Genomes and Genes
Affiliation: University of Cambridge
- Common variants in RB1 gene and risk of invasive ovarian cancerHonglin Song
Cancer Research UK Department of Oncology, Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom
Cancer Res 66:10220-6. 2006..The possible associations of rs2854344 and rs4151620 with ovarian cancer risk warrant confirmation in independent case-control studies before studies on their biological mode of action...
- Meta-analysis of 8q24 for seven cancers reveals a locus between NOV and ENPP2 associated with cancer developmentAbra G Brisbin
Department of Health Sciences Research, Mayo Clinic, Rochester, USA
BMC Med Genet 12:156. 2011..However, the abundance of associations around 128 Mb on chromosome 8 could mask the appearance of a weaker, but important, association elsewhere on 8q24...
- A Kallikrein 15 (KLK15) single nucleotide polymorphism located close to a novel exon shows evidence of association with poor ovarian cancer survivalJyotsna Batra
Australian Prostate Cancer Research centre Queensland and Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane, Queensland 4059, Australia
BMC Cancer 11:119. 2011..Our aim was to analyse the KLK15 gene for putative functional single nucleotide polymorphisms (SNPs) and assess the association of these and KLK15 HapMap tag SNPs with ovarian cancer survival...
- Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association studyHonglin Song
CR UK Department of Oncology, Strangeways Research Laboratory, University of Cambridge, Cambridge, UK
Hum Mol Genet 18:2297-304. 2009..However, none of the six confirmed breast cancer susceptibility variants we tested was associated with ovarian cancer risk. Further work will be needed to identify the causal variant associated with rs4954956 or elucidate its function...
- Effects of common germ-line genetic variation in cell cycle genes on ovarian cancer survivalHonglin Song
CR UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge CB1 8RN, United Kingdom
Clin Cancer Res 14:1090-5. 2008..Of particular interest are genes involved in cell cycle pathways, which regulate cell division and could plausibly influence clinical characteristics of multiple tumors types...
- Association study of prostate cancer susceptibility variants with risks of invasive ovarian, breast, and colorectal cancerHonglin Song
CR UK Department of Oncology, Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom
Cancer Res 68:8837-42. 2008..In conclusion, loci associated with risk of prostate cancer may also be associated with ovarian and breast cancer susceptibility. However, the effects are modest and warrant replication in larger studies...
- Tagging single nucleotide polymorphisms in the BRIP1 gene and susceptibility to breast and ovarian cancerHonglin Song
Cancer Research UK CRUK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, United Kingdom
PLoS ONE 2:e268. 2007..Germline BRIP1 mutations are associated with breast cancer and Fanconi anemia. Thus, common variants in the BRIP1 are candidates for breast and ovarian cancer susceptibility...
- Common variants in mismatch repair genes and risk of invasive ovarian cancerHonglin Song
CR UK Department of Oncology, University of Cambridge Strangeways Research Laboratory, Cambridge, UK
Carcinogenesis 27:2235-42. 2006..The observed association of PMS2 rs7797466 with ovarian cancer warrants confirmation in an independent study...
- Mismatch repair gene polymorphisms and survival in invasive ovarian cancer patientsAndrea Mann
CR UK Genetic Epidemiology Unit, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK
Eur J Cancer 44:2259-65. 2008..The aim of this study was to investigate the possible association between the common variants in MMR genes and invasive ovarian cancer overall survival...
- Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British populationKristy E Driver
Cancer Research UK Department of Oncology, Strangeways Research Laboratory, University of Cambridge, Cambridge CB1 8RN, UK
Carcinogenesis 29:333-41. 2008..010, P-trend = 0.048). Further large-scale studies are needed to confirm these results...
- Multiple loci with different cancer specificities within the 8q24 gene desertMaya Ghoussaini
Cancer Research UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, CB1 8RN, Cambridge, UK
J Natl Cancer Inst 100:962-6. 2008..We conclude that there are at least five separate functional variants in this region...
- A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2Honglin Song
Cancer Research UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK
Nat Genet 41:996-1000. 2009..82, 95% confidence interval (CI) 0.79-0.86, P(trend) = 5.1 x 10(-19)). The association differs by histological subtype, being strongest for serous ovarian cancers (OR 0.77, 95% CI 0.73-0.81, P(trend) = 4.1 x 10(-21))...
- Common variants at 19p13 are associated with susceptibility to ovarian cancerKelly L Bolton
Department of Oncology, University of Cambridge, Cambridge, UK
Nat Genet 42:880-4. 2010..Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development...
- Polymorphisms in DNA repair genes and epithelial ovarian cancer riskAnnika Auranen
CR UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory
Int J Cancer 117:611-8. 2005..8 (0.7-0.9) and 0.9 (0.7-1.2), respectively. In our study, some polymorphisms in XRCC2 and XRCC3 genes were associated with EOC risk. Further research on the role of these genes on epithelial ovarian cancer is warranted...
- GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancerPaul D P Pharoah
The Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK
Nat Genet 45:362-70, 370e1-2. 2013..1 × 10(-10)). An integrated molecular analysis of genes and regulatory regions at these loci provided evidence for functional mechanisms underlying susceptibility and implicated CHMP4C in the pathogenesis of ovarian cancer...
- The role of KRAS rs61764370 in invasive epithelial ovarian cancer: implications for clinical testingPaul D P Pharoah
Department of Oncology, University of Cambridge, Cambridge, United Kingdom
Clin Cancer Res 17:3742-50. 2011..However, only one published article, analyzing fewer than 1,000 subjects in total, has examined this association...
