P M Speight

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Salivary gland tumours
    P M Speight
    Department of Oral and Maxillofacial Pathology, Eastman Dental Institute for Oral Health Care Sciences, University College London, UK
    Oral Dis 8:229-40. 2002
  2. pmc Expression of Mcm2, geminin and Ki67 in normal oral mucosa, oral epithelial dysplasias and their corresponding squamous-cell carcinomas
    A Torres-Rendon
    Department of Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, UK
    Br J Cancer 100:1128-34. 2009
  3. ncbi request reprint Progress in determining the malignant potential of oral lesions
    C Scully
    Eastman Dental Institute for Oral Health Care Sciences, World Health Organisation Collaborating Centre for Oral Health, Disability and Culture, UCL University of London, 256 Gray s Inn Road, London WC1X 8LD, UK
    J Oral Pathol Med 32:251-6. 2003
  4. ncbi request reprint Oral yeast carriage correlates with presence of oral epithelial dysplasia
    M McCullough
    Department of Oral Medicine, Eastman Dental Institute for Oral Health Care Sciences, UCL, University of London, 256 Gray s Inn Road, London WC1X 8LD, UK
    Oral Oncol 38:391-3. 2002
  5. ncbi request reprint Metalloproteinase expression in normal and malignant oral keratinocytes: stimulation of MMP-2 and -9 by scatter factor
    J H Bennett
    Department of Oral Pathology, Eastman Dental Institute for Oral Health Care Sciences, University College London, UK
    Eur J Oral Sci 108:281-91. 2000
  6. doi request reprint DNA ploidy analysis by image cytometry helps to identify oral epithelial dysplasias with a high risk of malignant progression
    A Torres-Rendon
    Department of Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Claremont Crescent, S102TA Sheffield, UK
    Oral Oncol 45:468-73. 2009
  7. pmc Oral and pharyngeal cancer in South Asians and non-South Asians in relation to socioeconomic deprivation in South East England
    D R Moles
    Health Services Research, UCL Eastman Dental Institute, 256 Grays Inn Road, London WC1X 8LD, UK
    Br J Cancer 98:633-5. 2008
  8. ncbi request reprint Meta-analysis of measures of performance reported in oral cancer and precancer screening studies
    D R Moles
    Department of Oral Pathology, University College London, UK
    Br Dent J 192:340-4; discussion 332. 2002
  9. ncbi request reprint The histopathology of syphilis of the oral mucosa
    A W Barrett
    Oral and Maxillofacial Pathology, Eastman Dental Institute for Oral Healthcare Sciences, UCL, University of London, 256 Grays Inn Road, London, WC1X 8LD, UK
    J Oral Pathol Med 33:286-91. 2004
  10. ncbi request reprint Photodynamic therapy using mTHPC for malignant disease in the oral cavity
    K F Fan
    Department of Surgery, University College London Medical School, UK
    Int J Cancer 73:25-32. 1997

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Salivary gland tumours
    P M Speight
    Department of Oral and Maxillofacial Pathology, Eastman Dental Institute for Oral Health Care Sciences, University College London, UK
    Oral Dis 8:229-40. 2002
    ..Large malignancies tend to have a poor prognosis regardless of grade and even high-grade neoplasms may do well when they are small. A helpful guide to management of salivary cancers is the '4 cm rule'...
  2. pmc Expression of Mcm2, geminin and Ki67 in normal oral mucosa, oral epithelial dysplasias and their corresponding squamous-cell carcinomas
    A Torres-Rendon
    Department of Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, UK
    Br J Cancer 100:1128-34. 2009
    ..04), likewise there was a significant increase in the Mcm2/Ki67 and geminin/Ki67 ratios (P=0.04 and 0.02 respectively). Mcm2 and geminin proteins seem to be novel biomarkers of growth and may be useful prognostic tools for OED...
  3. ncbi request reprint Progress in determining the malignant potential of oral lesions
    C Scully
    Eastman Dental Institute for Oral Health Care Sciences, World Health Organisation Collaborating Centre for Oral Health, Disability and Culture, UCL University of London, 256 Gray s Inn Road, London WC1X 8LD, UK
    J Oral Pathol Med 32:251-6. 2003
    ..Recent data on molecular and DNA changes in potentially malignant lesions suggest that it is now feasible to identify those lesions that are truly potentially malignant...
