George Davey Smith

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. ncbi request reprint Association of C-reactive protein with blood pressure and hypertension: life course confounding and mendelian randomization tests of causality
    George Davey Smith
    Department of Social Medicine, University of Bristol, Bristol, UK
    Arterioscler Thromb Vasc Biol 25:1051-6. 2005
  2. pmc The applicability of measures of socioeconomic position to different ethnic groups within the UK
    Margaret Kelaher
    Centre for Health Policy, Programs and Economics, School of Population Health, University of Melbourne, 207 Bouverie St, Carlton Vic 3010, Australia
    Int J Equity Health 8:4. 2009
  3. pmc Differentials and income-related inequalities in maternal depression during the first two years after childbirth: birth cohort studies from Brazil and the UK
    Alicia Matijasevich
    Post Graduate Programme in Epidemiology, Federal University of Pelotas, RS, Brazil
    Clin Pract Epidemiol Ment Health 5:12. 2009
  4. pmc Socioeconomic position and overweight among adolescents: data from birth cohort studies in Brazil and the UK
    Alicia Matijasevich
    Post Graduate Programme in Epidemiology, Federal University of Pelotas, RS, Brazil
    BMC Public Health 9:105. 2009
  5. pmc Inverse association between gastroesophageal reflux and blood pressure: results of a large community based study
    Liam J Murray
    Bolton Hospitals NHS Trust, Bolton, UK
    BMC Gastroenterol 8:10. 2008
  6. pmc Leg length, insulin resistance, and coronary heart disease risk: the Caerphilly Study
    G D Smith
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    J Epidemiol Community Health 55:867-72. 2001
  7. ncbi request reprint Offspring birth weight and parental mortality: prospective observational study and meta-analysis
    George Davey Smith
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Am J Epidemiol 166:160-9. 2007
  8. ncbi request reprint Challenges and novel approaches in the epidemiological study of early life influences on later disease
    George Davey Smith
    Department of Social Medicine, University of Bristol, Canynge Hall, Bristol, UK
    Adv Exp Med Biol 646:1-14. 2009
  9. pmc Capitalizing on Mendelian randomization to assess the effects of treatments
    George Davey Smith
    MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol
    J R Soc Med 100:432-5. 2007
  10. pmc Health inequalities in Britain: continuing increases up to the end of the 20th century
    George Davey-Smith
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    J Epidemiol Community Health 56:434-5. 2002

Detail Information

Publications225 found, 100 shown here

  1. ncbi request reprint Association of C-reactive protein with blood pressure and hypertension: life course confounding and mendelian randomization tests of causality
    George Davey Smith
    Department of Social Medicine, University of Bristol, Bristol, UK
    Arterioscler Thromb Vasc Biol 25:1051-6. 2005
    ..C-reactive protein (CRP) has repeatedly been associated with blood pressure and prevalent and incident hypertension, but whether a causal link exists is uncertain...
  2. pmc The applicability of measures of socioeconomic position to different ethnic groups within the UK
    Margaret Kelaher
    Centre for Health Policy, Programs and Economics, School of Population Health, University of Melbourne, 207 Bouverie St, Carlton Vic 3010, Australia
    Int J Equity Health 8:4. 2009
    ..ethnic groups:1) Differences in response rate to conventional socioeconomic indicators2) Cultural and social differences in economic priorities/opportunities3) Differences in housing quality, assets and debt within socioeconomic strata..
  3. pmc Differentials and income-related inequalities in maternal depression during the first two years after childbirth: birth cohort studies from Brazil and the UK
    Alicia Matijasevich
    Post Graduate Programme in Epidemiology, Federal University of Pelotas, RS, Brazil
    Clin Pract Epidemiol Ment Health 5:12. 2009
    ....
  4. pmc Socioeconomic position and overweight among adolescents: data from birth cohort studies in Brazil and the UK
    Alicia Matijasevich
    Post Graduate Programme in Epidemiology, Federal University of Pelotas, RS, Brazil
    BMC Public Health 9:105. 2009
    ..The patterns of overweight/obesity differ by age, sex, rural or urban residence and socioeconomic position (SEP) and vary between and within countries...
  5. pmc Inverse association between gastroesophageal reflux and blood pressure: results of a large community based study
    Liam J Murray
    Bolton Hospitals NHS Trust, Bolton, UK
    BMC Gastroenterol 8:10. 2008
    ..In a cross-sectional community based study, as part of a randomised controlled trial of eradication of Helicobacter pylori infection, the association between blood pressure and symptoms of gastro-oesophageal reflux was examined...
  6. pmc Leg length, insulin resistance, and coronary heart disease risk: the Caerphilly Study
    G D Smith
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    J Epidemiol Community Health 55:867-72. 2001
    ..The mechanism for this association is not well understood, however, and this was investigated by examining components of stature, cardiovascular disease risk factors and subsequent coronary heart disease in a prospective study...
