Kevin W Southern

Summary

Affiliation: University of Liverpool
Country: UK

Publications

  1. doi request reprint Macrolide antibiotics for cystic fibrosis
    Kevin W Southern
    Institute of ChildHealth, University of Liverpool, Liverpool, UK
    Cochrane Database Syst Rev 11:CD002203. 2012
  2. ncbi request reprint Cystic fibrosis and formes frustes of CFTR-related disease
    Kevin W Southern
    Royal Liverpool Children s Hospital, Institute of Child Health, University of Liverpool, Liverpool, UK
    Respiration 74:241-51. 2007
  3. ncbi request reprint Establishing a diagnosis of cystic fibrosis
    K W Southern
    Institute of Child Health, University of Liverpool, Royal Liverpool Children s Hospital, Eaton Road, Alder Hey, Liverpool L12 2AP, UK
    Chron Respir Dis 1:205-10. 2004
  4. ncbi request reprint Azithromycin for cystic fibrosis
    K W Southern
    Institute of Child Health, University of Liverpool, Royal Liverpool Children s Hospital, Eaton Road, Alder Hey, Liverpool L12 2AP, UK
    Eur Respir J 24:834-8. 2004
  5. pmc Newborn screening for cystic fibrosis: the practical implications
    Kevin W Southern
    Institute of Child Health, The Royal Liverpool Children s Hospital, University of Liverpool, Eaton Road, Liverpool L12 2AP, UK
    J R Soc Med 97:57-9. 2004
  6. ncbi request reprint Newborn screening programmes for cystic fibrosis
    Kevin W Southern
    Institute of Child Health, University of Liverpool, Royal Liverpool Children s Hospital, Alder Hey, Liverpool L12 2AP, UK
    Paediatr Respir Rev 4:299-305. 2003
  7. ncbi request reprint Airway surface liquid recovered by lavage with perfluorocarbon liquid in cats
    K W Southern
    Departmentof Paediatrics, University of Liverpool, Liverpool, UK
    Eur J Clin Invest 32:956-61. 2002
  8. ncbi request reprint Macrolide antibiotics for cystic fibrosis
    Kevin W Southern
    Institute of Child Health, University of Liverpool, Alder Hey Children s NHS Foundation Trust, Eaton Road, Liverpool, Merseyside, UK, L12 2AP
    Cochrane Database Syst Rev 12:CD002203. 2011
  9. doi request reprint Intraclonal genetic diversity amongst cystic fibrosis and keratitis isolates of Pseudomonas aeruginosa
    Amanda J Hall
    1Institute of Infection and Global Health, University of Liverpool, Liverpool L69 3BX, UK
    J Med Microbiol 62:208-16. 2013
  10. doi request reprint Open adherence monitoring using routine data download from an adaptive aerosol delivery nebuliser in children with cystic fibrosis
    Paul S McNamara
    Respiratory Unit, Alder Hey Children s NHS Foundation Trust, Eaton Rd, Liverpool, L12 2AP, UK
    J Cyst Fibros 8:258-63. 2009

