Rosalind Smyth

Summary

Affiliation: University of Liverpool
Country: UK

Publications

  1. doi request reprint Oral calorie supplements for cystic fibrosis
    Rosalind L Smyth
    Institute of Child Health, University of Liverpool, Alder Hey Children s NHS Foundation Trust, Liverpool, UK
    Cochrane Database Syst Rev 10:CD000406. 2012
  2. pmc Feasibility study to inform the design of a randomised controlled trial to eradicate Pseudomonas aeruginosa infection in individuals with cystic fibrosis
    Helen R Hickey
    Medicines for Children Research Network Clinical Trials Unit, University of Liverpool, UK
    Trials 11:11. 2010
  3. ncbi request reprint Evidence-based pediatric pulmonary medicine: how can it help?
    R L Smyth
    University Department of Child Health, Royal Liverpool Children s Hospital, Alder Hey, United Kingdom
    Pediatr Pulmonol 25:118-27. 1998
  4. pmc Intravenous immunoglobulin for cystic fibrosis lung disease
    R L Smyth
    University of Liverpool, Institute of Child Health, Alder Hey Children s Hospital, Liverpool L12 2AP, UK
    Arch Dis Child 89:298-9. 2004
  5. ncbi request reprint Researching childhood illness: the need for methodological studies
    Rosalind L Smyth
    Institute of Child Health, University of Liverpool, Alder Hey Children s Hospital, Liverpool L12 2AP, UK
    Chronic Illn 2:183-4. 2006
  6. ncbi request reprint Cochrane systematic reviews in cystic fibrosis
    Rosalind Smyth
    Cochrane Cystic Fibrosis and Genetic Disorders Group, Department of Child Health, University of Liverpool, Liverpool, UK
    J R Soc Med 99:6-12. 2006
  7. pmc Making a difference: the clinical research programme for children
    Rosalind L Smyth
    School of Reproductive and Developmental Medicine, University of Liverpool, Alder Hey Children s Hospital, Liverpool L12 2AP, UK
    Arch Dis Child 92:835-7. 2007
  8. pmc A major new initiative to improve treatment for children
    R L Smyth
    Division of Child Health, School of Reproductive and Developmental Medicine, University of Liverpool, Alder Hey Children s Hospital, Liverpool, UK
    Arch Dis Child 91:212-3. 2006
  9. ncbi request reprint Bronchiolitis
    Rosalind L Smyth
    Division of Child Health, School of Reproductive and Developmental Medicine, University of Liverpool, Alder Hey Children s Hospital, Liverpool L12 2AP, UK
    Lancet 368:312-22. 2006
  10. ncbi request reprint Innate immunity in respiratory syncytial virus bronchiolitis
    Rosalind L Smyth
    Division of Child Health, School of Reproductive and Developmental Medicine, University of Liverpool, Alder Hey Children s Hospital, Liverpool, UK
    Exp Lung Res 33:543-7. 2007

Collaborators

Detail Information

Publications48

  1. doi request reprint Oral calorie supplements for cystic fibrosis
    Rosalind L Smyth
    Institute of Child Health, University of Liverpool, Alder Hey Children s NHS Foundation Trust, Liverpool, UK
    Cochrane Database Syst Rev 10:CD000406. 2012
    ..Oral calorie supplements are used to increase total daily calorie intake and improve weight gain. However, they are expensive and there are concerns they may reduce the amount of food eaten and not improve overall energy intake...
  2. pmc Feasibility study to inform the design of a randomised controlled trial to eradicate Pseudomonas aeruginosa infection in individuals with cystic fibrosis
    Helen R Hickey
    Medicines for Children Research Network Clinical Trials Unit, University of Liverpool, UK
    Trials 11:11. 2010
    ..The objective of this study was to assess the feasibility of conducting a randomised controlled trial comparing two treatment strategies to eradicate P aeruginosa in CF patients...
  3. ncbi request reprint Evidence-based pediatric pulmonary medicine: how can it help?
    R L Smyth
    University Department of Child Health, Royal Liverpool Children s Hospital, Alder Hey, United Kingdom
    Pediatr Pulmonol 25:118-27. 1998
    ..If applied appropriately, they can ensure that management of patients is based on clinically useful diagnostic tests and treatments that have been shown to be effective and not harmful...