  4. ncbi request reprint Oral yeast carriage correlates with presence of oral epithelial dysplasia
    M McCullough
    Department of Oral Medicine, Eastman Dental Institute for Oral Health Care Sciences, UCL, University of London, 256 Gray s Inn Road, London WC1X 8LD, UK
    Oral Oncol 38:391-3. 2002
    ..The results of the present study reveal that there is an interaction between oral carriage of yeast and oral epithelial dysplasia, however it remains unclear how yeast infection influences the development and progression of dysplasia...
  5. ncbi request reprint Metalloproteinase expression in normal and malignant oral keratinocytes: stimulation of MMP-2 and -9 by scatter factor
    J H Bennett
    Department of Oral Pathology, Eastman Dental Institute for Oral Health Care Sciences, University College London, UK
    Eur J Oral Sci 108:281-91. 2000
    ..The results indicate that SF stimulates MMP expression in UP, H376, H357, and normal oral mucosal cells and points to a role for SF in the regulation of oral keratinocyte behaviour in wound healing and neoplasia...
  6. doi request reprint DNA ploidy analysis by image cytometry helps to identify oral epithelial dysplasias with a high risk of malignant progression
    A Torres-Rendon
    Department of Oral and Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Claremont Crescent, S102TA Sheffield, UK
    Oral Oncol 45:468-73. 2009
    ..33 and 0.88, respectively. The PPV and NPV were 0.74 and 0.58. We conclude that aneuploid oral dysplastic lesions have a high risk of malignant progression and that DNA image cytometry might help to identify those lesions most at risk...
  7. pmc Oral and pharyngeal cancer in South Asians and non-South Asians in relation to socioeconomic deprivation in South East England
    D R Moles
    Health Services Research, UCL Eastman Dental Institute, 256 Grays Inn Road, London WC1X 8LD, UK
    Br J Cancer 98:633-5. 2008
    ..11, 1.67), but not of pharyngeal cancer than non-South Asian males, whereas South Asian females had much higher risks of these cancers (3.67; 95% CI: 2.97, 4.53 and 2.06; 95% CI: 1.44, 2.93), respectively, than non-South Asians...
  8. ncbi request reprint Meta-analysis of measures of performance reported in oral cancer and precancer screening studies
    D R Moles
    Department of Oral Pathology, University College London, UK
    Br Dent J 192:340-4; discussion 332. 2002
    ..To elicit a range of values for sensitivity, specificity and other measures of performance in screening for oral cancer and precancer...
  9. ncbi request reprint The histopathology of syphilis of the oral mucosa
    A W Barrett
    Oral and Maxillofacial Pathology, Eastman Dental Institute for Oral Healthcare Sciences, UCL, University of London, 256 Grays Inn Road, London, WC1X 8LD, UK
    J Oral Pathol Med 33:286-91. 2004
    ..Clinical manifestations are protean, and oral biopsies may be taken where the diagnosis is unsuspected, but data on the histopathology of oral mucosal syphilis are sparse...
  10. ncbi request reprint Photodynamic therapy using mTHPC for malignant disease in the oral cavity
    K F Fan
    Department of Surgery, University College London Medical School, UK
    Int J Cancer 73:25-32. 1997
    ..Most healed very well, but tongue tethering was seen in 1 patient and another had necrosis in normal areas due to light scattering within the mouth. PDT using mTHPC is a promising new treatment for patients with oral cancer...
  11. ncbi request reprint The frequency of fungal infection in biopsies of oral mucosal lesions
    A W Barrett
    Department of Oral Pathology, Eastman Dental Institute for Oral Health Care Sciences, University of London, UK
    Oral Dis 4:26-31. 1998
    ..To determine the frequency of fungal infection in biopsies of oral mucosal lesions...
  12. ncbi request reprint Adenosquamous carcinoma of the mouth: a rare variant of squamous cell carcinoma
    C Scully
    Eastman Dental Institute for Oral Health Care Sciences, University of London, UK
    Int J Oral Maxillofac Surg 28:125-8. 1999
    ..We report three further cases and review the literature, which suggests that this lesion should be regarded as a high-grade variant of squamous cell carcinoma...
