Research Topics
| Sean SpenceSummaryAffiliation: University of Sheffield Country: UK Publications
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Detail Information
Publications
Modafinil modulates anterior cingulate function in chronic schizophreniaSean A Spence
Sheffield Cognition and Neuroimaging, Academic Clinical Psychiatry, Division of Genomic Medicine, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK
Br J Psychiatry 187:55-61. 2005..Schizophrenia is associated with widespread cognitive deficits that have an impact on social function. Modafinil promotes wakefulness and is reported to enhance cognition...
A cognitive neurobiological account of deception: evidence from functional neuroimagingSean A Spence
Department of Academic Clinical Psychiatry, Division of Genomic Medicine, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK
Philos Trans R Soc Lond B Biol Sci 359:1755-62. 2004..The subject who lies may necessarily engage 'higher' brain centres, consistent with a purpose or intention (to deceive). While the principle of executive control during deception remains plausible, its precise anatomy awaits elucidation...
Looking for truth and finding lies: the prospects for a nascent neuroimaging of deceptionSean A Spence
Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S57JT, UK
Neurocase 14:68-81. 2008..However, such a procedure would only appear to be ethical when subjects volunteer to participate, as might occur during the investigation of alleged miscarriages of justice. We demonstrate how this might be approached...- Cognitive dysfunction in homeless adults: a systematic reviewSean Spence
Academic Clinical Psychiatry, Division of Genomic Medicine, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK
J R Soc Med 97:375-9. 2004..Such dysfunction might be expected to impact upon their ability to reintegrate into society, thereby undermining policies of inclusiveness. In clinical practice, assessment of homeless adults should include their cognitive state... - The deceptive brainSean A Spence
Academic Clinical Psychiatry, Division of Genomic Medicine, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK
J R Soc Med 97:6-9. 2004 - Speaking of secrets and lies: the contribution of ventrolateral prefrontal cortex to vocal deceptionSean A Spence
General Adult Psychiatry, Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK
Neuroimage 40:1411-8. 2008..The main effect of lying revealed significant activation of ventrolateral prefrontal cortices. These results replicate and extend our previous findings to those circumstances under which subjects are allowed to choose when to deceive... - If brain scans really detected deception, who would volunteer to be scanned?Sean A Spence
University of Sheffield, Academic Clinical Psychiatry, The Longley Centre, Sheffield, UK
J Forensic Sci 55:1352-5. 2010..Hence, in conclusion, if neuroimaging were to become an acceptable means of demonstrating innocence then incarcerated males may well constitute those volunteering for such investigation... - 'Munchausen's syndrome by proxy' or a 'miscarriage of justice'? An initial application of functional neuroimaging to the question of guilt versus innocenceSean A Spence
Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield, UK
Eur Psychiatry 23:309-14. 2008..Hence, while we have not 'proven' that this subject is innocent, we demonstrate that her behavioural and functional anatomical parameters behave as if she were... - Patients bearing gifts: are there strings attached?Sean A Spence
Academic Clinical Psychiatry, Division of Genomic Medicine, University of Sheffield, Sheffield S5 7JT
BMJ 331:1527-9. 2005 - Impact of modafinil on prefrontal executive function in schizophreniaMichael D Hunter
Academic Units of Clinical Psychiatry and Radiology, University of Sheffield, Sheffield, UK
Am J Psychiatry 163:2184-6. 2006..The purpose of this study was to investigate the acute effects of modafinil on prefrontal activation and cognitive control of motor activity in people with schizophrenia and prominent negative symptoms... - Expanding the response space in chronic schizophrenia: the relevance of left prefrontal cortexVenkatasubramanian Ganesan
Academic Clinical Psychiatry, Division of Genomic Medicine, University of Sheffield, Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK
Neuroimage 25:952-7. 2005..This study probed the ability of people with chronic schizophrenia to control their behavior in time by requiring them to deliberately vary responses within the temporal domain (i.e., to avoid regular inter-response intervals)... - Modafinil and unconstrained motor activity in schizophrenia: double-blind crossover placebo-controlled trialTom F D Farrow
SCANLab, Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Northern General Hospital, Norwood Grange Drive, Sheffield S5 7JT, UK
Br J Psychiatry 189:461-2. 2006..Patients' total activity was significantly greater when given the drug. These data suggest that modafinil increases quantifiable motor behaviour in schizophrenia and may have an impact on avolition... - A functional magnetic resonance imaging study of social cognition in schizophrenia during an acute episode and after recoveryKwang Hyuk Lee