  4. pmc Intravenous immunoglobulin for cystic fibrosis lung disease
    R L Smyth
    University of Liverpool, Institute of Child Health, Alder Hey Children s Hospital, Liverpool L12 2AP, UK
    Arch Dis Child 89:298-9. 2004
  5. ncbi request reprint Researching childhood illness: the need for methodological studies
    Rosalind L Smyth
    Institute of Child Health, University of Liverpool, Alder Hey Children s Hospital, Liverpool L12 2AP, UK
    Chronic Illn 2:183-4. 2006
  6. ncbi request reprint Cochrane systematic reviews in cystic fibrosis
    Rosalind Smyth
    Cochrane Cystic Fibrosis and Genetic Disorders Group, Department of Child Health, University of Liverpool, Liverpool, UK
    J R Soc Med 99:6-12. 2006
  7. pmc Making a difference: the clinical research programme for children
    Rosalind L Smyth
    School of Reproductive and Developmental Medicine, University of Liverpool, Alder Hey Children s Hospital, Liverpool L12 2AP, UK
    Arch Dis Child 92:835-7. 2007
  8. pmc A major new initiative to improve treatment for children
    R L Smyth
    Division of Child Health, School of Reproductive and Developmental Medicine, University of Liverpool, Alder Hey Children s Hospital, Liverpool, UK
    Arch Dis Child 91:212-3. 2006
  9. ncbi request reprint Bronchiolitis
    Rosalind L Smyth
    Division of Child Health, School of Reproductive and Developmental Medicine, University of Liverpool, Alder Hey Children s Hospital, Liverpool L12 2AP, UK
    Lancet 368:312-22. 2006
    ..Careful mapping of the inflammatory pathways in the pathogenesis of bronchiolitis should lead to development of new therapies to alleviate symptoms...
  10. ncbi request reprint Innate immunity in respiratory syncytial virus bronchiolitis
    Rosalind L Smyth
    Division of Child Health, School of Reproductive and Developmental Medicine, University of Liverpool, Alder Hey Children s Hospital, Liverpool, UK
    Exp Lung Res 33:543-7. 2007
    ..It is increasingly being recognized that the innate immune response may play a key role...
  11. pmc Asthma: a major pediatric health issue
    Rosalind L Smyth
    University of Liverpool, Institute of Child Health, Alder Hey Children s Hospital, Liverpool L12 2AP, UK
    Respir Res 3:S3-7. 2002
    ..Asthma may develop as a result of persistent activation of the immune system alone or in combination with physiologic airway remodeling in early childhood. Further studies are needed to confirm this hypothesis...
  12. pmc Intestinal inflammation in cystic fibrosis
    R L Smyth
    University Institute of Child Health, Royal Liverpool Children s Hospital, Liverpool L12 2AP, UK
    Arch Dis Child 82:394-9. 2000
    ....
  13. ncbi request reprint Respiratory syncytial virus bronchiolitis: disease severity, interleukin-8, and virus genotype
    Rosalind L Smyth
    Department of Child Health, University of Liverpool, Institute of Child Health, Alder Hey Children s Hospital, Liverpool, United Kingdom
    Pediatr Pulmonol 33:339-46. 2002
    ..This suggests that clinical manifestations of respiratory syncytial virus bronchiolitis are determined by local immunological responses to infection, rather than by characteristics of the infecting virus...
  14. ncbi request reprint The promise of and problems with evidence-based medicine for paediatric asthma management
    R L Smyth
    University Institute of Paediatric Health, Alder Hey Children s Hospital, Liverpool, UK
    Allergy 57:5-14. 2002
    ..If used appropriately, they can aid the clinician in making decisions about individual patients and provide a sound evidence base from which clinical guidelines can be developed...
  15. ncbi request reprint Interleukin 9 production in the lungs of infants with severe respiratory syncytial virus bronchiolitis
    Paul S McNamara
    Department of Child Health, University of Liverpool, Institute of Child Health, Alder Hey Children s Hospital, Liverpool, UK
    Lancet 363:1031-7. 2004
    ..We aimed to investigate whether interleukin 9 was produced in the lungs of infants with severe RSV disease and if found, from which cells it originated...
