J Speakman

Summary

Affiliation: University of Aberdeen
Country: UK

Publications

  1. pmc Repletion of TNFα or leptin in calorically restricted mice suppresses post-restriction hyperphagia
    Catherine Hambly
    Aberdeen Centre for Energy Regulation and Obesity, Rowett Institute of Nutrition and Health, University of Aberdeen, Bucksburn, Aberdeen AB21 9SB, Scotland, UK
    Dis Model Mech 5:83-94. 2012
  2. pmc Fat: an evolving issue
    John R Speakman
    Institute of Genetics and Developmental Biology, State Key Laboratory of Molecular Developmental Biology, Chinese Academy of Sciences, Beijing, China
    Dis Model Mech 5:569-73. 2012
  3. pmc Measuring energy metabolism in the mouse - theoretical, practical, and analytical considerations
    John R Speakman
    Key State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences Beijing, China Institute of Biological and Environmental Sciences, University of Aberdeen Aberdeen, Scotland, UK
    Front Physiol 4:34. 2013
  4. pmc Deleterious consequences of antioxidant supplementation on lifespan in a wild-derived mammal
    Colin Selman
    Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK
    Biol Lett 9:20130432. 2013
  5. pmc Thermoregulatory and cardiovascular responses to creatine, glycerol and alpha lipoic acid in trained cyclists
    Thelma P Polyviou
    Medical School, College of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, United Kingdom
    J Int Soc Sports Nutr 9:29. 2012
  6. doi request reprint Evolutionary perspectives on the obesity epidemic: adaptive, maladaptive, and neutral viewpoints
    John R Speakman
    Key State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Chaoyang, Beijing 100101, People s Republic of China
    Annu Rev Nutr 33:289-317. 2013
  7. pmc The '39 steps': an algorithm for performing statistical analysis of data on energy intake and expenditure
    John R Speakman
    Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, AB24 2TZ, Scotland, UK
    Dis Model Mech 6:293-301. 2013
  8. pmc A mathematical model of weight loss under total starvation: evidence against the thrifty-gene hypothesis
    John R Speakman
    Institute of Genetics and Developmental Biology, Key State Laboratory of Molecular Development, Chinese Academy of Sciences, Beijing, China
    Dis Model Mech 6:236-51. 2013
  9. pmc Set points, settling points and some alternative models: theoretical options to understand how genes and environments combine to regulate body adiposity
    John R Speakman
    Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, Scotland, AB39 2PN, UK
    Dis Model Mech 4:733-45. 2011
  10. ncbi request reprint Limits to sustained energy intake IX: a review of hypotheses
    John R Speakman
    Aberdeen Centre for Energy Regulation and Obesity, School of Biological Sciences, University of Aberdeen, Aberdeen, AB24 2TZ, UK
    J Comp Physiol B 175:375-94. 2005

Detail Information

Publications93

  1. pmc Repletion of TNFα or leptin in calorically restricted mice suppresses post-restriction hyperphagia
    Catherine Hambly
    Aberdeen Centre for Energy Regulation and Obesity, Rowett Institute of Nutrition and Health, University of Aberdeen, Bucksburn, Aberdeen AB21 9SB, Scotland, UK
    Dis Model Mech 5:83-94. 2012
    ..Signals from adipose tissue, including but not limited to leptin and TNFα, regulate PRH and might be targets for therapies that support people engaged in CR to reduce obesity...
  2. pmc Fat: an evolving issue
    John R Speakman
    Institute of Genetics and Developmental Biology, State Key Laboratory of Molecular Developmental Biology, Chinese Academy of Sciences, Beijing, China
    Dis Model Mech 5:569-73. 2012
    ..A better understanding of gene-by-environment interactions will also be key to understanding obesity in the years to come...
  3. pmc Measuring energy metabolism in the mouse - theoretical, practical, and analytical considerations
    John R Speakman
    Key State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences Beijing, China Institute of Biological and Environmental Sciences, University of Aberdeen Aberdeen, Scotland, UK
    Front Physiol 4:34. 2013
    ..This has been a matter of some discussion for at least 120 years. The statistically most appropriate approach is to use analysis of covariance with individual aspects of body composition as independent predictors...
  4. pmc Deleterious consequences of antioxidant supplementation on lifespan in a wild-derived mammal
    Colin Selman
    Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK
    Biol Lett 9:20130432. 2013
    ....
  5. pmc Thermoregulatory and cardiovascular responses to creatine, glycerol and alpha lipoic acid in trained cyclists
    Thelma P Polyviou
    Medical School, College of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, United Kingdom
    J Int Soc Sports Nutr 9:29. 2012
    ..abstract:..
  6. doi request reprint Evolutionary perspectives on the obesity epidemic: adaptive, maladaptive, and neutral viewpoints
    John R Speakman
    Key State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Chaoyang, Beijing 100101, People s Republic of China
    Annu Rev Nutr 33:289-317. 2013
    ....