Sheffield Cognition and Neuroimaging Laboratory SCANLab, Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Norwood Grange Dr, Sheffield S5 7JT, U K
Am J Psychiatry 163:1926-33. 2006.... - A systematic review of cognition in homeless children and adolescentsRandolph W Parks
Academic Clinical Psychiatry, University of Sheffield School of Medicine, The Longley Centre, Norwood Grange Drive, Sheffield, England
J R Soc Med 100:46-50. 2007..Conclusions We suggest that cognitive and mental health screening be incorporated into those intervention programs deployed to facilitate societal reintegration of homeless children and adolescents... - Re-examining thought insertion. Semi-structured literature review and conceptual analysisSimon Mullins
Academic Department of Psychiatry, University of Sheffield, UK
Br J Psychiatry 182:293-8. 2003..CONCLUSIONS: Despite its widespread occurrence and diagnostic application, thought insertion is an ill-understood and under researched symptom of psychosis. Its pathophysiology remains obscure... - Evidence of mnemonic ability selectively affecting truthful and deceptive response dynamicsTom F D Farrow
SCANLab, Academic Clinical Psychiatry, Department of Neuroscience, The Longley Centre, Northern General Hospital, University of Sheffield, England
Am J Psychol 123:447-53. 2010..We found that verbal memory performance differentially affects the temporal parameters of truth and deception... - Quantifiable change in functional brain response to empathic and forgivability judgments with resolution of posttraumatic stress disorderTom F D Farrow
Sheffield Cognition and Neuroimaging Laboratory SCANLab, Department of Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Northern General Hospital, Norwood Grange Drive, Sheffield, S5 7JT, UK
Psychiatry Res 140:45-53. 2005..Time and therapy are likely contributory factors that lead to a degree of 'normalisation' of the neural response to these social cognition tasks... - Sex and personality traits influence the difference between time taken to tell the truth or lieTom F D Farrow
Department of Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Northern General Hospital, UK
Percept Mot Skills 97:451-60. 2003..These preliminary data suggest that response time is systematically longer when telling a lie and that personality variables may play a part in this process... - Time perspective, depression, and substance misuse among the homelessGraham Pluck
Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield, South Yorkshire, SS 7JT7, England
J Psychol 142:159-68. 2008..Despite their current difficulties, including depression and drug abuse, the homeless individuals maintained a propensity toward future thinking characterized by striving to achieve their goals... - Structural brain correlates of unconstrained motor activity in people with schizophreniaTom F D Farrow
Sheffield Cognition and Neuroimaging Laboratory SCANLab, Department of Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Northern General Hospital, Norwood Grange Drive, Sheffield S5 7JT, UK
Br J Psychiatry 187:481-2. 2005..These data suggest that the volume of specific executive structures may affect (quantifiable) motor behaviours, having further implications for models of the 'will' and avolition... - Neurobehavioural and cognitive function is linked to childhood trauma in homeless adultsGraham Pluck
University of Sheffield, UK
Br J Clin Psychol 50:33-45. 2011.... - Approaching an ecologically valid functional anatomy of spontaneous "willed" actionMichael D Hunter
Sheffield Cognition and Neuroimaging Laboratory SCANLab, Academic Department of Psychiatry, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield, S5 7JT, UK
Neuroimage 20:1264-9. 2003..Our findings suggest that neural correlates of spontaneous willed action are distributed in executive and motor centres, and that temporal response dynamics differentiate "higher" regions from subordinate motor areas... - Defining thought broadcast. Semi-structured literature reviewAjaykumar V Pawar
Academic Clinical Psychiatry, University of Sheffield, UK
Br J Psychiatry 183:287-91. 2003..CONCLUSIONS: Thought broadcast means different things to different people. Inconsistent terminology might impair communication in clinical and research contexts... - Spatial and temporal dissociation in prefrontal cortex during action executionMichael D Hunter
Sheffield Cognition and Neuroimaging Laboratory, Academic Clinical Psychiatry, Division of Genomic Medicine, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK
Neuroimage 23:1186-91. 2004.... - A neural basis for the perception of voices in external auditory spaceMichael D Hunter
Sheffield Cognition and Neuroimaging Laboratory, Academic Department of Psychiatry, University of Sheffield, Sheffield, UK
Brain 126:161-9. 2003..Based on this, we suggest a model for the false perception of externally located auditory verbal hallucinations... - Prefrontal white matter--the tissue of lies?: Invited commentary on... Prefrontal white matter in pathological liarsSean A Spence
Br J Psychiatry 187:326-7. 2005 - Schneiderian first-rank symptoms and right parietal hyperactivation: a replication using FMRIVenkatasubramanian Ganesan
Am J Psychiatry 162:1545. 2005 - Childhood abuse and adult violence in homeless peopleSean A Spence
Psychiatry Clin Neurosci 60:259. 2006