G D Smith

Summary

Affiliation: University of Bristol
Country: UK

Publications

  1. pmc Smoking during pregnancy and offspring fat and lean mass in childhood
    Sam D Leary
    Department of Community Based Medicine, University of Bristol, 24, Tyndall Avenue, Bristol, BS8 1TQ, United Kingdom
    Obesity (Silver Spring) 14:2284-93. 2006
  2. pmc The association of the PON1 Q192R polymorphism with coronary heart disease: findings from the British Women's Heart and Health cohort study and a meta-analysis
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, UK
    BMC Genet 5:17. 2004
  3. pmc Birth weight of offspring and mortality in the Renfrew and Paisley study: prospective observational study
    G Davey Smith
    Department of Social Medicine, University of Bristol
    BMJ 315:1189-93. 1997
  4. ncbi request reprint Fibrinogen, C-reactive protein and coronary heart disease: does Mendelian randomization suggest the associations are non-causal?
    G Davey Smith
    Department of Social Medicine, University of Bristol, Bristol, UK
    QJM 97:163-6. 2004
  5. pmc Birth characteristics of offspring and parental diabetes: evidence for the fetal insulin hypothesis
    G Davey Smith
    Department of Social Medicine, University of Bristol, Bristol, UK
    J Epidemiol Community Health 58:126-8. 2004
  6. ncbi request reprint Does elevated plasma fibrinogen increase the risk of coronary heart disease? Evidence from a meta-analysis of genetic association studies
    George Davey Smith
    Department of Social Medicine, Canynge Hall, Bristol BS8 2PR, United Kingdom
    Arterioscler Thromb Vasc Biol 25:2228-33. 2005
  7. pmc Randomised by (your) god: robust inference from an observational study design
    George Davey Smith
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    J Epidemiol Community Health 60:382-8. 2006
  8. ncbi request reprint Screening for prostate cancer
    Stephen Frankel
    Department of Social Medicine, University of Bristol, Canynge Hall, BS8 2PR, Bristol, UK
    Lancet 361:1122-8. 2003
  9. pmc The conundrum of height and mortality
    George Davey Smith
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, BS8 2PR, UK
    West J Med 176:209. 2002
  10. ncbi request reprint Trends in resting pulse rate among students attending Glasgow University between 1948 and 1968: analyses of cross sectional surveys
    G Davey Smith
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, BS8 2PR, UK
    Int J Obes (Lond) 30:380-1. 2006

Collaborators

Detail Information

Publications148 found, 100 shown here

  1. pmc Smoking during pregnancy and offspring fat and lean mass in childhood
    Sam D Leary
    Department of Community Based Medicine, University of Bristol, 24, Tyndall Avenue, Bristol, BS8 1TQ, United Kingdom
    Obesity (Silver Spring) 14:2284-93. 2006
    ..This study examined the association between maternal and partner smoking during pregnancy and offspring total fat, truncal fat, and lean mass in childhood...
  2. pmc The association of the PON1 Q192R polymorphism with coronary heart disease: findings from the British Women's Heart and Health cohort study and a meta-analysis
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, UK
    BMC Genet 5:17. 2004
    ..We have examined the association of the PON1 Q192R polymorphism with CHD in a large cohort of British women and combined the results from our cohort study with those from all other published studies...
  3. pmc Birth weight of offspring and mortality in the Renfrew and Paisley study: prospective observational study
    G Davey Smith
    Department of Social Medicine, University of Bristol
    BMJ 315:1189-93. 1997
    ..To investigate the association between birth weight of offspring and mortality among fathers and mothers in the west of Scotland...
  4. ncbi request reprint Fibrinogen, C-reactive protein and coronary heart disease: does Mendelian randomization suggest the associations are non-causal?
    G Davey Smith
    Department of Social Medicine, University of Bristol, Bristol, UK
    QJM 97:163-6. 2004
  5. pmc Birth characteristics of offspring and parental diabetes: evidence for the fetal insulin hypothesis
    G Davey Smith
    Department of Social Medicine, University of Bristol, Bristol, UK
    J Epidemiol Community Health 58:126-8. 2004
  6. ncbi request reprint Does elevated plasma fibrinogen increase the risk of coronary heart disease? Evidence from a meta-analysis of genetic association studies
    George Davey Smith
    Department of Social Medicine, Canynge Hall, Bristol BS8 2PR, United Kingdom
    Arterioscler Thromb Vasc Biol 25:2228-33. 2005
    ..The purpose of this study was to assess whether a genetic variant associated with higher fibrinogen levels is associated with increased coronary heart disease (CHD) risk, as a test of the causal influence of fibrinogen on CHD...