  7. pmc The '39 steps': an algorithm for performing statistical analysis of data on energy intake and expenditure
    John R Speakman
    Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, AB24 2TZ, Scotland, UK
    Dis Model Mech 6:293-301. 2013
    ..We also provide interpretations of the results obtained at each step. We hope that this algorithm will assist in the statistically appropriate analysis of such data, a field in which there has been much confusion and some controversy...
  8. pmc A mathematical model of weight loss under total starvation: evidence against the thrifty-gene hypothesis
    John R Speakman
    Institute of Genetics and Developmental Biology, Key State Laboratory of Molecular Development, Chinese Academy of Sciences, Beijing, China
    Dis Model Mech 6:236-51. 2013
    ..The TGH is further weakened by the observation of no link between the effect size of these SNPs and their prevalence, which would be anticipated under the TGH model of selection if all the SNPs had arisen in the last 900,000 years...
  9. pmc Set points, settling points and some alternative models: theoretical options to understand how genes and environments combine to regulate body adiposity
    John R Speakman
    Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, Scotland, AB39 2PN, UK
    Dis Model Mech 4:733-45. 2011
    ..We discuss two additional models--the general intake model and the dual intervention point model--that address this issue and might offer better ways to understand how body fatness is controlled...
  10. ncbi request reprint Limits to sustained energy intake IX: a review of hypotheses
    John R Speakman
    Aberdeen Centre for Energy Regulation and Obesity, School of Biological Sciences, University of Aberdeen, Aberdeen, AB24 2TZ, UK
    J Comp Physiol B 175:375-94. 2005
    ..Current evidence with respect to these hypotheses is also reviewed. The limited evidence presently available does not unambiguously support any one of them...
  11. ncbi request reprint Correlations between physiology and lifespan--two widely ignored problems with comparative studies
    John R Speakman
    Aberdeen Centre for Energy Regulation and Obesity, School of Biological Sciences, University of Aberdeen, Aberdeen, Scotland, UK
    Aging Cell 4:167-75. 2005
    ....
  12. doi request reprint FTO effect on energy demand versus food intake
    John R Speakman
    Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen AB24 2TZ, Scotland, UK
    Nature 464:E1; discussion E2. 2010
    ..The Fto(-/-) mice showed no significant differences in food intake relative to wild-types litter-mates but had an elevated metabolic rate. The apparent contrasting effects of the gene in humans and mice is worthy of closer investigation...
  13. ncbi request reprint Comparison of different approaches for the calculation of energy expenditure using doubly labeled water in a small mammal
    John R Speakman
    Aberdeen Centre for Energy Regulation and Obesity, School of Biological Sciences, University of Aberdeen, Aberdeen AB24 2TZ, United Kingdom
    Physiol Biochem Zool 78:650-67. 2005
    ..These data strongly support the previous suggestion that for small mammals single-pool models provide more accurate estimates of energy demands than two-pool formulation of the DLW method...
  14. doi request reprint Limits to sustained energy intake. XIII. Recent progress and future perspectives
    John R Speakman
    Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, AB24 2TZ, UK
    J Exp Biol 214:230-41. 2011
    ....
  15. doi request reprint Tissue-specificity and ethnic diversity in obesity-related risk of cancer may be explained by variability in insulin response and insulin signaling pathways
    John R Speakman
    Aberdeen Centre for Energy Regulation and Obesity ACERO, Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK
    Obesity (Silver Spring) 18:1071-8. 2010
    ..Reduction of insulin levels in obesity as a strategy to reduce cancer risk may pose additional problems unless it is combined also with interventions that aim to limit nutrient influx...
  16. ncbi request reprint A nonadaptive scenario explaining the genetic predisposition to obesity: the "predation release" hypothesis
    John R Speakman
    Aberdeen Centre for Energy Regulation and Obesity, School of Biological Sciences, University of Aberdeen, Aberdeen, Scotland AB24 2TZ, UK
    Cell Metab 6:5-12. 2007
    ..Because this novel hypothesis involves random drift, rather than directed selection, it explains why, even in Western society, most people are not obese...
  17. ncbi request reprint Animal models of obesity
    J Speakman
    Aberdeen Centre for Energy Regulation and Obesity, School of Biological Sciences, University of Aberdeen, Aberdeen, UK
    Obes Rev 8:55-61. 2007
  18. ncbi request reprint Assortative mating for obesity
    John R Speakman
    Aberdeen Centre for Energy Regulation and Obesity, Division of Obesity and Metabolic Health, Rowett Research Institute, Aberdeen, Scotland, United Kingdom
    Am J Clin Nutr 86:316-23. 2007
    ..However, those studies all used body mass index or skinfold thicknesses to measure obesity and did not always account for potential confounding factors...
  19. pmc The physiological costs of reproduction in small mammals
    John R Speakman
    Aberdeen Centre for Energy Regulation and Obesity ACERO, School of Biological Sciences, University of Aberdeen, UK
    Philos Trans R Soc Lond B Biol Sci 363:375-98. 2008
    ..For some, we do not even know whether they are compensatory or obligatory. For almost all of them, we have no idea of exact mechanisms or how these costs translate into fitness trade-offs...
