Sean Spence

Summary

Affiliation: University of Sheffield
Country: UK

Publications

  1. ncbi request reprint Modafinil modulates anterior cingulate function in chronic schizophrenia
    Sean A Spence
    Sheffield Cognition and Neuroimaging, Academic Clinical Psychiatry, Division of Genomic Medicine, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK
    Br J Psychiatry 187:55-61. 2005
  2. pmc A cognitive neurobiological account of deception: evidence from functional neuroimaging
    Sean A Spence
    Department of Academic Clinical Psychiatry, Division of Genomic Medicine, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK
    Philos Trans R Soc Lond B Biol Sci 359:1755-62. 2004
  3. doi request reprint Looking for truth and finding lies: the prospects for a nascent neuroimaging of deception
    Sean A Spence
    Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S57JT, UK
    Neurocase 14:68-81. 2008
  4. pmc Cognitive dysfunction in homeless adults: a systematic review
    Sean Spence
    Academic Clinical Psychiatry, Division of Genomic Medicine, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK
    J R Soc Med 97:375-9. 2004
  5. pmc The deceptive brain
    Sean A Spence
    Academic Clinical Psychiatry, Division of Genomic Medicine, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK
    J R Soc Med 97:6-9. 2004
  6. doi request reprint Speaking of secrets and lies: the contribution of ventrolateral prefrontal cortex to vocal deception
    Sean A Spence
    General Adult Psychiatry, Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK
    Neuroimage 40:1411-8. 2008
  7. doi request reprint If brain scans really detected deception, who would volunteer to be scanned?
    Sean A Spence
    University of Sheffield, Academic Clinical Psychiatry, The Longley Centre, Sheffield, UK
    J Forensic Sci 55:1352-5. 2010
  8. ncbi request reprint 'Munchausen's syndrome by proxy' or a 'miscarriage of justice'? An initial application of functional neuroimaging to the question of guilt versus innocence
    Sean A Spence
    Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield, UK
    Eur Psychiatry 23:309-14. 2008
  9. pmc Patients bearing gifts: are there strings attached?
    Sean A Spence
    Academic Clinical Psychiatry, Division of Genomic Medicine, University of Sheffield, Sheffield S5 7JT
    BMJ 331:1527-9. 2005
  10. ncbi request reprint Impact of modafinil on prefrontal executive function in schizophrenia
    Michael D Hunter
    Academic Units of Clinical Psychiatry and Radiology, University of Sheffield, Sheffield, UK
    Am J Psychiatry 163:2184-6. 2006