  7. pmc Randomised by (your) god: robust inference from an observational study design
    George Davey Smith
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    J Epidemiol Community Health 60:382-8. 2006
  8. ncbi request reprint Screening for prostate cancer
    Stephen Frankel
    Department of Social Medicine, University of Bristol, Canynge Hall, BS8 2PR, Bristol, UK
    Lancet 361:1122-8. 2003
    ..Prostate cancer screening can be justified only in research programmes designed to assess its effectiveness and help identify the groups who may benefit...
  9. pmc The conundrum of height and mortality
    George Davey Smith
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, BS8 2PR, UK
    West J Med 176:209. 2002
  10. ncbi request reprint Trends in resting pulse rate among students attending Glasgow University between 1948 and 1968: analyses of cross sectional surveys
    G Davey Smith
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, BS8 2PR, UK
    Int J Obes (Lond) 30:380-1. 2006
    ..Evidence on long-term trends in physical activity is limited. We report that resting pulse rates--a proxy indicator of physical activity and fitness--increased among young adults attending Glasgow University between 1948 and 1968...
  11. pmc Could dehydration in infancy lead to high blood pressure?
    George Davey Smith
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    J Epidemiol Community Health 60:142-3. 2006
  12. pmc Life-course socioeconomic and behavioral influences on cardiovascular disease mortality: the collaborative study
    George Davey Smith
    Department of Social Medicine, University of Bristol, England
    Am J Public Health 92:1295-8. 2002
    ..This study sought to demonstrate life-course influences on cardiovascular disease (CVD)...
  13. ncbi request reprint Mendelian randomization: prospects, potentials, and limitations
    George Davey Smith
    Department of Social Medicine, Canynge Hall, Whiteladies Road, Bristol BS8 2PR
    Int J Epidemiol 33:30-42. 2004
  14. doi request reprint Assessing intrauterine influences on offspring health outcomes: can epidemiological studies yield robust findings?
    George Davey Smith
    MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, UK
    Basic Clin Pharmacol Toxicol 102:245-56. 2008
    ..Other epidemiological strategies are briefly reviewed. It is concluded that the naïve acceptance of findings utilizing conventional epidemiological methods in this setting is misplaced...
  15. pmc Adverse socioeconomic conditions in childhood and cause specific adult mortality: prospective observational study
    G D Smith
    Department of Social Medicine, University of Bristol, Canynge Hall, Bristol BS8 2PR
    BMJ 316:1631-5. 1998
    ..To investigate the association between social circumstances in childhood and mortality from various causes of death in adulthood...
  16. pmc Lifestyle, health, and health promotion in Nazi Germany
    George Davey Smith
    Department of Social Medicine, University of Bristol, Bristol BS8 2PR
    BMJ 329:1424-5. 2004
  17. pmc Is there an intrauterine influence on obesity? Evidence from parent child associations in the Avon Longitudinal Study of Parents and Children (ALSPAC)
    George Davey Smith
    Department of Social Medicine, University of Bristol, Bristol, UK
    Arch Dis Child 92:876-80. 2007
    ..If this mechanism is important, the association of maternal body mass index (BMI) with offspring BMI should be stronger than the association of paternal with offspring BMI...
  18. ncbi request reprint Commentary: Social capital, social epidemiology and disease aetiology
    George Davey Smith
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    Int J Epidemiol 33:691-700; discussion 705-9. 2004
  19. pmc What can mendelian randomisation tell us about modifiable behavioural and environmental exposures?
    George Davey Smith
    Department of Social Medicine, University of Bristol, Bristol BS8 2PR
    BMJ 330:1076-9. 2005
  20. ncbi request reprint Incidence of type 2 diabetes in the randomized multiple risk factor intervention trial
    George Davey Smith
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Ann Intern Med 142:313-22. 2005
    ..Weight loss and increased physical exercise reduce the risk for diabetes in people with impaired glucose tolerance. Randomized trial evidence on the effect of these interventions on people without impaired glucose tolerance is lacking...
  21. pmc Learning to live with complexity: ethnicity, socioeconomic position, and health in Britain and the United States
    G D Smith
    Department of Social Medicine, University of Bristol, England
    Am J Public Health 90:1694-8. 2000
    ..The only productive way forward is through studies that recognize the contingency of the relations between socioeconomic position, ethnicity, and particular health outcomes...
  22. ncbi request reprint Genetic epidemiology and public health: hope, hype, and future prospects
    George Davey Smith
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    Lancet 366:1484-98. 2005
    ....