  20. doi request reprint Polymorphisms of the FTO gene are associated with variation in energy intake, but not energy expenditure
    John R Speakman
    Division of Obesity and Metabolic Health, Rowett Research Institute, Aberdeen, Scotland, UK
    Obesity (Silver Spring) 16:1961-5. 2008
    ..2 and 9.5 MJ for the "at risk" AT and AA genotypes, respectively. Adjusting intake for BMR did not remove the significance (P = 0.043). FTO genotype probably affects obesity via effects on food intake rather than energy expenditure...
  21. doi request reprint The contribution of animal models to the study of obesity
    John Speakman
    Aberdeen Centre for Energy Regulation and Obesity, School of Biological Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK
    Lab Anim 42:413-32. 2008
    ....
  22. ncbi request reprint Thrifty genes for obesity and the metabolic syndrome--time to call off the search?
    John R Speakman
    School of Biological Sciences, University of Aberdeen, Aberdeen, Scotland, AB24 2TZ, UK
    Diab Vasc Dis Res 3:7-11. 2006
    ..Over the 40 or so years since Neel proposed the thrifty gene hypothesis, no convincing candidates for these genes have been discovered. My analysis suggests that perhaps it is time to call off the search...
  23. doi request reprint Thrifty genes for obesity, an attractive but flawed idea, and an alternative perspective: the 'drifty gene' hypothesis
    J R Speakman
    Institute of Biological and Environmental Sciences, University of Aberdeen, Tillydrone Ave, Aberdeen, Scotland, UK
    Int J Obes (Lond) 32:1611-7. 2008
    ..Together, these alternatives, based on central notion that genetic drift rather than positive selection was a dominant factor, may be called the 'drifty gene' hypothesis...
  24. ncbi request reprint The role of technology in the past and future development of the doubly labelled water method
    John R Speakman
    Aberdeen Centre for Energy Regulation and Obesity, School of Biological Sciences, University of Aberdeen and Division of Appetite and Obesity, Rowett Research Institute, Aberdeen, AB24 2TZ, Scotland, UK
    Isotopes Environ Health Stud 41:335-43. 2005
    ....
  25. doi request reprint Reverse epidemiology, obesity and mortality in chronic kidney disease: modelling mortality expectations using energetics
    John R Speakman
    Aberdeen Centre for Energy Regulation and Obesity, Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK
    Blood Purif 29:150-7. 2010
    ..Our aim was to use data on the scaling of daily energy expenditure, fat and lean tissue mass to predict the pattern of variation in mortality with obesity under the contrasting hypotheses...
  26. doi request reprint The heat dissipation limit theory and evolution of life histories in endotherms--time to dispose of the disposable soma theory?
    John R Speakman
    Institute of Biological and Environmental Sciences, University of Aberdeen, Tillydrone Avenue 2, Aberdeen AB242TZ, Scotland, UK
    Integr Comp Biol 50:793-807. 2010
    ..The HDL theory provides a novel mechanism underpinning the evolution of life history and ageing in endotherms, and makes a number of testable predictions that directly contrast with the predictions arising from the DST...
  27. ncbi request reprint Body size, energy metabolism and lifespan
    John R Speakman
    Aberdeen Centre for Energy Regulation and Obesity ACERO, School of Biological Sciences, University of Aberdeen, Aberdeen AB24 2TZ, Scotland, UK
    J Exp Biol 208:1717-30. 2005
    ..These new ideas concerning the manner in which mitochondria generate free radicals as a function of metabolism shed some light on the complexity of observations linking body size, metabolism and lifespan...
  28. doi request reprint Caloric restriction
    John R Speakman
    Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, Scotland, UK
    Mol Aspects Med 32:159-221. 2011
    ..Moreover, even if such drugs are developed how the current licensing system for drug use in western societies would cope with them may be a further obstacle to their use...
  29. doi request reprint The free-radical damage theory: Accumulating evidence against a simple link of oxidative stress to ageing and lifespan
    John R Speakman
    Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, Scotland, UK
    Bioessays 33:255-9. 2011
    ..Combined, these findings raise fundamental questions over whether the free-radical damage theory remains useful for understanding the ageing process, and variation in lifespan and life histories...
  30. ncbi request reprint Validation of dual energy X-ray absorptiometry (DXA) by comparison with chemical analysis of dogs and cats
    J R Speakman
    Aberdeen Centre for Energy Regulation and Obesity, Department of Zoology, University of Aberdeen, Aberdeen, Scotland, UK
    Int J Obes Relat Metab Disord 25:439-47. 2001
    ..Moreover, these previous validation studies have ground up entire carcasses prior to chemical analysis, thus potentially obscuring sources of error in the DXA analysis...
  31. ncbi request reprint Isotope dilution spaces of mice injected simultaneously with deuterium, tritium and oxygen-18
    E Krol
    Aberdeen Centre for Energy Regulation and Obesity, Department of Zoology, University of Aberdeen, Aberdeen AB24 2TZ, UK
    J Exp Biol 202:2839-49. 1999
    ....
  32. ncbi request reprint Preparing for inactivity: how insectivorous bats deposit a fat store for hibernation
    J R Speakman
    Aberdeen Centre for Energy Regulation and Obesity, Department of Zoology, University of Aberdeen, UK
    Proc Nutr Soc 58:123-31. 1999
    ....