  13. ncbi request reprint A clinicopathologic and immunohistochemical analysis of melanotic neuroectodermal tumor of infancy
    A W Barrett
    Oral and Maxillofacial Pathology Unit, Eastman Denatal Institute for Oral Healthcare Sciences, University College, London, United Kingdom
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 93:688-98. 2002
    ..5, specific cytokeratins, and Ki-67, markers not previously reported in this entity...
  14. ncbi request reprint Osteosarcoma of the jaws: a 30-year retrospective review
    J H Bennett
    Department of Oral Pathology, Eastman Dental Institute, University College London, UK
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 90:323-32. 2000
    ..Study Design: The clinical, radiographic, and histopathologic records of 25 patients were obtained for retrospective review. Supportive and follow-up clinical and histopathologic material was obtained from the referring clinicians...
  15. ncbi request reprint An audit of the efficacy of the oral brush biopsy technique in a specialist Oral Medicine unit
    T W J Poate
    Oral Medicine, Division of Maxillofacial Diagnostic, Medical and Surgical Sciences, Eastman Dental Institute for Oral Health Care Sciences, UCL, University of London, 256 Gray s Inn Road, London WC1X 8LD, UK
    Oral Oncol 40:829-34. 2004
    ..1%, while the negative predictive value was 60%. It is concluded that not all potentially malignant disease is detected with this non-invasive investigative procedure...
  16. ncbi request reprint Cell adhesion molecules and oral cancer
    G J Thomas
    Department of Oral Pathology, Eastman Dental Institute for Oral Health Care Sciences, University College London, UK
    Crit Rev Oral Biol Med 12:479-98. 2001
    ..However, up-regulation of certain integrins, such as alphavbeta6, has consistently been found in oral cancer, suggesting that it may play an active role in disease progression...
  17. ncbi request reprint Expression of the alphavbeta6 integrin promotes migration and invasion in squamous carcinoma cells
    G J Thomas
    Department of Oral Pathology, Eastman Dental Institute, University College London, UK
    J Invest Dermatol 117:67-73. 2001
    ..alphavbeta6 expression may have a significant role in contributing to the malignant behavior of epithelial cells...
  18. ncbi request reprint Transfection and ligation of CD40 in human oral keratinocytes affect proliferation, adhesion and migration but not apoptosis in vitro
    M Villarroel Dorrego
    Oral and Maxillofacial Pathology Unit, Eastman Dental Institute for Oral Healthcare Sciences, University College London, London, UK
    Clin Exp Dermatol 31:266-71. 2006
    ..The aim of this study was to investigate the functional significance of CD40 in the proliferation, apoptosis, adhesion and migration of human oral keratinocytes in vitro...
  19. ncbi request reprint Fluorescence biodistribution and photosensitising activity of toluidine blue o on rat buccal mucosa
    N Komerik
    Department of Microbiology, Oral Maxilofacial Surgery, Eastman Dental Institute for Oral Health Care Sciences, University College London, UK
    Lasers Med Sci 17:86-92. 2002
    ..The results of this study suggest that TBO-mediated PDT (within the concentrations and light doses tested) could be a safe antimicrobial approach for the oral infections without damaging the adjacent normal tissue...
  20. ncbi request reprint alpha v beta 6 Integrin upregulates matrix metalloproteinase 9 and promotes migration of normal oral keratinocytes
    G J Thomas
    Department of Oral Pathology, Eastman Dental Institute, University College London, UK
    J Invest Dermatol 116:898-904. 2001
    ..It appears that alpha v beta 6 may function in normal human oral keratinocyte migration through matrix-metalloproteinase-9-dependent and -independent mechanisms...
  21. pmc Binding of TGF-beta1 latency-associated peptide (LAP) to alpha(v)beta6 integrin modulates behaviour of squamous carcinoma cells
    G J Thomas
    Department of Oral Pathology, Eastman Dental Institute, University College London, UK
    Br J Cancer 87:859-67. 2002
    ....
  22. ncbi request reprint Labial tuberculosis: a unique cause of lip swelling complicating HIV infection
    S E Ilyas
    Oral Medicine, Eastman Dental Institute for Oral Health Care Sciences, UCL, University of London, London, UK
    HIV Med 3:283-6. 2002
    ..HIV disease has many oral manifestations including tuberculosis, which most commonly presents as irregular ulceration of the tongue or the palate. We detail an HIV-infected patient found to have tuberculosis of the lip...