  23. ncbi request reprint The incidence and aetiology of stroke in the Caerphilly and Speedwell Collaborative Studies II: risk factors for ischaemic stroke
    P McCarron
    Department of Social Medicine, University of Bristol, Bristol, UK
    Public Health 115:12-20. 2001
    ..Multivariate analyses revealed that, while there was some attenuation of the effect of social class, angina and elevated BP, the risks from atrial fibrillation and diabetes were increased...
  24. ncbi request reprint Height, leg length, and cancer: the Caerphilly Study
    David Gunnell
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    Nutr Cancer 47:34-9. 2003
    ..05; 0.94-1.18). Height-cancer associations were strongest for lung cancer (HR 1.21; 0.96-1.51). This analysis provides limited support for the suggestion that leg length is the component of height underlying height-cancer associations..
  25. pmc Homocysteine and ischaemic stroke in men: the Caerphilly study
    U B Fallon
    Department of Social Medicine, University of Bristol, Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    J Epidemiol Community Health 55:91-6. 2001
    ..To assess the risk of ischaemic stroke associated with total serum homocyst(e)ine (tHcy) concentration...
  26. ncbi request reprint Associations of size at birth and dual-energy X-ray absorptiometry measures of lean and fat mass at 9 to 10 y of age
    Imogen S Rogers
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Am J Clin Nutr 84:739-47. 2006
    ..Birth weight has been positively associated with risk of overweight in later life. However, little information exists on how weight and length at birth are associated with subsequent lean and total body fat...
  27. ncbi request reprint Early life determinants of adult blood pressure
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, Bristol, UK
    Curr Opin Nephrol Hypertens 14:259-64. 2005
    ..The purpose of this review is to provide a summary of the current evidence concerning the early life determinants of adult blood pressure...
  28. ncbi request reprint How accurately are height, weight and leg length reported by the elderly, and how closely are they related to measurements recorded in childhood?
    D Gunnell
    Department of Social Medicine, University of Bristol, Canynge Hall, Bristol, UK
    Int J Epidemiol 29:456-64. 2000
    ....
  29. pmc Ecological study of social fragmentation, poverty, and suicide
    E Whitley
    Department of Social Medicine, University of Bristol, Bristol BS8 2PR
    BMJ 319:1034-7. 1999
    ..To investigate the association between suicide and area based measures of deprivation and social fragmentation...
  30. ncbi request reprint Age at menarche: secular trends and association with adult anthropometric measures
    M Okasha
    Department of Social Medicine, University of Bristol, UK
    Ann Hum Biol 28:68-78. 2001
    ..The nature of the relationship between age at menarche and adult life anthropometric measures may be important in understanding the importance of this measure on disease in later life...
  31. ncbi request reprint The incidence and aetiology of stroke in the Caerphilly and Speedwell Collaborative Studies I: methods and incidence of events
    R Greenwood
    Department of Social Medicine, University of Bristol, Bristol, UK
    Public Health 115:4-11. 2001
    ....
  32. ncbi request reprint Shaving, coronary heart disease, and stroke: the Caerphilly Study
    Shah Ebrahim
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, United Kingdom
    Am J Epidemiol 157:234-8. 2003
    ..The relation with stroke events remains unexplained by smoking or social factors...
  33. ncbi request reprint Triglyceride as a risk factor for ischaemic heart disease in British men: effect of adjusting for measurement error
    M Egger
    Department of Social Medicine, University of Bristol, UK
    Atherosclerosis 143:275-84. 1999
    ....
  34. pmc Changes in blood pressure among students attending Glasgow University between 1948 and 1968: analyses of cross sectional surveys
    P McCarron
    Department of Social Medicine, University of Bristol, Bristol BS8 2PR, UK
    BMJ 322:885-9. 2001
    ..To examine the changes in blood pressure over time in a cohort of young adults attending university between 1948 and 1968...
  35. ncbi request reprint Homogeneous assay of rs4343, an ACE I/D proxy, and an analysis in the British Women's Heart and Health Study (BWHHS)
    Mohammad Reza Abdollahi
    Bristol Genetic Epidemiology Laboratory, University of Bristol, No 24 Tyndall Avenue, Bristol, BS8 1TQ, UK
    Dis Markers 24:11-7. 2008
    ..Liquid phase genotyping of SNP rs4343 may be preferable to gel based ACE I/D genotyping both for technical and functional reasons...
  36. ncbi request reprint Birth weight of offspring and subsequent cardiovascular mortality of the parents
    George Davey Smith
    Department of Social Medicine, University of Bristol, Bristol, UK
    Epidemiology 16:563-9. 2005
    ..However, it has also been hypothesized that common genetic factors could underlie both restricted fetal development and disease risk (the fetal insulin hypothesis)...
