W Franklin Smyth

Summary

Affiliation: University of Ulster
Country: UK

Publications

  1. ncbi request reprint Recent studies on the electrospray ionisation mass spectrometric behaviour of selected nitrogen-containing drug molecules and its application to drug analysis using liquid chromatography-electrospray ionisation mass spectrometry
    W F Smyth
    School of Biomedical Sciences, University of Ulster, Coleraine, Co Derry, BT52 1SA Northern Ireland, UK
    J Chromatogr B Analyt Technol Biomed Life Sci 824:1-20. 2005
  2. ncbi request reprint The characterisation of selected antidepressant drugs using electrospray ionisation with ion trap mass spectrometry and with quadrupole time-of-flight mass spectrometry and their determination by high-performance liquid chromatography/electrospray ionisat
    W Franklin Smyth
    School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, UK
    Rapid Commun Mass Spectrom 20:1637-42. 2006
  3. ncbi request reprint Recent studies of the electrospray ionisation behaviour of selected drugs and their application in capillary electrophoresis-mass spectrometry and liquid chromatography-mass spectrometry
    W Franklin Smyth
    School of Biomedical Sciences, University of Ulster, Coleraine, Co Derry, BT52 1SA North Ireland UK
    J Chromatogr A 1159:159-74. 2007
  4. ncbi request reprint An electrospray ionisation tandem mass spectrometric investigation of selected psychoactive pharmaceuticals and its application in drug and metabolite profiling by liquid chromatography/electrospray ionisation tandem mass spectrometry
    Bernadette Doherty
    School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, UK
    Rapid Commun Mass Spectrom 21:2031-8. 2007
  5. ncbi request reprint Characterisation of selected drugs with nitrogen-containing saturated ring structures by use of electrospray ionisation with ion-trap mass spectrometry
    W Franklin Smyth
    School of Biomedical Sciences, University of Ulster, BT52 1SA, Coleraine, N Ireland, UK
    Anal Bioanal Chem 378:1305-12. 2004
  6. ncbi request reprint A critical evaluation of high performance liquid chromatography-electrospray ionisation-mass spectrometry and capillary electrophoresis-electrospray-mass spectrometry for the detection and determination of small molecules of significance in clinical and f
    W Franklin Smyth
    School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland BT52 1SA, UK
    Electrophoresis 25:1413-46. 2004
  7. ncbi request reprint Recent applications of capillary electrophoresis-electrospray ionisation-mass spectrometry in drug analysis
    W Franklin Smyth
    School of Biomedical Sciences, University of Ulster, Coleraine, Co Derry, Northern Ireland
    Electrophoresis 26:1334-57. 2005
  8. doi request reprint The characterisation of coumarins from selected structural classes by electrospray ionisation quadrupole time-of-flight tandem mass spectrometry
    W Franklin Smyth
    Department of Pharmacy and Pharmaceutical Sciences, School of Biomedical Science, University of Ulster, Coleraine, UK
    Rapid Commun Mass Spectrom 25:1308-14. 2011
  9. ncbi request reprint A study of the analytical behaviour of selected psycho-active drugs using liquid chromatography, ion trap mass spectrometry, gas chromatography and polarography and the construction of an appropriate database for drug characterisation
    Bernadette Doherty
    School of Biomedical Science, University of Ulster, Coleraine BT52 1SA, Northern Ireland
    Talanta 72:755-61. 2007
  10. ncbi request reprint The characterisation of selected drugs with amine-containing side chains using electrospray ionisation and ion trap mass spectrometry and their determination by HPLC-ESI-MS
    Clare Joyce
    School of Biomedical Sciences, University of Ulster, Coleraine BT521SA, Northern Ireland, UK
    J Pharm Biomed Anal 36:465-76. 2004

Collaborators

  • Victor A Gault
  • Thomas J P Smyth
  • Stephen McClean
  • Bernadette Doherty
  • Virginia Rodríguez Robledo
  • Edmund O'Kane
  • Sara Moore
  • Julian C Leslie
  • Thomas J Smyth
  • Venkataraman N Ramachandran
  • Clare Joyce
  • Venkataraman Ramachandran
  • Peter Brooks
  • Virginia Rodriguez
  • Catherine J Hack
  • Jason Hopps
  • Fionnuala O'Donnell
  • Alex McGuigan
  • V N Ramachandran
  • Neil S Boyd
  • Daniel J Coulter
  • Robert C Robinson
  • Chris Shaw