  16. ncbi request reprint In a systematic review, infrared ear thermometry for fever diagnosis in children finds poor sensitivity
    Susanna R Dodd
    Centre for Medical Statistics and Health Evaluation, University of Liverpool, Liverpool, L69 3GS, United Kingdom
    J Clin Epidemiol 59:354-7. 2006
    ..To investigate sensitivity and specificity of infrared ear thermometry compared to rectal thermometry to detect fever in children...
  17. pmc Chemokine responses are increased in HIV-infected Malawian children with invasive pneumococcal disease
    Enitan D Carrol
    Malawi Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi
    J Acquir Immune Defic Syndr 44:443-50. 2007
    ..The aims of this study were to investigate the chemokine response to invasive pneumococcal disease (IPD) and to examine the influence of HIV infection on the chemokine response, pneumococcal bacterial loads, and outcome...
  18. ncbi request reprint Parental depression following the early diagnosis of cystic fibrosis: a matched, prospective study
    Claire Glasscoe
    University of Liverpool, Child Mental Health Unit, Royal Liverpool Children s Hospital, UK
    J Pediatr 150:185-91. 2007
    ..To assess risks for parental depression following the diagnosis of cystic fibrosis (CF) in a child...
  19. ncbi request reprint Cytokines in severe respiratory syncytial virus bronchiolitis
    Kevin J Mobbs
    Department of Medical Microbiology and Genitourinary Medicine, Liverpool, UK
    Pediatr Pulmonol 33:449-52. 2002
    ..These findings provide the first direct evidence in infants that in RSV bronchiolitis there are divergent T-cell responses and suggest that more than one mechanism may be responsible for immune-mediated disease enhancement...
  20. ncbi request reprint Interleukin-9 as a possible therapeutic target in both asthma and chronic obstructive airways disease
    Paul S McNamara
    Department of Child Health at the Institute of Child Health, Alder Hey Children s Hospital, Eaton Road, Liverpool L12 2AP, UK
    Drug News Perspect 18:615-21. 2005
    ..In this review we will summarize current knowledge about the immunobiology of IL-9 and discuss the role played by IL-9 in inflammation in both asthma and COPD, and its potential as a therapeutic target...
  21. ncbi request reprint Production of chemokines in the lungs of infants with severe respiratory syncytial virus bronchiolitis
    Paul S McNamara
    Department of Child Health, Institute of Child Health, Alder Hey Children s Hospital, University of Liverpool, Liverpool, United Kingdom
    J Infect Dis 191:1225-32. 2005
    ..However, little is known about pulmonary chemokine responses to RSV in humans. Our aim was to characterize the production of chemokines in the lungs of infants with RSV bronchiolitis and how this production changes over time...
  22. ncbi request reprint Dual infection of infants by human metapneumovirus and human respiratory syncytial virus is strongly associated with severe bronchiolitis
    Malcolm G Semple
    Department of Child Health, University of Liverpool, Liverpool, United Kingdom
    J Infect Dis 191:382-6. 2005
    ..99 [95% confidence interval, 5.0-24.12]; P<.001, by Fisher exact test). Dual infection by hMPV and hRSV is associated with severe bronchiolitis...
  23. ncbi request reprint Impact of human metapneumovirus and respiratory syncytial virus co-infection in severe bronchiolitis
    Paul S McNamara
    Institute of Child Health, Royal Liverpool Children s Hospital, Eaton Rd, Liverpool L12 2AP, United Kingdom
    Pediatr Pulmonol 42:740-3. 2007
    ..Here we show that RSV+/hMPV+ were clinically symptomatic for longer than RSV+/hMPV- infants, but that no differences in airway total cell concentration, differential cell count or cytokine/chemokine concentrations were detectable...
  24. ncbi request reprint Oral protein-energy supplements for children with chronic disease: systematic review
    Vanessa J Poustie
    Department of Child Health, University of Liverpool, Liverpool L69 3GB, UK
    Proc Nutr Soc 62:801-6. 2003
    ..Further randomised controlled trials are required to investigate the use of these products in children with chronic disease. Until further data are available, these products should be used with caution...
