Godfrey Smith

Summary

Affiliation: University of Glasgow
Country: UK

Publications

  1. ncbi request reprint Selective down-regulation of sub-endocardial ryanodine receptor expression in a rabbit model of left ventricular dysfunction
    Susan Currie
    Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    J Mol Cell Cardiol 39:309-17. 2005
  2. ncbi request reprint Mapping of epicardial activation in a rabbit model of chronic myocardial infarction:
    Nicola L Walker
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    J Cardiovasc Electrophysiol 18:862-8. 2007
  3. doi request reprint The link between repolarisation alternans and ventricular arrhythmia: does the cellular phenomenon extend to the clinical problem?
    Rachel C Myles
    BHF Glasgow Cardiovascular Research Centre, University of Glasgow, University Place, Glasgow, G12 8TA, UK
    J Mol Cell Cardiol 45:1-10. 2008
  4. pmc The effects of over-expression of the FK506-binding protein FKBP12.6 on K(+) currents in adult rabbit ventricular myocytes
    S Kettlewell
    Institute of Biomedical and Life Sciences, University of Glasgow, University Avenue, Glasgow, G12 8QQ, Scotland, UK
    Pflugers Arch 458:653-60. 2009
  5. ncbi request reprint Measurement of SR Ca2+ content in the presence of caffeine in permeabilised rat cardiac trabeculae
    G L Smith
    Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow, G12 8QQ, UK
    Pflugers Arch 437:139-48. 1998
  6. pmc Cytoplasmic versus intra-SR: the battle of the Ca2+ diffusion coefficients in cardiac muscle
    Godfrey Smith
    Biomedical and Life Sciences, Glasgow University, Glasgow, United Kingdom
    Biophys J 95:1005-6. 2008
  7. ncbi request reprint Na(+)/Ca(2+) exchanger expression and function in a rabbit model of myocardial infarction
    Godfrey L Smith
    Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
    J Cardiovasc Electrophysiol 17:S57-S63. 2006
  8. ncbi request reprint Matters of the heart: the physiology of cardiac function and failure
    Godfrey Smith
    Institute of Biomedical and Life Sciences IBLS, University of Glasgow, Glasgow G12 8QQ, UK
    Exp Physiol 92:973-86. 2007
  9. pmc Differential sensitivity of Ca²+ wave and Ca²+ spark events to ruthenium red in isolated permeabilised rabbit cardiomyocytes
    N Macquaide
    Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK
    J Physiol 588:4731-42. 2010
  10. ncbi request reprint P(i) inhibits the SR Ca(2+) pump and stimulates pump-mediated Ca(2+) leak in rabbit cardiac myocytes
    G L Smith
    Institute of Biomedical and Life Sciences, Glasgow University, Glasgow G12 8QQ, Scotland
    Am J Physiol Heart Circ Physiol 279:H577-85. 2000

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Selective down-regulation of sub-endocardial ryanodine receptor expression in a rabbit model of left ventricular dysfunction
    Susan Currie
    Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    J Mol Cell Cardiol 39:309-17. 2005
    ..There is a corresponding decrease in fractional SR Ca2+ release in cells isolated from the sub-endocardium of hearts from the LVD group, relating these selective biochemical alterations to changes in function...
  2. ncbi request reprint Mapping of epicardial activation in a rabbit model of chronic myocardial infarction:
    Nicola L Walker
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    J Cardiovasc Electrophysiol 18:862-8. 2007
    ..This study examines the consequences of a large transmural apical infarct on the epicardial electrical activity in isolated rabbit hearts...
  3. doi request reprint The link between repolarisation alternans and ventricular arrhythmia: does the cellular phenomenon extend to the clinical problem?
    Rachel C Myles
    BHF Glasgow Cardiovascular Research Centre, University of Glasgow, University Place, Glasgow, G12 8TA, UK
    J Mol Cell Cardiol 45:1-10. 2008
    ..The areas where experimental evidence is weak are highlighted, and areas for future research are outlined...