Collaborators

Detail Information

Publications23

  1. doi request reprint Macrolide antibiotics for cystic fibrosis
    Kevin W Southern
    Institute of ChildHealth, University of Liverpool, Liverpool, UK
    Cochrane Database Syst Rev 11:CD002203. 2012
    ..Macrolide antibiotics may have a modifying role in diseases which involve airway infection and inflammation, like cystic fibrosis...
  2. ncbi request reprint Cystic fibrosis and formes frustes of CFTR-related disease
    Kevin W Southern
    Royal Liverpool Children s Hospital, Institute of Child Health, University of Liverpool, Liverpool, UK
    Respiration 74:241-51. 2007
    ..In other cases where a mild CF phenotype is apparent, atypical CF is probably a better term. It remains unclear whether carrier status predisposes to certain conditions such as chronic rhinosinusitis or pancreatitis...
  3. ncbi request reprint Establishing a diagnosis of cystic fibrosis
    K W Southern
    Institute of Child Health, University of Liverpool, Royal Liverpool Children s Hospital, Eaton Road, Alder Hey, Liverpool L12 2AP, UK
    Chron Respir Dis 1:205-10. 2004
    ..In addition we will discuss situations in which genetic variations of the CFTR gene are not associated with a classical CF phenotype and the implications for practice in both paediatric and adult clinics...
  4. ncbi request reprint Azithromycin for cystic fibrosis
    K W Southern
    Institute of Child Health, University of Liverpool, Royal Liverpool Children s Hospital, Eaton Road, Alder Hey, Liverpool L12 2AP, UK
    Eur Respir J 24:834-8. 2004
    ..In addition, clinics should liaise closely with their microbiology departments and monitor resistance patterns...
  5. pmc Newborn screening for cystic fibrosis: the practical implications
    Kevin W Southern
    Institute of Child Health, The Royal Liverpool Children s Hospital, University of Liverpool, Eaton Road, Liverpool L12 2AP, UK
    J R Soc Med 97:57-9. 2004
  6. ncbi request reprint Newborn screening programmes for cystic fibrosis
    Kevin W Southern
    Institute of Child Health, University of Liverpool, Royal Liverpool Children s Hospital, Alder Hey, Liverpool L12 2AP, UK
    Paediatr Respir Rev 4:299-305. 2003
    ..Whichever algorithm is selected, the implementation of a successful programme relies on clear pathways and good information for parents...
  7. ncbi request reprint Airway surface liquid recovered by lavage with perfluorocarbon liquid in cats
    K W Southern
    Departmentof Paediatrics, University of Liverpool, Liverpool, UK
    Eur J Clin Invest 32:956-61. 2002
    ..Airway surface liquid (ASL) is difficult to sample. Lavage with an immiscible perfluorocarbon (PFC) liquid to recover ASL was evaluated in cats...
  8. ncbi request reprint Macrolide antibiotics for cystic fibrosis
    Kevin W Southern
    Institute of Child Health, University of Liverpool, Alder Hey Children s NHS Foundation Trust, Eaton Road, Liverpool, Merseyside, UK, L12 2AP
    Cochrane Database Syst Rev 12:CD002203. 2011
    ..Macrolide antibiotics may have a modifying role in diseases which involve airway infection and inflammation, like cystic fibrosis...
  9. doi request reprint Intraclonal genetic diversity amongst cystic fibrosis and keratitis isolates of Pseudomonas aeruginosa
    Amanda J Hall
    1Institute of Infection and Global Health, University of Liverpool, Liverpool L69 3BX, UK
    J Med Microbiol 62:208-16. 2013
    ..The discordance with respect to two of the isolates identified by array-tube genotyping as clone D, when using all the other typing methods, emphasizes the need to use more than one method for reliable identification of strains...
  10. doi request reprint Open adherence monitoring using routine data download from an adaptive aerosol delivery nebuliser in children with cystic fibrosis
    Paul S McNamara
    Respiratory Unit, Alder Hey Children s NHS Foundation Trust, Eaton Rd, Liverpool, L12 2AP, UK
    J Cyst Fibros 8:258-63. 2009
    ..Using one such device, we have monitored nebulised antibiotic adherence in children with Cystic Fibrosis (CF)...
  11. doi request reprint A reference interval for sweat chloride in infants aged between five and six weeks of age
    Rajamanickam Jayaraj
    Institute of Child Health, University of Liverpool, Liverpool, UK
    Ann Clin Biochem 46:73-8. 2009
    ..In addition, we compared the gold standard method of sweat testing (quantitative pilocarpine iontophoresis [QPIT, coulometry]) with an emerging methodology (Macroduct [ISE])...