  25. doi request reprint Detection and characterisation of human metapneumovirus from children with acute respiratory symptoms in north-west England, UK
    Mark J Hopkins
    Liverpool Specialist Virology Centre, Royal Liverpool University Hospital, Liverpool, UK
    J Clin Virol 42:273-9. 2008
    ..Five distinct lineages of the virus genome have been described...
  26. pmc A systematic review of studies that aim to determine which outcomes to measure in clinical trials in children
    Ian Sinha
    Institute of Child Health, University of Liverpool, Liverpool, United Kingdom
    PLoS Med 5:e96. 2008
    ..Our aim was to systematically review studies that address the process of selecting outcomes or outcome domains to measure in clinical trials in children...
  27. pmc Human metapneumovirus in severe respiratory syncytial virus bronchiolitis
    Julie Greensill
    University of Liverpool, Liverpool, United Kingdom
    Emerg Infect Dis 9:372-5. 2003
    ..Seventy percent of them were coinfected with metapneumovirus. Such coinfection might be a factor influencing the severity of bronchiolitis...
  28. pmc Severe respiratory syncytial virus bronchiolitis in infants is associated with reduced airway interferon gamma and substance P
    Malcolm G Semple
    Division of Child Health, School of Reproductive and Developmental Medicine, University of Liverpool, Liverpool, United Kingdom
    PLoS ONE 2:e1038. 2007
    ..Aim: to determine if factors mediating proposed mechanisms for severe bronchiolitis differ with severity of disease...
  29. doi request reprint Innate immune response and bronchiolitis and preschool recurrent wheeze
    Clare Halfhide
    Institute of Child Health, University of Liverpool, Royal Liverpool Children s Hospital, Eaton Road, Liverpool, UK
    Paediatr Respir Rev 9:251-62. 2008
    ....
  30. ncbi request reprint Adjusting for publication bias: modelling the selection process
    Carrol Preston
    Centre for Medical Statistics and Health Evaluation, University of Liverpool, UK
    J Eval Clin Pract 10:313-22. 2004
    ..Methods that adjust combined estimates should not be used to provide an alternative answer but to consider the robustness of the combined estimate to publication bias...
  31. ncbi request reprint Infrared ear thermometry compared with rectal thermometry in children: a systematic review
    Jean V Craig
    University of Liverpool, Institute of Child Health, Alder Hey Children s Hospital, Liverpool L12 2AP, UK
    Lancet 360:603-9. 2002
    ..Our aim was to evaluate agreement between temperature measured at the rectum and ear in children...
  32. ncbi request reprint The pathogenesis of respiratory syncytial virus disease in childhood
    Paul S McNamara
    Department of Child Health, Institute of Child Health, Alder Hey Children s Hospital, Liverpool, UK
    Br Med Bull 61:13-28. 2002
    ..However, there is compelling evidence to suggest that the host cell immune response also has a prominent role in disease pathogenesis. Non-immunological factors may also be important...
  33. pmc Systematic reviews and lifelong diseases
    Heather E Elphick
    University of Liverpool Institute of Child Health, Alder Hey Children s Hospital, Liverpool L12 2AP
    BMJ 325:381-4. 2002
  34. ncbi request reprint Controlled clinical trials in cystic fibrosis--are we doing better?
    Tracy Ann Briggs
    Institute of Child Health, University of Liverpool, UK
    J Cyst Fibros 5:3-8. 2006
    ..The trend for an increasing proportion of trials to be multicentre is encouraging. There are however, still deficiencies in the design of clinical trials in CF...
  35. ncbi request reprint Using disease registries for pharmacoepidemiological research: a case study of data from a cystic fibrosis registry
    Judith Strobl
    Prescribing Research Group, Department of Pharmacology and Therapeutics, Ashton Street New Medical Building, University of Liverpool, L69 3GE, UK
    Pharmacoepidemiol Drug Saf 12:467-73. 2003
    ..The Epidemiologic Registry of Cystic Fibrosis (ERCF) was a multicentre, longitudinal follow-up project of cystic fibrosis patients enrolled at some 200 centres in nine European countries between 1994 and 1999...