Detail Information

Publications17

  1. ncbi request reprint Recent studies on the electrospray ionisation mass spectrometric behaviour of selected nitrogen-containing drug molecules and its application to drug analysis using liquid chromatography-electrospray ionisation mass spectrometry
    W F Smyth
    School of Biomedical Sciences, University of Ulster, Coleraine, Co Derry, BT52 1SA Northern Ireland, UK
    J Chromatogr B Analyt Technol Biomed Life Sci 824:1-20. 2005
    ....
  2. ncbi request reprint The characterisation of selected antidepressant drugs using electrospray ionisation with ion trap mass spectrometry and with quadrupole time-of-flight mass spectrometry and their determination by high-performance liquid chromatography/electrospray ionisat
    W Franklin Smyth
    School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, UK
    Rapid Commun Mass Spectrom 20:1637-42. 2006
    ....
  3. ncbi request reprint Recent studies of the electrospray ionisation behaviour of selected drugs and their application in capillary electrophoresis-mass spectrometry and liquid chromatography-mass spectrometry
    W Franklin Smyth
    School of Biomedical Sciences, University of Ulster, Coleraine, Co Derry, BT52 1SA North Ireland UK
    J Chromatogr A 1159:159-74. 2007
    ..Analytical information on, for example, sample concentration techniques, separation conditions, recoveries from biological media and limits of detection/quantitation (LODs and LOQs) are provided...
  4. ncbi request reprint An electrospray ionisation tandem mass spectrometric investigation of selected psychoactive pharmaceuticals and its application in drug and metabolite profiling by liquid chromatography/electrospray ionisation tandem mass spectrometry
    Bernadette Doherty
    School of Biomedical Sciences, University of Ulster, Coleraine BT52 1SA, UK
    Rapid Commun Mass Spectrom 21:2031-8. 2007
    ..These fragmentation studies were then utilised in the development of a liquid chromatographic method to identify the drugs and their metabolites in human hair and saliva samples, thus providing relevant profiling information...
  5. ncbi request reprint Characterisation of selected drugs with nitrogen-containing saturated ring structures by use of electrospray ionisation with ion-trap mass spectrometry
    W Franklin Smyth
    School of Biomedical Sciences, University of Ulster, BT52 1SA, Coleraine, N Ireland, UK
    Anal Bioanal Chem 378:1305-12. 2004
    ..The data presented in this paper therefore provide useful information on the structure of these heterocyclic compounds which could be used to characterise unknown drug compounds isolated from natural sources, for example...
  6. ncbi request reprint A critical evaluation of high performance liquid chromatography-electrospray ionisation-mass spectrometry and capillary electrophoresis-electrospray-mass spectrometry for the detection and determination of small molecules of significance in clinical and f
    W Franklin Smyth
    School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland BT52 1SA, UK
    Electrophoresis 25:1413-46. 2004
    ..Analytical information on, for example, sample concentration techniques, HPLC and CE separation conditions, recoveries from biological media and limits of detection (LODs) are provided...
  7. ncbi request reprint Recent applications of capillary electrophoresis-electrospray ionisation-mass spectrometry in drug analysis
    W Franklin Smyth
    School of Biomedical Sciences, University of Ulster, Coleraine, Co Derry, Northern Ireland
    Electrophoresis 26:1334-57. 2005
    ..Potential applications of CE-MS to particular drugs or drug classes are also briefly discussed in the text...
  8. doi request reprint The characterisation of coumarins from selected structural classes by electrospray ionisation quadrupole time-of-flight tandem mass spectrometry
    W Franklin Smyth
    Department of Pharmacy and Pharmaceutical Sciences, School of Biomedical Science, University of Ulster, Coleraine, UK
    Rapid Commun Mass Spectrom 25:1308-14. 2011
    ..The ESI-QTOF-MS/MS behaviour of some naturally occurring and synthetic quinolines which are structurally similar or fragment similarly are included where appropriate...
  9. ncbi request reprint A study of the analytical behaviour of selected psycho-active drugs using liquid chromatography, ion trap mass spectrometry, gas chromatography and polarography and the construction of an appropriate database for drug characterisation
    Bernadette Doherty
