Research Topics
| Nicole SoranzoSummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
Positive selection on a high-sensitivity allele of the human bitter-taste receptor TAS2R16Nicole Soranzo
Department of Biology, University College London, United Kingdom
Curr Biol 15:1257-65. 2005..The G protein-coupled receptor encoded by TAS2R16 mediates response to salicin, amygdalin, and many bitter beta-glucopyranosides. beta-glucopyranosides are ubiquitous in nature, with many having a highly toxic cyanogenic activity...- Genetic association studies: web-based resources for effective screening and assessment of candidate genes and pathwaysNicole Soranzo
Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
Hum Genomics 1:307-9. 2004..Here, web resources created to aid access to such data, starting from a gene, disease or pathway of interest, are reviewed... 
Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoinSarah K Tate
Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, United Kingdom
Proc Natl Acad Sci U S A 102:5507-12. 2005..Although the case made here is compelling, our results cannot be considered definitive or ready for clinical application until they are confirmed by independent replication...- Identifying candidate causal variants responsible for altered activity of the ABCB1 multidrug resistance geneNicole Soranzo
Department of Biology, University College London, London WC1E 6BT, United Kingdom
Genome Res 14:1333-44. 2004..Finally, we describe a set of six haplotype tagging single-nucleotide polymorphisms that represent common ABCB1 variation surrounding 3435C>T in Europeans... - The role of common variation in drug transporter genes in refractory epilepsyNicole Soranzo
Department of Biology, University College London, Queen Square, London, UK
Expert Opin Pharmacother 6:1305-12. 2005.... - A single-nucleotide polymorphism tagging set for human drug metabolism and transportKourosh R Ahmadi
Department of Biology (Galton Lab, University College London, The Darwin Building, Gower Street, London WC1E 6BT, UK
Nat Genet 37:84-9. 2005..The analyses also suggest that rare variation is not amenable to tagging strategies... - Following the dogma: molecular evolutionists move from genes to messages and proteinsNicole Soranzo
Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
Trends Genet 18:497-9. 2002 - Positive selection on MMP3 regulation has shaped heart disease riskMatthew V Rockman
Department of Biology, Duke University, Box 90338, Durham, NC 27708, USA
Curr Biol 14:1531-9. 2004..The polymorphism contributes to variation in arterial traits and to the risk of coronary heart disease and its progression... - A multicenter study of BRD2 as a risk factor for juvenile myoclonic epilepsyGianpiero L Cavalleri
The Department of Clinical Neurological Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland
Epilepsia 48:706-12. 2007..Here we examine the association between the candidate causal SNP (the promoter variant rs3918149) and JME in five independent cohorts comprising in total 531 JME cases and 1,390 healthy controls... - Lack of support for a role for RLIP76 (RALBP1) in response to treatment or predisposition to epilepsyNicole Soranzo
Department of Clinical and Experimental Epilepsy, Institute of Neurology, UCL, London, UK
Epilepsia 48:674-83. 2007..Knowledge of which transporters may be critical in drug resistance is important for design of potential therapies. We tested the hypothesis that RLIP76 mediates AED resistance using methods complementary to those in the original report... - Influence of ABCB1, ABCC1, ABCC2, and ABCG2 haplotypes on the cellular exposure of nelfinavir in vivoSara Colombo
Division of Clinical Pharmacology, University Hospital, Lausanne, Switzerland
Pharmacogenet Genomics 15:599-608. 2005..Genetic polymorphism in these genes may be associated with changes in transport function... - Positive selection on a human-specific transcription factor binding site regulating IL4 expressionMatthew V Rockman
Department of Biology, Duke University, Box 90338, Durham, NC 27708, USA
Curr Biol 13:2118-23. 2003..The allele frequencies of this binding site represent local adaptation to diverse pathogenic challenges; disease states associated with the common derived allele are side-effects of positive selection on other IL4 functions... 
Ancient and recent positive selection transformed opioid cis-regulation in humansMatthew V Rockman
Department of Biology, Duke University, Durham, North Carolina, USA
PLoS Biol 3:e387. 2005....- Population genetic and phylogenetic evidence for positive selection on regulatory mutations at the factor VII locus in humansMatthew W Hahn
Department of Biology, Duke University, Durham, North Carolina 27708, USA
Genetics 167:867-77. 2004..Our results thus further support the hypothesis that regulatory mutations have been important in human evolution... - Promoter polymorphisms and allelic imbalance in ABCB1 expressionCorinne Loeuillet
Institute of Microbiology, University Hospital, Lausanne, Switzerland
Pharmacogenet Genomics 17:951-9. 2007..The results of association studies have, however, been variable and it is not currently clear whether this polymorphism is functional or is in linkage disequilibrium with functionally distinct alleles... - Genome-wide association analysis identifies 20 loci that influence adult heightMichael N Weedon
Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter EX1 2LU, UK
Nat Genet 40:575-83. 2008..Finally, our results provide insights into the genetic architecture of a classic quantitative trait... - Common variants near MC4R are associated with fat mass, weight and risk of obesityRuth J F Loos
MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
Nat Genet 40:768-75. 2008....