  4. pmc The effects of over-expression of the FK506-binding protein FKBP12.6 on K(+) currents in adult rabbit ventricular myocytes
    S Kettlewell
    Institute of Biomedical and Life Sciences, University of Glasgow, University Avenue, Glasgow, G12 8QQ, Scotland, UK
    Pflugers Arch 458:653-60. 2009
    ..These data suggest that FKBP12.6 can modulate APD via changes in I (K1) independently of calcineurin binding, suggesting that FKBP12.6 may affect APD by direct interaction with I (K1)...
  5. ncbi request reprint Measurement of SR Ca2+ content in the presence of caffeine in permeabilised rat cardiac trabeculae
    G L Smith
    Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow, G12 8QQ, UK
    Pflugers Arch 437:139-48. 1998
    ..6 mmol/l SR volume)...
  6. pmc Cytoplasmic versus intra-SR: the battle of the Ca2+ diffusion coefficients in cardiac muscle
    Godfrey Smith
    Biomedical and Life Sciences, Glasgow University, Glasgow, United Kingdom
    Biophys J 95:1005-6. 2008
  7. ncbi request reprint Na(+)/Ca(2+) exchanger expression and function in a rabbit model of myocardial infarction
    Godfrey L Smith
    Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
    J Cardiovasc Electrophysiol 17:S57-S63. 2006
    ..However, in a subset of studies, reduced activity of NCX has been reported. Left ventricular dysfunction (LVD) was induced in the rabbit eight weeks after an apical myocardial infarction...
  8. ncbi request reprint Matters of the heart: the physiology of cardiac function and failure
    Godfrey Smith
    Institute of Biomedical and Life Sciences IBLS, University of Glasgow, Glasgow G12 8QQ, UK
    Exp Physiol 92:973-86. 2007
    ..ii) The use of regular exercise training to improve cardiac performance in heart failure. This appears to act by normalizing a number of aspects of myocardial physiology...
  9. pmc Differential sensitivity of Ca²+ wave and Ca²+ spark events to ruthenium red in isolated permeabilised rabbit cardiomyocytes
    N Macquaide
    Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK
    J Physiol 588:4731-42. 2010
    ..Therefore inhibition of Ca²(+) waves without affecting Ca²(+) sparks may be explained by block of small, non-spark producing clusters of RyRs that are important to the process of Ca²(+) wave propagation...
  10. ncbi request reprint P(i) inhibits the SR Ca(2+) pump and stimulates pump-mediated Ca(2+) leak in rabbit cardiac myocytes
    G L Smith
    Institute of Biomedical and Life Sciences, Glasgow University, Glasgow G12 8QQ, Scotland
    Am J Physiol Heart Circ Physiol 279:H577-85. 2000
    ..In conclusion, P(i) decreases the Ca(2+) uptake capacity of cardiac SR via a decrease in pump rate and an increase in Ca(2+) pump-dependent Ca(2+) leak...
  11. pmc A comparison of the effects of ATP and tetracaine on spontaneous Ca(2+) release from rat permeabilised cardiac myocytes
    G L Smith
    Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    J Physiol 534:37-47. 2001
    ..But recovery after incubation with 300 microM tetracaine resulted in SR Ca(2+) release with no coherent wave pattern. The reason for this discrepancy is discussed...
  12. pmc Effect of activation sequence on transmural patterns of repolarization and action potential duration in rabbit ventricular myocardium
    Rachel C Myles
    British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom
    Am J Physiol Heart Circ Physiol 299:H1812-22. 2010
    ....
  13. ncbi request reprint Metabolic monitoring of the electrically stimulated single heart cell within a microfluidic platform
    Wei Cheng
    Bioelectronics Research Centre, Department of Electronics and Electrical Engineering, University of Glasgow, Glasgow, UK
    Lab Chip 6:1424-31. 2006
    ..Finally, the relative amounts of intra- and extra-cellular lactate produced during field stimulation were determined, using cell electroporation where necessary...