  36. ncbi request reprint High prevalence but low impact of data extraction and reporting errors were found in Cochrane systematic reviews
    Ashley P Jones
    Alder Hey Children s Hospital, The University of Liverpool, Institute of Child Health, Eaton Road, Liverpool, L12 2AP, England
    J Clin Epidemiol 58:741-2. 2005
    ..Incorrect data extraction can lead to false conclusions. The objective of this study was to retrospectively repeat the data extraction in all systematic reviews conducted by the Cochrane Cystic Fibrosis and Genetic Disorders Group...
  37. ncbi request reprint Key developments in paediatrics
    Stephen P Brearey
    Division of Child Health, School of Reproductive and Developmental Medicine, University of Liverpool Institute of Child Health, Alder Hey Children s Hospital
    Practitioner 248:874, 876, 879 passim. 2004
  38. pmc Outcomes in clinical trials of inhaled corticosteroids for children with asthma are narrowly focussed on short term disease activity
    Ian P Sinha
    Institute of Child Health, University of Liverpool, Liverpool, United Kingdom
    PLoS ONE 4:e6276. 2009
    ....
  39. ncbi request reprint Drug development for children: how is pharma tackling an unmet need?
    Daniel B Hawcutt
    Division of Child Health, School of Reproductive and Developmental Medicine, University of Liverpool, Alder Hey Children s Hospital, Liverpool, L12 2AP, UK
    IDrugs 11:502-7. 2008
    ....
  40. ncbi request reprint Design of clinical trials in cystic fibrosis
    Kevin W Southern
    Lancet 361:349-50; aurhor reply 350. 2003
  41. pmc Oral protein energy supplements for children with cystic fibrosis: CALICO multicentre randomised controlled trial
    Vanessa J Poustie
    University of Liverpool Division of Child Health, Royal Liverpool Children s Hospital, Liverpool L12 2AP
    BMJ 332:632-6. 2006
    ..To determine whether oral protein energy supplements, used long term in children with cystic fibrosis who are moderately malnourished, improve nutritional and other outcomes...
  42. pmc High pneumococcal DNA loads are associated with mortality in Malawian children with invasive pneumococcal disease
    Enitan D Carrol
    Malawi Liverpool Wellcome Trust Clinical Research Programme, Department of Paediatrics, College of Medicine, University of Malawi, Blantyre, Malawi
    Pediatr Infect Dis J 26:416-22. 2007
    ..Using real-time PCR, we aimed to determine pneumococcal DNA loads in blood and CSF, and their relationship to cytokine concentrations, clinical presentation and outcome...
  43. ncbi request reprint Update on Cochrane data on paediatric respiratory diseases
    Malcolm G Semple
    Institute of Child Health, University of Liverpool, Alder Hey, Eaton Road, L12 2AP, Liverpool, UK
    Paediatr Respir Rev 4:250-66. 2003
    ..The Cochrane Collaboration has fostered the development and dissemination of systematic reviews throughout the world. We have identified and summarised The Cochrane systematic reviews of relevance to the paediatric pulmonologist...
  44. ncbi request reprint CD8+ T cell responses in bronchoalveolar lavage fluid and peripheral blood mononuclear cells of infants with severe primary respiratory syncytial virus infections
    Jojanneke Heidema
    Division of Pediatrics, Wilhelmina Children s Hospital, University Medical Center, Utrecht, The Netherlands
    J Immunol 179:8410-7. 2007
    ..The lack of a correlation between RSV-specific T cell numbers and parameters of disease severity make a prominent role in immune pathology unlikely, in contrast the T cells might be involved in the recovery process...
  45. ncbi request reprint Treatment of acute wheezing episodes in young children
    Rosalind L Smyth
    J Pediatr 145:151-2. 2004
  46. ncbi request reprint Daily activity and disease status in cystic fibrosis: an important area for research
    Rosalind L Smyth
    J Pediatr 147:281-3. 2005
  47. ncbi request reprint Medicines for children
    Rosalind L Smyth
    Lancet 368:645-6. 2006
  48. ncbi request reprint The new European regulation on pediatric medicines: regulatory perspective
    Daniel B Hawcutt
    Paediatr Drugs 10:143-6. 2008