Reecha Sofat

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi Genetic variation in complement factor H and risk of coronary heart disease: eight new studies and a meta-analysis of around 48,000 individuals
    Reecha Sofat
    Centre for Clinical Pharmacology, Division of Medicine, University College London, Rayne Building, 5 University Street, London WC1E 6JF, UK
    Atherosclerosis 213:184-90. 2010
  2. ncbi Complement factor H genetic variant and age-related macular degeneration: effect size, modifiers and relationship to disease subtype
    Reecha Sofat
    Centre for Clinical Pharmacology, Department of Medicine, University College London, London, UK
    Int J Epidemiol 41:250-62. 2012
  3. ncbi Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip
    Philippa J Talmud
    Centre for Cardiovascular Genetics, Department of Medicine, University College London, London WC1E 6JF, UK
    Am J Hum Genet 85:628-42. 2009
  4. ncbi Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms
    Reecha Sofat
    Centre for Clinical Pharmacology, Department of Medicine, University College London, London, United Kingdom
    Circulation 121:52-62. 2010
  5. ncbi Association of a sequence variant in DAB2IP with coronary heart disease
    Seamus C Harrison
    BHF Laboratories, Department of Medicine, Centre for Cardiovascular Genetics, University College London UCL, The Rayne Building, 5 University Street, London WC1E 6JF, UK
    Eur Heart J 33:881-8. 2012
  6. ncbi Complex disease genetics: present and future translational applications
    Michael V Holmes
    Centre for Clinical Pharmacology, Division of Medicine, University College London, Rayne Institute, 5 University Street, London, WC1E 6JJ, UK
    Genome Med 1:104. 2009
  7. ncbi Role of NADPH oxidase in endothelial ischemia/reperfusion injury in humans
    Stavros P Loukogeorgakis
    Institute of Child Health, University College London, UK
    Circulation 121:2310-6. 2010
  8. ncbi Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials
    Michael V Holmes
    Research Department of Epidemiology and Public Health, University College London, London, UK
    Lancet 378:584-94. 2011
  9. ncbi Critical appraisal of CRP measurement for the prediction of coronary heart disease events: new data and systematic review of 31 prospective cohorts
    Tina Shah
    Centre for Clinical Pharmacology, University College London, London, UK
    Int J Epidemiol 38:217-31. 2009

Detail Information

Publications9

  1. ncbi Genetic variation in complement factor H and risk of coronary heart disease: eight new studies and a meta-analysis of around 48,000 individuals
    Reecha Sofat
    Centre for Clinical Pharmacology, Division of Medicine, University College London, Rayne Building, 5 University Street, London WC1E 6JF, UK
    Atherosclerosis 213:184-90. 2010
    ..To investigate the association of polymorphisms in complement factor H (CFH) and coronary heart disease (CHD) using meta-analysis...
  2. ncbi Complement factor H genetic variant and age-related macular degeneration: effect size, modifiers and relationship to disease subtype
    Reecha Sofat
    Centre for Clinical Pharmacology, Department of Medicine, University College London, London, UK
    Int J Epidemiol 41:250-62. 2012
    ..Previous studies have been case-control studies in populations of European ancestry with little differentiation in AMD subtype, and insufficient power to confirm or refute effect modification by smoking...
  3. ncbi Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip
    Philippa J Talmud
    Centre for Cardiovascular Genetics, Department of Medicine, University College London, London WC1E 6JF, UK
    Am J Hum Genet 85:628-42. 2009
    ..These genes provide further insights into lipid metabolism and the likely effects of modifying the encoded targets therapeutically...
  4. ncbi Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms
    Reecha Sofat
    Centre for Clinical Pharmacology, Department of Medicine, University College London, London, United Kingdom
    Circulation 121:52-62. 2010
    ..We hypothesized that common single-nucleotide polymorphisms in the CETP gene could help distinguish mechanism-based from off-target actions of CETP inhibitors to inform on the validity of CETP as a therapeutic target...
  5. ncbi Association of a sequence variant in DAB2IP with coronary heart disease
    Seamus C Harrison
    BHF Laboratories, Department of Medicine, Centre for Cardiovascular Genetics, University College London UCL, The Rayne Building, 5 University Street, London WC1E 6JF, UK
    Eur Heart J 33:881-8. 2012
    ..We also sought to examine whether this variant, in combination with a chromosome 9p21 CHD variant (rs10757278) and the Framingham risk score (FRS), could improve the prediction of events compared with the FRS alone...
  6. ncbi Complex disease genetics: present and future translational applications
    Michael V Holmes
    Centre for Clinical Pharmacology, Division of Medicine, University College London, Rayne Institute, 5 University Street, London, WC1E 6JJ, UK
    Genome Med 1:104. 2009
    ..ABSTRACT: A report on the British Atherosclerosis Society autumn meeting 'Genetics of Complex Diseases', Cambridge, UK, 17-18 September 2009...
  7. ncbi Role of NADPH oxidase in endothelial ischemia/reperfusion injury in humans
    Stavros P Loukogeorgakis
    Institute of Child Health, University College London, UK
    Circulation 121:2310-6. 2010
    ..These patients have a molecular lesion in a subunit of NADPH oxidase that renders the enzyme inactive...
  8. ncbi Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials
    Michael V Holmes
    Research Department of Epidemiology and Public Health, University College London, London, UK
    Lancet 378:584-94. 2011
    ..We aimed to reduce the effect of small-study bias and investigate whether folate status modifies the association between MTHFR 677C→T and stroke in a genetic analysis and meta-analysis of randomised controlled trials...
  9. ncbi Critical appraisal of CRP measurement for the prediction of coronary heart disease events: new data and systematic review of 31 prospective cohorts
    Tina Shah
    Centre for Clinical Pharmacology, University College London, London, UK
    Int J Epidemiol 38:217-31. 2009
    ..Non-uniform reporting of relevant relationships and metrics hampers critical appraisal of the clinical utility of C-reactive protein (CRP) measurement for prediction of later coronary events...