  14. pmc Extracellular recordings of field potentials from single cardiomyocytes
    Norbert Klauke
    Department of Electronics, University of Glasgow, Glasgow G12 8LT, United Kingdom
    Biophys J 91:2543-51. 2006
    ..This data demonstrate the feasibility of the use of a microfluidic bath design to limit the extracellular resistance between two ends of an isolated cardiomyocyte...
  15. ncbi request reprint Effects of calsequestrin over-expression on excitation-contraction coupling in isolated rabbit cardiomyocytes
    Stewart L W Miller
    Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Cardiovasc Res 67:667-77. 2005
    ..This study investigated the role of calsequestrin (CSQ) in the control of excitation-contraction (E-C) coupling in the heart...
  16. doi request reprint Microfluidic cell arrays for metabolic monitoring of stimulated cardiomyocytes
    Wei Cheng
    Department of Electronics, University of Glasgow, UK
    Electrophoresis 31:1405-13. 2010
    ..This array system has the potential of simultaneous electrochemical and optical monitoring of extracellular and intracellular metabolites from single beating heart cells at a controlled metabolic state...
  17. pmc Dysregulation of cadherins in the intercalated disc of the spontaneously hypertensive stroke-prone rat
    Margaret Anne Craig
    BHF Glasgow Cardiovascular Research Centre, University of Glasgow, 126 University Place, Glasgow, G12 8TA, UK
    J Mol Cell Cardiol 48:1121-8. 2010
    ..Therefore, remodelling of the intercalated disc in the hearts of SHRSP animals may contribute to the altered function observed in these animals...
  18. doi request reprint Confocal and multiphoton imaging of intracellular Ca(2+)
    Godfrey Smith
    School of Life Sciences, University of Glasgow, United Kingdom
    Methods Cell Biol 99:225-61. 2010
    ..Finally, the combined emission spectra of Ca(2+) and voltage sensitive dyes are compared to allow the choice of the optimum combination to allow simultaneous intracellular Ca(2+) and membrane voltage measurement...
  19. ncbi request reprint Assessment of sarcoplasmic reticulum Ca(2+) flux pathways in cardiomyocytes from rabbits with infarct-induced left-ventricular dysfunction
    Paul Neary
    Department of Medical Cardiology, Glasgow Royal Infirmary, Glasgow G31 2ER, UK
    Pflugers Arch 444:360-71. 2002
    ..Reduced background Ca(2+) leak from the SR may compensate partly for the reduced Ca(2+) uptake capacity of the SR in the LVD group...
  20. pmc Evidence of intercellular coupling between co-cultured adult rabbit ventricular myocytes and myofibroblasts
    Lisa Chilton
    Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK
    J Physiol 583:225-36. 2007
    ..This work indicates the nature of the gap junction-mediated bi-directional interactions that occur between ventricular myocyte and myofibroblast...
  21. ncbi request reprint Activation or inactivation of cardiac Akt/mTOR signaling diverges physiological from pathological hypertrophy
    Ole Johan Kemi
    Institute of Biomedical and Life Sciences, University of Glasgow, UK
    J Cell Physiol 214:316-21. 2008
    ....
  22. pmc Temperature preconditioning: a cold-hearted answer to ischaemic reperfusion injury?
    Iffath A Ghouri
    Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
    J Physiol 585:649-50. 2007
  23. ncbi request reprint Exercise-induced changes in calcium handling in left ventricular cardiomyocytes
    Ole J Kemi
    Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
    Front Biosci 13:356-68. 2008
    ..In particular, exercise training is able to restore depressed contractility and calcium cycling associated with heart failure, to a value comparable to healthy individuals...
  24. doi request reprint Myocardial sarcoplasmic reticulum Ca2+ ATPase function is increased by aerobic interval training
    Ole Johan Kemi
    Institute of Biomedical and Life Sciences, University of Glasgow, UK
    Eur J Cardiovasc Prev Rehabil 15:145-8. 2008
    ..Exercise training improves myocardial Ca-handling, but SERCA-2a function is uncertain. We assessed SERCA-2a activity after exercise training...
