Jeremy P E Spencer

Summary

Affiliation: University of Reading
Country: UK

Publications

  1. doi request reprint The impact of fruit flavonoids on memory and cognition
    Jeremy P E Spencer
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading, UK
    Br J Nutr 104:S40-7. 2010
  2. doi request reprint Neuroinflammation: modulation by flavonoids and mechanisms of action
    Jeremy P E Spencer
    Molecular Nutrition Group, Centre for Integrative Neuroscience and Neurodynamics, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG6 6AP, UK
    Mol Aspects Med 33:83-97. 2012
  3. ncbi request reprint The genotypic variation of the antioxidant potential of different tomato varieties
    Jeremy P E Spencer
    Antioxidant Research Group, Wolfson Centre for Age Related Disease, GKT School of Biomedical Science, King s College London, London SE1 9RT, UK
    Free Radic Res 39:1005-16. 2005
  4. pmc The interactions of flavonoids within neuronal signalling pathways
    Jeremy P E Spencer
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading, RG2 6AP, UK
    Genes Nutr 2:257-73. 2007
  5. doi request reprint The impact of flavonoids on memory: physiological and molecular considerations
    Jeremy P E Spencer
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading, UK RG2 6AP
    Chem Soc Rev 38:1152-61. 2009
  6. ncbi request reprint Biomarkers of the intake of dietary polyphenols: strengths, limitations and application in nutrition research
    Jeremy P E Spencer
    School of Chemistry, Food and Pharmacy, University of Reading, Whiteknights, Reading RG6 6AP, UK
    Br J Nutr 99:12-22. 2008
  7. pmc Flavonoids and brain health: multiple effects underpinned by common mechanisms
    Jeremy P E Spencer
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading, RG2 6AP, UK
    Genes Nutr 4:243-50. 2009
  8. doi request reprint Food for thought: the role of dietary flavonoids in enhancing human memory, learning and neuro-cognitive performance
    Jeremy P E Spencer
    Molecular Nutrition Group, School of Chemistry, Food Biosciences and Pharmacy, University of Reading, Reading RG2 6AP, UK
    Proc Nutr Soc 67:238-52. 2008
  9. doi request reprint Flavonoids and cognition: the molecular mechanisms underlying their behavioural effects
    Jeremy P E Spencer
    Molecular Nutrition Group, Department of Food and Nutritional Sciences, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG66AP, UK
    Arch Biochem Biophys 492:1-9. 2009
  10. doi request reprint Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain
    Jeremy P E Spencer
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG2 6AP, UK
    Proc Nutr Soc 69:244-60. 2010

Collaborators

Detail Information

Publications67

  1. doi request reprint The impact of fruit flavonoids on memory and cognition
    Jeremy P E Spencer
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading, UK
    Br J Nutr 104:S40-7. 2010
    ..Overall, the review attempts to provide an initial insight into the potential impact of regular flavonoid-rich fruit consumption on normal or abnormal deteriorations in cognitive performance...
  2. doi request reprint Neuroinflammation: modulation by flavonoids and mechanisms of action
    Jeremy P E Spencer
    Molecular Nutrition Group, Centre for Integrative Neuroscience and Neurodynamics, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG6 6AP, UK
    Mol Aspects Med 33:83-97. 2012
    ..As such, flavonoids represent important precursor molecules in the quest to develop of a new generation of drugs capable of counteracting neuroinflammation and neurodegenerative disease...
  3. ncbi request reprint The genotypic variation of the antioxidant potential of different tomato varieties
    Jeremy P E Spencer
    Antioxidant Research Group, Wolfson Centre for Age Related Disease, GKT School of Biomedical Science, King s College London, London SE1 9RT, UK
    Free Radic Res 39:1005-16. 2005
    ..We show that the flavonol rutin contributes to the greatest extent to the antioxidant capacity of tomatoes and suggest that this flavonoid may be a useful target for up-regulation in tomatoes in order to improve their antioxidant status...