    School of Biomedical Science, University of Ulster, Coleraine BT52 1SA, Northern Ireland
    Talanta 72:755-61. 2007
    ..Application is found in the determination of selected drug compounds in hair samples...
  10. ncbi request reprint The characterisation of selected drugs with amine-containing side chains using electrospray ionisation and ion trap mass spectrometry and their determination by HPLC-ESI-MS
    Clare Joyce
    School of Biomedical Sciences, University of Ulster, Coleraine BT521SA, Northern Ireland, UK
    J Pharm Biomed Anal 36:465-76. 2004
    ..Amphetamine, clenbuterol, flurazepam and methadone can be identified and determined in mixtures at low ng/ml concentrations by the application of HPLC-ESI-MS which can also be used for their analysis in saliva samples...
  11. doi request reprint Investigation of antibacterial phytochemicals in the bark and leaves of Ficus coronata by high-performance liquid chromatography-electrospray ionization-ion trap mass spectrometry (HPLC-ESI-MS(n) ) and ESI-MS(n)
    Thomas J P Smyth
    Department of Pharmacy and Pharmaceutical Sciences, School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland
    Electrophoresis 33:713-8. 2012
    ..Structures are also proposed for known compounds that have not been previously reported for F. coronata...
  12. doi request reprint Mass spectrometric characterisation and quantitation of selected low molecular mass compounds from the venom of Haplopelma lividum (Theraphosidae)
    Sara Moore
    The SAAD Centre for Pharmacy and Diabetes, Biomedical Sciences Research Institute, University of Ulster, Coleraine BT52 1SA, UK
    Rapid Commun Mass Spectrom 23:1747-55. 2009
    ..002%. The limits of detection and quantification were established for each of the identified components. The fragmentation profile for histamine has also been proposed...
  13. ncbi request reprint Characterisation and determination of indole alkaloids in frog-skin secretions by electrospray ionisation ion trap mass spectrometry
    Stephen McClean
    School of Biomedical Sciences, University of Ulster, Coleraine, County Londonderry BT52 1SA, N Ireland, UK
    Rapid Commun Mass Spectrom 16:346-54. 2002
    ..The concentrations of 5-HT, N'-methyl 5-HT and 5-HTQ were found to be 2.68, 0.26 and 0.54 microg per mg of skin secretion, respectively...
  14. ncbi request reprint Recent applications of capillary electrophoresis-electrospray ionisation-mass spectrometry in drug analysis
    W Franklin Smyth
    School of Biomedical Sciences, University of Ulster, Coleraine, UK
    Electrophoresis 27:2051-62. 2006
    ..Analytical information on, for example, sample concentration techniques, CE separation conditions, recoveries from biological media and limits of detection are provided...
  15. doi request reprint Characterisation of oxazepam degradation products by high-performance liquid chromatography/electrospray ionisation mass spectrometry and electrospray ionisation quadrupole time-of-flight tandem mass spectrometry
    Thomas J P Smyth
    School of Biomedical Science, University of Ulster, Coleraine BT52 1SA, Northern Ireland, UK
    Rapid Commun Mass Spectrom 24:651-8. 2010
    ....
  16. ncbi request reprint Characterisation of nicotine and related compounds using electrospray ionisation with ion trap mass spectrometry and with quadrupole time-of-flight mass spectrometry and their detection by liquid chromatography/electrospray ionisation mass spectrometry
    Thomas J Smyth
    School of Biomedical Sciences, University of Ulster, Coleraine, BT52 1SA, UK
    Rapid Commun Mass Spectrom 21:557-66. 2007
    ..4 min (m/z 159). For quality control of nicotine replacement therapy products, these nicotine impurities can be readily identified and determined at levels up to 0.3% for single impurities and up to 1.0% for total impurities...
  17. doi request reprint A study of the analytical behaviour of selected new molecular entities using electrospray ionisation ion trap mass spectrometry, liquid chromatography, gas chromatography and polarography and their determination in serum at therapeutic concentrations
    Virginia Rodríguez Robledo
    Department of Analytical Chemistry and Food Technology, University of Castilla La Mancha, Ciudad Real, Spain
    Anal Chim Acta 623:221-30. 2008
    ..In addition, this method was compared to the application of gas liquid chromatography-flame ionisation detection (GLC-FID) and differential pulse polarography (DPP) for the analysis of these NMEs in serum...