Research Topics
| Jeremy P E SpencerSummaryAffiliation: University of Reading Country: UK Publications
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Detail Information
Publications
Neuroinflammation: modulation by flavonoids and mechanisms of actionJeremy P E Spencer
Molecular Nutrition Group, Centre for Integrative Neuroscience and Neurodynamics, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG6 6AP, UK
Mol Aspects Med 33:83-97. 2012..As such, flavonoids represent important precursor molecules in the quest to develop of a new generation of drugs capable of counteracting neuroinflammation and neurodegenerative disease...
The interactions of flavonoids within neuronal signalling pathwaysJeremy P E Spencer
Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading, RG2 6AP, UK
Genes Nutr 2:257-73. 2007..Future research directions are outlined in relation to their precise site(s) of action within the signalling pathways and the sequence of events that allow them to regulate neuronal function in the central nervous system...
Biomarkers of the intake of dietary polyphenols: strengths, limitations and application in nutrition researchJeremy P E Spencer
School of Chemistry, Food and Pharmacy, University of Reading, Whiteknights, Reading RG6 6AP, UK
Br J Nutr 99:12-22. 2008..This review identifies the criteria that must be considered in the development of such biomarkers. In addition, we provide an assessment of the limited number of potential biomarkers of polyphenol intake currently available...- Flavonoids and brain health: multiple effects underpinned by common mechanismsJeremy P E Spencer
Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading, RG2 6AP, UK
Genes Nutr 4:243-50. 2009.... - Flavonoids and cognition: the molecular mechanisms underlying their behavioural effectsJeremy P E Spencer
Molecular Nutrition Group, Department of Food and Nutritional Sciences, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG66AP, UK
Arch Biochem Biophys 492:1-9. 2009..Together, these processes act to maintain the number and quality of synaptic connections in the brain, a factor known to be essential for efficient LTP, synaptic plasticity and ultimately the efficient working of memory... - Beyond antioxidants: the cellular and molecular interactions of flavonoids and how these underpin their actions on the brainJeremy P E Spencer
Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG2 6AP, UK
Proc Nutr Soc 69:244-60. 2010..The present review explores the potential inhibitory or stimulatory actions of flavonoids within these three systems and describes how such interactions are likely to underlie neurological effects... - The genotypic variation of the antioxidant potential of different tomato varietiesJeremy P E Spencer
Antioxidant Research Group, Wolfson Centre for Age Related Disease, GKT School of Biomedical Science, King s College London, London SE1 9RT, UK
Free Radic Res 39:1005-16. 2005..We show that the flavonol rutin contributes to the greatest extent to the antioxidant capacity of tomatoes and suggest that this flavonoid may be a useful target for up-regulation in tomatoes in order to improve their antioxidant status... - Food for thought: the role of dietary flavonoids in enhancing human memory, learning and neuro-cognitive performanceJeremy P E Spencer
Molecular Nutrition Group, School of Chemistry, Food Biosciences and Pharmacy, University of Reading, Reading RG2 6AP, UK
Proc Nutr Soc 67:238-52. 2008..The present review explores the potential of flavonoids and their metabolite forms to promote memory and learning through their interactions with neuronal signalling pathways pivotal in controlling LTP and memory in human subjects... - The impact of fruit flavonoids on memory and cognitionJeremy P E Spencer
Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading, UK
Br J Nutr 104:S40-7. 2010..Overall, the review attempts to provide an initial insight into the potential impact of regular flavonoid-rich fruit consumption on normal or abnormal deteriorations in cognitive performance... - The impact of flavonoids on memory: physiological and molecular considerationsJeremy P E Spencer
Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading, UK RG2 6AP
Chem Soc Rev 38:1152-61. 2009.... - Flavonoids: modulators of brain function?Jeremy P E Spencer
Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG2 6AP, UK
Br J Nutr 99:ES60-77. 2008..Future research directions are outlined in relation to the precise site(s) of action of flavonoids within signalling pathways and the sequence of events that allow them to regulate neuronal function... - Sulforaphane protects cortical neurons against 5-S-cysteinyl-dopamine-induced toxicity through the activation of ERK1/2, Nrf-2 and the upregulation of detoxification enzymesDavid Vauzour
School of Chemistry, Food and Pharmacy, The University of Reading, Whiteknights, Reading, UK
Mol Nutr Food Res 54:532-42. 2010..These data suggest that SFN stimulates the NF-E2-related factor-2 pathway of antioxidant gene expression in neurons and may protect against neuronal injury relevant to the aetiology of Parkinson's disease... - Neuroprotective effects of hesperetin in mouse primary neurones are independent of CREB activationStephanie Rainey-Smith
King s College London, The Wolfson Centre for Age Related Diseases, Guy s Hospital Campus, London SE1 1UL, UK
Neurosci Lett 438:29-33. 2008..The effects of hesperetin are cell-type dependent and, unlike the flavanol (-)epicatechin, neuroprotection in vitro is not associated with enhanced CREB phosphorylation or CRE-mediated gene expression... - Blueberry supplementation induces spatial memory improvements and region-specific regulation of hippocampal BDNF mRNA expression in young ratsCatarina Rendeiro
Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading, RG6 6AP, UK
Psychopharmacology (Berl) 223:319-30. 2012..However, to date, there have been only a limited number of studies investigating the effects of flavonoid-rich foods on cognition in young/healthy animals... - Hydroxytyrosol inhibits the proliferation of human colon adenocarcinoma cells through inhibition of ERK1/2 and cyclin D1Giulia Corona
Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading, UK
Mol Nutr Food Res 53:897-903. 2009..These findings are of particular relevance due to the high colonic concentration of HT compared to the other olive oil polyphenols and may help explain the inverse link between colon cancer and olive oil consumption... - Inhibition of p38/CREB phosphorylation and COX-2 expression by olive oil polyphenols underlies their anti-proliferative effectsGiulia Corona
Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Whiteknights Campus, Reading RG2 6AP, UK
Biochem Biophys Res Commun 362:606-11. 2007..9+/-9.3%). Our data suggest that olive oil polyphenols may exert chemopreventative effects in the large intestine by interacting with signalling pathways responsible for colorectal cancer development... - Distribution of [3H]trans-resveratrol in rat tissues following oral administrationManal Abd El-Mohsen
School of Food Biosciences, University of Reading, Whiteknights, Reading RG6 6AP, UK
Br J Nutr 96:62-70. 2006..The present study provides additional information about the nature of resveratrol metabolites and which forms might be responsible for its in vivo biological effects... - The citrus flavanone naringenin inhibits inflammatory signalling in glial cells and protects against neuroinflammatory injuryKaterina Vafeiadou
Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG2 6AP, UK
Arch Biochem Biophys 484:100-9. 2009..Taken together, our results suggest that naringenin may produce an anti-inflammatory effect in LPS/IFN-gamma stimulated glial cells that may be due to its interaction with p38 signalling cascades and the STAT-1 transcription factor... - Prebiotic evaluation of cocoa-derived flavanols in healthy humans by using a randomized, controlled, double-blind, crossover intervention studyXenofon Tzounis
Department of Food and Nutritional Sciences, The University of Reading, Reading, UK
Am J Clin Nutr 93:62-72. 2011..The absorption of cocoa flavanols in the small intestine is limited, and the majority of the flavanols reach the large intestine where they may be metabolized by resident microbiota... - Champagne wine polyphenols protect primary cortical neurons against peroxynitrite-induced injuryDavid Vauzour
Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, The University of Reading, P O Box 226, Whiteknights, Reading RG6 6AP, United Kingdom
J Agric Food Chem 55:2854-60. 2007..1 and 10 microM. Together, these data suggest that polyphenols present in Champagne wine may induce a neuroprotective effect against oxidative neuronal injury... - Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levelsClaire M Williams
School of Psychology and Clinical Language Sciences, University of Reading, Reading RG2 6AP, UK
Free Radic Biol Med 45:295-305. 2008.... - The reaction of flavonoid metabolites with peroxynitriteSusan E Pollard
Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG2 6AP, UK
Biochem Biophys Res Commun 350:960-8. 2006..Such products may represent novel metabolic products in vivo and may also express cellular activity... - Glial metabolism of quercetin reduces its neurotoxic potentialKaterina Vafeiadou
Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG2 6AP, UK
Arch Biochem Biophys 478:195-200. 2008..We propose that glial cells act to protect neurons against the neurotoxic effects of quercetin and that 2'-glutathionyl-quercetin represents a novel quercetin metabolite... - Peroxynitrite induced formation of the neurotoxins 5-S-cysteinyl-dopamine and DHBT-1: implications for Parkinson's disease and protection by polyphenolsDavid Vauzour
Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, The University of Reading, P O Box 226, Whiteknights Campus, Reading RG6 6AP, UK
Arch Biochem Biophys 476:145-51. 2008..These data suggest that polyphenols may protect against neuronal injury induced by endogenous neurotoxins relevant to the aetiology of the Parkinson disease... - Flavonoids as modulators of memory and learning: molecular interactions resulting in behavioural effectsCatarina Rendeiro
Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG6 6AP, UK
Proc Nutr Soc 71:246-62. 2012.... - Polyphenols and human health: prevention of disease and mechanisms of actionDavid Vauzour
Molecular Nutrition Group, Department of Food and Nutritional Sciences, School of Chemistry, Food and Pharmacy, The University of Reading, UK
Nutrients 2:1106-31. 2010.... - Caffeic acid, tyrosol and p-coumaric acid are potent inhibitors of 5-S-cysteinyl-dopamine induced neurotoxicityDavid Vauzour
Molecular Nutrition Group, Department of Food and Nutritional Sciences, School of Chemistry, Food and Pharmacy, The University of Reading, P O Box 226, Whiteknights, Reading RG66AP, UK
Arch Biochem Biophys 501:106-11. 2010..1+/-3.0%, p<0.001) at the same concentration. These data indicate that hydroxycinnamates, phenolic acids and phenolic alcohol are also capable of inducing neuroprotective effects to a similar extent to that seen with flavonoids... - Involvement of ERK, Akt and JNK signalling in H2O2-induced cell injury and protection by hydroxytyrosol and its metabolite homovanillic alcoholAlessandra Incani
Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Whiteknights, Reading, UK
Mol Nutr Food Res 54:788-96. 2010..We suggest that one potential protective effect exerted by olive oil polyphenols against oxidative kidney cell injury may be attributed to the interactions of HT and HVA with these important intracellular signalling pathways... - The fate of olive oil polyphenols in the gastrointestinal tract: implications of gastric and colonic microflora-dependent biotransformationGiulia Corona
Molecular Nutrition Group, School of Food Biosciences, University of Reading, UK
Free Radic Res 40:647-58. 2006..Our study provides additional information regarding the breakdown of complex olive oil polyphenols in the GI tract, in particular the stomach and the large intestine... - Influence of sugar type on the bioavailability of cocoa flavanolsAna Rodriguez-Mateos
Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG6 6AP, UK
Br J Nutr 108:2243-50. 2012.... - Cognitive tests used in chronic adult human randomised controlled trial micronutrient and phytochemical intervention studiesAnna L Macready
School of Psychology and Clinical Language Sciences, University of Reading, Reading, UK
