M G Spillantini

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. ncbi request reprint Microtubule-associated protein tau, heparan sulphate and alpha-synuclein in several neurodegenerative diseases with dementia
    M G Spillantini
    MRC Brain Repair Centre and Department of Neurology, University of Cambridge, UK
    Acta Neuropathol 97:585-94. 1999
  2. ncbi request reprint Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease
    M Goedert
    Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
    Biochim Biophys Acta 1502:110-21. 2000
  3. pmc Human stem cell-derived neurons: a system to study human tau function and dysfunction
    Mariangela Iovino
    Department of Clinical Neurosciences, Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 5:e13947. 2010
  4. pmc Familial multiple system tauopathy with presenile dementia: a disease with abundant neuronal and glial tau filaments
    M G Spillantini
    Medical Research Council Cambridge Centre for Brain Repair, University of Cambridge, United Kingdom
    Proc Natl Acad Sci U S A 94:4113-8. 1997
  5. doi request reprint Release of growth factors by neuronal precursor cells as a treatment for diseases with tau pathology
    Maria Grazia Spillantini
    Department of Clinical Neurosciences, University of Cambridge, Cambridge UK
    Arch Ital Biol 149:215-23. 2011
  6. ncbi request reprint The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy
    M G Spillantini
    Department of Neurology and Brain Repair Centre, University of Cambridge, Cambridge, UK
    Ann N Y Acad Sci 920:16-27. 2000
  7. ncbi request reprint Mutations in the tau gene (MAPT) in FTDP-17: the family with Multiple System Tauopathy with Presenile Dementia (MSTD)
    Maria Grazia Spillantini
    Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Robinson Way, Cambridge CB2 2PY, UK
    J Alzheimers Dis 9:373-80. 2006
  8. ncbi request reprint Frontotemporal dementia and Parkinsonism linked to chromosome 17: a new group of tauopathies
    M G Spillantini
    MRC Brain Repair Centre and Department of Neurology, University of Cambridge, UK
    Brain Pathol 8:387-402. 1998
  9. pmc Tau pathology in two Dutch families with mutations in the microtubule-binding region of tau
    M G Spillantini
    Department of Neurology, University of Cambridge, United Kingdom
    Am J Pathol 153:1359-63. 1998
  10. ncbi request reprint Tau gene mutation K257T causes a tauopathy similar to Pick's disease
    C Rizzini
    Brain Repair Centre and Department of Neurology, University of Cambridge, United Kingdom
    J Neuropathol Exp Neurol 59:990-1001. 2000

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Microtubule-associated protein tau, heparan sulphate and alpha-synuclein in several neurodegenerative diseases with dementia
    M G Spillantini
    MRC Brain Repair Centre and Department of Neurology, University of Cambridge, UK
    Acta Neuropathol 97:585-94. 1999
    ....
  2. ncbi request reprint Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease
    M Goedert
    Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
    Biochim Biophys Acta 1502:110-21. 2000
    ..Several missense mutations also have a stimulatory effect on heparin-induced tau filament formation. Assembly of tau into filaments may be the gain of toxic function that is believed to underlie the demise of affected brain cells...
  3. pmc Human stem cell-derived neurons: a system to study human tau function and dysfunction
    Mariangela Iovino
    Department of Clinical Neurosciences, Cambridge Centre for Brain Repair, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 5:e13947. 2010
    ..In this study, we have investigated whether human embryonic stem cell-derived neurons could be a good model to study human tau distribution, function and dysfunction...
  4. pmc Familial multiple system tauopathy with presenile dementia: a disease with abundant neuronal and glial tau filaments
    M G Spillantini
    Medical Research Council Cambridge Centre for Brain Repair, University of Cambridge, United Kingdom
    Proc Natl Acad Sci U S A 94:4113-8. 1997
    ....
  5. doi request reprint Release of growth factors by neuronal precursor cells as a treatment for diseases with tau pathology
    Maria Grazia Spillantini
    Department of Clinical Neurosciences, University of Cambridge, Cambridge UK
    Arch Ital Biol 149:215-23. 2011
    ..A nonsignificant increase of brain derived neurotrophic factor expression was instead found in the area of the cortex where neuronal death was rescued...
  6. ncbi request reprint The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy
    M G Spillantini
    Department of Neurology and Brain Repair Centre, University of Cambridge, Cambridge, UK
    Ann N Y Acad Sci 920:16-27. 2000
    ..The new work has established the alpha-synucleinopathies as a major class of neurodegenerative disease...