  4. pmc The interactions of flavonoids within neuronal signalling pathways
    Jeremy P E Spencer
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading, RG2 6AP, UK
    Genes Nutr 2:257-73. 2007
    ..Future research directions are outlined in relation to their precise site(s) of action within the signalling pathways and the sequence of events that allow them to regulate neuronal function in the central nervous system...
  5. doi request reprint The impact of flavonoids on memory: physiological and molecular considerations
    Jeremy P E Spencer
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading, UK RG2 6AP
    Chem Soc Rev 38:1152-61. 2009
    ....
  6. ncbi request reprint Biomarkers of the intake of dietary polyphenols: strengths, limitations and application in nutrition research
    Jeremy P E Spencer
    School of Chemistry, Food and Pharmacy, University of Reading, Whiteknights, Reading RG6 6AP, UK
    Br J Nutr 99:12-22. 2008
    ..This review identifies the criteria that must be considered in the development of such biomarkers. In addition, we provide an assessment of the limited number of potential biomarkers of polyphenol intake currently available...
  7. pmc Flavonoids and brain health: multiple effects underpinned by common mechanisms
    Jeremy P E Spencer
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading, RG2 6AP, UK
    Genes Nutr 4:243-50. 2009
    ....
  8. doi request reprint Food for thought: the role of dietary flavonoids in enhancing human memory, learning and neuro-cognitive performance
    Jeremy P E Spencer
    Molecular Nutrition Group, School of Chemistry, Food Biosciences and Pharmacy, University of Reading, Reading RG2 6AP, UK
    Proc Nutr Soc 67:238-52. 2008
    ..The present review explores the potential of flavonoids and their metabolite forms to promote memory and learning through their interactions with neuronal signalling pathways pivotal in controlling LTP and memory in human subjects...
  9. doi request reprint Flavonoids and cognition: the molecular mechanisms underlying their behavioural effects
    Jeremy P E Spencer
    Molecular Nutrition Group, Department of Food and Nutritional Sciences, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG66AP, UK
    Arch Biochem Biophys 492:1-9. 2009
    ..Together, these processes act to maintain the number and quality of synaptic connections in the brain, a factor known to be essential for efficient LTP, synaptic plasticity and ultimately the efficient working of memory...
  10. doi request reprint Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brain
    Jeremy P E Spencer
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG2 6AP, UK
    Proc Nutr Soc 69:244-60. 2010
    ..The present review explores the potential inhibitory or stimulatory actions of flavonoids within these three systems and describes how such interactions are likely to underlie neurological effects...
  11. doi request reprint Flavonoids: modulators of brain function?
    Jeremy P E Spencer
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG2 6AP, UK
    Br J Nutr 99:ES60-77. 2008
    ..Future research directions are outlined in relation to the precise site(s) of action of flavonoids within signalling pathways and the sequence of events that allow them to regulate neuronal function...
  12. doi request reprint Sulforaphane protects cortical neurons against 5-S-cysteinyl-dopamine-induced toxicity through the activation of ERK1/2, Nrf-2 and the upregulation of detoxification enzymes
    David Vauzour
    School of Chemistry, Food and Pharmacy, The University of Reading, Whiteknights, Reading, UK
    Mol Nutr Food Res 54:532-42. 2010
    ..These data suggest that SFN stimulates the NF-E2-related factor-2 pathway of antioxidant gene expression in neurons and may protect against neuronal injury relevant to the aetiology of Parkinson's disease...
  13. doi request reprint Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activation
    Stephanie Rainey-Smith
    King s College London, The Wolfson Centre for Age Related Diseases, Guy s Hospital Campus, London SE1 1UL, UK
    Neurosci Lett 438:29-33. 2008
    ..The effects of hesperetin are cell-type dependent and, unlike the flavanol (-)epicatechin, neuroprotection in vitro is not associated with enhanced CREB phosphorylation or CRE-mediated gene expression...