Nutr Res Rev 23:200-29. 2010.... - Inhibition of cellular proliferation by the genistein metabolite 5,7,3',4'-tetrahydroxyisoflavone is mediated by DNA damage and activation of the ATR signalling pathwayDavid Vauzour
Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Whiteknights, Reading RG2 6AP, UK
Arch Biochem Biophys 468:159-66. 2007..This may represent one mechanism by which genistein exerts its cellular activity in vivo... - Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neuronsDavid Vauzour
Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading, UK
J Neurochem 103:1355-67. 2007..Thus, flavanones may protect neurons against oxidative insults via the modulation of neuronal apoptotic machinery... - Flavanol monomer-induced changes to the human faecal microfloraXenofon Tzounis
Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG2 6AP, UK
Br J Nutr 99:782-92. 2008..Together these data suggest that the consumption of flavanol-rich foods may support gut health through their ability to exert prebiotic actions... - Regulation of NF-κB activity in astrocytes: effects of flavonoids at dietary-relevant concentrationsAlison Spilsbury
Reading School of Pharmacy, University of Reading, Reading RG6 6UB, UK
Biochem Biophys Res Commun 418:578-83. 2012..1-1 μM) for 18 h. None of the flavonoids modulated constitutive or TNFα-induced NF-κB activity. Therefore, we conclude that NF-κB signalling in astrocytes is not a major target for flavonoids... - The impact of flavonoids on spatial memory in rodents: from behaviour to underlying hippocampal mechanismsCatarina Rendeiro
School of Psychology and Clinical Language Sciences, University of Reading, Reading, RG6 6AP, UK
Genes Nutr 4:251-70. 2009.... - Absorption, tissue distribution and excretion of pelargonidin and its metabolites following oral administration to ratsManal Abd El Mohsen
Antioxidant Research Group, Wolfson Centre for Age-Related Diseases, GKT School of Biomedical Sciences, King's College, London SE1 9RT, UK
Br J Nutr 95:51-8. 2006..However, the amounts recovered dropped to 1.2 % only 18 h post-gavage, with the urine and faecal content constituting almost 90 % of the total recovered pelargonidin... - The reaction of flavanols with nitrous acid protects against N-nitrosamine formation and leads to the formation of nitroso derivatives which inhibit cancer cell growthStephanie Y H Lee
Molucular Nutrition Group, School of Biosciences, University of Reading, Reading RG2 6AP, UK
Free Radic Biol Med 40:323-34. 2006..These effects highlight multiple routes in which dietary derived flavanols may exert beneficial effects in the gastrointestinal tract... - Flavonoids and cognitive function: a review of human randomized controlled trial studies and recommendations for future studiesAnna L Macready
School of Psychology and Clinical Language Sciences, University of Reading, Earley Gate, Whiteknights, PO Box 238, Reading, RG6 6AL, UK
Genes Nutr 4:227-42. 2009..Overall, while initial results are encouraging, future studies need to pay careful attention when selecting cognitive measures, especially in terms of ensuring that tasks are actually sensitive enough to detect treatment effects... - Flavonoids: antioxidants or signalling molecules?Robert J Williams
Wolfson Centre for Age Related Diseases, GKT School of Biomedical Sciences, King s College London, Guy s Campus, London SE1 9RT, UK
Free Radic Biol Med 36:838-49. 2004..antioxidants or modulators of cell signalling, and the influence of their metabolism on these properties are key to the evaluation of these potent biomolecules as anticancer agents, cardioprotectants, and inhibitors of neurodegeneration.. - Inhibition of the formation of the neurotoxin 5-S-cysteinyl-dopamine by polyphenolsDavid Vauzour
Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, The University of Reading, Whiteknights Campus, Reading RG6 6AP, UK
Biochem Biophys Res Commun 362:340-6. 2007.... - Moderate Champagne consumption promotes an acute improvement in acute endothelial-independent vascular function in healthy human volunteersDavid Vauzour
Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading, UK
