P Dunlop
    Division of Divisions of Gastroenterology, University Hospital, Nottingham, United Kingdom
    Am J Gastroenterol 98:1578-83. 2003
    ..Our aim was to determine whether postinfective IBS (PI-IBS) has histological or clinical features that are distinct from those of IBS patients with no history of preceding infection...
  56. ncbi Magnetic resonance imaging of the behaviour of oil-in-water emulsions in the gastric lumen of man
    Luca Marciani
    Wolfson Digestive Diseases Centre, Queen s Medical Centre, University Hospital, Nottingham NG7 2RD, UK
    Br J Nutr 95:331-9. 2006
    ..These pilot data suggest that gastric processing and emptying of high-fat foods could be manipulated by careful choice of emulsifier...
  57. ncbi Gallbladder contraction, gastric emptying and antral motility: single visit assessment of upper GI function in untreated celiac disease using echo-planar MRI
    Luca Marciani
    Wolfson Digestive Diseases Centre, School of Medical and Surgical Sciences, University Hospital, Nottingham, Nottingham, UK
    J Magn Reson Imaging 22:634-8. 2005
    ..To assess gallbladder contraction, gastric emptying, and antral motility in untreated celiac patients and healthy controls using a single MRI examination...
  58. ncbi Age-related decline in rectal mucosal lymphocytes and mast cells
    Simon P Dunlop
    Division of Gastroenterology, University Hospital, Nottingham, NG7 2UH, UK
    Eur J Gastroenterol Hepatol 16:1011-5. 2004
    ....
  59. doi Effect of intragastric acid stability of fat emulsions on gastric emptying, plasma lipid profile and postprandial satiety
    Luca Marciani
    Wolfson Digestive Diseases Centre, Queen s Medical Centre, Nottingham University Hospitals, University of Nottingham, Nottingham NG7 2UH, UK
    Br J Nutr 101:919-28. 2009
    ..This shows that it is possible to delay gastric emptying and increase satiety by stabilising the intragastric distribution of fat emulsions against the gastric acid environment. This could have implications for the design of novel foods...
  60. ncbi Monitoring of gallbladder and gastric coordination by EPI
    Luca Marciani
    Sir Peter Mansfield Magnetic Resonance Centre, School of Physics and Astronomy, University of Nottingham, UK
    J Magn Reson Imaging 21:82-5. 2005
    ..To assess for the first time the potential of echo-planar magnetic resonance imaging (EPI) for measuring simultaneously both gallbladder and gastric emptying...
  61. ncbi Enhancement of intragastric acid stability of a fat emulsion meal delays gastric emptying and increases cholecystokinin release and gallbladder contraction
    Luca Marciani
    Wolfson Digestive Diseases Centre, QMC, Nottingham Univ Hospital, Univ of Nottingham, Nottingham NG7 2UH, UK
    Am J Physiol Gastrointest Liver Physiol 292:G1607-13. 2007
    ..Manipulation of the acid stability of fat emulsion added to preprocessed foods could maximize satiety signaling and, in turn, help to reduce overconsumption of calories...
  62. ncbi Functional bowel disorders
    George F Longstreth
    Kaiser Permanente Medical Care Program, San Diego, California 92120, USA
    Gastroenterology 130:1480-91. 2006
    ..Treatment of FBDs is based on an individualized evaluation, explanation, and reassurance. Alterations in diet, drug treatment aimed at predominant symptoms, and psychotherapy may be beneficial...
  63. ncbi Echo-planar magnetic resonance imaging of Gaviscon alginate rafts in-vivo
    Luca Marciani
    Magnetic Resonance Centre, School of Physics and Astronomy, Nottingham NG7 2RD, UK
    J Pharm Pharmacol 54:1351-6. 2002
    ..The T2(-1) data showed potential for assessment of dynamic changes in the physicochemical properties of the alginate rafts in-vivo. We conclude that EPI shows great potential in assessing alginate rafts formation in-vivo...
  64. ncbi Gastric juice, gastric tissue and blood antibiotic concentrations following omeprazole, amoxicillin and clarithromycin triple therapy
    Masahiko Nakamura
    Research Center for Clinical Pharmacology, Center for Basic Research, Kitasato Institute, Tokyo, Japan
    Helicobacter 8:294-9. 2003
    ..Amoxicillin and clarithromycin are key antibiotics in proton pump inhibitor-based Helicobacter pylori eradication therapies...
  65. ncbi Abnormalities of serotonin metabolism and their relation to symptoms in untreated celiac disease
    Nicholas S Coleman
    Division of Gastroenterology, School of Medical and Surgical Sciences, University Hospital, Nottingham, United Kingdom
    Clin Gastroenterol Hepatol 4:874-81. 2006
    ..Our aim was to determine how this inflammatory lesion influenced 5-HT bioavailability and how changes in 5-HT related to the symptoms of nausea, vomiting, and diarrhea seen in untreated celiac patients...
  66. doi The effects of fasting and refeeding with a 'metabolic preconditioning' drink on substrate reserves and mononuclear cell mitochondrial function
    Sherif Awad
    Division of Gastrointestinal Surgery, Nottingham Digestive Diseases Centre NIHR Biomedical Research Unit, Nottingham University Hospitals, Queen s Medical Centre, Nottingham NG7 2UH, UK
    Clin Nutr 29:538-44. 2010
    ....
  67. ncbi In vivo imaging of intragastric gelation and its effect on satiety in humans
    Caroline L Hoad
    Sir Peter Mansfield Magnetic Resonance Centre, University of Nottingham, Nottingham, UK
    J Nutr 134:2293-300. 2004
    ..Agents that gel on contact with acid may be useful additions to weight-reducing diets. We hypothesize that this effect is due to distension in the gastric antrum and/or altered transport of nutrients to the small intestine in the lumps...
  68. ncbi Relative importance of enterochromaffin cell hyperplasia, anxiety, and depression in postinfectious IBS
    Simon P Dunlop
    Wolfson Digestive Diseases Centre, University Hospital, Nottingham, England
    Gastroenterology 125:1651-9. 2003
    ..Our aim was to prospectively determine the relative importance of both psychological and histologic factors in the development of PI-IBS after Campylobacter infection...
  69. ncbi Patterns of pain in diverticular disease and the influence of acute diverticulitis
    John Simpson
    Division of Surgery, University of Nottingham, Nottingham, UK
    Eur J Gastroenterol Hepatol 15:1005-10. 2003
    ..While the association of recurrent bouts of abdominal pain with colonic diverticulosis is well recognized, the cause of this pain is obscure since in most cases it occurs without obvious diverticulitis or other potential causes...
  70. ncbi Neuropathology of IBS?
    Robin C Spiller
    Gastroenterology 123:2144-7. 2002
  71. ncbi Information assimilation and distribution challenges and goals for real and virtual journals
    Irvin M Modlin
    Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Clin Gastroenterol 39:181-8. 2005
    ....