  14. pmc Dietary levels of pure flavonoids improve spatial memory performance and increase hippocampal brain-derived neurotrophic factor
    Catarina Rendeiro
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading, United Kingdom
    PLoS ONE 8:e63535. 2013
    ..Our data support the claim that flavonoids are likely causal agents in mediating the cognitive effects of flavonoid-rich foods...
  15. doi request reprint Blueberry supplementation induces spatial memory improvements and region-specific regulation of hippocampal BDNF mRNA expression in young rats
    Catarina Rendeiro
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading, RG6 6AP, UK
    Psychopharmacology (Berl) 223:319-30. 2012
    ..However, to date, there have been only a limited number of studies investigating the effects of flavonoid-rich foods on cognition in young/healthy animals...
  16. doi request reprint Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells through inhibition of ERK1/2 and cyclin D1
    Giulia Corona
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading, UK
    Mol Nutr Food Res 53:897-903. 2009
    ..These findings are of particular relevance due to the high colonic concentration of HT compared to the other olive oil polyphenols and may help explain the inverse link between colon cancer and olive oil consumption...
  17. ncbi request reprint Distribution of [3H]trans-resveratrol in rat tissues following oral administration
    Manal Abd El-Mohsen
    School of Food Biosciences, University of Reading, Whiteknights, Reading RG6 6AP, UK
    Br J Nutr 96:62-70. 2006
    ..The present study provides additional information about the nature of resveratrol metabolites and which forms might be responsible for its in vivo biological effects...
  18. ncbi request reprint Inhibition of p38/CREB phosphorylation and COX-2 expression by olive oil polyphenols underlies their anti-proliferative effects
    Giulia Corona
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Whiteknights Campus, Reading RG2 6AP, UK
    Biochem Biophys Res Commun 362:606-11. 2007
    ..9+/-9.3%). Our data suggest that olive oil polyphenols may exert chemopreventative effects in the large intestine by interacting with signalling pathways responsible for colorectal cancer development...
  19. ncbi request reprint The reaction of flavonoid metabolites with peroxynitrite
    Susan E Pollard
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG2 6AP, UK
    Biochem Biophys Res Commun 350:960-8. 2006
    ..Such products may represent novel metabolic products in vivo and may also express cellular activity...
  20. doi request reprint The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injury
    Katerina Vafeiadou
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG2 6AP, UK
    Arch Biochem Biophys 484:100-9. 2009
    ..Taken together, our results suggest that naringenin may produce an anti-inflammatory effect in LPS/IFN-gamma stimulated glial cells that may be due to its interaction with p38 signalling cascades and the STAT-1 transcription factor...
  21. doi request reprint Prebiotic evaluation of cocoa-derived flavanols in healthy humans by using a randomized, controlled, double-blind, crossover intervention study
    Xenofon Tzounis
    Department of Food and Nutritional Sciences, The University of Reading, Reading, UK
    Am J Clin Nutr 93:62-72. 2011
    ..The absorption of cocoa flavanols in the small intestine is limited, and the majority of the flavanols reach the large intestine where they may be metabolized by resident microbiota...
  22. doi request reprint Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels
    Claire M Williams
    School of Psychology and Clinical Language Sciences, University of Reading, Reading RG2 6AP, UK
    Free Radic Biol Med 45:295-305. 2008
    ....
  23. ncbi request reprint Champagne wine polyphenols protect primary cortical neurons against peroxynitrite-induced injury
    David Vauzour
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, The University of Reading, P O Box 226, Whiteknights, Reading RG6 6AP, United Kingdom
    J Agric Food Chem 55:2854-60. 2007
    ..1 and 10 microM. Together, these data suggest that polyphenols present in Champagne wine may induce a neuroprotective effect against oxidative neuronal injury...