Detail Information

Publications28

  1. ncbi request reprint Modafinil modulates anterior cingulate function in chronic schizophrenia
    Sean A Spence
    Sheffield Cognition and Neuroimaging, Academic Clinical Psychiatry, Division of Genomic Medicine, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK
    Br J Psychiatry 187:55-61. 2005
    ..Schizophrenia is associated with widespread cognitive deficits that have an impact on social function. Modafinil promotes wakefulness and is reported to enhance cognition...
  2. pmc A cognitive neurobiological account of deception: evidence from functional neuroimaging
    Sean A Spence
    Department of Academic Clinical Psychiatry, Division of Genomic Medicine, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK
    Philos Trans R Soc Lond B Biol Sci 359:1755-62. 2004
    ..The subject who lies may necessarily engage 'higher' brain centres, consistent with a purpose or intention (to deceive). While the principle of executive control during deception remains plausible, its precise anatomy awaits elucidation...
  3. doi request reprint Looking for truth and finding lies: the prospects for a nascent neuroimaging of deception
    Sean A Spence
    Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S57JT, UK
    Neurocase 14:68-81. 2008
    ..However, such a procedure would only appear to be ethical when subjects volunteer to participate, as might occur during the investigation of alleged miscarriages of justice. We demonstrate how this might be approached...
  4. pmc Cognitive dysfunction in homeless adults: a systematic review
    Sean Spence
    Academic Clinical Psychiatry, Division of Genomic Medicine, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK
    J R Soc Med 97:375-9. 2004
    ..Such dysfunction might be expected to impact upon their ability to reintegrate into society, thereby undermining policies of inclusiveness. In clinical practice, assessment of homeless adults should include their cognitive state...
  5. pmc The deceptive brain
    Sean A Spence
    Academic Clinical Psychiatry, Division of Genomic Medicine, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK
    J R Soc Med 97:6-9. 2004
  6. doi request reprint Speaking of secrets and lies: the contribution of ventrolateral prefrontal cortex to vocal deception
    Sean A Spence
    General Adult Psychiatry, Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK
    Neuroimage 40:1411-8. 2008
    ..The main effect of lying revealed significant activation of ventrolateral prefrontal cortices. These results replicate and extend our previous findings to those circumstances under which subjects are allowed to choose when to deceive...
  7. doi request reprint If brain scans really detected deception, who would volunteer to be scanned?
    Sean A Spence
    University of Sheffield, Academic Clinical Psychiatry, The Longley Centre, Sheffield, UK
    J Forensic Sci 55:1352-5. 2010
    ..Hence, in conclusion, if neuroimaging were to become an acceptable means of demonstrating innocence then incarcerated males may well constitute those volunteering for such investigation...
  8. ncbi request reprint 'Munchausen's syndrome by proxy' or a 'miscarriage of justice'? An initial application of functional neuroimaging to the question of guilt versus innocence
    Sean A Spence
    Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield, UK
    Eur Psychiatry 23:309-14. 2008
    ..Hence, while we have not 'proven' that this subject is innocent, we demonstrate that her behavioural and functional anatomical parameters behave as if she were...
  9. pmc Patients bearing gifts: are there strings attached?
    Sean A Spence
    Academic Clinical Psychiatry, Division of Genomic Medicine, University of Sheffield, Sheffield S5 7JT
    BMJ 331:1527-9. 2005
  10. ncbi request reprint Impact of modafinil on prefrontal executive function in schizophrenia
    Michael D Hunter
    Academic Units of Clinical Psychiatry and Radiology, University of Sheffield, Sheffield, UK
    Am J Psychiatry 163:2184-6. 2006
    ..The purpose of this study was to investigate the acute effects of modafinil on prefrontal activation and cognitive control of motor activity in people with schizophrenia and prominent negative symptoms...
  11. ncbi request reprint Expanding the response space in chronic schizophrenia: the relevance of left prefrontal cortex
    Venkatasubramanian Ganesan
    Academic Clinical Psychiatry, Division of Genomic Medicine, University of Sheffield, Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK
    Neuroimage 25:952-7. 2005
    ..This study probed the ability of people with chronic schizophrenia to control their behavior in time by requiring them to deliberately vary responses within the temporal domain (i.e., to avoid regular inter-response intervals)...
  12. ncbi request reprint Modafinil and unconstrained motor activity in schizophrenia: double-blind crossover placebo-controlled trial
    Tom F D Farrow
    SCANLab, Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Northern General Hospital, Norwood Grange Drive, Sheffield S5 7JT, UK
    Br J Psychiatry 189:461-2. 2006
    ..Patients' total activity was significantly greater when given the drug. These data suggest that modafinil increases quantifiable motor behaviour in schizophrenia and may have an impact on avolition...
  13. ncbi request reprint A functional magnetic resonance imaging study of social cognition in schizophrenia during an acute episode and after recovery
    Kwang Hyuk Lee
    Sheffield Cognition and Neuroimaging Laboratory SCANLab, Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Norwood Grange Dr, Sheffield S5 7JT, U K