  33. ncbi request reprint Age-related changes in the metabolism and body composition of three dog breeds and their relationship to life expectancy
    J R Speakman
    Aberdeen Centre for Energy Regulation and Obesity, School of Biological Sciences, Zoology Building, University of Aberdeen, Aberdeen AB24 2TZ, Scotland, UK
    Aging Cell 2:265-75. 2003
    ..These contrasting correlations suggest that metabolism is affecting life expectancy in different ways at these different levels of enquiry...
  34. ncbi request reprint Physical activity and resting metabolic rate
    John R Speakman
    Aberdeen Centre for Energy Regulation and Obesity, Division of Energy Balance and Obesity, Rowett Research Institute, Aberdeen AB21 9SB, UK
    Proc Nutr Soc 62:621-34. 2003
    ..Extreme interventions, however, may induce reductions in RMR, in spite of the increased lean tissue mass, similar to the changes observed in animals in response to flight...
  35. doi request reprint Associations between energy demands, physical activity, and body composition in adult humans between 18 and 96 y of age
    John R Speakman
    Aberdeen Centre for Energy Regulation and Obesity, Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, Scotland
    Am J Clin Nutr 92:826-34. 2010
    ..Associations between body composition and the energy expended on basal metabolism and activity are complex and age dependent...
  36. ncbi request reprint Uncoupled and surviving: individual mice with high metabolism have greater mitochondrial uncoupling and live longer
    John R Speakman
    Aberdeen Centre for Energy Regulation and Obesity ACERO, School of Biological Sciences, University of Aberdeen, Aberdeen, Scotland, UK AB24 2TZ
    Aging Cell 3:87-95. 2004
    ..Individuals with high metabolism were therefore more uncoupled, had greater resting and total daily energy expenditures and survived longest - supporting the 'uncoupling to survive' hypothesis...
  37. ncbi request reprint The history and theory of the doubly labeled water technique
    J R Speakman
    Department of Zoology, University of Aberdeen, Scotland, United Kingdom
    Am J Clin Nutr 68:932S-938S. 1998
    ....
  38. ncbi request reprint Obesity: part one - the greatest health threat facing mankind
    John R Speakman
    University of Aberdeen, UK
    Biologist (London) 50:10-4. 2003
    ..In the 15 minutes it will take you to read this article nine people in the USA, and one person in the UK, will have died as a direct consequence of obesity related illnesses.'..
  39. ncbi request reprint The functional significance of individual variation in basal metabolic rate
    John R Speakman
    Aberdeen Centre for Energy Regulation and Obesity, School of Biological Sciences, University of Aberdeen, Aberdeen AB24 2TZ, Scotland, United Kingdom
    Physiol Biochem Zool 77:900-15. 2004
    ..At this level there is very little support for the suggestion that variation in RMRt (and thus BMR) is sustained by associations with SusMR...
  40. ncbi request reprint Starving for life: what animal studies can and cannot tell us about the use of caloric restriction to prolong human lifespan
    John R Speakman
    School of Biological Sciences, University of Aberdeen, Aberdeen AB24 2TZ, Scotland, UK
    J Nutr 137:1078-86. 2007
    ..However, what is unclear from animal studies is whether taking drugs that suppress appetite will generate the same impact on longevity or whether the neuroendocrine correlates of hunger play an integral role in mediating CRs effects...
  41. ncbi request reprint Living fast, dying when? The link between aging and energetics
    John R Speakman
    Aberdeen Centre for Energy Regulation and Obesity, University of Aberdeen, Aberdeen, UK
    J Nutr 132:1583S-97S. 2002
    ..This review reveals that there might be contrasting effects of resting and nonresting energy expenditure on aging, with increases in the former being protective and increases in the latter being harmful...
  42. doi request reprint Increased television viewing is associated with elevated body fatness but not with lower total energy expenditure in children
    Diane M Jackson
    Division of Obesity and Metabolic Health, Rowett Institute of Nutrition and Health, University of Aberdeen, Bucksburn, Aberdeen, Scotland, UK
    Am J Clin Nutr 89:1031-6. 2009
    ..Television (TV) viewing in children is associated with a higher body mass index, but it is unknown whether this reflects body fatness, and, if it does, why...
  43. ncbi request reprint Life-long vitamin C supplementation in combination with cold exposure does not affect oxidative damage or lifespan in mice, but decreases expression of antioxidant protection genes
    Colin Selman
    Aberdeen Centre for Energy Regulation and Obesity ACERO, School of Biological Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK
    Mech Ageing Dev 127:897-904. 2006
    ....
  44. ncbi request reprint Factors influencing variation in basal metabolic rate include fat-free mass, fat mass, age, and circulating thyroxine but not sex, circulating leptin, or triiodothyronine
    Alexandra M Johnstone
    Aberdeen Centre for Energy Regulation and Obesity, Division of Energy Balance and Obesity, Rowett Research Institute, Aberdeen, Scotland, United Kingdom
    Am J Clin Nutr 82:941-8. 2005
    ..All studies agree that variation in fat-free mass (FFM) plays a major role, but effects of fat mass (FM), age, sex, and the hormones leptin, triiodothyrionine (T3), and thyroxine (T4) remain uncertain...
