Noel H Smith
Affiliation: University of Sussex
- The global distribution and phylogeography of Mycobacterium bovis clonal complexesNoel H Smith
Animal Health and Veterinary Laboratories Agency, Weybridge, New Haw, Surrey KT15 3NB, UK
Infect Genet Evol 12:857-65. 2012..bovis clonal complexes has shown surprising geographical localisation of molecular types but also hints strongly that much of the worldwide distribution of bovine pathogen resulted from human trade in cattle within the last 200 years...
- Naming spoligotype patterns for the RD9-deleted lineage of the Mycobacterium tuberculosis complex; www.Mbovis.orgNoel H Smith
Centre for the Study of Evolution, University of Sussex and Animal Health and Veterinary Laboratories Agency, Weybridge, New Haw, Surrey KT15 3NB, UK
Infect Genet Evol 12:873-6. 2012..bovis. The history of the database is described, as well as the method for submitting new patterns to the database and the functionality of the website...
- Ecotypes of the Mycobacterium tuberculosis complexNoel H Smith
TB Research Group, Veterinary Laboratories Agency, VLA, Addlestone, Surrey KT15 3NB, UK
J Theor Biol 239:220-5. 2006..Finally, we discuss the application of the ecotype concept to this series of clades and suggest that the M. tuberculosis complex may best be described as a series of host-adapted ecotypes...
- European 1: a globally important clonal complex of Mycobacterium bovisNoel H Smith
Centre for Study of Evolution, University of Sussex, Animal Health and Veterinary Laboratories Agency, Weybridge, New Haw, Surrey KT15 3NB, UK
Infect Genet Evol 11:1340-51. 2011..bovis and indicates that much of the current global distribution of this important veterinary pathogen has resulted from relatively recent International trade in cattle...
- Myths and misconceptions: the origin and evolution of Mycobacterium tuberculosisNoel H Smith
Veterinary Laboratories Agency VLA, Weybridge, New Haw, Addlestone, Surrey KT15 3NB, UK
Nat Rev Microbiol 7:537-44. 2009..We discuss a series of misconceptions about the origin of both M. tuberculosis and the disease it causes that have arisen over the years, and identify a number of unanswered questions that could provide insight into both these areas...
- Mycobacterium microti: More diverse than previously thoughtN H Smith
VLA Weybridge, New Haw, Surrey, United Kingdom
J Clin Microbiol 47:2551-9. 2009..The location of the cats with M. microti infection suggests that they do not overlap geographically with the strains of Mycobacterium bovis in Great Britain...
- Molecular characterisation of Mycobacterium bovis isolated from cattle slaughtered at the Bamako abattoir in MaliBorna Muller
Swiss Tropical Institute, Basel, Switzerland
BMC Vet Res 4:26. 2008..Of 3330 animals screened only 60 exhibited gross visible lesions. From these animals, twenty strains of M. bovis were isolated and characterised by spoligotyping...
- Molecular characterization of Mycobacterium bovis strains isolated from cattle slaughtered at two abattoirs in AlgeriaNaima Sahraoui
Département Vétérinaire, Université Saad Dahlab, Blida, Algeria
BMC Vet Res 5:4. 2009..In 260 animals, gross visible granulomatous lesions were detected and put into culture. Bacterial isolates were subsequently analysed by molecular methods...
- African 2, a clonal complex of Mycobacterium bovis epidemiologically important in East AfricaStefan Berg
VLA Weybridge, New Haw, Surrey KT15 3NB, United Kingdom
J Bacteriol 193:670-8. 2011..bovis have, in general, four or more copies of the insertion sequence IS6110, in contrast to the majority of M. bovis strains isolated from cattle, which are thought to carry only one or a few copies...
- The population structure of Mycobacterium bovis in Great Britain: clonal expansionNoel H Smith
Centre for the Study of Evolution, University of Sussex, Falmer, Brighton BN1 9QL, United Kingdom
Proc Natl Acad Sci U S A 100:15271-5. 2003..A similar pattern is observed in M. tuberculosis (the main cause of tuberculosis in humans). The significance of clonal expansion in other bacteria that have recombination is discussed...
- Bottlenecks and broomsticks: the molecular evolution of Mycobacterium bovisNoel H Smith
Veterinary Laboratories Agency, Weybridge, New Haw, Addlestone, Surrey, KT15 3NB UK
Nat Rev Microbiol 4:670-81. 2006..We also discuss the practical implications of applying this knowledge to understanding the spread of infection and the development of improved vaccines and diagnostic tests...
- Recent advances in our knowledge of Mycobacterium bovis: a feeling for the organismR Glyn Hewinson
TB Research Group, Veterinary Laboratories Agency, Weybridge, Addlestone, Surrey KT15 3NB, UK
Vet Microbiol 112:127-39. 2006..bovis and BCG will allow insight into how BCG became attenuated following serial passage on artificial growth media and reveal clues into how to improve the vaccine efficacy of BCG...
- The burden of mycobacterial disease in ethiopian cattle: implications for public healthStefan Berg
TB Research Group, Veterinary Laboratories Agency, Weybridge, New Haw, Addlestone, Surrey, United Kingdom
PLoS ONE 4:e5068. 2009..Furthermore, Ethiopia has one of the highest incidence rates of human extrapulmonary TB in the world, a clinical presentation that is often associated with transmission of M. bovis from cattle to humans...