Br J Nutr 103:1168-78. 2010..Our data suggest that a daily moderate consumption of Champagne wine may improve vascular performance via the delivery of phenolic constituents capable of improving NO bioavailability and reducing matrix metalloproteinase activity... - The neuroprotective potential of flavonoids: a multiplicity of effectsDavid Vauzour
Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading, RG2 6AP, UK
Genes Nutr 3:115-26. 2008..The intense interest in the development of drugs capable of enhancing brain function means that flavonoids may represent important precursor molecules in the quest to develop of a new generation of brain enhancing drugs... - Impact of the quantity and flavonoid content of fruits and vegetables on markers of intake in adults with an increased risk of cardiovascular disease: the FLAVURS trialMary F Chong
Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, University of Reading, Whiteknights, PO Box 266, Reading, Berkshire, RG6 6AP, UK
Eur J Nutr 52:361-78. 2013..We aimed to design and validate a dietary strategy of increasing flavonoid-rich versus flavonoid-poor F&V consumption on nutrient biomarker profile... - Age-associated changes in protein oxidation and proteasome activities in rat brain: modulation by antioxidantsManal M Abd El Mohsen
Molecular Nutrition Group, School of Food Biosciences, University of Reading, P O Box 226, Whiteknights, Reading RG6 6AP, UK
Biochem Biophys Res Commun 336:386-91. 2005..However, both melatonin and coenzyme Q10 treatments inhibited beta-glutamyl peptide hydrolase activity. This suggests that these molecules can alter proteasome function independently of their antioxidant actions... - Activation of glutathione peroxidase via Nrf1 mediates genistein's protection against oxidative endothelial cell injuryEva Hernandez-Montes
Molecular Nutrition Group, School of Chemistry, Food Biosciences and Pharmacy, University of Reading, Reading RG6 6AP, UK
Biochem Biophys Res Commun 346:851-9. 2006..These results suggest that genistein-induced protective effects depend primarily on the activation of glutathione peroxidase mediated by Nrf1 activation, and not on Nrf2 activation or increases in glutathione synthesis... - MAPK signaling in neurodegeneration: influences of flavonoids and of nitric oxideHagen Schroeter
Antioxidant Research Group, Wolfson Centre for Age-Related Diseases and Centre for Neuroscience Research, Guy's, King's and St Thomas's School of Biomedical Sciences, King's College, Guy's Campus, Hodgkin Bldg, 3rd Floor, London SE1 9RT, UK
Neurobiol Aging 23:861-80. 2002..This review addresses recent findings on the biological effects of flavonoids and nitric oxide in neurodegeneration and aims to elucidate the rationale for their prospective use as modulators of cellular signal transduction... - Cellular uptake and metabolism of flavonoids and their metabolites: implications for their bioactivityJeremy P E Spencer
Antioxidant Research Group, Wolfson Centre for Age Related Diseases, GKT School of Biomedical School, King s College London, UK
Arch Biochem Biophys 423:148-61. 2004..Uptake and metabolism of the circulating forms of flavanols, flavonols, and flavanones into cells of the skin, the brain, and cancer cells is reviewed and potential biological relevance to intracellular formed metabolites is discussed... - Modulation of peroxynitrite-induced fibroblast injury by hesperetin: a role for intracellular scavenging and modulation of ERK signallingSusan E Pollard
Molecular Nutrition Group, School of Chemistry, Food Biosciences and Pharmacy, University of Reading, Reading RG6 6AP, UK
Biochem Biophys Res Commun 347:916-23. 2006..We propose that the protective potential of hesperetin in fibroblasts may be mediated both by intracellular scavenging of peroxynitrite and by modulation of fibroblast signalling... - Insights into dietary flavonoids as molecular templates for the design of anti-platelet drugsBernice Wright
Institute for Cardiovascular and Metabolic Research, Schools of Biological Sciences, University of Reading, Berkshire, Reading RG6 6UB, UK