  45. ncbi request reprint Factors influencing the daily energy expenditure of small mammals
    J Speakman
    Department of Zoology, University of Aberdeen
    Proc Nutr Soc 56:1119-36. 1997
  46. ncbi request reprint Mice with low metabolic rates are not susceptible to weight gain when fed a high-fat diet
    Catherine Hambly
    School of Biological Sciences, Aberdeen Center for Energy Regulation and Obesity, University of Aberdeen, Aberdeen, UK
    Obes Res 13:556-66. 2005
    ..We hypothesized that MLs might, therefore, be more likely to increase their body and fat mass when exposed to a high-fat diet (HFD)...
  47. ncbi request reprint Does body mass play a role in the regulation of food intake?
    John R Speakman
    Aberdeen Centre for Energy Regulation and Obesity, Division of Appetite and Energy Balance, Rowett Research Institute, Aberdeen AB21 9SB, UK
    Proc Nutr Soc 61:473-87. 2002
    ..This model has some important implications for the interpretations that we place on the molecular events in the brain, and ultimately in the search for pharmaceutical agents for alleviation of obesity...
  48. ncbi request reprint Obesity: the integrated roles of environment and genetics
    John R Speakman
    Aberdeen Centre for Energy Regulation and Obesity, Division of Energy Balance and Obesity, Rowett Research Institute, Aberdeen AB21 9SB, Scotland
    J Nutr 134:2090S-2105S. 2004
    ..In particular, we know nothing about how the target body weight in the brain is encoded. As our understanding in this field advances, new drug targets are likely to emerge and allow us to treat this crippling disorder...
  49. ncbi request reprint Long-term cold acclimation leads to high Q10 effects on oxygen consumption of loggerhead sea turtles Caretta caretta
    Sandra Hochscheid
    School of Biological Sciences, University of Aberdeen, Aberdeen AB24 2TZ, Scotland, United Kingdom
    Physiol Biochem Zool 77:209-22. 2004
    ..3. On the basis of the range of body masses of the turtles used in this study (2-60 kg), the intraspecific scaling exponent for VO2 was 0.353...
  50. ncbi request reprint Intake compensates for resting metabolic rate variation in female C57BL/6J mice fed high-fat diets
    Sarah L Johnston
    Obesity and Metabolic Health Division, Rowett Research Institute, Bucksburn, Aberdeen, United Kingdom
    Obesity (Silver Spring) 15:600-6. 2007
    ..The literature is divided over whether variation in resting metabolic rate (RMR) is related to subsequent obesity. We set out to see whether the effect of RMR on weight gain in mice could be revealed with high-fat feeding...
  51. ncbi request reprint Contribution of different mechanisms to compensation for energy restriction in the mouse
    Catherine Hambly
    Aberdeen Centre for Energy Regulation and Obesity ACERO, Division of Appetite and Energy Balance, Rowett Research Institute, Greenburn Road, Bucksburn, United Kingdom
    Obes Res 13:1548-57. 2005
    ..We examined the compensatory responses of mice to a 20% dietary restriction...
  52. ncbi request reprint The consequences of acute cold exposure on protein oxidation and proteasome activity in short-tailed field voles, microtus agrestis
    Colin Selman
    Aberdeen Centre for Energy Expenditure and Obesity ACERO, Department of Zoology, Aberdeen University, UK
    Free Radic Biol Med 33:259-65. 2002
    ..This protection may be a very important factor in sustaining uncoupled respiration, which underpins nonshivering thermogenesis at cold temperatures...
  53. ncbi request reprint Limits to sustained energy intake. X. Effects of fur removal on reproductive performance in laboratory mice
    Elzbieta Krol
    School of Biological Sciences, University of Aberdeen, Aberdeen Centre for Energy Regulation and Obesity, Aberdeen, AB24 2TZ, UK
    J Exp Biol 210:4233-43. 2007
    ....
  54. pmc The impact of experimentally elevated energy expenditure on oxidative stress and lifespan in the short-tailed field vole Microtus agrestis
    Colin Selman
    Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK
    Proc Biol Sci 275:1907-16. 2008
    ..These data suggest that in captive animals physiologically mediated costs on life history do not result from increased energy expenditure and consequent elevations in oxidative stress and reduced survival...
  55. doi request reprint Lifelong alpha-tocopherol supplementation increases the median life span of C57BL/6 mice in the cold but has only minor effects on oxidative damage
    Colin Selman
    Integrative Physiology, School of Biological Sciences, University of Aberdeen, Aberdeen, United Kingdom
    Rejuvenation Res 11:83-96. 2008
    ..However, these signaling pathways now require further investigation to establish their exact role in life span extension following alpha-tocopherol supplementation...
  56. doi request reprint Protein synthesis and antioxidant capacity in aging mice: effects of long-term voluntary exercise
    Lobke M Vaanholt
    Department of Behavioural Biology, University of Groningen, P O Box 14, 9750 AA Haren, The Netherlands
    Physiol Biochem Zool 81:148-57. 2008
    ..Long-term elevations in voluntary exercise did not result in elevations in antioxidant enzyme activities or protein synthesis rates...