  24. doi request reprint Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: implications for Parkinson's disease and protection by polyphenols
    David Vauzour
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, The University of Reading, P O Box 226, Whiteknights Campus, Reading RG6 6AP, UK
    Arch Biochem Biophys 476:145-51. 2008
    ..These data suggest that polyphenols may protect against neuronal injury induced by endogenous neurotoxins relevant to the aetiology of the Parkinson disease...
  25. doi request reprint Glial metabolism of quercetin reduces its neurotoxic potential
    Katerina Vafeiadou
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG2 6AP, UK
    Arch Biochem Biophys 478:195-200. 2008
    ..We propose that glial cells act to protect neurons against the neurotoxic effects of quercetin and that 2'-glutathionyl-quercetin represents a novel quercetin metabolite...
  26. doi request reprint Impact of the quantity and flavonoid content of fruits and vegetables on markers of intake in adults with an increased risk of cardiovascular disease: the FLAVURS trial
    Mary F Chong
    Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Whiteknights, PO Box 266, Reading, Berkshire, RG6 6AP, UK
    Eur J Nutr 52:361-78. 2013
    ..We aimed to design and validate a dietary strategy of increasing flavonoid-rich versus flavonoid-poor F&V consumption on nutrient biomarker profile...
  27. doi request reprint Flavonoids as modulators of memory and learning: molecular interactions resulting in behavioural effects
    Catarina Rendeiro
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG6 6AP, UK
    Proc Nutr Soc 71:246-62. 2012
    ....
  28. pmc Polyphenols and human health: prevention of disease and mechanisms of action
    David Vauzour
    Molecular Nutrition Group, Department of Food and Nutritional Sciences, School of Chemistry, Food and Pharmacy, The University of Reading, UK
    Nutrients 2:1106-31. 2010
    ....
  29. doi request reprint Caffeic acid, tyrosol and p-coumaric acid are potent inhibitors of 5-S-cysteinyl-dopamine induced neurotoxicity
    David Vauzour
    Molecular Nutrition Group, Department of Food and Nutritional Sciences, School of Chemistry, Food and Pharmacy, The University of Reading, P O Box 226, Whiteknights, Reading RG66AP, UK
    Arch Biochem Biophys 501:106-11. 2010
    ..1+/-3.0%, p<0.001) at the same concentration. These data indicate that hydroxycinnamates, phenolic acids and phenolic alcohol are also capable of inducing neuroprotective effects to a similar extent to that seen with flavonoids...
  30. doi request reprint Involvement of ERK, Akt and JNK signalling in H2O2-induced cell injury and protection by hydroxytyrosol and its metabolite homovanillic alcohol
    Alessandra Incani
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Whiteknights, Reading, UK
    Mol Nutr Food Res 54:788-96. 2010
    ..We suggest that one potential protective effect exerted by olive oil polyphenols against oxidative kidney cell injury may be attributed to the interactions of HT and HVA with these important intracellular signalling pathways...
  31. ncbi request reprint The fate of olive oil polyphenols in the gastrointestinal tract: implications of gastric and colonic microflora-dependent biotransformation
    Giulia Corona
    Molecular Nutrition Group, School of Food Biosciences, University of Reading, UK
    Free Radic Res 40:647-58. 2006
    ..Our study provides additional information regarding the breakdown of complex olive oil polyphenols in the GI tract, in particular the stomach and the large intestine...
  32. doi request reprint Influence of sugar type on the bioavailability of cocoa flavanols
    Ana Rodriguez-Mateos
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG6 6AP, UK
    Br J Nutr 108:2243-50. 2012
    ....
  33. ncbi request reprint Inhibition of cellular proliferation by the genistein metabolite 5,7,3',4'-tetrahydroxyisoflavone is mediated by DNA damage and activation of the ATR signalling pathway
    David Vauzour
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Whiteknights, Reading RG2 6AP, UK
    Arch Biochem Biophys 468:159-66. 2007
    ..This may represent one mechanism by which genistein exerts its cellular activity in vivo...