  7. ncbi request reprint Offspring birth weight and parental mortality: prospective observational study and meta-analysis
    George Davey Smith
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Am J Epidemiol 166:160-9. 2007
    ..The stronger association in mothers is consistent with intergenerational effects on intrauterine growth and with the fetal origins hypothesis...
  8. ncbi request reprint Challenges and novel approaches in the epidemiological study of early life influences on later disease
    George Davey Smith
    Department of Social Medicine, University of Bristol, Canynge Hall, Bristol, UK
    Adv Exp Med Biol 646:1-14. 2009
    ..Other epidemiological strategies are briefly reviewed. It is concluded that the naïve acceptance of findings utilising conventional epidemiological methods in this setting is misplaced...
  9. pmc Capitalizing on Mendelian randomization to assess the effects of treatments
    George Davey Smith
    MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol
    J R Soc Med 100:432-5. 2007
  10. pmc Health inequalities in Britain: continuing increases up to the end of the 20th century
    George Davey-Smith
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    J Epidemiol Community Health 56:434-5. 2002
  11. pmc Lactase persistence-related genetic variant: population substructure and health outcomes
    George Davey Smith
    MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, UK
    Eur J Hum Genet 17:357-67. 2009
    ..19 (0.87, 1.64). The lactase persistence variant could contribute to the examination of data for the existence of, and then statistical control for, population substructure in genetic association studies...
  12. pmc Clustered environments and randomized genes: a fundamental distinction between conventional and genetic epidemiology
    George Davey Smith
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    PLoS Med 4:e352. 2007
    ....
  13. ncbi request reprint Strengthening causal inference in cardiovascular epidemiology through Mendelian randomization
    George Davey Smith
    MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, UK
    Ann Med 40:524-41. 2008
    ..We present examples of the use of the Mendelian randomization approach and discuss both the limitations and potentials of this strategy...
  14. ncbi request reprint Folate supplementation and cardiovascular disease
    George Davey Smith
    Department of Social Medicine, University of Bristol, Bristol BS8 2PR, UK
    Lancet 366:1679-81. 2005
  15. ncbi request reprint Life-course approaches to inequalities in adult chronic disease risk
    George Davey Smith
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    Proc Nutr Soc 66:216-36. 2007
    ....
  16. ncbi request reprint Associations of folate, vitamin B12, homocysteine, and folate-pathway polymorphisms with prostate-specific antigen velocity in men with localized prostate cancer
    Simon M Collin
    School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
    Cancer Epidemiol Biomarkers Prev 19:2833-8. 2010
    ..We investigated whether these and other elements of folate metabolism were associated with prostate-specific antigen (PSA) velocity (PSAV) as a proxy measure of prostate cancer progression in men with localized prostate cancer...
  17. pmc The methylenetetrahydrofolate reductase C677T genotype and the risk of obesity in three large population-based cohorts
    Sarah J Lewis
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS82PR, UK
    Eur J Endocrinol 159:35-40. 2008
    ..We sought to determine whether MTHFR C677T genotype was associated with obesity...
  18. pmc Independent associations of fasting insulin, glucose, and glycated haemoglobin with stroke and coronary heart disease in older women
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    PLoS Med 4:e263. 2007
    ..Our aim was to determine the independent associations of fasting insulin, glucose, and glycated haemoglobin with coronary heart disease and stroke in older women...
  19. pmc Is infant weight associated with childhood blood pressure? Analysis of the Promotion of Breastfeeding Intervention Trial (PROBIT) cohort
    Kate Tilling
    Department of Social Medicine, University of Bristol, Bristol, UK
    Int J Epidemiol 40:1227-37. 2011
    ..We examined associations between weight gain in infancy and early childhood and blood pressure at the age of 6.5 years in healthy children born at term...
  20. pmc What are the causal effects of breastfeeding on IQ, obesity and blood pressure? Evidence from comparing high-income with middle-income cohorts
    Marie Jo A Brion
    MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, UK
    Int J Epidemiol 40:670-80. 2011
    ..This is applied to assessing causal effects of breastfeeding on child blood pressure (BP), body mass index (BMI) and intelligence quotient (IQ)...
  21. ncbi request reprint Breast-feeding and cancer: the Boyd Orr cohort and a systematic review with meta-analysis
    Richard M Martin
    Department of Social Medicine, University of Bristol, Canynge Hall, Bristol BS8 2PR, United Kingdom
    J Natl Cancer Inst 97:1446-57. 2005
    ..We investigated associations between breast-feeding during infancy and adult cancer incidence and mortality in a cohort study and meta-analyses of published studies...
  22. pmc Maternal smoking during pregnancy and offspring trajectories of height and adiposity: comparing maternal and paternal associations
    Laura D Howe
    MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK
    Int J Epidemiol 41:722-32. 2012
    ..Causality for obesity is not established. Causality is well-supported for birth length, but evidence on persistence of height deficits is inconsistent...
