Nicole Soranzo

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Positive selection on a high-sensitivity allele of the human bitter-taste receptor TAS2R16
    Nicole Soranzo
    Department of Biology, University College London, United Kingdom
    Curr Biol 15:1257-65. 2005
  2. ncbi request reprint Genetic association studies: web-based resources for effective screening and assessment of candidate genes and pathways
    Nicole Soranzo
    Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Hum Genomics 1:307-9. 2004
  3. pmc Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin
    Sarah K Tate
    Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 102:5507-12. 2005
  4. pmc Identifying candidate causal variants responsible for altered activity of the ABCB1 multidrug resistance gene
    Nicole Soranzo
    Department of Biology, University College London, London WC1E 6BT, United Kingdom
    Genome Res 14:1333-44. 2004
  5. ncbi request reprint The role of common variation in drug transporter genes in refractory epilepsy
    Nicole Soranzo
    Department of Biology, University College London, Queen Square, London, UK
    Expert Opin Pharmacother 6:1305-12. 2005
  6. ncbi request reprint A single-nucleotide polymorphism tagging set for human drug metabolism and transport
    Kourosh R Ahmadi
    Department of Biology Galton Lab, University College London, The Darwin Building, Gower Street, London WC1E 6BT, UK
    Nat Genet 37:84-9. 2005
  7. ncbi request reprint Following the dogma: molecular evolutionists move from genes to messages and proteins
    Nicole Soranzo
    Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Trends Genet 18:497-9. 2002
  8. ncbi request reprint Positive selection on MMP3 regulation has shaped heart disease risk
    Matthew V Rockman
    Department of Biology, Duke University, Box 90338, Durham, NC 27708, USA
    Curr Biol 14:1531-9. 2004
  9. ncbi request reprint A multicenter study of BRD2 as a risk factor for juvenile myoclonic epilepsy
    Gianpiero L Cavalleri
    The Department of Clinical Neurological Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland
    Epilepsia 48:706-12. 2007
  10. ncbi request reprint Lack of support for a role for RLIP76 (RALBP1) in response to treatment or predisposition to epilepsy
    Nicole Soranzo
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, UCL, London, UK
    Epilepsia 48:674-83. 2007

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Positive selection on a high-sensitivity allele of the human bitter-taste receptor TAS2R16
    Nicole Soranzo
    Department of Biology, University College London, United Kingdom
    Curr Biol 15:1257-65. 2005
    ..The G protein-coupled receptor encoded by TAS2R16 mediates response to salicin, amygdalin, and many bitter beta-glucopyranosides. beta-glucopyranosides are ubiquitous in nature, with many having a highly toxic cyanogenic activity...
  2. ncbi request reprint Genetic association studies: web-based resources for effective screening and assessment of candidate genes and pathways
    Nicole Soranzo
    Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Hum Genomics 1:307-9. 2004
    ..Here, web resources created to aid access to such data, starting from a gene, disease or pathway of interest, are reviewed...
  3. pmc Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin
    Sarah K Tate
    Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 102:5507-12. 2005
    ..Although the case made here is compelling, our results cannot be considered definitive or ready for clinical application until they are confirmed by independent replication...
  4. pmc Identifying candidate causal variants responsible for altered activity of the ABCB1 multidrug resistance gene
    Nicole Soranzo
    Department of Biology, University College London, London WC1E 6BT, United Kingdom
    Genome Res 14:1333-44. 2004
    ..Finally, we describe a set of six haplotype tagging single-nucleotide polymorphisms that represent common ABCB1 variation surrounding 3435C>T in Europeans...
  5. ncbi request reprint The role of common variation in drug transporter genes in refractory epilepsy
    Nicole Soranzo
    Department of Biology, University College London, Queen Square, London, UK
    Expert Opin Pharmacother 6:1305-12. 2005
    ....