  34. doi request reprint Cognitive tests used in chronic adult human randomised controlled trial micronutrient and phytochemical intervention studies
    Anna L Macready
    School of Psychology and Clinical Language Sciences, University of Reading, Reading, UK
    Nutr Res Rev 23:200-29. 2010
    ....
  35. ncbi request reprint The reaction of flavanols with nitrous acid protects against N-nitrosamine formation and leads to the formation of nitroso derivatives which inhibit cancer cell growth
    Stephanie Y H Lee
    Molucular Nutrition Group, School of Biosciences, University of Reading, Reading RG2 6AP, UK
    Free Radic Biol Med 40:323-34. 2006
    ..These effects highlight multiple routes in which dietary derived flavanols may exert beneficial effects in the gastrointestinal tract...
  36. ncbi request reprint Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons
    David Vauzour
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading, UK
    J Neurochem 103:1355-67. 2007
    ..Thus, flavanones may protect neurons against oxidative insults via the modulation of neuronal apoptotic machinery...
  37. ncbi request reprint Flavanol monomer-induced changes to the human faecal microflora
    Xenofon Tzounis
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG2 6AP, UK
    Br J Nutr 99:782-92. 2008
    ..Together these data suggest that the consumption of flavanol-rich foods may support gut health through their ability to exert prebiotic actions...
  38. pmc Insights into dietary flavonoids as molecular templates for the design of anti-platelet drugs
    Bernice Wright
    Institute for Cardiovascular and Metabolic Research, Schools of Biological Sciences, University of Reading, Berkshire, Reading RG6 6UB, UK
    Cardiovasc Res 97:13-22. 2013
    ..This focussed review highlights the potential of flavonoids to guide the design of clinically safer, more selective, and potent small-molecule inhibitors of cell signalling, applicable to anti-platelet therapy...
  39. doi request reprint Blueberry intervention improves vascular reactivity and lowers blood pressure in high-fat-, high-cholesterol-fed rats
    Ana Rodriguez-Mateos
    Department of Food and Nutritional Sciences, University of Reading, Reading RG6 6AP, UK
    Br J Nutr 109:1746-54. 2013
    ..These data suggest that BB consumption can lower BP and improve endothelial dysfunction induced by a high fat, high cholesterol containing diet...
  40. doi request reprint Regulation of NF-κB activity in astrocytes: effects of flavonoids at dietary-relevant concentrations
    Alison Spilsbury
    Reading School of Pharmacy, University of Reading, Reading RG6 6UB, UK
    Biochem Biophys Res Commun 418:578-83. 2012
    ..1-1 μM) for 18 h. None of the flavonoids modulated constitutive or TNFα-induced NF-κB activity. Therefore, we conclude that NF-κB signalling in astrocytes is not a major target for flavonoids...
  41. pmc The impact of flavonoids on spatial memory in rodents: from behaviour to underlying hippocampal mechanisms
    Catarina Rendeiro
    School of Psychology and Clinical Language Sciences, University of Reading, Reading, RG6 6AP, UK
    Genes Nutr 4:251-70. 2009
    ....
  42. ncbi request reprint Inhibition of the formation of the neurotoxin 5-S-cysteinyl-dopamine by polyphenols
    David Vauzour
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, The University of Reading, Whiteknights Campus, Reading RG6 6AP, UK
    Biochem Biophys Res Commun 362:340-6. 2007
    ....
  43. ncbi request reprint Flavonoids: antioxidants or signalling molecules?
    Robert J Williams
    Wolfson Centre for Age Related Diseases, GKT School of Biomedical Sciences, King s College London, Guy s Campus, London SE1 9RT, UK
    Free Radic Biol Med 36:838-49. 2004
    ..antioxidants or modulators of cell signalling, and the influence of their metabolism on these properties are key to the evaluation of these potent biomolecules as anticancer agents, cardioprotectants, and inhibitors of neurodegeneration..