  37. ncbi request reprint Low birth weight is associated with higher adult total cholesterol concentration in men: findings from an occupational cohort of 25,843 employees
    Anna A Davies
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Rd, Bristol BS8 2PR, UK
    Circulation 110:1258-62. 2004
    ..We aimed to determine whether birth weight predicted adult TC in a large sample population...
  38. ncbi request reprint Population requirement for primary hip-replacement surgery: a cross-sectional study
    S Frankel
    Department of Social Medicine, University of Bristol
    Lancet 353:1304-9. 1999
    ..We set out to estimate the population requirement for primary total hip replacement in England...
  39. ncbi request reprint The socioeconomic position of employed women, risk factors and mortality
    P Heslop
    Department of Social Medicine, University of Bristol, UK
    Soc Sci Med 53:477-85. 2001
    ..Thus, a broader range of explanatory factors for mortality differentials than currently exists must be considered, and must include consideration of factors operating throughout the lifecourse...
  40. pmc Homocysteine and coronary heart disease in the Caerphilly cohort: a 10 year follow up
    U B Fallon
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Rd, Bristol BS8 2PR, UK
    Heart 85:153-8. 2001
    ..Prospective assessment of the risk of coronary heart disease associated with total serum homocyst(e)ine (homocysteine) concentration...
  41. pmc Leg length, insulin resistance, and coronary heart disease risk: the Caerphilly Study
    G D Smith
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    J Epidemiol Community Health 55:867-72. 2001
    ..The mechanism for this association is not well understood, however, and this was investigated by examining components of stature, cardiovascular disease risk factors and subsequent coronary heart disease in a prospective study...
  42. pmc Milk, coronary heart disease and mortality
    A R Ness
    Department of Social Medicine, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    J Epidemiol Community Health 55:379-82. 2001
    ..To study the association between reported milk consumption and cardiovascular and all cause mortality...
  43. doi request reprint Association between C-reactive protein genotype, circulating levels, and aortic pulse wave velocity
    Wiebke Schumacher
    MRC CAiTE Centre, University of Bristol, Bristol, UK
    Hypertension 53:150-7. 2009
    ..Further studies are needed to confirm these findings, particularly in view of the central role CRP has played in cardiovascular disease so far...
  44. doi request reprint The burden of disease associated with filaggrin mutations: a population-based, longitudinal birth cohort study
    John Henderson
    Department of Community Based Medicine, University of Bristol, Bristol, United Kingdom
    J Allergy Clin Immunol 121:872-7.e9. 2008
    ..Atopic disease is a major health problem. Mutations in the filaggrin gene (FLG) confer major susceptibility to eczema and related asthma...
  45. ncbi request reprint Change in job satisfaction, and its association with self-reported stress, cardiovascular risk factors and mortality
    Pauline Heslop
    Department of Social Medicine, University of Bristol, UK
    Soc Sci Med 54:1589-99. 2002
    ..There was also no evidence to suggest that men or women reporting job dissatisfaction on one occasion or on two occasions several years apart, had a significantly greater risk of mortality from CVD...
  46. ncbi request reprint The association between mother and child MTHFR C677T polymorphisms, dietary folate intake and childhood atopy in a population-based, longitudinal birth cohort
    R Granell
    ALSPAC, Department of Social Medicine, University of Bristol, Bristol, UK
    Clin Exp Allergy 38:320-8. 2008
    ..A recent study suggested a link between folate metabolism and atopy, based on a positive association between a common polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene and allergic sensitization in Danish adults...
  47. pmc Screening for chlamydial infections and the risk of ectopic pregnancy in a county in Sweden: ecological analysis
    M Egger
    Department of Social Medicine, University of Bristol, Bristol BS8 2PR
    BMJ 316:1776-80. 1998
    ..To analyse trends in rates of genital chlamydial infection and ectopic pregnancy between 1985 and 1995 in a county in Sweden...
  48. ncbi request reprint The long-term effect of dietary advice on the diet of men with angina: the diet and angina randomized trial
    A R Ness
    Unit of Paediatric and Perinatal Epidemiology, University of Bristol, Bristol, UK
    J Hum Nutr Diet 17:117-9. 2004
    ..The long-term effects on diet of dietary advice to eat fruit and vegetables or fatty fish are not well described...
  49. doi request reprint The association of smoking and cardiovascular disease in a population with low cholesterol levels: a study of 648,346 men from the Korean national health system prospective cohort study
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, Bristol, UK
    Stroke 39:760-7. 2008
    ..The effect of smoking on stroke subtypes is particularly unclear...
