Affiliation: University College London
- Genetic variation in complement factor H and risk of coronary heart disease: eight new studies and a meta-analysis of around 48,000 individualsReecha Sofat
Centre for Clinical Pharmacology, Division of Medicine, University College London, Rayne Building, 5 University Street, London WC1E 6JF, UK
Atherosclerosis 213:184-90. 2010..To investigate the association of polymorphisms in complement factor H (CFH) and coronary heart disease (CHD) using meta-analysis...
- Complement factor H genetic variant and age-related macular degeneration: effect size, modifiers and relationship to disease subtypeReecha Sofat
Centre for Clinical Pharmacology, Department of Medicine, University College London, London, UK
Int J Epidemiol 41:250-62. 2012..Previous studies have been case-control studies in populations of European ancestry with little differentiation in AMD subtype, and insufficient power to confirm or refute effect modification by smoking...
- Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChipPhilippa J Talmud
Centre for Cardiovascular Genetics, Department of Medicine, University College London, London WC1E 6JF, UK
Am J Hum Genet 85:628-42. 2009..These genes provide further insights into lipid metabolism and the likely effects of modifying the encoded targets therapeutically...
- Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphismsReecha Sofat
Centre for Clinical Pharmacology, Department of Medicine, University College London, London, United Kingdom
Circulation 121:52-62. 2010..We hypothesized that common single-nucleotide polymorphisms in the CETP gene could help distinguish mechanism-based from off-target actions of CETP inhibitors to inform on the validity of CETP as a therapeutic target...
- Distribution and determinants of circulating complement factor H concentration determined by a high-throughput immunonephelometric assayReecha Sofat
Centre for Clinical Pharmacology, Division of Medicine, University College London, Rayne Building, 5 University Street, London, WC1E 6JJ, UK
J Immunol Methods 390:63-73. 2013..Research on complement factor H (fH) in human disease is hampered by lack of an assay suitable for use in large-scale epidemiological studies. We describe the development and validation of a high throughput nephelometric assay for fH...
- Association of a sequence variant in DAB2IP with coronary heart diseaseSeamus C Harrison
BHF Laboratories, Department of Medicine, Centre for Cardiovascular Genetics, University College London UCL, The Rayne Building, 5 University Street, London WC1E 6JF, UK
Eur Heart J 33:881-8. 2012..We also sought to examine whether this variant, in combination with a chromosome 9p21 CHD variant (rs10757278) and the Framingham risk score (FRS), could improve the prediction of events compared with the FRS alone...
- Complex disease genetics: present and future translational applicationsMichael V Holmes
Centre for Clinical Pharmacology, Division of Medicine, University College London, Rayne Institute, 5 University Street, London, WC1E 6JJ, UK
Genome Med 1:104. 2009..ABSTRACT: A report on the British Atherosclerosis Society autumn meeting 'Genetics of Complex Diseases', Cambridge, UK, 17-18 September 2009...
- Role of NADPH oxidase in endothelial ischemia/reperfusion injury in humansStavros P Loukogeorgakis
Institute of Child Health, University College London, UK
Circulation 121:2310-6. 2010..These patients have a molecular lesion in a subunit of NADPH oxidase that renders the enzyme inactive...
- Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trialsMichael V Holmes
Research Department of Epidemiology and Public Health, University College London, London, UK
Lancet 378:584-94. 2011..We aimed to reduce the effect of small-study bias and investigate whether folate status modifies the association between MTHFR 677C→T and stroke in a genetic analysis and meta-analysis of randomised controlled trials...
- Critical appraisal of CRP measurement for the prediction of coronary heart disease events: new data and systematic review of 31 prospective cohortsTina Shah
Centre for Clinical Pharmacology, University College London, London, UK
Int J Epidemiol 38:217-31. 2009..Non-uniform reporting of relevant relationships and metrics hampers critical appraisal of the clinical utility of C-reactive protein (CRP) measurement for prediction of later coronary events...