  44. pmc Flavonoids and cognitive function: a review of human randomized controlled trial studies and recommendations for future studies
    Anna L Macready
    School of Psychology and Clinical Language Sciences, University of Reading, Earley Gate, Whiteknights, PO Box 238, Reading, RG6 6AL, UK
    Genes Nutr 4:227-42. 2009
    ..Overall, while initial results are encouraging, future studies need to pay careful attention when selecting cognitive measures, especially in terms of ensuring that tasks are actually sensitive enough to detect treatment effects...
  45. ncbi request reprint Absorption, tissue distribution and excretion of pelargonidin and its metabolites following oral administration to rats
    Manal Abd El Mohsen
    Antioxidant Research Group, Wolfson Centre for Age Related Diseases, GKT School of Biomedical Sciences, King s College, London SE1 9RT, UK
    Br J Nutr 95:51-8. 2006
    ..However, the amounts recovered dropped to 1.2 % only 18 h post-gavage, with the urine and faecal content constituting almost 90 % of the total recovered pelargonidin...
  46. doi request reprint A role for hippocampal PSA-NCAM and NMDA-NR2B receptor function in flavonoid-induced spatial memory improvements in young rats
    Catarina Rendeiro
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG6 6AP, UK School of Psychology and Clinical Language Sciences, University of Reading, Reading RG6 6AL, UK
    Neuropharmacology 79:335-44. 2014
    ....
  47. pmc The neuroprotective potential of flavonoids: a multiplicity of effects
    David Vauzour
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading, RG2 6AP, UK
    Genes Nutr 3:115-26. 2008
    ..The intense interest in the development of drugs capable of enhancing brain function means that flavonoids may represent important precursor molecules in the quest to develop of a new generation of brain enhancing drugs...
  48. doi request reprint Moderate Champagne consumption promotes an acute improvement in acute endothelial-independent vascular function in healthy human volunteers
    David Vauzour
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading, UK
    Br J Nutr 103:1168-78. 2010
    ..Our data suggest that a daily moderate consumption of Champagne wine may improve vascular performance via the delivery of phenolic constituents capable of improving NO bioavailability and reducing matrix metalloproteinase activity...
  49. doi request reprint Flavonoid inhibitory pharmacodynamics on platelet function in physiological environments
    Bernice Wright
    Institute for Cardiovascular and Metabolic Research ICMR, Schools of Biological Sciences, University of Reading, Hopkins Building, Reading, Berkshire RG6 6UB, UK
    Food Funct 4:1803-10. 2013
    ..We conclude that flavonoid structures may be a major influence of their activities in vivo with methylated metabolites and those of flavones being more potent than those of flavonols and flavanones. ..
  50. doi request reprint Phenolic acid intake, delivered via moderate champagne wine consumption, improves spatial working memory via the modulation of hippocampal and cortical protein expression/activation
    Giulia Corona
    1 Molecular Nutrition Group, Centre for Integrative Neuroscience and Neurodynamics, School of Chemistry, Food and Pharmacy, University of Reading, Reading, United Kingdom
    Antioxid Redox Signal 19:1676-89. 2013
    ..To address this, we investigated the effects of moderate Champagne wine intake, which is rich in these components, on spatial memory and related mechanisms relative to the alcohol- and energy-matched controls...
  51. ncbi request reprint Age-associated changes in protein oxidation and proteasome activities in rat brain: modulation by antioxidants
    Manal M Abd El Mohsen
    Molecular Nutrition Group, School of Food Biosciences, University of Reading, P O Box 226, Whiteknights, Reading RG6 6AP, UK
    Biochem Biophys Res Commun 336:386-91. 2005
    ..However, both melatonin and coenzyme Q10 treatments inhibited beta-glutamyl peptide hydrolase activity. This suggests that these molecules can alter proteasome function independently of their antioxidant actions...