- A risk prediction algorithm for ovarian cancer incorporating BRCA1, BRCA2, common alleles and other familial effectsSarah Jervis
Department of Public and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK
J Med Genet 52:465-75. 2015..Therefore, a currently unresolved problem in clinical genetics is how to counsel women with family history of OvC but no identifiable BRCA1/2 mutations...
- The contribution of deleterious germline mutations in BRCA1, BRCA2 and the mismatch repair genes to ovarian cancer in the populationHonglin Song
CR UK Department of Oncology, University of Cambridge, Strangeways Research Laboratory, Cambridge, UK
Hum Mol Genet 23:4703-9. 2014..The development of next generation sequencing technologies enables rapid mutation screening for multiple susceptibility genes at once, suggesting that routine clinical testing of all incidence cases should be considered. ..
- Network-Based Integration of GWAS and Gene Expression Identifies a HOX-Centric Network Associated with Serous Ovarian Cancer RiskSiddhartha P Kar
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom
Cancer Epidemiol Biomarkers Prev 24:1574-84. 2015..We hypothesized that some of these loci function through nearby transcription factor (TF) genes and that putative target genes of these TFs as identified by coexpression may also be enriched for additional EOC risk associations...
- Ovarian cancer familial relative risks by tumour subtypes and by known ovarian cancer genetic susceptibility variantsSarah Jervis
Department of Public and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK
J Med Genet 51:108-13. 2014..In addition, no data currently exist on the FRRs associated with EOC after exclusion of BRCA1 or BRCA2 mutation carriers...
- Five glutathione s-transferase gene variants in 23,452 cases of lung cancer and 30,397 controls: meta-analysis of 130 studiesZheng Ye
Department of Public Health and Primary Care, University of Cambridge, Strangeways Site, Cambridge, United Kingdom
PLoS Med 3:e91. 2006..It has been suggested that polymorphisms in the GST genes are risk factors for lung cancer, but a large number of studies have reported apparently conflicting results...
- Glutathione s-transferase polymorphisms (GSTM1, GSTP1 and GSTT1) and the risk of acute leukaemia: a systematic review and meta-analysisZheng Ye
Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge CB1 8RN, UK
Eur J Cancer 41:980-9. 2005..It is conceivable that GSTM1 and GSTT1 null genotypes may thus play a role in leukemogenesis. A review of the 30 case-control studies indicates that greater attention should be paid to the design of future studies...
- Identification of six new susceptibility loci for invasive epithelial ovarian cancerKaroline B Kuchenbaecker
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Nat Genet 47:164-71. 2015..Incorporating these variants into risk assessment tools will improve clinical risk predictions for BRCA1 and BRCA2 mutation carriers. ..
- Antioxidant vitamins intake and the risk of coronary heart disease: meta-analysis of cohort studiesZheng Ye
Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
Eur J Cardiovasc Prev Rehabil 15:26-34. 2008..We undertook a meta-analysis of cohort studies to examine the relations between antioxidant vitamins (vitamins C, E, and beta-carotene) and CHD risk...
- The effects of common genetic variants in oncogenes on ovarian cancer survivalLydia Quaye
Gynaecological Cancer Research Laboratory, UCL EGA Institute for Women s Health, University College London, London, United Kingdom
Clin Cancer Res 14:5833-9. 2008..The aim of this study was to evaluate associations between common germline genetic variants in the oncogenes BRAF, ERBB2, KRAS, NMI, and PIK3CA, and survival after a diagnosis of epithelial ovarian cancer...
- STK15 polymorphisms and association with risk of invasive ovarian cancerRichard A Dicioccio
Department of Cancer Genetics, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
Cancer Epidemiol Biomarkers Prev 13:1589-94. 2004..These results suggest a model of dominant inheritance of ovarian cancer risk by the I31 allele of F31I and that the I31 allele may be a common ovarian cancer susceptibility allele of low penetrance...
- Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancerSimon A Gayther
Translational Research Laboratories, University College London, London, United Kingdom
Cancer Res 67:3027-35. 2007..This study highlights the need for multicenter collaborations for genetic association studies...
- A common variant of the p16(INK4a) genetic region is associated with physical function in older peopleDavid Melzer
Peninsula Medical School, RD and E Wonford Site, Barrack Road, Exeter EX2 5DW, UK
Mech Ageing Dev 128:370-7. 2007..The mechanism involved may be via greater cellular restorative activity and reduced stem cell senescence...
- Association between single-nucleotide polymorphisms in hormone metabolism and DNA repair genes and epithelial ovarian cancer: results from two Australian studies and an additional validation setJonathan Beesley
Queensland Institute of Medical Research, Herston, Queensland, Australia
Cancer Epidemiol Biomarkers Prev 16:2557-65. 2007..Further analyses of SNPs in this gene are therefore warranted to determine whether SRD5A2 plays a role in ovarian cancer predisposition...
- Consortium analysis of 7 candidate SNPs for ovarian cancerSusan J Ramus
Translational Research Laboratory, University College London EGA Institute for Women s Health, London, United Kingdom
Int J Cancer 123:380-8. 2008..These null results for SNPs identified from relatively large initial studies shows the importance of replicating associations by a consortium approach...
- Correlation of serum VEGF levels with clinical stage, therapy efficacy, tumor metastasis and patient survival in ovarian cancerLi Li
Department of Gynecologic Oncology, Guangxi Medical University Cancer Institute and Hospital, Nanning 530021, China
Anticancer Res 24:1973-9. 2004....