Cardiovasc Res 97:13-22. 2013..This focussed review highlights the potential of flavonoids to guide the design of clinically safer, more selective, and potent small-molecule inhibitors of cell signalling, applicable to anti-platelet therapy... - Metabolism of tea flavonoids in the gastrointestinal tractJeremy P E Spencer
olfson Centre for Age Related Disease, GKT School of Biomedical Science, King s College London, London, SE1 9RT, UK
J Nutr 133:3255S-3261S. 2003..This review will highlight the major sites of flavanol metabolism in the gastrointestinal tract and the processes that give rise to potential bioactive forms of flavan-3-ols in vivo... - Dietary flavonoids as potential neuroprotectantsKuresh A Youdim
Wolfson Center for Age-Related Diseases, Guy's King's and St. Thomas's School of Biomedical Sciences, King's College, London, UK
Biol Chem 383:503-19. 2002..Such mechanisms might involve their interaction with cell signalling cascades, their influence on gene expression and the down regulation of pathways leading to cell death... - The effect of dietary nitrate on salivary, plasma, and urinary nitrate metabolism in humansAnanth S Pannala
Centre for Age-Related Diseases, GKT School of Biomedical Sciences, King's College London, London, UK
Free Radic Biol Med 34:576-84. 2003..High dietary nitrate consumption does not cause a significant acute change in plasma concentrations of 3-nitrotyrosine or in platelet function... - Substrate specificity of human glutamine transaminase K as an aminotransferase and as a cysteine S-conjugate beta-lyaseArthur J L Cooper
Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY, USA
Arch Biochem Biophys 474:72-81. 2008..The importance of transamination, oxidation and beta-elimination reactions involving 5-S-l-cysteinyldopamine, 5-S-l-cysteinyl-l-DOPA and Se-methyl-l-selenocysteine in human tissues and their biological relevance are discussed... - Do mitochondriotropic antioxidants prevent chlorinative stress-induced mitochondrial and cellular injury?Matthew Whiteman
Institute of Biomedical and Clinical Sciences, Peninsula Medical School, Universities of Exeter and Plymouth, St Luke s Campus, Exeter, Devon, England
Antioxid Redox Signal 10:641-50. 2008..Our study highlights the potential application of mitochondria-specific targeted antioxidants for the prevention of cellular dysfunction and cell death under conditions of chlorinative stress, as occurs during chronic inflammation... - 5-s-Cysteinyl-conjugates of catecholamines induce cell damage, extensive DNA base modification and increases in caspase-3 activity in neuronsJeremy P E Spencer
Wolfson Centre for Age Related Diseases, GKT School of Biomedical Sciences, King s College London
J Neurochem 81:122-9. 2002..Indeed, intracellular ROS were observed to rise sharply on exposure to the conjugates. These results suggest one mechanism by which oxidative stress may occur in the substantia nigra in Parkinson's disease... - The pro-inflammatory oxidant hypochlorous acid induces Bax-dependent mitochondrial permeabilisation and cell death through AIF-/EndoG-dependent pathwaysMatthew Whiteman
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Republic of Singapore
Cell Signal 19:705-14. 2007..Our study provides a novel insight into the potential mechanisms of cell death in the inflamed human joint... - c-Jun N-terminal kinase (JNK)-mediated modulation of brain mitochondria function: new target proteins for JNK signalling in mitochondrion-dependent apoptosisHagen Schroeter
Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, 1985 Zonal Avenue, Los Angeles 90089-9121, USA
Biochem J 372:359-69. 2003..Taken together, JNK-dependent phosphorylation of mitochondrial proteins including, but not limited to, Bcl-2/Bcl-x(L) may represent a potential of the modulation of mitochondrial function during apoptosis... - Loss of 3-chlorotyrosine by inflammatory oxidants: implications for the use of 3-chlorotyrosine as a bio-marker in vivoMatthew Whiteman
Institute of Biomedical and Clinical Sciences, Peninsula Medical School, St Luke s Campus, Magdalen Road, Exeter, EX1 2LU England, UK
Biochem Biophys Res Commun 371:50-3. 2008..This finding could account for some of the discrepancies reported between 3-chlorotyrosine levels in tissues in the literature...