  57. doi request reprint The impact of acute caloric restriction on the metabolic phenotype in male C57BL/6 and DBA/2 mice
    Sarah Hempenstall
    Integrative Physiology, Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK
    Mech Ageing Dev 131:111-8. 2010
    ..These strain-specific differences in glucose homeostatic parameters may underlie the reported unresponsiveness of DBA/2 mice to CR. We also demonstrate delineation in the response of insulin and IGF-1 to acute CR in mice...
  58. ncbi request reprint A life history model of somatic damage associated with resource acquisition: damage protection or prevention?
    Jonathan M Yearsley
    The Macaulay Institute, Craigiebuckler, Aberdeen, AB15 8QH, UK
    J Theor Biol 235:305-17. 2005
    ..The results from our models are discussed in light of published data. Resource acquisition is shown to be a potentially important mechanism for controlling somatic damage which deserves further study...
  59. ncbi request reprint Hunger does not diminish over time in mice under protracted caloric restriction
    Catherine Hambly
    Aberdeen Centre for Energy Regulation and Obesity ACERO, Rowett Research Institute, Bucksburn, Aberdeen, Scotland, United Kingdom
    Rejuvenation Res 10:533-42. 2007
    ....
  60. ncbi request reprint Sex- and concentration-dependent effects of predator feces on seasonal regulation of body mass in the bank vole Clethrionomys glareolus
    Wendy L Tidhar
    Aberdeen Centre for Energy Regulation and Obesity ACERO, School of Biological Sciences, University of Aberdeen, Aberdeen AB14 2TZ, Scotland, UK
    Horm Behav 52:436-44. 2007
    ..The consequences of mass loss in females may be more significant as this may delay the onset of breeding or reduce the size or number of young, thereby negatively affecting breeding success...
  61. ncbi request reprint Calorie-restricted mice that gorge show less ability to compensate for reduced energy intake
    Catherine Hambly
    Division of Obesity and Metabolic Health, Rowett Research Institute, Bucksburn, Aberdeen AB21 9BS Scotland, UK
    Physiol Behav 92:985-92. 2007
    ..The reduced leptin levels may drive the gorging behaviour...
  62. ncbi request reprint Regional blood flow in sea turtles: implications for heat exchange in an aquatic ectotherm
    Sandra Hochscheid
    Department of Zoology, University of Aberdeen, Tillydrone Avenue, Aberdeen AB24 2TZ, Scotland, United Kingdom
    Physiol Biochem Zool 75:66-76. 2002
    ..Our data suggest that by varying circulation of the front flippers, turtles are capable of either transporting heat quickly into the body or retaining heat inside the body, depending on the prevailing thermal demands...
  63. ncbi request reprint Antioxidant enzyme activities, lipid peroxidation, and DNA oxidative damage: the effects of short-term voluntary wheel running
    Colin Selman
    Aberdeen Centre for Energy Expenditure and Obesity ACERO, Department of Zoology, Aberdeen University, Aberdeen AB24 2TZ, Scotland, UK
    Arch Biochem Biophys 401:255-61. 2002
    ..There was no evidence of any significant increase in any oxidative stress parameter in running individuals, despite having significantly elevated energy expenditures compared to sedentary controls...
  64. ncbi request reprint Voluntary exercise has only limited effects on activity of antioxidant enzymes and does not cause oxidative damage in a small mammal
    Colin Selman
    Aberdeen Centre for Energy Expenditure and Obesity, Department of Zoology, Aberdeen University, Aberdeen, UK
    J Nutr 132:1784S-6S. 2002
  65. ncbi request reprint Associations between basal metabolic rate and reproductive performance in C57BL/6J mice
    Sarah L Johnston
    Division of Obesity and Metabolic Health, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
    J Exp Biol 210:65-74. 2007
    ..In this context, a high BMR may actually be disadvantageous, conflicting with the idea that high BMR may bring reproductive benefits...
  66. doi request reprint Vitamin E supplementation and mammalian lifespan
    Ruth Banks
    Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK
    Mol Nutr Food Res 54:719-25. 2010
    ..We suggest that the role of this pathway in life span extension following supplementation of vitamin E now requires further investigation...
  67. doi request reprint Quantitative trait Loci for regional adiposity in mouse lines divergently selected for food intake
    Kellie A Rance
    Aberdeen Centre for Energy Regulation and Obesity, School of Biological Sciences, University of Aberdeen, UK
    Obesity (Silver Spring) 15:2994-3004. 2007
    ..The aim of this study was to map quantitative trait loci (QTLs) associated with regional fat depots in mouse lines divergently selected for food intake corrected for body mass...
  68. ncbi request reprint PIXImus DXA with different software needs individual calibration to accurately predict fat mass
    Sarah L Johnston
    Aberdeen Center for Energy Regulation and Obesity, Obesity and Metabolic Health Division, Rowett Research Institute, Aberdeen, Scotland, UK
    Obes Res 13:1558-65. 2005
    ..To validate GE PIXImus2 DXA fat mass (FM) estimates by chemical analysis, to compare previously published correction equations with an equation from our machine, and to determine intermachine variation...
