Research Topics
Genomes and GenesSpecies | G C S SmithSummaryAffiliation: University of Cambridge Country: UK Publications
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Publications
Expression of gastrin-releasing peptide is increased by prolonged stretch of human myometrium, and antagonists of its receptor inhibit contractilityMark Tattersall
Department of Obstetrics and Gynaecology, University of Cambridge, The Rosie Hospital, Cambridge, UK
J Physiol 590:2081-93. 2012..Incubation of myometrium with GRP receptor antagonists attenuates the effect of stretch. GRP may be a target for novel therapies to reduce the risk of preterm birth in multiple pregnancy...- Risk of placenta previa in second birth after first birth cesarean section: a population-based study and meta-analysisIpek Gurol-Urganci
Department of Health Services Research and Policy, London School of Hygiene and Tropical Medicine, London, UK
BMC Pregnancy Childbirth 11:95. 2011..Objective: To compare the risk of placenta previa at second birth among women who had a cesarean section (CS) at first birth with women who delivered vaginally... - Causes of death and associated conditions (Codac): a utilitarian approach to the classification of perinatal deathsJ Frederik Frøen
Department of Genes and Environment, Division of Epidemiology, Norwegian Institute of Public Health, Nydalen, Oslo, Norway
BMC Pregnancy Childbirth 9:22. 2009..The appropriately applied Codac system promises to better manage information on causes of perinatal deaths, the conditions associated with them, and the most common clinical scenarios for future study and comparisons... - Study protocol. A prospective cohort study of unselected primiparous women: the pregnancy outcome prediction studyDharmintra Pasupathy
Department of Obstetrics and Gynaecology, University of Cambridge, Cambridge, UK
BMC Pregnancy Childbirth 8:51. 2008..Here, we report a study design where the primary aim is to generate clinically useful methods to screen women to assess their risk of adverse pregnancy outcome... 
Maternal and biochemical predictors of antepartum stillbirth among nulliparous women in relation to gestational age of fetal deathG C S Smith
Department of Obstetrics and Gynaecology, Cambridge University, Rosie Maternity Hospital, Cambridge, UK
BJOG 114:705-14. 2007..To determine whether maternal serum levels of alphafetoprotein (alpha-FP) and human chorionic gonadotrophin (hCG) at 15-21 weeks provided clinically useful prediction of stillbirth in first pregnancies...- Birth order of twins and risk of perinatal death related to delivery in England, Northern Ireland, and Wales, 1994-2003: retrospective cohort studyGordon C S Smith
Department of Obstetrics and Gynaecology, Cambridge University, Box 223, The Rosie Hospital, Cambridge CB2 2QQ
BMJ 334:576. 2007..To determine the effect of birth order on the risk of perinatal death in twin pregnancies... - Maternal uterine artery Doppler flow velocimetry and the risk of stillbirthGordon C S Smith
Department of Obstetrics and Gynaecology, Cambridge University, Rosie Maternity Hospital, Cambridge, UK
Obstet Gynecol 109:144-51. 2007..We sought to relate the risk of antepartum stillbirth to uterine artery Doppler flow velocimetry at 22-24 weeks... - Maternal obesity in early pregnancy and risk of spontaneous and elective preterm deliveries: a retrospective cohort studyGordon C S Smith
Department of Obstetrics and Gynaecology, Cambridge University, Rosie Maternity Hospital, Cambridge, England
Am J Public Health 97:157-62. 2007..We sought to determine the association between maternal body mass index and risk of preterm delivery... - Predicting antepartum stillbirthGordon C S Smith
Obstetrics and Gynaecology, Cambridge University, Cambridge, UK
Curr Opin Obstet Gynecol 18:625-30. 2006..Rates of stillbirth in the developed world have been static or rising in recent years. Clinical prediction of stillbirth risk may allow interventional studies... - Previous preeclampsia, preterm delivery, and delivery of a small for gestational age infant and the risk of unexplained stillbirth in the second pregnancy: a retrospective cohort study, Scotland, 1992-2001Gordon C S Smith
Department of Obstetrics and Gynaecology, Cambridge University, The Rosie Hospital, Cambridge, UK
Am J Epidemiol 165:194-202. 2007..63, 9.32). Associations were stronger with SGA unexplained stillbirths. The authors conclude that complicated first births of liveborn infants are associated with an increased risk of unexplained stillbirth in the next pregnancy... - Maternal and biochemical predictors of spontaneous preterm birth among nulliparous women: a systematic analysis in relation to the degree of prematurityGordon C S Smith
Department of Obstetrics and Gynaecology, Cambridge University, Cambridge, CB2 2QQ, UK
Int J Epidemiol 35:1169-77. 2006..However, it is unclear whether these associations are strong enough to offer clinically useful prediction. It is also unclear whether the predictive power of these factors varies in relation to the degree of prematurity... - First cesarean birth and subsequent fertilityGordon C S Smith
Department of Obstetrics, Cambridge University, Cambridge, United Kingdom
Fertil Steril 85:90-5. 2006..To determine whether cesarean delivery is independently associated with later subfertility... - Predicting the risk for sudden infant death syndrome from obstetric characteristics: a retrospective cohort study of 505,011 live birthsGordon C S Smith
Department of Obstetrics and Gynaecology, Cambridge University, Cambridge, United Kingdom
Pediatrics 117:60-6. 2006..We sought to develop a simple robust method for assessing the risk for sudden infant death syndrome (SIDS) on the basis of obstetric characteristics... - Circulating angiogenic factors in early pregnancy and the risk of preeclampsia, intrauterine growth restriction, spontaneous preterm birth, and stillbirthGordon C S Smith
Department of Obstetrics and Gynaecology, Cambridge University, Cambridge, United Kingdom
Obstet Gynecol 109:1316-24. 2007..To estimate the relationship between maternal serum levels of placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) in early pregnancy with the risk of subsequent adverse outcome... - StillbirthGordon C S Smith
Department of Obstetrics and Gynaecology, Cambridge University, Cambridge, UK
Lancet 370:1715-25. 2007.... 
