Affiliation: University College London
- Genetic variation in complement factor H and risk of coronary heart disease: eight new studies and a meta-analysis of around 48,000 individualsReecha Sofat
Centre for Clinical Pharmacology, Division of Medicine, University College London, Rayne Building, 5 University Street, London WC1E 6JF, UK
Atherosclerosis 213:184-90. 2010..To investigate the association of polymorphisms in complement factor H (CFH) and coronary heart disease (CHD) using meta-analysis...
- Complement factor H genetic variant and age-related macular degeneration: effect size, modifiers and relationship to disease subtypeReecha Sofat
Centre for Clinical Pharmacology, Department of Medicine, University College London, London, UK
Int J Epidemiol 41:250-62. 2012..Previous studies have been case-control studies in populations of European ancestry with little differentiation in AMD subtype, and insufficient power to confirm or refute effect modification by smoking...
- Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChipPhilippa J Talmud
Centre for Cardiovascular Genetics, Department of Medicine, University College London, London WC1E 6JF, UK
Am J Hum Genet 85:628-42. 2009..These genes provide further insights into lipid metabolism and the likely effects of modifying the encoded targets therapeutically...
- Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphismsReecha Sofat
Centre for Clinical Pharmacology, Department of Medicine, University College London, London, United Kingdom
Circulation 121:52-62. 2010..We hypothesized that common single-nucleotide polymorphisms in the CETP gene could help distinguish mechanism-based from off-target actions of CETP inhibitors to inform on the validity of CETP as a therapeutic target...
- Distribution and determinants of circulating complement factor H concentration determined by a high-throughput immunonephelometric assayReecha Sofat
Centre for Clinical Pharmacology, Division of Medicine, University College London, Rayne Building, 5 University Street, London, WC1E 6JJ, UK
J Immunol Methods 390:63-73. 2013..Research on complement factor H (fH) in human disease is hampered by lack of an assay suitable for use in large-scale epidemiological studies. We describe the development and validation of a high throughput nephelometric assay for fH...
- Comparative efficacy and tolerability of anti-epileptic drugs for refractory focal epilepsy: systematic review and network meta-analysis reveals the need for long term comparator trialsPritesh N Bodalia
Genetic Epidemiology Group, Department of Epidemiology and Public Health, Division of Population Health, University College London, London, WC1E 6BT, UK Department of Pharmacy, Royal National Orthopaedic Hospital, Middlesex, HA7 4LP, UK
Br J Clin Pharmacol 76:649-67. 2013..To evaluate the comparative efficacy (50% reduction in seizure frequency) and tolerability (premature withdrawal due to adverse events) of anti-epileptic drugs (AEDs) for refractory epilepsy...
- Association of a sequence variant in DAB2IP with coronary heart diseaseSeamus C Harrison
BHF Laboratories, Department of Medicine, Centre for Cardiovascular Genetics, University College London UCL, The Rayne Building, 5 University Street, London WC1E 6JF, UK
Eur Heart J 33:881-8. 2012..We also sought to examine whether this variant, in combination with a chromosome 9p21 CHD variant (rs10757278) and the Framingham risk score (FRS), could improve the prediction of events compared with the FRS alone...
- Complex disease genetics: present and future translational applicationsMichael V Holmes
Centre for Clinical Pharmacology, Division of Medicine, University College London, Rayne Institute, 5 University Street, London, WC1E 6JJ, UK
Genome Med 1:104. 2009..ABSTRACT: A report on the British Atherosclerosis Society autumn meeting 'Genetics of Complex Diseases', Cambridge, UK, 17-18 September 2009...
- Role of NADPH oxidase in endothelial ischemia/reperfusion injury in humansStavros P Loukogeorgakis
Institute of Child Health, University College London, UK
Circulation 121:2310-6. 2010..These patients have a molecular lesion in a subunit of NADPH oxidase that renders the enzyme inactive...
- Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trialsMichael V Holmes
Research Department of Epidemiology and Public Health, University College London, London, UK
Lancet 378:584-94. 2011..We aimed to reduce the effect of small-study bias and investigate whether folate status modifies the association between MTHFR 677C→T and stroke in a genetic analysis and meta-analysis of randomised controlled trials...
- Critical appraisal of CRP measurement for the prediction of coronary heart disease events: new data and systematic review of 31 prospective cohortsTina Shah
Centre for Clinical Pharmacology, University College London, London, UK
Int J Epidemiol 38:217-31. 2009..Non-uniform reporting of relevant relationships and metrics hampers critical appraisal of the clinical utility of C-reactive protein (CRP) measurement for prediction of later coronary events...