  7. ncbi request reprint Mutations in the tau gene (MAPT) in FTDP-17: the family with Multiple System Tauopathy with Presenile Dementia (MSTD)
    Maria Grazia Spillantini
    Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, Robinson Way, Cambridge CB2 2PY, UK
    J Alzheimers Dis 9:373-80. 2006
    ..Proc. Natl. Acad. Sci. USA 95, 7737-7741] reported a mutation at position + 3 in the intron following alternatively spliced exon 10 of the tau gene in a family...
  8. ncbi request reprint Frontotemporal dementia and Parkinsonism linked to chromosome 17: a new group of tauopathies
    M G Spillantini
    MRC Brain Repair Centre and Department of Neurology, University of Cambridge, UK
    Brain Pathol 8:387-402. 1998
    ..The presence of abundant tau deposits in the majority of these families define this disorder as a new tauopathy...
  9. pmc Tau pathology in two Dutch families with mutations in the microtubule-binding region of tau
    M G Spillantini
    Department of Neurology, University of Cambridge, United Kingdom
    Am J Pathol 153:1359-63. 1998
    ....
  10. ncbi request reprint Tau gene mutation K257T causes a tauopathy similar to Pick's disease
    C Rizzini
    Brain Repair Centre and Department of Neurology, University of Cambridge, United Kingdom
    J Neuropathol Exp Neurol 59:990-1001. 2000
    ..Taken together, the present findings indicate that the K257T mutation in Tau can cause a dementing condition similar to Pick's disease...
  11. ncbi request reprint Tau gene mutations in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Their relevance for understanding the neurogenerative process
    M Goedert
    Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
    Ann N Y Acad Sci 920:74-83. 2000
    ..The new work has shown that dysfunction of tau protein causes neurodegeneration...
  12. pmc Cloning and sequencing of the cDNA encoding an isoform of microtubule-associated protein tau containing four tandem repeats: differential expression of tau protein mRNAs in human brain
    M Goedert
    Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 8:393-9. 1989
    ..Taken in conjunction with previous findings, the present results indicate that both the three and four repeat-containing tau protein isoforms are present in the core of the paired helical filament...
  13. pmc alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies
    M G Spillantini
    Medical Research Council Centre for Brain Repair and Department of Neurology, University of Cambridge, Robinson Way, Cambridge CB2 2PY, United Kingdom
    Proc Natl Acad Sci U S A 95:6469-73. 1998
    ..These findings indicate that alpha-synuclein forms the major filamentous component of Lewy bodies and Lewy neurites...
  14. pmc Mutation in the tau gene in familial multiple system tauopathy with presenile dementia
    M G Spillantini
    Medical Research Council Centre for Brain Repair and Department of Neurology, University of Cambridge, Robinson Way, Cambridge CB2 2PY, UK
    Proc Natl Acad Sci U S A 95:7737-41. 1998
    ..The results show that dysregulation of tau protein production can cause neurodegeneration and imply that the FTDP-17 gene is the tau gene. This work has major implications for Alzheimer's disease and other tauopathies...
  15. pmc Atrophy patterns in histologic vs clinical groupings of frontotemporal lobar degeneration
    J M S Pereira
    Department of Clinical Neurosciences, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Neurology 72:1653-60. 2009
    ..Our aim was to test the hypothesis that clinical, but not pathologic, classification (FTD with ubiquitin inclusions [FTD-U] and FTD with tau inclusions [FTD-T]) is associated with predictable patterns of regional atrophy...
  16. pmc Different configurational states of beta-amyloid and their distributions relative to plaques and tangles in Alzheimer disease
    M G Spillantini
    Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    Proc Natl Acad Sci U S A 87:3947-51. 1990
    ..These antibodies, in conjunction with anti-tau antibodies, were used to demonstrate a close spatial relationship between amyloid deposits and neurofibrillary tangles...
  17. ncbi request reprint The effect of truncated human alpha-synuclein (1-120) on dopaminergic cells in a transgenic mouse model of Parkinson's disease
    A W Michell
    Department of Clinical Neuroscience, University of Cambridge and Cambridge Centre for Brain Repair, Cambridge, CB2 2PY, UK
    Cell Transplant 16:461-74. 2007
    ..These results suggest that alpha-synuclein (1-120) renders dopaminergic cells more susceptible to stress, which may have important implications as to how this truncated protein might contribute to dopaminergic cell death in sporadic PD...