Cervical length at mid-pregnancy and the risk of primary cesarean deliveryGordon C S Smith
Department of Obstetrics and Gynaecology, Cambridge University, Cambridge, United Kingdom
N Engl J Med 358:1346-53. 2008..We hypothesized that a long cervix in mid-pregnancy would be associated with an increased risk of cesarean delivery during labor at term...- Disruption of paraoxonase 3 impairs proliferation and antioxidant defenses in human A549 cells and causes embryonic lethality in miceSarah L Kempster
Department of Obstetrics and Gynaecology, University of Cambridge, Cambridge, UK
Am J Physiol Endocrinol Metab 302:E103-7. 2012..008) but not 2% oxygen. We conclude that the absence of Pon3 in mice resulted in increased rates of early fetal and neonatal death. Knockdown of PON3 in human cells reduced cell proliferation and total antioxidant capacity... - Recurrent miscarriage is associated with a family history of ischaemic heart disease: a retrospective cohort studyG C S Smith
Department of Obstetrics and Gynaecology, Cambridge University, Rosie Maternity Hospital, Cambridge, UK
BJOG 118:557-63. 2011..To determine whether women experiencing recurrent miscarriage were more likely to have a family history of cardiovascular disease... - Predicting antepartum stillbirthGordon C S Smith
Obstetrics and Gynaecology, Cambridge University, Rosie Maternity Hospital, Cambridge, United Kingdom
Clin Obstet Gynecol 53:597-606. 2010..This review summarizes a number of factors which identify women at increased risk of stillbirth, including maternal characteristics, blood tests, and biophysical tests... - Caesarean section and risk of unexplained stillbirth in subsequent pregnancyGordon C S Smith
Department of Obstetrics and Gynaecology, Cambridge University, Cambridge, UK
Lancet 362:1779-84. 2003..We aimed to establish whether previous caesarean delivery is associated with an increased risk of antepartum stillbirth... - Birth weight and the risk of cardiovascular disease in the maternal grandparentsGordon C S Smith
Department of Obstetrics and Gynaecology, University of Cambridge, The Rosie Hospital, Cambridge CB2 0SW, UK
Am J Epidemiol 171:736-44. 2010..Familial aggregation of common determinants of pregnancy complications and cardiovascular disease is the likely explanation for the relation between an infant's birth weight and the risk of cardiovascular disease in other family members... - The perinatal implications of angiogenic factorsGordon C S Smith
Department of Obstetrics and Gynaecology, Cambridge University and NIHR Cambridge Comprehensive Biomedical Research Centre, Cambridge, UK
Curr Opin Obstet Gynecol 21:111-6. 2009..To summarize recent findings relating maternal circulating levels of proteins associated with angiogenesis and the outcome of pregnancy... - Age at menarche and the risk of operative first deliveryG C S Smith
Department of Obstetrics and Gynaecology, Cambridge University, Cambridge, UK
BJOG 116:1613-21. 2009..The aim of this study was to test a prediction from the hypothesis, namely, that the risk of operative first delivery would decline with later age at menarche... - The effect of delaying childbirth on primary cesarean section ratesGordon C S Smith
Department of Obstetrics and Gynaecology, Cambridge University, The Rosie Hospital, Cambridge, United Kingdom
PLoS Med 5:e144. 2008.... - Neonatal outcomes with caesarean delivery at termDharmintra Pasupathy
Department of Obstetrics and Gynaecology, Cambridge University, Rosie Maternity Hospital, Cambridge CB2 2SW, UK
Arch Dis Child Fetal Neonatal Ed 93:F174-5. 2008 - Pregnancy-associated plasma protein A and alpha-fetoprotein and prediction of adverse perinatal outcomeGordon C S Smith
Department of Obstetrics and Gynaecology, Cambridge University, Cambridge, United Kingdom
Obstet Gynecol 107:161-6. 2006..To describe the association between pregnancy associated plasma protein A (PAPP-A), alpha-fetoprotein (AFP) and adverse perinatal outcome... - Sudden infant death syndrome and complications in other pregnanciesGordon C S Smith
Department of Obstetrics and Gynaecology, Cambridge University, Rosie Hospital, Cambridge CB2 2SW, UK
Lancet 366:2107-11. 2005..We postulated that women whose infants died from SIDS would be more likely to have had obstetric complications in their other pregnancies... - Estimating risks of perinatal deathGordon C S Smith