  23. ncbi request reprint Physical activity and blood pressure in childhood: findings from a population-based study
    Sam D Leary
    Department of Oral and Dental Science, University of Bristol, 24 Tyndall Avenue, Bristol, BS8 1TQ UK
    Hypertension 51:92-8. 2008
    ..03 (95% CI -0.54, 0.48) mm Hg per 15 minutes/d MVPA. In conclusion, higher levels of PA were associated with lower BP, and results suggested that the volume of activity may be more important than the intensity...
  24. ncbi request reprint The association of insulin-like-growth factor 1 (IGF-1) with incident coronary heart disease in women: findings from the prospective British Women's Heart and Health Study
    Debbie A Lawlor
    MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, BS8 2PR, ul, UK
    Atherosclerosis 201:198-204. 2008
    ..To examine the association of insulin-like-growth factor 1 (IGF-1) with coronary heart disease (CHD) in women...
  25. doi request reprint Socioeconomic disparities in trajectories of adiposity across childhood
    Laura D Howe
    Department of Social Medicine, University of Bristol, UK
    Int J Pediatr Obes 6:e144-53. 2011
    ..Socioeconomic inequalities in obesity are consistently observed in high-income countries. The development of such inequalities across childhood; however, has not been studied using longitudinal data...
  26. pmc Circulating folate, vitamin B12, homocysteine, vitamin B12 transport proteins, and risk of prostate cancer: a case-control study, systematic review, and meta-analysis
    Simon M Collin
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Cancer Epidemiol Biomarkers Prev 19:1632-42. 2010
    ..Disturbed folate metabolism is associated with an increased risk of some cancers. Our objective was to determine whether blood levels of folate, vitamin B(12), and related metabolites were associated with prostate cancer risk...
  27. pmc Effects of promoting longer-term and exclusive breastfeeding on cardiometabolic risk factors at age 11.5 years: a cluster-randomized, controlled trial
    Richard M Martin
    School of Social and Community Medicine, University of Bristol, Bristol, UK R M M, R P, Y F, G D S Medical Research Council University of Bristol Integrated Epidemiology Unit, University of Bristol, Bristol, UK R M M, G D S National Institute for Health Research, Bristol Biomedical Research Unit in Nutrition, Bristol, UK R M M Departments of Pediatrics and of Epidemiology, Biostatistics, and Occupational Health, McGill University Faculty of Medicine, Montreal, Canada M S K National Research and Applied Medicine Mother and Child Centre, Minsk, Belarus K V, N B, N S, N G Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, UK T P and Obesity Prevention Program, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA J T, M W G, E O
    Circulation 129:321-9. 2014
    ..We investigated the effects of an experimental intervention to promote increased duration of exclusive breastfeeding on cardiometabolic risk factors in childhood...
  28. pmc Vitamin B-12 status during pregnancy and child's IQ at age 8: a Mendelian randomization study in the Avon longitudinal study of parents and children
    Carolina Bonilla
    School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
    PLoS ONE 7:e51084. 2012
    ..Our findings suggest that maternal vitamin B-12 may not have an important effect on offspring cognitive ability. However, further examination of this issue is warranted...
  29. pmc Maternal and offspring fasting glucose and type 2 diabetes-associated genetic variants and cognitive function at age 8: a Mendelian randomization study in the Avon Longitudinal Study of Parents and Children
    Carolina Bonilla
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    BMC Med Genet 13:90. 2012
    ..These associations could be explained by confounding...
  30. doi request reprint Genome-wide prediction of childhood asthma and related phenotypes in a longitudinal birth cohort
    Ben D Spycher
    School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
    J Allergy Clin Immunol 130:503-9.e7. 2012
    ..Childhood wheezing and asthma vary greatly in clinical presentation and time course. The extent to which phenotypic variation reflects heterogeneity in disease pathways is unclear...
  31. pmc Objectively measured physical activity and fat mass in a large cohort of children
    Andy R Ness
    Department of Oral and Dental Science, University of Bristol, United Kingdom
    PLoS Med 4:e97. 2007
    ..Previous studies have been unable to characterise the association between physical activity and obesity, possibly because most relied on inaccurate measures of physical activity and obesity...
  32. ncbi request reprint Leptin and coronary heart disease risk: prospective case control study of British women
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    Obesity (Silver Spring) 15:1694-701. 2007
    ..Our objective was to examine the association of serum leptin levels with CHD in a prospective study of women...
  33. pmc IQ, educational attainment, memory and plasma lipids: associations with apolipoprotein E genotype in 5995 children
    Amy E Taylor
    MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, UK
    Biol Psychiatry 70:152-8. 2011
    ..Although there is also evidence of milder cognitive impairment in later life in carriers of the APOE ε4 allele, there have been few studies investigating the impact of APOE genotype on cognitive function in children...