  18. ncbi request reprint PTL-1, a microtubule-associated protein with tau-like repeats from the nematode Caenorhabditis elegans
    M Goedert
    MRC Laboratory of Molecular Biology, Cambridge, UK
    J Cell Sci 109:2661-72. 1996
    ..These findings indicate that MAPs of the tau/MAP2/MAP4 family are found throughout much of the animal kingdom, where they may play a role in specialised processes requiring microtubules...
  19. ncbi request reprint A novel tau mutation (N296N) in familial dementia with swollen achromatic neurons and corticobasal inclusion bodies
    M G Spillantini
    Brain Repair Centre, University of Cambridge, UK
    Ann Neurol 48:939-43. 2000
    ..By exon trapping, the mutation produced an increase in the splicing in of exon 10, indicating that it probably causes disease through an overproduction of four-repeat tau...
  20. ncbi request reprint alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome
    G K Tofaris
    Cambridge Centre for Brain Repair and Neurology Department, University of Cambridge, Forvie Site, Robinson Way, CB2 2PY, Cambridge, UK
    FEBS Lett 509:22-6. 2001
    ..These findings suggest an ubiquitin-independent mechanism of proteasomal degradation for alpha-synuclein and other natively unfolded proteins...
  21. ncbi request reprint Identification of two distinct synucleins from human brain
    R Jakes
    MRC Laboratory of Molecular Biology, Cambridge, UK
    FEBS Lett 345:27-32. 1994
    ..We refer to the 140 and 134 amino acid proteins as alpha-synuclein and beta-synuclein, respectively. Both synucleins are expressed predominantly in brain, where they are concentrated in presynaptic nerve terminals...
  22. ncbi request reprint Filamentous nerve cell inclusions in neurodegenerative diseases
    M Goedert
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Curr Opin Neurobiol 8:619-32. 1998
    ....
  23. doi request reprint Abnormally phosphorylated tau is associated with neuronal and axonal loss in experimental autoimmune encephalomyelitis and multiple sclerosis
    J M Anderson
    Department of Clinical Neurosciences, Cambridge Centre for Brain Repair, University of Cambridge, Forvie Site, Robinson Way, Cambridge, UK
    Brain 131:1736-48. 2008
    ..Together, these observations provide the first evidence implicating abnormal tau in the neurodegenerative phase of tissue injury in experimental and human demyelinating disease...
  24. pmc From genetics to pathology: tau and alpha-synuclein assemblies in neurodegenerative diseases
    M Goedert
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Philos Trans R Soc Lond B Biol Sci 356:213-27. 2001
    ....
  25. pmc Cloning of a big tau microtubule-associated protein characteristic of the peripheral nervous system
    M Goedert
    Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    Proc Natl Acad Sci U S A 89:1983-7. 1992
    ....
  26. ncbi request reprint Segmental and developmental regulation of a presumptive T-cell oncogene in the central nervous system
    J M Greenberg
    Laboratory of Molecular Biology, Cambridge, UK
    Nature 344:158-60. 1990
    ..Thus, this presumptive T-cell oncogene is both developmentally regulated and segmentally restricted in a tissue different from that in which the original tumour arose...
  27. pmc Nerve growth factor mRNA and protein increase in hypothalamus in a mouse model of aggression
    M G Spillantini
    Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom
    Proc Natl Acad Sci U S A 86:8555-9. 1989
    ..The present results firmly establish that nerve cells constitute the major source in NGF in the brain. They also open the way to understanding the regulation of NGF biosynthesis in the central nervous system...
  28. ncbi request reprint Assignment of human alpha-synuclein (SNCA) and beta-synuclein (SNCB) genes to chromosomes 4q21 and 5q35
    M G Spillantini
    MRC Laboratory of Molecular Biology, Cambridge, United Kingdom
    Genomics 27:379-81. 1995
  29. ncbi request reprint Physiological and pathological properties of alpha-synuclein
    G K Tofaris
    Cambridge Centre for Brain Repair and Department of Clinical Neuroscience Forvie Site, Robinson Way, Cambridge CB2 2PY, United Kingdom
    Cell Mol Life Sci 64:2194-201. 2007
    ..Here we review the function of alpha-synuclein and recent insight into the mechanisms by which it aggregates...
  30. ncbi request reprint Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene rhombotin: evidence for thymus expression
    T Boehm
    Medical Research Council Laboratory of Molecular Biology, Cambridge, UK
    Oncogene 6:695-703. 1991
    ....