  50. ncbi request reprint Associations of gestational age and intrauterine growth with systolic blood pressure in a family-based study of 386,485 men in 331,089 families
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, Bristol, UK
    Circulation 115:562-8. 2007
    ..We conducted a family-based study to explore mechanisms underlying the associations of birth weight and gestational age with systolic blood pressure measured at 17 to 19 years of age...
  51. pmc Association of maternal weight gain in pregnancy with offspring obesity and metabolic and vascular traits in childhood
    Abigail Fraser
    Medical Research Council Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, UK
    Circulation 121:2557-64. 2010
    ..We sought to examine the association of gestational weight gain (GWG) and prepregnancy weight with offspring adiposity and cardiovascular risk factors...
  52. ncbi request reprint The association of socio-economic position across the life course and age at menopause: the British Women's Heart and Health Study
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, Bristol, UK
    BJOG 110:1078-87. 2003
    ..To assess the association of indicators of adverse socio-economic position from across the life course with age at menopause...
  53. ncbi request reprint Increasing mortality differentials by residential area level of poverty: Britain 1981-1997
    M Shaw
    School of Geographical Sciences, University of Bristol, UK
    Soc Sci Med 51:151-3. 2000
    ..A commitment to redistributive social policies is necessary if the trend of increasing inequality is to be reversed...
  54. ncbi request reprint Promotion of condom use in a high-risk setting in Nicaragua: a randomised controlled trial
    M Egger
    Department of Social Medicine, University of Bristol, UK
    Lancet 355:2101-5. 2000
    ..In Latin America, motels rent rooms for commercial and non-commercial sex. We investigated the impact of providing health-education material and condoms on condom use in Managua, Nicaragua...
  55. ncbi request reprint Uses and abuses of meta-analysis
    M Egger
    Department of Social Medicine, University of Bristol
    Clin Med 1:478-84. 2001
    ..We argue that meta-analysis should be performed only within the framework of systematic reviews--that is, reviews prepared using a systematic approach to minimise bias and address the combinability of studies...
  56. ncbi request reprint Cardiovascular risk and hormone replacement therapy
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, Bristol, UK
    Curr Opin Obstet Gynecol 18:658-65. 2006
    ..The purpose of this review is to summarize the studies in humans of the relationship between hormone replacement therapy and coronary heart disease and stroke...
  57. ncbi request reprint Meta-analyses of observational and genetic association studies of folate intakes or levels and breast cancer risk
    Sarah J Lewis
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    J Natl Cancer Inst 98:1607-22. 2006
    ....
  58. ncbi request reprint The publication process itself was the major cause of publication bias in genetic epidemiology
    Michael Calnan
    Medical Research Councils Health Services Research Collaboration, UK
    J Clin Epidemiol 59:1312-8. 2006
    ..How do scientists in the field of genetic epidemiology see the problem of publication bias, what are the possible solutions and what particular pressures are they under that might either promote or prevent publication and other biases?..
  59. ncbi request reprint Epidemiologic evidence for the fetal overnutrition hypothesis: findings from the mater-university study of pregnancy and its outcomes
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, Bristol, UK
    Am J Epidemiol 165:418-24. 2007
    ..0001). In sensitivity analyses taking account of different plausible levels of nonpaternity (up to 15%), the greater maternal effect remained. These findings provide some support for the fetal overnutrition hypothesis...
  60. ncbi request reprint The association of oestrogen receptor alpha-haplotypes with cardiovascular risk factors in the British Women's Heart and Health Study
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Rd, Bristol, BS8 2PR, UK
    Eur Heart J 27:1597-604. 2006
    ..We aimed to replicate these findings in a general population sample...
  61. pmc Does current evidence justify prostate cancer screening in Europe?
    Richard M Martin
    Epidemiology, Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    Nat Clin Pract Oncol 2:538-9. 2005
  62. ncbi request reprint Association between birth weight and blood pressure is robust, amplifies with age, and may be underestimated
    Anna A Davies
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Rd, Bristol, BS8 2PR, United Kingdom
    Hypertension 48:431-6. 2006
    ....
  63. ncbi request reprint Similar associations of parental prenatal smoking suggest child blood pressure is not influenced by intrauterine effects
    Marie Jo A Brion
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, United Kingdom
    Hypertension 49:1422-8. 2007
    ..36 to 0.87; P=0.4 fully adjusted), providing further evidence that differences in child blood pressure observed in minimally adjusted models are not because of a biological influence of maternal smoking on the intrauterine environment...