  34. ncbi request reprint Parents' growth in childhood and the birth weight of their offspring
    Richard M Martin
    Department of Social Medicine, University of Bristol, Bristol, UK
    Epidemiology 15:308-16. 2004
    ..We investigated the influence of the childhood growth of the mother or father on the birth weight of their first-born offspring...
  35. pmc Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with spinal BMD in 9-year-old children
    Colin D Steer
    Department of Community Based Medicine, University of Bristol, Bristol, United Kingdom
    J Bone Miner Res 24:117-24. 2009
    ..To the extent that these findings reflect known influences of C677T MTHFR genotype on plasma homocysteine levels, our results suggest that the latter is an important regulator of spinal BMD in childhood...
  36. pmc Homogeneous assay of rs4343, an ACE I/D proxy, and an analysis in the British Women's Heart and Health Study (BWHHS)
    Mohammad Reza Abdollahi
    Bristol Genetic Epidemiology Laboratory, University of Bristol, No 24 Tyndall Avenue, Bristol, BS8 1TQ, UK
    Dis Markers 24:11-7. 2008
    ..Liquid phase genotyping of SNP rs4343 may be preferable to gel based ACE I/D genotyping both for technical and functional reasons...
  37. pmc The association between irregular menstruations and acne with asthma and atopy phenotypes
    Bruna Galobardes
    School of Social and Community Medicine, University of Bristol, Bristol, UK
    Am J Epidemiol 176:733-7. 2012
    ..In summary, the authors found evidence for a potentially etiologic role of irregular menstruations with some specific asthma phenotypes, namely, atopic asthma and atopy, but not with nonatopic asthma...
  38. pmc Adult height variants affect birth length and growth rate in children
    Lavinia Paternoster
    MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK
    Hum Mol Genet 20:4069-75. 2011
    ..SNPs associated with adult height influence birth length and have an increasing effect on growth from late infancy through to late childhood. By age 10, they explain half the height variance (∼5%) of that explained in adults (∼10%)...
  39. ncbi request reprint Interleukin-6 and incident coronary heart disease: results from the British Women's Heart and Health Study
    Abigail Fraser
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    Atherosclerosis 202:567-72. 2009
    ..The purpose of this study was to determine whether IL-6 is associated with incident coronary heart disease (CHD) events independently of established risk factors and to examine its predictive ability for future CHD events...
  40. pmc Socio-economic position and adiposity among children and their parents in the Republic of Belarus
    Rita Patel
    Department of Social Medicine, University of Bristol, Bristol, UK
    Eur J Public Health 21:158-65. 2011
    ..Socio-economic differences in the prevalence of overweight/obesity may be one factor through which health inequalities arise and may vary by the population studied...
  41. pmc Exploring the developmental overnutrition hypothesis using parental-offspring associations and FTO as an instrumental variable
    Debbie A Lawlor
    Medical Research Council Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom
    PLoS Med 5:e33. 2008
    ..If true, this would result in the obesity epidemic progressing across generations irrespective of environmental or genetic changes. It is therefore important to robustly test this hypothesis...
  42. pmc Association between childhood socioeconomic status and coronary heart disease risk among postmenopausal women: findings from the British Women's Heart and Health Study
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Rd, Bristol, England
    Am J Public Health 94:1386-92. 2004
    ..We assessed the association between childhood socioeconomic status (SES) and coronary heart disease among postmenopausal women...
  43. ncbi request reprint Gamma-glutamyltransferase is associated with incident vascular events independently of alcohol intake: analysis of the British Women's Heart and Health Study and Meta-Analysis
    Abigail Fraser
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Rd, Bristol BS8 2PR, UK
    Arterioscler Thromb Vasc Biol 27:2729-35. 2007
    ..Alanine aminotransferase (ALT) is the enzyme most closely associated with liver fat content...
  44. ncbi request reprint Birth weight; postnatal, infant, and childhood growth; and obesity in young adulthood: evidence from the Barry Caerphilly Growth Study
    Anne McCarthy
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Am J Clin Nutr 86:907-13. 2007
    ..Birth weight has been shown to be positively associated with adult obesity, but relatively few studies have examined the associations with growth in specific periods of early childhood...
  45. ncbi request reprint Similar associations of parental prenatal smoking suggest child blood pressure is not influenced by intrauterine effects
    Marie Jo A Brion
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, United Kingdom
    Hypertension 49:1422-8. 2007
    ..36 to 0.87; P=0.4 fully adjusted), providing further evidence that differences in child blood pressure observed in minimally adjusted models are not because of a biological influence of maternal smoking on the intrauterine environment...
  46. ncbi request reprint Lack of emergence of associations between selected maternal exposures and offspring blood pressure at age 15 years
    Sam D Leary
    Lifecourse Epidemiology and Population Oral Health Research Group, School of Oral and Dental Sciences, University of Bristol, Bristol, UK
    J Epidemiol Community Health 67:320-6. 2013
    ..A recent review found little evidence for substantial effects of modifiable maternal exposures on offspring blood pressure (BP), but this may have been because almost all the studies reported on BP in early and mid-childhood...