    Am J Psychiatry 163:1926-33. 2006
    ....
  14. pmc A systematic review of cognition in homeless children and adolescents
    Randolph W Parks
    Academic Clinical Psychiatry, University of Sheffield School of Medicine, The Longley Centre, Norwood Grange Drive, Sheffield, England
    J R Soc Med 100:46-50. 2007
    ..Conclusions We suggest that cognitive and mental health screening be incorporated into those intervention programs deployed to facilitate societal reintegration of homeless children and adolescents...
  15. ncbi request reprint Re-examining thought insertion. Semi-structured literature review and conceptual analysis
    Simon Mullins
    Academic Department of Psychiatry, University of Sheffield, UK
    Br J Psychiatry 182:293-8. 2003
    ..Thought insertion is commonly regarded as diagnostic of schizophrenia. Little is known of its aetiology or pathophysiology...
  16. ncbi request reprint Evidence of mnemonic ability selectively affecting truthful and deceptive response dynamics
    Tom F D Farrow
    SCANLab, Academic Clinical Psychiatry, Department of Neuroscience, The Longley Centre, Northern General Hospital, University of Sheffield, England
    Am J Psychol 123:447-53. 2010
    ..We found that verbal memory performance differentially affects the temporal parameters of truth and deception...
  17. ncbi request reprint Quantifiable change in functional brain response to empathic and forgivability judgments with resolution of posttraumatic stress disorder
    Tom F D Farrow
    Sheffield Cognition and Neuroimaging Laboratory SCANLab, Department of Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Northern General Hospital, Norwood Grange Drive, Sheffield, S5 7JT, UK
    Psychiatry Res 140:45-53. 2005
    ..Time and therapy are likely contributory factors that lead to a degree of 'normalisation' of the neural response to these social cognition tasks...
  18. ncbi request reprint Sex and personality traits influence the difference between time taken to tell the truth or lie
    Tom F D Farrow
    Department of Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Northern General Hospital, UK
    Percept Mot Skills 97:451-60. 2003
    ..These preliminary data suggest that response time is systematically longer when telling a lie and that personality variables may play a part in this process...
  19. doi request reprint Time perspective, depression, and substance misuse among the homeless
    Graham Pluck
    Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield, South Yorkshire, SS 7JT7, England
    J Psychol 142:159-68. 2008
    ..Despite their current difficulties, including depression and drug abuse, the homeless individuals maintained a propensity toward future thinking characterized by striving to achieve their goals...
  20. ncbi request reprint Structural brain correlates of unconstrained motor activity in people with schizophrenia
    Tom F D Farrow
    Sheffield Cognition and Neuroimaging Laboratory SCANLab, Department of Academic Clinical Psychiatry, University of Sheffield, The Longley Centre, Northern General Hospital, Norwood Grange Drive, Sheffield S5 7JT, UK
    Br J Psychiatry 187:481-2. 2005
    ..These data suggest that the volume of specific executive structures may affect (quantifiable) motor behaviours, having further implications for models of the 'will' and avolition...
  21. doi request reprint Neurobehavioural and cognitive function is linked to childhood trauma in homeless adults
    Graham Pluck
    University of Sheffield, UK
    Br J Clin Psychol 50:33-45. 2011
    ....
  22. ncbi request reprint Approaching an ecologically valid functional anatomy of spontaneous "willed" action
    Michael D Hunter
    Sheffield Cognition and Neuroimaging Laboratory SCANLab, Academic Department of Psychiatry, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield, S5 7JT, UK
    Neuroimage 20:1264-9. 2003
    ..Our findings suggest that neural correlates of spontaneous willed action are distributed in executive and motor centres, and that temporal response dynamics differentiate "higher" regions from subordinate motor areas...
  23. ncbi request reprint Defining thought broadcast. Semi-structured literature review
    Ajaykumar V Pawar
    Academic Clinical Psychiatry, University of Sheffield, UK
    Br J Psychiatry 183:287-91. 2003
    ..The symptom of thought broadcast may have diagnostic significance but its definition varies...
  24. ncbi request reprint Spatial and temporal dissociation in prefrontal cortex during action execution
    Michael D Hunter
    Sheffield Cognition and Neuroimaging Laboratory, Academic Clinical Psychiatry, Division of Genomic Medicine, University of Sheffield, The Longley Centre, Norwood Grange Drive, Sheffield S5 7JT, UK
    Neuroimage 23:1186-91. 2004
    ....
  25. ncbi request reprint A neural basis for the perception of voices in external auditory space
    Michael D Hunter
    Sheffield Cognition and Neuroimaging Laboratory, Academic Department of Psychiatry, University of Sheffield, Sheffield, UK
    Brain 126:161-9. 2003
    ..Based on this, we suggest a model for the false perception of externally located auditory verbal hallucinations...
  26. ncbi request reprint Prefrontal white matter--the tissue of lies?: Invited commentary on... Prefrontal white matter in pathological liars
    Sean A Spence
    Br J Psychiatry 187:326-7. 2005
  27. ncbi request reprint Schneiderian first-rank symptoms and right parietal hyperactivation: a replication using FMRI
    Venkatasubramanian Ganesan
    Am J Psychiatry 162:1545. 2005
  28. ncbi request reprint Childhood abuse and adult violence in homeless people
    Sean A Spence
    Psychiatry Clin Neurosci 60:259. 2006