  12. ncbi request reprint A survey of newborn screening for cystic fibrosis in Europe
    Kevin W Southern
    University of Liverpool, Royal Liverpool Children s Hospital, Liverpool, United Kingdom
    J Cyst Fibros 6:57-65. 2007
    ..Following identification of the CFTR gene, DNA analysis for common CF-associated mutations has been increasingly used as a second tier test. The aim of this study was to survey the current practice of CF NBS programmes in Europe...
  13. ncbi request reprint Electrical potential difference across the nasal epithelium is reduced in premature infants with chronic lung disease but is not associated with lower airway inflammation
    Erol A Gaillard
    Institute of Child Health, University of Liverpool, Royal Liverpool Children s Hospital, Liverpool L12 2AP, United Kingdom
    Pediatr Res 61:77-82. 2007
    ..We conclude that infants with chronic lung disease postnatally have a persistently reduced absorptive airway ion transport capacity...
  14. doi request reprint New nebulizer technology to monitor adherence and nebulizer performance in cystic fibrosis
    Pamela McCormack
    Department of Physiotherapy, Alder Hey Children s NHS Foundation Trust Hospital, Liverpool, UK
    J Aerosol Med Pulm Drug Deliv 25:307-9. 2012
    ..Electronic data capture enables CF teams to work in an open partnership with patients to achieve the common goals of improving drug delivery and reducing patient burden...
  15. ncbi request reprint Nasal airway ion transport and lung function in young people with cystic fibrosis
    Helen L Wallace
    Institute of Child Health, Alder Hey Children s Hospital, Eaton Road, Liverpool L12 2AP UK
    Am J Respir Crit Care Med 168:594-600. 2003
    ..We suggest that although an ion transport abnormality initiates lung disease, other factors (e.g., environmental and genetic modifiers) are more influential in determining disease severity...
  16. doi request reprint Embryonic lung growth is normal in a cftr-knockout mouse model
    Helen L Wallace
    Department of Physiology, University of Liverpool, Liverpool, United Kingdom
    Exp Lung Res 34:717-27. 2008
    ..Smooth muscle distribution surrounding the airway appeared normally distributed in all genotypes. These data suggest that normal embryonic lung growth, ASM differentiation and airway peristalsis are CFTR independent...
  17. doi request reprint Pneumococcal vaccines for cystic fibrosis
    Laura Burgess
    Alder Hey Children s NHS Foundation Trust, Liverpool, UK
    Cochrane Database Syst Rev 9:CD008865. 2012
    ..In the USA and UK pneumococcal vaccination is currently recommended for all children and adults with cystic fibrosis...
  18. doi request reprint Sodium channel blockers for cystic fibrosis
    Elinor F Burrows
    Respiratory Department, Alder Hey Children s NHS Foundation Trust, Liverpool, UK
    Cochrane Database Syst Rev 3:CD005087. 2012
    ..Over-absorption of sodium results in the dehydration of the liquid that lines the airway surface and is a primary defect in people with CF...
  19. ncbi request reprint Pulmonary edema in meningococcal septicemia associated with reduced epithelial chloride transport
    Michael Eisenhut
    Institute of Child Health, University of Liverpool, UK
    Pediatr Crit Care Med 7:119-24. 2006
    ..To test the hypothesis that meningococcal septicemia-related pulmonary edema is associated with a systemic abnormality of epithelial sodium and chloride transport and to investigate an association with hormones regulating Na transport...
  20. doi request reprint Airway ion transport impacts on disease presentation and severity in cystic fibrosis
    Teresinha Leal
    Clinical Chemistry, Universite Catholique de Louvain, Brussels, Belgium
    Clin Biochem 41:764-72. 2008
    ..Abnormal airway ion transport is a feature of cystic fibrosis. The aim of this study was to investigate whether distinct components of ion transport are associated with the clinical expression and severity of the disease...
  21. pmc Acute renal failure in people with cystic fibrosis
    Kevin W Southern
    Thorax 62:472-3. 2007
  22. ncbi request reprint Design of clinical trials in cystic fibrosis
    Kevin W Southern
    Lancet 361:349-50; aurhor reply 350. 2003
  23. ncbi request reprint Employing the nasal potential difference as a diagnostic test for cystic fibrosis in neonates: potential pitfalls
    Erol A Gaillard
    J Pediatr 141:295-6. 2002