  47. ncbi request reprint Maternal anemia, iron intake in pregnancy, and offspring blood pressure in the Avon Longitudinal Study of Parents and Children
    Marie Jo A Brion
    MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, UK
    Am J Clin Nutr 88:1126-33. 2008
    ..Studies in pregnant women are limited in number, have had inconsistent results, and have not accounted for maternal iron supplementation...
  48. ncbi request reprint Genetic association study of BDNF in depression: finding from two cohort studies and a meta-analysis
    Lina Chen
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 147:814-21. 2008
    ..89-1.26, P = 0.537) comparing MM with VV genotypes and an OR of 0.97 (95% CI: 0.89-1.05, P = 0.403) comparing MV with VV genotypes. Our findings suggest that BDNF genotype does not exert a major influence on the development of depression...
  49. pmc Smoking during pregnancy and offspring fat and lean mass in childhood
    Sam D Leary
    Department of Community Based Medicine, University of Bristol, 24, Tyndall Avenue, Bristol, BS8 1TQ, United Kingdom
    Obesity (Silver Spring) 14:2284-93. 2006
    ..This study examined the association between maternal and partner smoking during pregnancy and offspring total fat, truncal fat, and lean mass in childhood...
  50. pmc Association of maternal weight gain in pregnancy with offspring obesity and metabolic and vascular traits in childhood
    Abigail Fraser
    Medical Research Council Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, UK
    Circulation 121:2557-64. 2010
    ..We sought to examine the association of gestational weight gain (GWG) and prepregnancy weight with offspring adiposity and cardiovascular risk factors...
  51. ncbi request reprint Height, leg length, and cancer: the Caerphilly Study
    David Gunnell
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    Nutr Cancer 47:34-9. 2003
    ..05; 0.94-1.18). Height-cancer associations were strongest for lung cancer (HR 1.21; 0.96-1.51). This analysis provides limited support for the suggestion that leg length is the component of height underlying height-cancer associations..
  52. pmc Complexity of a complex trait locus: HP, HPR, haemoglobin and cholesterol
    Philip A I Guthrie
    Bristol Genetic Epidemiology Laboratory BGEL, MRC Centre for Causal Analyses in Translational Epidemiology MRC CAiTE, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Clifton BS8 2BN, UK
    Gene 499:8-13. 2012
    ....
  53. pmc Genome-wide association study of three-dimensional facial morphology identifies a variant in PAX3 associated with nasion position
    Lavinia Paternoster
    MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, UK
    Am J Hum Genet 90:478-85. 2012
    ..Our findings show that common variants within this gene also influence normal craniofacial development...
  54. pmc Socioeconomic differences in childhood growth trajectories: at what age do height inequalities emerge?
    Laura D Howe
    MRC Centre for Causal Analyses in Translational Epidemiology, Oakfield House, Oakfield Grove, Bristol BS8 2BN, UK
    J Epidemiol Community Health 66:143-8. 2012
    ..Socioeconomic differentials in adult height are frequently observed, but the age at which these inequalities emerge and the patterns they follow through childhood are unknown...
  55. pmc Social inequalities in height: persisting differences today depend upon height of the parents
    Bruna Galobardes
    School of Social and Community Medicine, Causal Analysis in Translation Epidemiology Centre, University of Bristol, Bristol, United Kingdom
    PLoS ONE 7:e29118. 2012
    ..The objective of this study is to investigate inequalities in height in a cohort of children born in the early 1990s in England, and to evaluate which factors might explain any identified inequalities...
  56. doi request reprint Using genetic loci to understand the relationship between adiposity and psychological distress: a Mendelian Randomization study in the Copenhagen General Population Study of 53,221 adults
    Debbie A Lawlor
    MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, UK
    J Intern Med 269:525-37. 2011
    ..We used genetic variants that are robustly associated with adiposity to examine the causal association of adiposity with psychological distress...
  57. pmc Obstetrician-assessed maternal health at pregnancy predicts offspring future health
    Debbie A Lawlor
    MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, United Kingdom
    PLoS ONE 2:e666. 2007
    ..We aimed to examine the association between obstetrician assessment of maternal physical health at the time of pregnancy and offspring cardiovascular disease risk...
  58. ncbi request reprint Instrumental variable estimation of causal risk ratios and causal odds ratios in Mendelian randomization analyses
    Tom M Palmer
    MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
    Am J Epidemiol 173:1392-403. 2011
    ..Based on the theoretical properties of the estimators, structural mean models make weaker assumptions than other IV estimators and can therefore be expected to be consistent in a wider range of situations...
  59. pmc Relation of maternal prepregnancy body mass index with offspring bone mass in childhood: is there evidence for an intrauterine effect?
    Corrie Macdonald-Wallis
    MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, United Kingdom
    Am J Clin Nutr 92:872-80. 2010
    ..Evidence indicates that intrauterine skeletal development has implications for bone mass in later life and that maternal fat stores in pregnancy are important for fetal bone mineral accrual...