  23. ncbi request reprint Opportunistic screening for oral cancer and precancer in general dental practice: results of a demonstration study
    K Lim
    Department of Oral and Maxillofacial Pathology, Eastman Dental Institute
    Br Dent J 194:497-502; discussion 493. 2003
    ..To demonstrate the feasibility of opportunistic oral cancer and precancer screening in general dental practice and to determine the prevalence of relevant lesions and risk habits in a population of general dental practice attenders...
  24. ncbi request reprint Clinico-pathological features of squamous cell carcinoma of the oral cavity in patients <40 years of age
    T Sasaki
    Department of Oral and Maxillofacial Surgery, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    J Oral Pathol Med 34:129-33. 2005
    ..The purpose of this study was to evaluate the clinico-pathological features of oral SCC among young people...
  25. doi request reprint Expression of Mcm-2, Ki-67 and geminin in benign and malignant salivary gland tumours
    P A Vargas
    Department of Oral Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, UK
    J Oral Pathol Med 37:309-18. 2008
    ..The aims of this study were to determine the expression of Mcm-2, Ki-67 and geminin in salivary gland (SG) tumours, and to evaluate their usefulness for diagnosis or for prediction of tumour behaviour...
  26. ncbi request reprint Transfection of CD40 in a human oral squamous cell carcinoma keratinocyte line upregulates immune potency and costimulatory molecules
    M Villarroel Dorrego
    Department of Oral Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield S10 2TA, UK
    Br J Dermatol 154:231-8. 2006
    ..The significance of this expression, or whether it is accompanied by upregulation of membrane-bound costimulatory molecules, is unknown...
  27. ncbi request reprint The cost-effectiveness of screening for oral cancer in primary care
    P M Speight
    School of Clinical Dentistry, University of Sheffield, UK
    Health Technol Assess 10:1-144, iii-iv. 2006
    ..To use a decision-analytic model to determine the incremental costs and outcomes of alternative oral cancer screening programmes conducted in a primary care environment...
  28. ncbi request reprint The range and demographics of salivary gland tumours diagnosed in a UK population
    A V Jones
    Department of Oral Pathology, School of Clinical Dentistry, University of Sheffileld, Claremont Crescent, Sheffield, S10 2TA, UK
    Oral Oncol 44:407-17. 2008
    ..This study has confirmed that some tumours have a predilection for certain sites and that the risk of malignant disease is also greater at specific sites within the oral cavity...
  29. ncbi request reprint AlphaVbeta6 integrin promotes invasion of squamous carcinoma cells through up-regulation of matrix metalloproteinase-9
    G J Thomas
    Department of Oral Pathology, Eastman Dental Institute, University College London, 256 Gray's Inn Road, London WC1X 8L6, United Kingdom
    Int J Cancer 92:641-50. 2001
    ..Our results suggest a possible mechanism for the involvement of alphaVbeta6 in squamous carcinoma in vivo...
  30. ncbi request reprint DNA ploidy analysis in salivary gland tumours by image cytometry
    P A Vargas
    Department of Oral Diagnosis, Oral Pathology Section, Dental School of Piracicaba, University of Campinas UNICAMP, Piracicaba SP, Brazil
    J Oral Pathol Med 36:371-6. 2007
    ..To determine whether DNA ploidy by image cytometry is a good diagnostic tool to distinguish benign and malignant salivary gland tumours...
  31. ncbi request reprint Re: Eisen, D & Frist, S--letter
    S R Porter
    Oral Oncol 41:861. 2005
  32. ncbi request reprint Matrix metalloproteinases and oral cancer
    G T Thomas
    Department of Oral Pathology, Eastman Dental Institute for Oral Healthcare Sciences, University of London, UK
    Oral Oncol 35:227-33. 1999
    ....
  33. pmc Tumour-derived TGF-beta1 modulates myofibroblast differentiation and promotes HGF/SF-dependent invasion of squamous carcinoma cells
    M P Lewis
    Eastman Dental Institute, University College, London, UK
    Br J Cancer 90:822-32. 2004
    ....