  64. pmc A non-synonymous variant in ADH1B is strongly associated with prenatal alcohol use in a European sample of pregnant women
    Luisa Zuccolo
    Department of Social Medicine, University of Bristol, Bristol, UK
    Hum Mol Genet 18:4457-66. 2009
    ..We confirmed the established association of rs1229984 with reduced alcohol consumption over the life-course, contributing new evidence of an effect before and during pregnancy...
  65. doi request reprint Associations between the ability to detect a bitter taste, dietary behavior, and growth: a preliminary report
    Jean Golding
    Centre for Child and Adolescent Health, University of Bristol, Bristol, United Kingdom
    Ann N Y Acad Sci 1170:553-7. 2009
    ..Children who were tasters (75% of sample) were slightly more likely to have been described as fussy eaters than the nontasters, and the supertasters were more likely to be in the lowest height decile at age 10...
  66. ncbi request reprint Maternal anemia, iron intake in pregnancy, and offspring blood pressure in the Avon Longitudinal Study of Parents and Children
    Marie Jo A Brion
    MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, UK
    Am J Clin Nutr 88:1126-33. 2008
    ..Studies in pregnant women are limited in number, have had inconsistent results, and have not accounted for maternal iron supplementation...
  67. pmc Lactase persistence-related genetic variant: population substructure and health outcomes
    George Davey Smith
    MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, UK
    Eur J Hum Genet 17:357-67. 2009
    ..19 (0.87, 1.64). The lactase persistence variant could contribute to the examination of data for the existence of, and then statistical control for, population substructure in genetic association studies...
  68. doi request reprint Parental drug use, early adversities, later childhood problems and children's use of tobacco and alcohol at age 10: birth cohort study
    John Macleod
    Department of Social Medicine, University of Bristol, Bristol, UK
    Addiction 103:1731-43. 2008
    ..To estimate the prevalence of alcohol and tobacco use among children at age 10 years and to investigate possible influences on this...
  69. doi request reprint The scope for biased recall of risk-factor exposure in case-control studies: evidence from a cohort study of Scottish men
    Chris Metcalfe
    Department of Social Medicine, University of Bristol, Bristol, UK
    Scand J Public Health 36:442-5. 2008
    ..Case-control studies are prone to recall bias, a participant's case-control status influencing their recall of exposure to risk factors. We aimed to demonstrate empirically the scope for this bias...
  70. ncbi request reprint Is Mendelian randomization 'lost in translation?': comments on 'Mendelian randomization equals instrumental variable analysis with genetic instruments' by Wehby et al
    Debbie A Lawlor
    MRC Centre for Causal Analysis in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol BS8 2PR, UK
    Stat Med 27:2750-5. 2008
  71. pmc The methylenetetrahydrofolate reductase C677T genotype and the risk of obesity in three large population-based cohorts
    Sarah J Lewis
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS82PR, UK
    Eur J Endocrinol 159:35-40. 2008
    ..We sought to determine whether MTHFR C677T genotype was associated with obesity...
  72. doi request reprint Modifiable maternal exposures and offspring blood pressure: a review of epidemiological studies of maternal age, diet, and smoking
    Marie Jo A Brion
    Department of Social Medicine, University of Bristol, Bristol BS8 2PR, United Kingdom
    Pediatr Res 63:593-8. 2008
    ..03 to 0.21, I = 89.8%). In sum, there is little empirical evidence that the maternal exposures reviewed program offspring BP. Other components of offspring health may be more susceptible to effects of programming in utero...
  73. doi request reprint The association of insulin-like-growth factor 1 (IGF-1) with incident coronary heart disease in women: findings from the prospective British Women's Heart and Health Study
    Debbie A Lawlor
    MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, BS8 2PR, ul, UK
    Atherosclerosis 201:198-204. 2008
    ..To examine the association of insulin-like-growth factor 1 (IGF-1) with coronary heart disease (CHD) in women...
  74. doi request reprint Childhood stature and adult cancer risk: the Boyd Orr cohort
    Elise Whitley
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, BS8 2PR, England, UK
    Cancer Causes Control 20:243-51. 2009
    ..8+ years). There was no evidence that any of the five indicators of childhood growth was more strongly related to cancer risk than the other measures...
  75. pmc Intrauterine effects of maternal prepregnancy overweight on child cognition and behavior in 2 cohorts
    Marie Jo Brion
    MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, United Kingdom
    Pediatrics 127:e202-11. 2011
    ..However, few studies of humans have explored this, and it is unclear if intrauterine mechanisms or confounding factors drive these associations...