  60. ncbi request reprint Intrauterine growth and intelligence within sibling pairs: findings from the Aberdeen children of the 1950s cohort
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Pediatrics 117:e894-902. 2006
    ..The objective of this study was to examine whether the established positive association between birth weight and childhood psychometric intelligence is seen within singleton sibling pairs from the same family as well as between nonsiblings...
  61. ncbi request reprint Association between C-reactive protein genotype, circulating levels, and aortic pulse wave velocity
    Wiebke Schumacher
    MRC CAiTE Centre, University of Bristol, Bristol, UK
    Hypertension 53:150-7. 2009
    ..Further studies are needed to confirm these findings, particularly in view of the central role CRP has played in cardiovascular disease so far...
  62. ncbi request reprint The scope for biased recall of risk-factor exposure in case-control studies: evidence from a cohort study of Scottish men
    Chris Metcalfe
    Department of Social Medicine, University of Bristol, Bristol, UK
    Scand J Public Health 36:442-5. 2008
    ..Case-control studies are prone to recall bias, a participant's case-control status influencing their recall of exposure to risk factors. We aimed to demonstrate empirically the scope for this bias...
  63. doi request reprint Immediate postnatal growth is associated with blood pressure in young adulthood: the Barry Caerphilly Growth Study
    Yoav Ben-Shlomo
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Hypertension 52:638-44. 2008
    ....
  64. ncbi request reprint The association of oestrogen receptor alpha-haplotypes with cardiovascular risk factors in the British Women's Heart and Health Study
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Rd, Bristol, BS8 2PR, UK
    Eur Heart J 27:1597-604. 2006
    ..We aimed to replicate these findings in a general population sample...
  65. pmc Molecular and population analysis of natural selection on the human haptoglobin duplication
    Santiago Rodriguez
    MRC Centre for Causal Analyses in Translational Epidemiology CAiTE Bristol Genetic Epidemiology Laboratories BGEL, School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, United Kingdom
    Ann Hum Genet 76:352-62. 2012
    ..1. Taken together, our results represent the first molecular analysis of natural selection in the Hp CNV genetic region...
  66. ncbi request reprint Modifiable maternal exposures and offspring blood pressure: a review of epidemiological studies of maternal age, diet, and smoking
    Marie Jo A Brion
    Department of Social Medicine, University of Bristol, Bristol BS8 2PR, United Kingdom
    Pediatr Res 63:593-8. 2008
    ..03 to 0.21, I = 89.8%). In sum, there is little empirical evidence that the maternal exposures reviewed program offspring BP. Other components of offspring health may be more susceptible to effects of programming in utero...
  67. ncbi request reprint Hyperinsulinaemia and increased risk of breast cancer: findings from the British Women's Heart and Health Study
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    Cancer Causes Control 15:267-75. 2004
    ..To assess the association between fasting insulin levels and breast cancer...
  68. ncbi request reprint Meta-analyses of observational and genetic association studies of folate intakes or levels and breast cancer risk
    Sarah J Lewis
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    J Natl Cancer Inst 98:1607-22. 2006
    ....
  69. pmc Carrier status for the common R501X and 2282del4 filaggrin mutations is not associated with hearing phenotypes in 5,377 children from the ALSPAC cohort
    Santiago Rodriguez
    Bristol Genetic Epidemiology Laboratories BGEL, Department of Social Medicine, University of Bristol, Bristol, UK
    PLoS ONE 4:e5784. 2009
    ..Filaggrin is expressed in the tympanic membrane and could alter its mechanical properties, but the relationship between genetic variation in FLG and hearing has not yet been tested...
  70. ncbi request reprint Associations of gestational age and intrauterine growth with systolic blood pressure in a family-based study of 386,485 men in 331,089 families
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, Bristol, UK
    Circulation 115:562-8. 2007
    ..We conducted a family-based study to explore mechanisms underlying the associations of birth weight and gestational age with systolic blood pressure measured at 17 to 19 years of age...
  71. pmc A non-synonymous variant in ADH1B is strongly associated with prenatal alcohol use in a European sample of pregnant women
    Luisa Zuccolo
    Department of Social Medicine, University of Bristol, Bristol, UK
    Hum Mol Genet 18:4457-66. 2009
    ..We confirmed the established association of rs1229984 with reduced alcohol consumption over the life-course, contributing new evidence of an effect before and during pregnancy...
  72. doi request reprint Use of genotype frequencies in medicated groups to investigate prescribing practice: APOE and statins as a proof of principle
    Neil M Davies
    MRC Centre CAiTE and Bristol Genetic Epidemiology Laboratories, School of Social and Community Medicine, University of Bristol, Bristol, UK
    Clin Chem 57:502-10. 2011
    ..As an example, we hypothesized that because APOE (apolipoprotein E) alleles affect the LDL cholesterol (LDLc) concentration, APOE genotype frequencies in statin takers should act as a proxy for the prevailing treatment threshold of LDLc...