  25. ncbi request reprint Depressed inotropic response to increased preload in rabbit hearts with left-ventricular dysfunction induced by chronic myocardial infarction
    G Andre Ng
    Deparment of Medical Cardiology, University of Glasgow, Glasgow, G12 8 QQ, UK
    Pflugers Arch 444:513-22. 2002
    ..These changes appear not to be accompanied by altered passive mechanical properties...
  26. ncbi request reprint Microfluidic partitioning of the extracellular space around single cardiac myocytes
    Norbert Klauke
    Department of Electronics, University of Glasgow, Glasgow G12 8LT, Scotland
    Anal Chem 79:1205-12. 2007
    ....
  27. ncbi request reprint Abnormal contractile activity and calcium cycling in cardiac myocytes isolated from DMPK knockout mice
    Gurman S Pall
    Division of Molecular Genetics, Faculty of Biomedical and Life Sciences, Anderson College, University of Glasgow, Scotland, United Kingdom
    Physiol Genomics 13:139-46. 2003
    ..These observations suggest dmpk has a modulatory role in the control of intracellular Ca(2+) concentration in mouse ventricular cardiomyocytes, loss of which may contribute to cardiac dysfunction in DM1...
  28. pmc Stimulation of single isolated adult ventricular myocytes within a low volume using a planar microelectrode array
    Norbert Klauke
    Department of Electronics, University of Glasgow, Glasgow, United Kingdom
    Biophys J 85:1766-74. 2003
    ..Whereas this arrangement could be used to create a screening assay for drugs, individual microchannels (100 pL) can also be used to study the effects of limited extracellular volume on the contractility of single cardiac myocytes...
  29. pmc Calcium/calmodulin-dependent protein kinase IIdelta associates with the ryanodine receptor complex and regulates channel function in rabbit heart
    Susan Currie
    Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK
    Biochem J 377:357-66. 2004
    ..These results suggest the existence of an endogenous CaMKIIdelta that associates directly with RyR2 and specifically modulates RyR2 activity...
  30. pmc Aerobic interval training enhances cardiomyocyte contractility and Ca2+ cycling by phosphorylation of CaMKII and Thr-17 of phospholamban
    Ole J Kemi
    Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Mol Cell Cardiol 43:354-61. 2007
    ..These observations indicate that calcium/calmodulin-dependent kinase IIdelta contributes significantly to the functional adaptation of the cardiomyocyte to regular exercise training...
  31. ncbi request reprint Characteristics of the in vitro hypoxic pulmonary vasoconstrictor response in isolated equine and bovine pulmonary arterial rings
    Karen E MacEachern
    University of Glasgow Veterinary School, Bearsden, Glasgow, Scotland G61 1QH, UK
    Vet Anaesth Analg 31:239-49. 2004
    ..This study compared the HPV response in isolated pulmonary artery vessels from equivalent regions of equine and bovine lung...
  32. ncbi request reprint Stimulation of isolated ventricular myocytes within an open architecture microarray
    Norbert Klauke
    Department of Elecronics and Electrical Engineering, Rankine Building, University of Glasgow, Glasgow G12 8LT, UK
    IEEE Trans Biomed Eng 52:531-8. 2005
    ....
  33. doi request reprint Sorcin modulates cardiac L-type Ca2+ current by functional interaction with the alpha1C subunit in rabbits
    Mark R Fowler
    Faculty of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, UK
    Exp Physiol 93:1233-8. 2008
    ..These data suggest that sorcin interacts with LTCC via its C-terminal domain, which alters current magnitude and tau(fast). These effects appear to be influenced by the prevailing experimental conditions...
  34. doi request reprint Onset of experimental severe cardiac fibrosis is mediated by overexpression of Angiotensin-converting enzyme 2
    Rachel Masson
    BHF GCRC, University of Glasgow, 126 University Place, Glasgow, G12 8TA United Kingdom
    Hypertension 53:694-700. 2009
    ..This study demonstrates that sustained overexpression of ACE2 in the heart in vivo leads to the onset of severe fibrosis...
