Research Topics
| M D SnapeSummaryAffiliation: University of Oxford Country: UK Publications
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Detail Information
Publications
The challenge of post-implementation surveillance for novel meningococcal vaccinesMatthew D Snape
Oxford Universities Hospitals NHS Trust, United Kingdom
Vaccine 30:B67-72. 2012..Although designed to prevent serogroup B meningococcal disease the vaccine antigens are not serogroup specific, creating the potential for multiple definitions of vaccine effectiveness and vaccine failure...
Immunogenicity of two investigational serogroup B meningococcal vaccines in the first year of life: a randomized comparative trialMatthew D Snape
Department of Paediatrics, Oxford Vaccine Group, University of Oxford, Oxford, United Kingdom
Pediatr Infect Dis J 29:e71-9. 2010....
Demonstration of immunologic memory using serogroup C meningococcal glycoconjugate vaccineMatthew D Snape
Department of Paediatrics, University of Oxford, Oxford, UK
Pediatr Infect Dis J 28:92-7. 2009..We therefore assessed the use of glycoconjugate vaccines as an alternative method of demonstrating immunologic memory...
Seroprotection against serogroup C meningococcal disease in adolescents in the United Kingdom: observational studyM D Snape
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford OX3 7LJ
BMJ 336:1487-91. 2008..To determine the persistence of bactericidal antibody titres following immunisation with serogroup C meningococcal glycoconjugate vaccine at age 6-15 years in order to examine changes in persistence of antibodies with age...
Meningococcal polysaccharide-protein conjugate vaccinesMatthew D Snape
Department of Paediatrics, Oxford Vaccine Group, University of Oxford, Oxford, UK
Lancet Infect Dis 5:21-30. 2005..Clinical trials are underway to assess new combination conjugate vaccines (containing A, C, Y, and W polysaccharides), and it is probable that these more broadly protective vaccines will become available in the near future...
Immunogenicity of a tetravalent meningococcal glycoconjugate vaccine in infants: a randomized controlled trialMatthew D Snape
Oxford Vaccine Group, University of Oxford, England
JAMA 299:173-84. 2008..However, the currently licensed vaccine is poorly immunogenic in infancy, when the highest rates of disease are observed...
Serogroup C meningococcal glycoconjugate vaccine in adolescents: persistence of bactericidal antibodies and kinetics of the immune response to a booster vaccine more than 3 years after immunizationMatthew D Snape
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford, OX3 7LJ, United Kingdom
Clin Infect Dis 43:1387-94. 2006....
African tick bite feverMatthew D Snape
Department of Paediatrics, University of Oxford, Oxford, UK
Lancet Infect Dis 6:750. 2006
Lack of serum bactericidal activity in preschool children two years after a single dose of serogroup C meningococcal polysaccharide-protein conjugate vaccineMatthew D Snape
Oxford Vaccine Group, Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Oxford, United Kingdom
Pediatr Infect Dis J 24:128-31. 2005..A serum bactericidal titer of <1/8 correlates with susceptibility to invasive meningococcal disease. We assessed this correlate of protection in a cohort of children approximately 2 years after a single dose of vaccine...
Appearance of peripheral blood plasma cells and memory B cells in a primary and secondary immune response in humansGeraldine Blanchard-Rohner
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Centre for Clinical Vaccinology and Tropical Medicine, Oxford, United Kingdom
Blood 114:4998-5002. 2009....
Immunogenicity and immune memory of a nonadjuvanted quadrivalent meningococcal glycoconjugate vaccine in infantsKirsten P Perrett
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Centre for Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK
Pediatr Infect Dis J 28:186-93. 2009..We evaluated the immunogenicity and reactogenicity of a novel quadrivalent nonadjuvanted meningococcal glycoconjugate vaccine (MenACWY-CRM) in healthy infants...
Plasma and memory B-cell kinetics in infants following a primary schedule of CRM 197-conjugated serogroup C meningococcal polysaccharide vaccineDominic F Kelly
Oxford Vaccine Group, Department of Paediatrics, Oxford University, Oxford, UK
Immunology 127:134-43. 2009..This study provides data on B-cell kinetics following a primary schedule of immunization in young infants upon which to base further studies of the underlying cellular mechanism of humoral immunity...
The magnitude of the antibody and memory B cell responses during priming with a protein-polysaccharide conjugate vaccine in human infants is associated with the persistence of antibody and the intensity of booster responseGeraldine Blanchard Rohner
Oxford Vaccine Group, Centre for Clinical Vaccinology and Tropical Medicine, Churchill Hospital, Oxford, UK
J Immunol 180:2165-73. 2008..These findings suggest that these two parameters are good markers of B cell responses to priming and can be used as predictors of long term humoral immunity induced by glycoconjugate vaccines received in early infancy...
A 1-year follow-on study from a randomised, head-to-head, multicentre, open-label study of two pandemic influenza vaccines in childrenP De Whalley
Department of Paediatrics, University of Oxford, Oxford, UK
Health Technol Assess 15:v-vi, xi-xiii, 1-128. 2011..Pandemic influenza A H1N1 infections occurred worldwide from 2009. Children were particularly vulnerable. Novel vaccines were used during the pandemic...
Maintenance of immune response throughout childhood following serogroup C meningococcal conjugate vaccination in early childhoodA Khatami
Oxford Vaccine Group, University of Oxford, CCVTM, Churchill Drive, Churchill Hospital, Oxford, OX3 7LJ, UK
Clin Vaccine Immunol 18:2038-42. 2011..Sustaining high levels of antibody through booster vaccination in this cohort is likely necessary to avoid a resurgence of disease in the decade ahead...
Safety and immunogenicity of AS03B adjuvanted split virion versus non-adjuvanted whole virion H1N1 influenza vaccine in UK children aged 6 months-12 years: open label, randomised, parallel group, multicentre studyClaire S Waddington
Oxford Vaccine Group, Department of Paediatrics, University of Oxford, Oxford OX3 7LJ
BMJ 340:c2649. 2010..To compare the safety, reactogenicity, and immunogenicity of an adjuvanted split virion H1N1 vaccine and a non-adjuvanted whole virion vaccine used in the pandemic immunisation programme in the United Kingdom...