  76. ncbi request reprint Gamma-glutamyltransferase is associated with incident vascular events independently of alcohol intake: analysis of the British Women's Heart and Health Study and Meta-Analysis
    Abigail Fraser
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Rd, Bristol BS8 2PR, UK
    Arterioscler Thromb Vasc Biol 27:2729-35. 2007
    ..Alanine aminotransferase (ALT) is the enzyme most closely associated with liver fat content...
  77. ncbi request reprint Birth weight; postnatal, infant, and childhood growth; and obesity in young adulthood: evidence from the Barry Caerphilly Growth Study
    Anne McCarthy
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Am J Clin Nutr 86:907-13. 2007
    ..Birth weight has been shown to be positively associated with adult obesity, but relatively few studies have examined the associations with growth in specific periods of early childhood...
  78. ncbi request reprint Life-course approaches to inequalities in adult chronic disease risk
    George Davey Smith
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    Proc Nutr Soc 66:216-36. 2007
    ....
  79. doi request reprint Association of folate-pathway gene polymorphisms with the risk of prostate cancer: a population-based nested case-control study, systematic review, and meta-analysis
    Simon M Collin
    Department of Social Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS United Kingdom
    Cancer Epidemiol Biomarkers Prev 18:2528-39. 2009
    ..Our meta-analysis suggests that known common folate-pathway single nucleotide polymorphisms do not have significant effects on susceptibility to prostate cancer...
  80. ncbi request reprint A meta-analysis of the MTHFR C677T polymorphism and schizophrenia risk
    Sarah J Lewis
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Am J Med Genet B Neuropsychiatr Genet 135:2-4. 2005
    ..Larger studies of this issue are required, together with studies of maternal genotype which could identify whether maternal folate status during pregnancy is important...
  81. pmc Association between childhood socioeconomic status and coronary heart disease risk among postmenopausal women: findings from the British Women's Heart and Health Study
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Rd, Bristol, England
    Am J Public Health 94:1386-92. 2004
    ..We assessed the association between childhood socioeconomic status (SES) and coronary heart disease among postmenopausal women...
  82. ncbi request reprint Does the misreporting of adult body size depend upon an individual's height and weight? Methodological debate
    David Gunnell
    Department of Social Medicine, University of Bristol, Bristol BS8 2PR, UK
    Int J Epidemiol 33:1398-9. 2004
  83. ncbi request reprint Hyperinsulinaemia and increased risk of breast cancer: findings from the British Women's Heart and Health Study
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, UK
    Cancer Causes Control 15:267-75. 2004
    ..To assess the association between fasting insulin levels and breast cancer...
  84. ncbi request reprint Access to health care resources in the UK: the case of care for arthritis
    Carol Propper
    Department of Economics and CMPO, University of Bristol, Bristol, UK
    Health Econ 14:391-406. 2005
    ..The results also show the importance of the interaction between the public and private sectors in the UK...
  85. ncbi request reprint Subgroup analyses in randomized trials: risks of subgroup-specific analyses; power and sample size for the interaction test
    Sara T Brookes
    Department of Social Medicine, University of Bristol, Whiteladies Road, Bristol, BS8 2PR, UK
    J Clin Epidemiol 57:229-36. 2004
    ..Moreover, trials designed to detect overall treatment effects have limited power to detect treatment-subgroup interactions. This article quantifies the error rates associated with subgroup analyses...
  86. pmc Poverty, child undernutrition and morbidity: new evidence from India
    Shailen Nandy
    School for Policy Studies, University of Bristol, Bristol, England
    Bull World Health Organ 83:210-6. 2005
    ....
  87. ncbi request reprint Could associations between breastfeeding and insulin-like growth factors underlie associations of breastfeeding with adult chronic disease? The Avon Longitudinal Study of Parents and Children
    Richard M Martin
    Department of Social Medicine, University of Bristol, Bristol, UK
    Clin Endocrinol (Oxf) 62:728-37. 2005
    ..We investigated associations of having been breastfed with serum IGF-I and IGFBP-3 in childhood...
  88. ncbi request reprint Breast-feeding and childhood cancer: A systematic review with metaanalysis
    Richard M Martin
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    Int J Cancer 117:1020-31. 2005
    ..Our estimates suggest that increasing breast-feeding from 50% to 100% would prevent at most 5% of cases of childhood acute leukemia or lymphoma. (c) 2005 Wiley-Liss, Inc...
  89. ncbi request reprint Alcohol, ALDH2, and esophageal cancer: a meta-analysis which illustrates the potentials and limitations of a Mendelian randomization approach
    Sarah J Lewis
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol BS8 2PR, United Kingdom
    Cancer Epidemiol Biomarkers Prev 14:1967-71. 2005
    ..The two different processes operating as a result of the ALDH2 genotype have implications for the interpretation of studies using the Mendelian randomization paradigm...