  31. ncbi request reprint Familial frontotemporal dementia with ubiquitin-positive inclusions is linked to chromosome 17q21-22
    S M Rosso
    Department of Neurology, Erasmus Medical Centre Rotterdam, The Netherlands
    Brain 124:1948-57. 2001
    ..Further characterization of the ubiquitin-positive inclusions may clarify the neurodegenerative pathways involved in this subtype of FTD...
  32. ncbi request reprint Tau gene mutation G389R causes a tauopathy with abundant pick body-like inclusions and axonal deposits
    J R Murrell
    Department of Pathology and Laboratory Medicine and Indiana Alzheimer Disease Center, Indiana University School of Medicine, Indianapolis 46202, USA
    J Neuropathol Exp Neurol 58:1207-26. 1999
    ..Taken together, the present findings indicate that the G389R mutation in Tau can cause a dementing condition that closely resembles Pick's disease...
  33. ncbi request reprint Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau
    O Bugiani
    Istituto Neurologico Carlo Besta, Milano, Italy
    J Neuropathol Exp Neurol 58:667-77. 1999
    ..Biochemically, recombinant tau protein with the P301S mutation showed a greatly reduced ability to promote microtubule assembly...
  34. ncbi request reprint A novel leukoencephalopathy associated with tau deposits primarily in white matter glia
    J M Powers
    Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Box 626, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Acta Neuropathol 106:181-7. 2003
    ..The precise relationship between this disorder and other frontotemporal degenerations/tauopathies, as well as the pathogenetic basis of the leukoencephalopathy, remains to be determined...
  35. pmc Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17
    L Varani
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom
    Proc Natl Acad Sci U S A 96:8229-34. 1999
    ..By exon trapping, the reduction in thermodynamic stability is correlated with increased splicing in of exon 10...
  36. ncbi request reprint Phenotypic variation in hereditary frontotemporal dementia with tau mutations
    J C van Swieten
    Department of Neurology, Erasmus University Rotterdam, The Netherlands
    Ann Neurol 46:617-26. 1999
    ..The slower progression of the disease in the R406W family might be explained by the microtubule-binding properties of the mutant protein...
  37. ncbi request reprint Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease
    M Goedert
    Medical Research Council, Laboratory of Molecular Biology, Cambridge, England
    Neuron 3:519-26. 1989
    ..Antisera raised against synthetic peptides corresponding to these different human tau isoforms demonstrate that multiple tau protein isoforms are incorporated into the neurofibrillary tangles of Alzheimer's disease...
  38. ncbi request reprint Pick's disease associated with the novel Tau gene mutation K369I
    M Neumann
    Institute of Neuropathology, Ludwig Maximilians University, Munich, Germany
    Ann Neurol 50:503-13. 2001
    ..Taken together, results indicate that the K369I mutation in Tau can cause a dementing disease with a neuropathology like that of Pick's disease...
  39. ncbi request reprint [Familial fronto-temporal dementia with brain stem ubiquitin-positive neuronal inclusions]
    A C Bruni
    Centro Regionale di Neurogenetica, Lamezia Terme CZ, Italie
    Rev Neurol (Paris) 160:1171-9. 2004
    ..A few, such as tauopathies due to mutations of the gene coding for tau protein (MAPtau form a well-defined group. Definition and grouping of other types of FTD is still problematic...
  40. ncbi request reprint Chromosome 3 linked frontotemporal dementia (FTD-3)
    S Gydesen
    Frontotemporal Dementia Research in Jutland Association FreJA, Denmark
    Neurology 59:1585-94. 2002
    ..The authors have identified and studied a large kindred in which frontotemporal dementia (FTD) is inherited as an autosomal dominant trait. The trait has been mapped to the pericentromeric region of chromosome 3...
  41. ncbi request reprint The human glutamate receptor cDNA GluR1: cloning, sequencing, expression and localization to chromosome 5
    M C Potier
    Medical Research Council, Laboratory of Molecular Biology, Cambridge, England
    DNA Seq 2:211-8. 1992
    ..Dot blot analysis of flow-sorted human chromosomes showed that the GluR1 gene maps to chromosome 5...
  42. ncbi request reprint Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein
    A Probst
    Abteilung Neuropathologie, Institut fur Pathologie, Universitat Basel, Switzerland
    Acta Neuropathol 99:469-81. 2000
    ..Taken together, these findings demonstrate that overexpression of human four-repeat tau leads to a central and peripheral axonopathy that results in nerve cell dysfunction and amyotrophy...