Affiliation: University College London
- Relationship between past airway pathology and current lung function in preschool wheezersS Sonnappa
Portex Unit, Respiratory Medicine and Physiology, University College London Institute of Child Health, London WC1N 1EH, UK
Eur Respir J 38:1431-6. 2011..RBM thickness and EG2+ cells at age 2 yrs show a significant positive association with F(eNO) at age 5 yrs. Although lung function was abnormal at age 5 yrs in severe wheezers, this did not correlate with past RBM thickness...
- Comparison of urokinase and video-assisted thoracoscopic surgery for treatment of childhood empyemaSamatha Sonnappa
Department of Respiratory Medicine, Great Ormond Street Hospital for Children NHS Trust, London, United Kingdom
Am J Respir Crit Care Med 174:221-7. 2006..Despite increasing incidence and morbidity, little evidence exists to inform the best management approach in childhood empyema...
- Treatment approaches for empyema in childrenSamatha Sonnappa
Portex Respiratory Unit, Great Ormond Street Hospital and Institute of Child Health London, UK
Paediatr Respir Rev 8:164-70. 2007....
- Ethnic differences in fraction of exhaled nitric oxide and lung function in healthy young childrenSamatha Sonnappa
Portex Unit Respiratory Medicine and Physiology, University College of London Institute of Child Health and Great Ormond Street Hospital for Children, 30, Guilford St, London, WC1N 1EH, England
Chest 140:1325-31. 2011....
- Repeatability and bronchodilator reversibility of lung function in young childrenSamatha Sonnappa
Portex Unit, Respiratory Medicine and Physiology, UCL Institute of Child Health, London, UK
Eur Respir J 42:116-24. 2013..These findings will help to interpret the effect of therapeutic interventions in children with respiratory diseases. ..
- Age and height dependence of lung clearance index and functional residual capacitySooky Lum
Portex Respiratory Unit, UCL Institute of Child Health, London, UK
Eur Respir J 41:1371-7. 2013..Although a constant upper normal limit would suffice for cross-sectional clinical assessments from 6 years of age, appropriate reference equations are essential for accurate interpretation of results during early childhood...
- Increased airway smooth muscle in preschool wheezers who have asthma at school ageRuth O'Reilly
Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, and Leukocyte Biology, National Heart and Lung Institute, Imperial College London, London, United Kingdom
J Allergy Clin Immunol 131:1024-32, 1032.e1-16. 2013..Increased airway smooth muscle (ASM) is a feature of established asthma in schoolchildren, but nothing is known about ASM in preschool wheezers...
- Symptom-pattern phenotype and pulmonary function in preschool wheezersSamatha Sonnappa
Portex Unit, Respiratory Medicine and Physiology, UCL Institute of Child Health, London, United Kingdom
J Allergy Clin Immunol 126:519-26.e1-7. 2010..Pulmonary function in preschool wheezing phenotypes based on wheeze onset and duration and atopic status has been extensively described but has not been studied in symptom-pattern phenotypes of episodic (viral) and multiple-trigger wheeze...
- Systemic diseases and the lungRobert Dinwiddie
Respiratory Unit, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London WC1N 3JH, UK
Paediatr Respir Rev 6:181-9. 2005..The outcome is variable and depends on the ability to control the underlying condition. Long-term chronic lung damage is not unusual and these diseases, when they affect the lung, carry a small but significant mortality...
- Early life influences on the development of chronic obstructive pulmonary diseaseJanet Stocks
Portex Unit, University College London Institute of Child Health, 30, Guilford Street, London WC1N 1EH, UK
Ther Adv Respir Dis 7:161-73. 2013..This review focuses on factors that adversely influence lung development in utero and during the first 5 years of life, thereby predisposing to subsequent COPD...
- Evaluation and use of childhood lung function tests in cystic fibrosisJanet Stocks
UCL Institute of Child Health and Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK
Curr Opin Pulm Med 18:602-8. 2012..This article reviews lung function tests that can be used during the first 5 years of life and discusses their potential applications as objective outcomes for clinical monitoring or research...
- The Young Everest Study: preliminary report of changes in sleep and cerebral blood flow velocity during slow ascent to altitude in unacclimatised childrenJohanna C Gavlak
Department of Paediatric Respiratory Medicine, Great Ormond Street Hospital for Children NHS Trust, Walrus Ward Level 1, Morgan Stanley Clinical Building, Great Ormond Street, London WC1N 3JH, UK
Arch Dis Child 98:356-62. 2013..Cerebral blood flow velocity (CBFV) and sleep physiology in healthy children exposed to hypoxia and hypocarbia are under-researched...