  52. ncbi request reprint Activation of glutathione peroxidase via Nrf1 mediates genistein's protection against oxidative endothelial cell injury
    Eva Hernandez-Montes
    Molecular Nutrition Group, School of Chemistry, Food Biosciences and Pharmacy, University of Reading, Reading RG6 6AP, UK
    Biochem Biophys Res Commun 346:851-9. 2006
    ..These results suggest that genistein-induced protective effects depend primarily on the activation of glutathione peroxidase mediated by Nrf1 activation, and not on Nrf2 activation or increases in glutathione synthesis...
  53. ncbi request reprint Metabolism of tea flavonoids in the gastrointestinal tract
    Jeremy P E Spencer
    olfson Centre for Age Related Disease, GKT School of Biomedical Science, King s College London, London, SE1 9RT, UK
    J Nutr 133:3255S-3261S. 2003
    ..This review will highlight the major sites of flavanol metabolism in the gastrointestinal tract and the processes that give rise to potential bioactive forms of flavan-3-ols in vivo...
  54. ncbi request reprint The effect of dietary nitrate on salivary, plasma, and urinary nitrate metabolism in humans
    Ananth S Pannala
    Centre for Age Related Diseases, GKT School of Biomedical Sciences, King s College London, London, UK
    Free Radic Biol Med 34:576-84. 2003
    ..High dietary nitrate consumption does not cause a significant acute change in plasma concentrations of 3-nitrotyrosine or in platelet function...
  55. doi request reprint The effect of processing on chlorogenic acid content of commercially available coffee
    Charlotte E Mills
    Department of Food and Nutritional Sciences, School of Chemistry, Food and Pharmacy, University of Reading, Whiteknights, Reading RG6 6AP, UK
    Food Chem 141:3335-40. 2013
    ..These results highlight the broad range of CGA quantity in commercial coffee and demonstrate that coffee choice is important in delivering optimum CGA intake to consumers...
  56. ncbi request reprint MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxide
    Hagen Schroeter
    Antioxidant Research Group, Wolfson Centre for Age Related Diseases and Centre for Neuroscience Research, Guy s, King s and St Thomas s School of Biomedical Sciences, King s College, Guy s Campus, Hodgkin Bldg, 3rd Floor, London SE1 9RT, UK
    Neurobiol Aging 23:861-80. 2002
    ..This review addresses recent findings on the biological effects of flavonoids and nitric oxide in neurodegeneration and aims to elucidate the rationale for their prospective use as modulators of cellular signal transduction...
  57. ncbi request reprint Modulation of peroxynitrite-induced fibroblast injury by hesperetin: a role for intracellular scavenging and modulation of ERK signalling
    Susan E Pollard
    Molecular Nutrition Group, School of Chemistry, Food Biosciences and Pharmacy, University of Reading, Reading RG6 6AP, UK
    Biochem Biophys Res Commun 347:916-23. 2006
    ..We propose that the protective potential of hesperetin in fibroblasts may be mediated both by intracellular scavenging of peroxynitrite and by modulation of fibroblast signalling...
  58. ncbi request reprint Cellular uptake and metabolism of flavonoids and their metabolites: implications for their bioactivity
    Jeremy P E Spencer
    Antioxidant Research Group, Wolfson Centre for Age Related Diseases, GKT School of Biomedical School, King s College London, UK
    Arch Biochem Biophys 423:148-61. 2004
    ..Uptake and metabolism of the circulating forms of flavanols, flavonols, and flavanones into cells of the skin, the brain, and cancer cells is reviewed and potential biological relevance to intracellular formed metabolites is discussed...
  59. doi request reprint Procyanidin, anthocyanin, and chlorogenic Acid contents of highbush and lowbush blueberries
    Ana Rodriguez-Mateos
    Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG2 6AP, United Kingdom
    J Agric Food Chem 60:5772-8. 2012
    ..9 mg/100 g FW for delphinidin and between 37.1 and 62.2 mg/100 g FW for malvidin. Flavanol dimers were the most abundant flavanols, with a mean percentage of 24 ± 1.5% of the total, with flavanol monomers representing 11 ± 0.7%. ..