  73. ncbi request reprint Homocysteine and cerebral infarction in finnish male smokers
    Una B Fallon
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Rd, Bristol BS8 2PR, UK
    Stroke 34:1359-63. 2003
    ..Homocysteine is associated with stroke, but it is not clear whether this relationship is causal. We examined the association between total serum homocysteine concentration (tHcy) and cerebral infarction in a cohort of Finnish male smokers...
  74. pmc Changes in ponderal index and body mass index across childhood and their associations with fat mass and cardiovascular risk factors at age 15
    Laura D Howe
    MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom
    PLoS ONE 5:e15186. 2010
    ....
  75. ncbi request reprint Mendelian randomization: prospects, potentials, and limitations
    George Davey Smith
    Department of Social Medicine, Canynge Hall, Whiteladies Road, Bristol BS8 2PR
    Int J Epidemiol 33:30-42. 2004
  76. ncbi request reprint The associations between birthweight and adult markers of liver damage and function
    Abigail Fraser
    Department of Social Medicine, University of Bristol, Bristol, UK
    Paediatr Perinat Epidemiol 22:12-21. 2008
    ....
  77. ncbi request reprint Association of folate-pathway gene polymorphisms with the risk of prostate cancer: a population-based nested case-control study, systematic review, and meta-analysis
    Simon M Collin
    Department of Social Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS United Kingdom
    Cancer Epidemiol Biomarkers Prev 18:2528-39. 2009
    ..Our meta-analysis suggests that known common folate-pathway single nucleotide polymorphisms do not have significant effects on susceptibility to prostate cancer...
  78. pmc Association of insulin resistance with depression: cross sectional findings from the British Women's Heart and Health Study
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, Bristol BS8 2PR
    BMJ 327:1383-4. 2003
  79. ncbi request reprint Could associations between breastfeeding and insulin-like growth factors underlie associations of breastfeeding with adult chronic disease? The Avon Longitudinal Study of Parents and Children
    Richard M Martin
    Department of Social Medicine, University of Bristol, Bristol, UK
    Clin Endocrinol (Oxf) 62:728-37. 2005
    ..We investigated associations of having been breastfed with serum IGF-I and IGFBP-3 in childhood...
  80. pmc The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participants
    Debbie A Lawlor
    MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, Bristol, United Kingdom
    PLoS ONE 3:e3011. 2008
    ..Our objective was to examine the association between CRP genetic variant +1444C>T (rs1130864) and CHD risk in the largest study to date of this association...
  81. ncbi request reprint Early life determinants of adult blood pressure
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, Bristol, UK
    Curr Opin Nephrol Hypertens 14:259-64. 2005
    ..The purpose of this review is to provide a summary of the current evidence concerning the early life determinants of adult blood pressure...
  82. pmc Does current evidence justify prostate cancer screening in Europe?
    Richard M Martin
    Epidemiology, Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    Nat Clin Pract Oncol 2:538-9. 2005
  83. ncbi request reprint Associations of size at birth and dual-energy X-ray absorptiometry measures of lean and fat mass at 9 to 10 y of age
    Imogen S Rogers
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Am J Clin Nutr 84:739-47. 2006
    ..Birth weight has been positively associated with risk of overweight in later life. However, little information exists on how weight and length at birth are associated with subsequent lean and total body fat...
  84. ncbi request reprint Birth weight is inversely associated with incident coronary heart disease and stroke among individuals born in the 1950s: findings from the Aberdeen Children of the 1950s prospective cohort study
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, Bristol, BS8 2PR, United Kingdom
    Circulation 112:1414-8. 2005
    ....
  85. pmc Socioeconomic position and hormone replacement therapy use: explaining the discrepancy in evidence from observational and randomized controlled trials
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, Bristol BS7 8QA, UK
    Am J Public Health 94:2149-54. 2004
    ..We assessed the association between life-course socioeconomic status or position (SEP) and hormone replacement therapy (HRT)...
  86. ncbi request reprint The association of smoking and cardiovascular disease in a population with low cholesterol levels: a study of 648,346 men from the Korean national health system prospective cohort study
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, Bristol, UK
    Stroke 39:760-7. 2008
    ..The effect of smoking on stroke subtypes is particularly unclear...
  87. doi request reprint Parental drug use, early adversities, later childhood problems and children's use of tobacco and alcohol at age 10: birth cohort study
    John Macleod
    Department of Social Medicine, University of Bristol, Bristol, UK
    Addiction 103:1731-43. 2008
    ..To estimate the prevalence of alcohol and tobacco use among children at age 10 years and to investigate possible influences on this...
  88. ncbi request reprint Adult blood pressure and climate conditions in infancy: a test of the hypothesis that dehydration in infancy is associated with higher adult blood pressure
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, Bristol, UK
    Am J Epidemiol 163:608-14. 2006
    ..These findings provide some evidence in favor of the hypothesis that dehydration in infancy is associated with higher adult blood pressure...