  35. doi request reprint Complex modulation of L-type Ca(2+) current inactivation by sorcin in isolated rabbit cardiomyocytes
    Mark R Fowler
    University of Glasgow, UK
    Pflugers Arch 457:1049-60. 2009
    ..Under normal conditions, sorcin slows I (Ca,L) inactivation because the effects of Ca(2+)-dependant inactivation out-weigh the effects on voltage-dependant inactivation...
  36. ncbi request reprint Microfluidic systems to examine intercellular coupling of pairs of cardiac myocytes
    Norbert Klauke
    Department of Electronics, University of Glasgow, Glasgow, UK G12 8LT
    Lab Chip 7:731-9. 2007
    ..Using this platform, it is also possible to make simultaneous optical recordings (including fluorescence and cell contraction) to explore the effect of drugs on one or both cells, within the doublet...
  37. pmc cGMP signals modulate cAMP levels in a compartment-specific manner to regulate catecholamine-dependent signaling in cardiac myocytes
    Alessandra Stangherlin
    Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow, United Kingdom
    Circ Res 108:929-39. 2011
    ..cAMP and cGMP are intracellular second messengers involved in heart pathophysiology. cGMP can potentially affect cAMP signals via cGMP-regulated phosphodiesterases (PDEs)...
  38. ncbi request reprint Heterogeneity of ventricular fibrillation dominant frequency during global ischemia in isolated rabbit hearts
    Jane Caldwell
    Division of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK
    J Cardiovasc Electrophysiol 18:854-61. 2007
    ..Ventricular fibrillation (VF) studies show that ECG-dominant frequency (DF) decreases as ischemia develops. This study investigates the contribution of the principle ischemic metabolic components to this decline...
  39. ncbi request reprint Ultra-low-volume, real-time measurements of lactate from the single heart cell using microsystems technology
    Xinxia Cai
    Bioelectronics Research Centre, Department of Electronics and Electrical Engineering, University of Glasgow, UK
    Anal Chem 74:908-14. 2002
    ..We also show the use of respiratory uncouplers to simulate ischemia in the single myocyte and show that, as expected, the rate of lactate production from the hypoxic heart cell is greater than that within the normoxic healthy myocyte...
  40. ncbi request reprint The C terminus (amino acids 75-94) and the linker region (amino acids 42-54) of the Ca2+-binding protein S100A1 differentially enhance sarcoplasmic Ca2+ release in murine skinned skeletal muscle fibers
    Patrick Most
    Abteilung Innere Medizin III Kardiologie, Universitat Heidelberg, 69115 Heidelberg, Germany
    J Biol Chem 278:26356-64. 2003
    ..Thus, our data suggest that S100A1 may serve as an endogenous enhancer of SR Ca2+ release and might therefore be of physiological relevance in the process of excitation-contraction coupling in skeletal muscle...
  41. ncbi request reprint Aerobic exercise reduces cardiomyocyte hypertrophy and increases contractility, Ca2+ sensitivity and SERCA-2 in rat after myocardial infarction
    Ulrik Wisløff
    Department of Physiology and Biomedical Engineering, Norwegian University of Science and Technology, Olav Kyrres gt 3, N 7489 Trondheim, Norway
    Cardiovasc Res 54:162-74. 2002
    ....
  42. ncbi request reprint Effects of adenovirus-mediated sorcin overexpression on excitation-contraction coupling in isolated rabbit cardiomyocytes
    Tim Seidler
    Department of Cardiology and Pneumology, Georg August University Goettingen, Goettingen, Germany
    Circ Res 93:132-9. 2003
    ..The effect of sorcin overexpression on Ca2+ sparks indicates an effect on the ryanodine receptor that may also influence excitation-contraction coupling...
  43. ncbi request reprint Excessive sarcoplasmic/endoplasmic reticulum Ca2+-ATPase expression causes increased sarcoplasmic reticulum Ca2+ uptake but decreases myocyte shortening
    Nils Teucher
    Department of Cardiology and Pneumology, University of Goettingen, Goettingen, Germany
    Circulation 110:3553-9. 2004
    ..We investigated the effects of different levels of SERCA1a expression on contractility and Ca2+ cycling. We tested whether increased SERCA1a expression levels enhance myocyte contractility in a gene-dose-dependent manner...