  90. ncbi request reprint The relation between birth weight and intima-media thickness in middle-aged adults
    Kate Tilling
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Road, Bristol, UK
    Epidemiology 15:557-64. 2004
    ..Here, we investigate the relation between reported birth weight and atherosclerosis in middle age...
  91. ncbi request reprint Is the association between parity and coronary heart disease due to biological effects of pregnancy or adverse lifestyle risk factors associated with child-rearing? Findings from the British Women's Heart and Health Study and the British Regional Heart St
    Debbie A Lawlor
    Department of Social Medicine, University of Bristol, Bristol, UK
    Circulation 107:1260-4. 2003
    ..Parity is associated with coronary heart disease (CHD) risk. In the present study, we assessed the associations between number of children and CHD in both women and men...
  92. ncbi request reprint Breast-feeding and cancer: the Boyd Orr cohort and a systematic review with meta-analysis
    Richard M Martin
    Department of Social Medicine, University of Bristol, Canynge Hall, Bristol BS8 2PR, United Kingdom
    J Natl Cancer Inst 97:1446-57. 2005
    ..We investigated associations between breast-feeding during infancy and adult cancer incidence and mortality in a cohort study and meta-analyses of published studies...
  93. ncbi request reprint Homocysteine and cerebral infarction in finnish male smokers
    Una B Fallon
    Department of Social Medicine, University of Bristol, Canynge Hall, Whiteladies Rd, Bristol BS8 2PR, UK
    Stroke 34:1359-63. 2003
    ..Homocysteine is associated with stroke, but it is not clear whether this relationship is causal. We examined the association between total serum homocysteine concentration (tHcy) and cerebral infarction in a cohort of Finnish male smokers...
  94. pmc Association of COMT Val(108/158)Met genotype and cigarette smoking in pregnant women
    Marcus R Munafo
    School of Experimental Psychology, University of Bristol, 12a Priory Road, Bristol BS8 1TU, UK
    Nicotine Tob Res 13:55-63. 2011
    ..While the COMT gene is therefore one of the more promising candidate genes for smoking behavior, some inconsistencies have begun to emerge...
  95. ncbi request reprint Infant nutrition and blood pressure in early adulthood: the Barry Caerphilly Growth study
    Richard M Martin
    Department of Social Medicine, University of Bristol, United Kingdom
    Am J Clin Nutr 77:1489-97. 2003
    ..Evidence suggests that environmental factors acting early in life may affect blood pressure in adulthood...
  96. doi request reprint Strengthening causal inference in cardiovascular epidemiology through Mendelian randomization
    George Davey Smith
    MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, UK
    Ann Med 40:524-41. 2008
    ..We present examples of the use of the Mendelian randomization approach and discuss both the limitations and potentials of this strategy...
  97. ncbi request reprint Physical activity and blood pressure in childhood: findings from a population-based study
    Sam D Leary
    Department of Oral and Dental Science, University of Bristol, 24 Tyndall Avenue, Bristol, BS8 1TQ UK
    Hypertension 51:92-8. 2008
    ..03 (95% CI -0.54, 0.48) mm Hg per 15 minutes/d MVPA. In conclusion, higher levels of PA were associated with lower BP, and results suggested that the volume of activity may be more important than the intensity...
  98. pmc Clustered environments and randomized genes: a fundamental distinction between conventional and genetic epidemiology
    George Davey Smith
    Department of Social Medicine, University of Bristol, Bristol, United Kingdom
    PLoS Med 4:e352. 2007
    ....
  99. doi request reprint The associations between birthweight and adult markers of liver damage and function
    Abigail Fraser
    Department of Social Medicine, University of Bristol, Bristol, UK
    Paediatr Perinat Epidemiol 22:12-21. 2008
    ....
  100. pmc Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism is associated with spinal BMD in 9-year-old children
    Colin D Steer
    Department of Community Based Medicine, University of Bristol, Bristol, United Kingdom
    J Bone Miner Res 24:117-24. 2009
    ..To the extent that these findings reflect known influences of C677T MTHFR genotype on plasma homocysteine levels, our results suggest that the latter is an important regulator of spinal BMD in childhood...
  101. ncbi request reprint Parents' growth in childhood and the birth weight of their offspring
    Richard M Martin
    Department of Social Medicine, University of Bristol, Bristol, UK
    Epidemiology 15:308-16. 2004
    ..We investigated the influence of the childhood growth of the mother or father on the birth weight of their first-born offspring...