  60. doi request reprint Effect of cultivar type and ripening on the polyphenol content of date palm fruit
    Noura M S Eid
    Molecular Nutrition Group, Department of Food and Nutritional Sciences, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG6 6AP, United Kingdom
    J Agric Food Chem 61:2453-60. 2013
    ..These data suggest dates are a significant source of polyphenols, especially if the earlier edible ripening stages are consumed or utilized as food ingredients...
  61. ncbi request reprint Dietary flavonoids as potential neuroprotectants
    Kuresh A Youdim
    Wolfson Center for Age Related Diseases, Guy s King s and St Thomas s School of Biomedical Sciences, King s College, London, UK
    Biol Chem 383:503-19. 2002
    ..Such mechanisms might involve their interaction with cell signalling cascades, their influence on gene expression and the down regulation of pathways leading to cell death...
  62. ncbi request reprint The pro-inflammatory oxidant hypochlorous acid induces Bax-dependent mitochondrial permeabilisation and cell death through AIF-/EndoG-dependent pathways
    Matthew Whiteman
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Republic of Singapore
    Cell Signal 19:705-14. 2007
    ..Our study provides a novel insight into the potential mechanisms of cell death in the inflamed human joint...
  63. pmc c-Jun N-terminal kinase (JNK)-mediated modulation of brain mitochondria function: new target proteins for JNK signalling in mitochondrion-dependent apoptosis
    Hagen Schroeter
    Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles 90089 9121, USA
    Biochem J 372:359-69. 2003
    ..Taken together, JNK-dependent phosphorylation of mitochondrial proteins including, but not limited to, Bcl-2/Bcl-x(L) may represent a potential of the modulation of mitochondrial function during apoptosis...
  64. ncbi request reprint 5-s-Cysteinyl-conjugates of catecholamines induce cell damage, extensive DNA base modification and increases in caspase-3 activity in neurons
    Jeremy P E Spencer
    Wolfson Centre for Age Related Diseases, GKT School of Biomedical Sciences, King s College London
    J Neurochem 81:122-9. 2002
    ..Indeed, intracellular ROS were observed to rise sharply on exposure to the conjugates. These results suggest one mechanism by which oxidative stress may occur in the substantia nigra in Parkinson's disease...
  65. pmc Substrate specificity of human glutamine transaminase K as an aminotransferase and as a cysteine S-conjugate beta-lyase
    Arthur J L Cooper
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY, USA
    Arch Biochem Biophys 474:72-81. 2008
    ..The importance of transamination, oxidation and beta-elimination reactions involving 5-S-l-cysteinyldopamine, 5-S-l-cysteinyl-l-DOPA and Se-methyl-l-selenocysteine in human tissues and their biological relevance are discussed...
  66. ncbi request reprint Do mitochondriotropic antioxidants prevent chlorinative stress-induced mitochondrial and cellular injury?
    Matthew Whiteman
    Institute of Biomedical and Clinical Sciences, Peninsula Medical School, Universities of Exeter and Plymouth, St Luke s Campus, Exeter, Devon, England
    Antioxid Redox Signal 10:641-50. 2008
    ..Our study highlights the potential application of mitochondria-specific targeted antioxidants for the prevention of cellular dysfunction and cell death under conditions of chlorinative stress, as occurs during chronic inflammation...
  67. doi request reprint Loss of 3-chlorotyrosine by inflammatory oxidants: implications for the use of 3-chlorotyrosine as a bio-marker in vivo
    Matthew Whiteman
    Institute of Biomedical and Clinical Sciences, Peninsula Medical School, St Luke s Campus, Magdalen Road, Exeter, EX1 2LU England, UK
    Biochem Biophys Res Commun 371:50-3. 2008
    ..This finding could account for some of the discrepancies reported between 3-chlorotyrosine levels in tissues in the literature...