  69. doi request reprint Maximal heat dissipation capacity and hyperthermia risk: neglected key factors in the ecology of endotherms
    John R Speakman
    Institute of Biological and Environmental Sciences, University of Aberdeen, Tillydrone Avenue 2, Aberdeen, Scotland, UK
    J Anim Ecol 79:726-46. 2010
    ....
  70. doi request reprint Doubly labelled water: Multi-point and two-point methods in pre-school children
    Kurosh Djafarian
    Aberdeen Centre for Energy Regulation and Obesity, Rowett Research Institute, Bucksburn, Aberdeen, United Kingdom
    Int J Pediatr Obes 5:102-10. 2010
    ....
  71. ncbi request reprint A paternally imprinted QTL for mature body mass on mouse chromosome 8
    Kellie A Rance
    Aberdeen Centre for Energy Regulation and Obesity ACERO, School of Biological Sciences, University of Aberdeen, Tillydrone Avenue, Aberdeen, AB24 2TZ, UK
    Mamm Genome 16:567-77. 2005
    ....
  72. doi request reprint Evaluating energy intake measurement in free-living subjects: when to record and for how long?
    Claire L Fyfe
    Division of Obesity and Metabolic Health, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen AB21 9SB, UK
    Public Health Nutr 13:172-80. 2010
    ..To nutritionally analyse mean energy intake (EI) from different 3 d intervals within a 7 d recording period and to evaluate the seasonal effect on energy and nutrient intake...
  73. ncbi request reprint Regulation of body mass and adiposity in the field vole, Microtus agrestis: a model of leptin resistance
    Elzbieta Krol
    Aberdeen Centre for Energy Regulation and Obesity ACERO, School of Biological Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK
    J Endocrinol 192:271-8. 2007
    ..However, the mechanism by which these changes may be linked to alterations in digestive efficiency that underpin the changes in adiposity, or how the differences are signalled by changes in photoperiod, remains unclear...
  74. ncbi request reprint Climate-mediated energetic constraints on the distribution of hibernating mammals
    Murray M Humphries
    Department of Zoology, University of Aberdeen, Aberdeen AB24 3TZ, UK
    Nature 418:313-6. 2002
    ..Bioenergetics can provide the simple link between climate and biogeography needed to predict the consequences of climate change...
  75. ncbi request reprint The measurement of resting metabolic rate in preschool children
    Diane M Jackson
    Division of Vascular Health, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, Scotland
    Obesity (Silver Spring) 15:1930-2. 2007
    ..This study examined the repeatability of measuring resting metabolic rate (RMR) in preschool children and the effect of different calculation protocols...
  76. ncbi request reprint Seasonal variation in the metabolic rate and body composition of female grey seals: fat conservation prior to high-cost reproduction in a capital breeder?
    Carol E Sparling
    Sea Mammal Research Unit, Gatty Marine Laboratory, University of St Andrews, St Andrews, Fife, UK
    J Comp Physiol B 176:505-12. 2006
    ..RMR of juveniles showed no clear seasonal patterns, but did increase with increasing mass. These data support the hypothesis that seasonal variation in RMR in female grey seals is related to the high costs of breeding...
  77. pmc Birds sacrifice oxidative protection for reproduction
    Popko Wiersma
    Zoological Laboratory of the University of Groningen, 9750 AA Haren, The Netherlands
    Proc Biol Sci 271:S360-3. 2004
    ..This result suggests that senescence acceleration by increased reproductive effort is at least in part mediated by oxidative stress...
  78. ncbi request reprint Differential energy costs of winter acclimatized common spiny mice Acomys cahirinus from two adjacent habitats
    Michael Scantlebury
    Department of Biology, University of Haifa Oranim, Tivon 36006, Israel
    Comp Biochem Physiol A Mol Integr Physiol 137:419-23. 2004
    ..We suggest that physiological plasticity in energy expenditure, which exists both temporally and spatially, combined with stable WTO, perhaps reflecting a xeric ancestry, has enabled A. cahirinus to invade a wide range of habitats...
  79. ncbi request reprint Optimal body size and energy expenditure during winter: why are voles smaller in declining populations?
    Torbjørn Ergon
    Centre for Ecological and Evolutionary Synthesis, Department of Biology, University of Oslo, P O Box 1050, Blindern, 0316 Oslo, Norway
    Am Nat 163:442-57. 2004
    ..This suggests that variation in wintering body mass between sites was due to variation in food quality/availability and not adjustments in foraging activity to varying risks of predation...
  80. ncbi request reprint Effects of mass and body composition on fasting fuel utilisation in grey seal pups (Halichoerus grypus Fabricius): an experimental study using supplementary feeding
    Kimberley A Bennett
    NERC Sea Mammal Research Unit, Gatty Marine Laboratory, University of St Andrews, Fife, KY16 8LB, UK
    J Exp Biol 210:3043-53. 2007
    ..Pups that receive greater maternal provisioning and lay down more protein may have increased survival chances at sea. This study highlights the importance of protein reserves in first year survival of grey seal pups...