  6. ncbi request reprint A single-nucleotide polymorphism tagging set for human drug metabolism and transport
    Kourosh R Ahmadi
    Department of Biology Galton Lab, University College London, The Darwin Building, Gower Street, London WC1E 6BT, UK
    Nat Genet 37:84-9. 2005
    ..The analyses also suggest that rare variation is not amenable to tagging strategies...
  7. ncbi request reprint Following the dogma: molecular evolutionists move from genes to messages and proteins
    Nicole Soranzo
    Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Trends Genet 18:497-9. 2002
  8. ncbi request reprint Positive selection on MMP3 regulation has shaped heart disease risk
    Matthew V Rockman
    Department of Biology, Duke University, Box 90338, Durham, NC 27708, USA
    Curr Biol 14:1531-9. 2004
    ..The polymorphism contributes to variation in arterial traits and to the risk of coronary heart disease and its progression...
  9. ncbi request reprint A multicenter study of BRD2 as a risk factor for juvenile myoclonic epilepsy
    Gianpiero L Cavalleri
    The Department of Clinical Neurological Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland
    Epilepsia 48:706-12. 2007
    ..Here we examine the association between the candidate causal SNP (the promoter variant rs3918149) and JME in five independent cohorts comprising in total 531 JME cases and 1,390 healthy controls...
  10. ncbi request reprint Lack of support for a role for RLIP76 (RALBP1) in response to treatment or predisposition to epilepsy
    Nicole Soranzo
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, UCL, London, UK
    Epilepsia 48:674-83. 2007
    ..Knowledge of which transporters may be critical in drug resistance is important for design of potential therapies. We tested the hypothesis that RLIP76 mediates AED resistance using methods complementary to those in the original report...
  11. ncbi request reprint Influence of ABCB1, ABCC1, ABCC2, and ABCG2 haplotypes on the cellular exposure of nelfinavir in vivo
    Sara Colombo
    Division of Clinical Pharmacology, University Hospital, Lausanne, Switzerland
    Pharmacogenet Genomics 15:599-608. 2005
    ..Genetic polymorphism in these genes may be associated with changes in transport function...
  12. ncbi request reprint Positive selection on a human-specific transcription factor binding site regulating IL4 expression
    Matthew V Rockman
    Department of Biology, Duke University, Box 90338, Durham, NC 27708, USA
    Curr Biol 13:2118-23. 2003
    ..The allele frequencies of this binding site represent local adaptation to diverse pathogenic challenges; disease states associated with the common derived allele are side-effects of positive selection on other IL4 functions...
  13. pmc Ancient and recent positive selection transformed opioid cis-regulation in humans
    Matthew V Rockman
    Department of Biology, Duke University, Durham, North Carolina, USA
    PLoS Biol 3:e387. 2005
    ....
  14. pmc Population genetic and phylogenetic evidence for positive selection on regulatory mutations at the factor VII locus in humans
    Matthew W Hahn
    Department of Biology, Duke University, Durham, North Carolina 27708, USA
    Genetics 167:867-77. 2004
    ..Our results thus further support the hypothesis that regulatory mutations have been important in human evolution...
  15. ncbi request reprint Promoter polymorphisms and allelic imbalance in ABCB1 expression
    Corinne Loeuillet
    Institute of Microbiology, University Hospital, Lausanne, Switzerland
    Pharmacogenet Genomics 17:951-9. 2007
    ..The results of association studies have, however, been variable and it is not currently clear whether this polymorphism is functional or is in linkage disequilibrium with functionally distinct alleles...
  16. pmc Genome-wide association analysis identifies 20 loci that influence adult height
    Michael N Weedon
    Genetics of Complex Traits, Institute of Biomedical and Clinical Science, Peninsula Medical School, Magdalen Road, Exeter EX1 2LU, UK
    Nat Genet 40:575-83. 2008
    ..Finally, our results provide insights into the genetic architecture of a classic quantitative trait...
  17. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....