  89. ncbi request reprint The fat mass- and obesity-associated locus and dietary intake in children
    Nicholas J Timpson
    MRC CAiTE Centre, Department of Social Medicine, Bristol University, Bristol, UK
    Am J Clin Nutr 88:971-8. 2008
    ..A region of chromosome 16 containing the fat mass-and obesity-associated gene (FTO) is reproducibly associated with fat mass and body mass index (BMI), risk of obesity, and adiposity...
  90. ncbi request reprint Shaving, coronary heart disease, and stroke: the Caerphilly Study
    Shah Ebrahim
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, United Kingdom
    Am J Epidemiol 157:234-8. 2003
    ..The relation with stroke events remains unexplained by smoking or social factors...
  91. ncbi request reprint Low birth weight is associated with higher adult total cholesterol concentration in men: findings from an occupational cohort of 25,843 employees
    Anna A Davies
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Rd, Bristol BS8 2PR, UK
    Circulation 110:1258-62. 2004
    ..We aimed to determine whether birth weight predicted adult TC in a large sample population...
  92. ncbi request reprint Birth weight of offspring and subsequent cardiovascular mortality of the parents
    George Davey Smith
    Department of Social Medicine, University of Bristol, Bristol, UK
    Epidemiology 16:563-9. 2005
    ..However, it has also been hypothesized that common genetic factors could underlie both restricted fetal development and disease risk (the fetal insulin hypothesis)...
  93. pmc Indigenous health and socioeconomic status in India
    S V Subramanian
    Harvard School of Public Health, Boston, Massachusetts, United States of America, 2 University of Bristol, Bristol, United Kingdom
    PLoS Med 3:e421. 2006
    ....
  94. ncbi request reprint Frequent job change and associated health
    Chris Metcalfe
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, UK
    Soc Sci Med 56:1-15. 2003
    ..However, the observed relationship between frequent job changing and a higher incidence of health risk behaviours, in the absence of a relationship with poorer health, invites further research...
  95. ncbi request reprint The association of ambient outdoor temperature throughout pregnancy and offspring birthweight: findings from the Aberdeen Children of the 1950s cohort
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, Canyage Hall, Whiteladies Road, Bristol BS7 8PR, UK
    BJOG 112:647-57. 2005
    ..We assessed the effect of mean ambient outdoor temperature during gestation on birthweight...
  96. ncbi request reprint Nutritional interventions and outcome in patients with cancer or preinvasive lesions: systematic review
    Anna A Davies
    Department of Social Medicine, University of Bristol, Lower Maudlin St, Bristol BS1 2LY, UK
    J Natl Cancer Inst 98:961-73. 2006
    ....
  97. ncbi request reprint Smoking during pregnancy and components of stature in offspring
    Sam Leary
    Unit of Paediatric and Perinatal Epidemiology, Department of Community Based Medicine, University of Bristol, Bristol BS8 1TQ, UK
    Am J Hum Biol 18:502-12. 2006
    ..Smoking at any time in pregnancy reduces offspring height and its components, and in particular leg length and leg-to-trunk ratio at age 7.5...
  98. pmc Serum cholesterol, haemorrhagic stroke, ischaemic stroke, and myocardial infarction: Korean national health system prospective cohort study
    Shah Ebrahim
    Department of Social Medicine, University of Bristol, Bristol BS8 2PR
    BMJ 333:22. 2006
    ..To investigate risk factors, such as heavy alcohol consumption, that might explain any increased risk of haemorrhagic stroke associated with low blood cholesterol...
  99. ncbi request reprint Genetic variants in the vitamin d receptor are associated with advanced prostate cancer at diagnosis: findings from the prostate testing for cancer and treatment study and a systematic review
    Lina Chen
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Cancer Epidemiol Biomarkers Prev 18:2874-81. 2009
    ..84; 95% confidence interval, 0.71-1.00; P(unadjusted) = 0.050; P(adjusted) = 0.014). Our finding provides some support for the hypothesis that low levels of vitamin D may increase the risk of prostate cancer progression...
  100. ncbi request reprint Change in job satisfaction, and its association with self-reported stress, cardiovascular risk factors and mortality
    Pauline Heslop
    Department of Social Medicine, University of Bristol, UK
    Soc Sci Med 54:1589-99. 2002
    ..There was also no evidence to suggest that men or women reporting job dissatisfaction on one occasion or on two occasions several years apart, had a significantly greater risk of mortality from CVD...
  101. ncbi request reprint The burden of disease associated with filaggrin mutations: a population-based, longitudinal birth cohort study
    John Henderson
    Department of Community Based Medicine, University of Bristol, Bristol, United Kingdom
    J Allergy Clin Immunol 121:872-7.e9. 2008
    ..Atopic disease is a major health problem. Mutations in the filaggrin gene (FLG) confer major susceptibility to eczema and related asthma...