  81. pmc AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons
    Marc Claret
    Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London, United Kingdom
    J Clin Invest 117:2325-36. 2007
    ....
  82. pmc The role of insulin receptor substrate 2 in hypothalamic and beta cell function
    Agharul I Choudhury
    Centre for Diabetes and Endocrinology, Rayne Institute, University College London, London, United Kingdom
    J Clin Invest 115:940-50. 2005
    ..Our findings demonstrate a critical role for IRS2 in beta cell and hypothalamic function and provide insights into the role of RIPCre neurons, a distinct hypothalamic neuronal population, in growth and energy homeostasis...
  83. ncbi request reprint Predicting the effects of body fatness on food intake and performance of sheep
    Bert J Tolkamp
    Animal Nutrition and Health Department, Scottish Agricultural College, Edinburgh EH9 3JG, UK
    Br J Nutr 97:1206-15. 2007
    ..The biological implications of the hypothesis that body fatness acts upon voluntary intake via its effects on energetic efficiency are discussed...
  84. ncbi request reprint Long-term divergent selection on fatness in mice indicates a regulation system independent of leptin production and reception
    Lutz Bunger
    Institute of Cell, Animal and Population Biology, University of Edinburgh, UK
    FASEB J 17:85-7. 2003
    ....
  85. ncbi request reprint A theory of associating food types with their postingestive consequences
    Jonathan M Yearsley
    Macaulay Institute, Craigiebuckler, Aberdeen AB15 8QH, United Kingdom
    Am Nat 167:705-16. 2006
    ..We discuss the ecological and behavioral implications of making associational errors and contrast the timescale and mechanisms of our theory with those of existing theory...
  86. doi request reprint Stable carbon isotopes in exhaled breath as tracers for dietary information in birds and mammals
    Christian C Voigt
    Evolutionary Ecology Research Group, Leibniz Institute for Zoo and Wildlife Research, Alfred Kowalke Strasse 17, D 10315 Berlin, Germany
    J Exp Biol 211:2233-8. 2008
    ..5+/-1.8 per thousand (N=6 species) after endogenous substrates were in isotopic equilibrium with exogenous substrates...
  87. doi request reprint Nutrient routing in omnivorous animals tracked by stable carbon isotopes in tissue and exhaled breath
    Christian C Voigt
    Research Group Evolutionary Ecology, Leibniz Institute for Zoo and Wildlife Research, Alfred Kowalke Strasse 17, 10315 Berlin, Germany
    Oecologia 157:31-40. 2008
    ....
  88. ncbi request reprint Prevention of diet-induced obesity and impaired glucose tolerance in rats following administration of leptin to their mothers
    Claire J Stocker
    Clore Laboratory, Univ of Buckingham, Buckingham, UK
    Am J Physiol Regul Integr Comp Physiol 292:R1810-8. 2007
    ..A similar trend was seen for male rats fed on the obesogenic diet. Thus leptin levels during pregnancy and lactation can affect the development of energy balance regulatory systems in their offspring...
  89. ncbi request reprint Exercise by lifelong voluntary wheel running reduces subsarcolemmal and interfibrillar mitochondrial hydrogen peroxide production in the heart
    Sharon Judge
    Univ of Florida, College of Medicine, Dept of Aging and Geriatric Research, Genomics and Biomarkers Core Institute on Aging, Biochemistry of Aging Laboratory, Gainesville, FL 32608, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1564-72. 2005
    ..The health benefits of chronic exercise may be, at least partially, due to a reduction in mitochondrial oxidant production; however, we could not detect a significant reduction in several selected parameters of oxidative stress...
  90. doi request reprint Divergent physical activity and novel alternative responses to high fat feeding in polygenic fat and lean mice
    Matjaz Simoncic
    Biotechnical Faculty, Zootechnical Department, University of Ljubljana, 1230, Domzale, Slovenia
    Behav Genet 38:292-300. 2008
    ....
  91. ncbi request reprint Effect of mild restriction of food intake on the speed of racing Greyhounds
    Richard C Hill
    Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610 0126, USA
    Am J Vet Res 66:1065-70. 2005
    ..To determine whether mild restriction of food intake affects clinicopathologic variables, body composition, and performance of dogs undertaking intense sprint exercise...
  92. ncbi request reprint Energy expenditure of calorically restricted rats is higher than predicted from their altered body composition
    Colin Selman
    University of Florida, Department of Aging and Geriatric Research, College of Medicine, Gainesville, 32608, USA
    Mech Ageing Dev 126:783-93. 2005
    ....
  93. ncbi request reprint Field energetics of free-living, lactating and non-lactating echidnas (Tachyglossus aculeatus)
    Jutta Schmid
    Department of Experimental Ecology, University of Ulm, Albert Einstein Allee 11, D 89069 Ulm, Germany
    Comp Biochem Physiol A Mol Integr Physiol 136:903-9. 2003
    ..At least part of their energy minimising strategy could involve the use of moderate heterothermy, allowing a greater proportion of daily energy expenditure to diverted to milk production...