  44. ncbi request reprint S100A1 decreases calcium spark frequency and alters their spatial characteristics in permeabilized adult ventricular cardiomyocytes
    Mirko Völkers
    Department of Internal Medicine III, Laboratory for Cardiac Stem Cell and Gene Therapy, Division of Cardiology, INF 350, University of Heidelberg, 69120 Heidelberg, Germany
    Cell Calcium 41:135-43. 2007
    ..6) remained unaltered by S100A1. Hence, we propose S100A1 as a novel inhibitory modulator of RyR2 function at diastolic Ca2+-concentrations in rabbit ventricular cardiomyocytes...
  45. ncbi request reprint Carbon monoxide levels experienced by heavy smokers impair aerobic capacity and cardiac contractility and induce pathological hypertrophy
    Anja Bye
    Department of Circulation and Medical Imaging, Faculty of Medicine, The Norwegian University of Science and Technology NTNU, Trondheim, Norway
    Inhal Toxicol 20:635-46. 2008
    ..Long-term CO exposure reduces aerobe capacity and contractile function and leads to pathological hypertrophy. Impaired Ca2 + handling and increased growth factor signaling seem to be responsible for these pathological changes...
  46. ncbi request reprint The W105G and W99G sorcin mutants demonstrate the role of the D helix in the Ca(2+)-dependent interaction with annexin VII and the cardiac ryanodine receptor
    Gianni Colotti
    Consiglio Nazionale delle Ricerche, Institute of Molecular Biology and Pathology, Department of Biochemical Sciences A Rossi Fanelli, University of Rome La Sapienza, 00185 Rome, Italy
    Biochemistry 45:12519-29. 2006
    ..The same activation process may apply to other PEF proteins in view of the D helix conservation...
  47. ncbi request reprint Nitric oxide synthase type-1 modulates cardiomyocyte contractility and calcium handling: association with low intrinsic aerobic capacity
    Morten A Høydal
    Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, St Olavs Hospital, Trondheim, Norway
    Eur J Cardiovasc Prev Rehabil 14:319-25. 2007
    ..Our working hypothesis was that NOS-1 modulates cardiomyocyte contractility more markedly in rat lines with low versus high congenital aerobic fitness...
  48. ncbi request reprint Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study
    Ulrik Wisløff
    Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Olav Kyrres gt 9, 7489 Trondheim, Norway
    Circulation 115:3086-94. 2007
    ..Our objective was to compare training programs with moderate versus high exercise intensity with regard to variables associated with cardiovascular function and prognosis in patients with postinfarction heart failure...
  49. ncbi request reprint Negative inotropy of the gastric proton pump inhibitor pantoprazole in myocardium from humans and rabbits: evaluation of mechanisms
    Wolfgang Schillinger
    Herzzentrum, Kardiologie und Pneumologie, Georg August Universitaet Goettingen, Robert Koch Strasse 40, 37099 Goettingen, Germany
    Circulation 116:57-66. 2007
    ..Proton pump inhibitors are used extensively for acid-related gastrointestinal diseases. Their effect on cardiac contractility has not been assessed directly...
  50. ncbi request reprint Overexpression of FK-506 binding protein 12.0 modulates excitation contraction coupling in adult rabbit ventricular cardiomyocytes
    Tim Seidler
    Department of Cardiology and Pneumology, Georg August University Goettingen, Germany
    Circ Res 101:1020-9. 2007
    ..6 isomer. In conclusion, FKBP12.0-RyR2 interaction can regulate the gain of excitation-contraction coupling...
  51. ncbi request reprint How does thrombolysis increase defibrillation success?
    Jane Cochrane Caldwell
    Med Hypotheses 68:1183-4. 2007
  52. ncbi request reprint Electrical coupling of fibroblasts and myocytes: relevance for cardiac propagation
    Peter Kohl
    University Laboratory of Physiology, OX1 3PT Oxford, UK
    J Electrocardiol 38:45-50. 2005
    ..This article reviews the currently available experimental and theoretical evidence on the previous scenarios, and highlights areas for further research...