Department of Obstetrics and Gynaecology, Cambridge University, Cambridge, UK
Am J Obstet Gynecol 192:17-22. 2005.... - Combined logistic and Bayesian modeling of cesarean section riskGordon C S Smith
Department of Obstetrics and Gynaecology, Cambridge University, Box 223, The Rosie Hospital, Robinson Way, Cambridge, CB2 2QQ, United Kingdom
Am J Obstet Gynecol 191:2029-34. 2004..This study was undertaken to develop a simple and robust method for predicting risk of cesarean section... - Neonatal respiratory morbidity at term and the risk of childhood asthmaG C S Smith
Department of Obstetrics and Gynaecology, Cambridge University, Cambridge, UK
Arch Dis Child 89:956-60. 2004..To determine whether neonatal respiratory morbidity at term is associated with an increased risk of later asthma and whether this may explain previously described associations between caesarean delivery and asthma... - Second-trimester maternal serum levels of alpha-fetoprotein and the subsequent risk of sudden infant death syndromeGordon C S Smith
Department of Obstetrics and Gynaecology, Cambridge University, Cambridge, United Kingdom
N Engl J Med 351:978-86. 2004..It is unknown whether alpha-fetoprotein levels also predict the risk of SIDS... - First trimester origins of fetal growth impairmentGordon C S Smith
Department of Obstetrics and Gynaecology, Rosie Maternity Hospital, Cambridge University, UK
Semin Perinatol 28:41-50. 2004..These analyses suggest that in some women complications of late pregnancy have their origins in the very earliest weeks of gestation and precede first attendance for prenatal care... - Parachute use to prevent death and major trauma related to gravitational challenge: systematic review of randomised controlled trialsGordon C S Smith
Department of Obstetrics and Gynaecology, Cambridge University, Cambridge CB2 2QQ
BMJ 327:1459-61. 2003..To determine whether parachutes are effective in preventing major trauma related to gravitational challenge... - Interpregnancy interval and risk of preterm birth and neonatal death: retrospective cohort studyGordon C S Smith
Department of Obstetrics and Gynaecology, Cambridge University, Box The Rosie Hospital, Cambridge CB2 2QQ
BMJ 327:313. 2003..To determine whether a short interval between pregnancies is an independent risk factor for adverse obstetric outcome... - Risk of sudden infant death syndrome and week of gestation of term birthGordon C S Smith
Department of Obstetrics and Gynaecology, Cambridge University, Rosie Maternity Hospital, United Kingdom
Pediatrics 111:1367-71. 2003..We sought to determine if the risk of sudden infant death syndrome (SIDS) varied according to week of delivery at term among elective and nonelective births... - Spontaneous loss of early pregnancy and risk of ischaemic heart disease in later life: retrospective cohort studyGordon C S Smith
Department of Obstetrics and Gynaecology, Cambridge University, Box 223, The Rosie Hospital, Cambridge CB2 2QQ
BMJ 326:423-4. 2003 - Birth order, gestational age, and risk of delivery related perinatal death in twins: retrospective cohort studyGordon C S Smith
Department of Obstetrics and Gynaecology, Rosie Maternity Hospital, Cambridge CB2 2QQ
BMJ 325:1004. 2002..To determine whether twins born second are at increased risk of perinatal death because of complications during labour and delivery... - Factors predisposing to perinatal death related to uterine rupture during attempted vaginal birth after caesarean section: retrospective cohort studyGordon C S Smith
Department of Obstetrics and Gynaecology, Cambridge University, Cambridge CB2 2QQ
BMJ 329:375. 2004..To determine the factors associated with an increased risk of perinatal death related to uterine rupture during attempted vaginal birth after caesarean section... - Early-pregnancy origins of low birth weightGordon C S Smith
Department of Obstetrics and Gynaecology, University of Cambridge, The Rosie Hospital, Robinson Way, Cambridge CB2 2QQ, UK
Nature 417:916. 2002 - Risk of perinatal death associated with labor after previous cesarean delivery in uncomplicated term pregnanciesGordon C S Smith
Department of Obstetrics and Gynaecology, Cambridge University, Rosie Maternity Hospital, Cambridge, CB2 2QQ, England
JAMA 287:2684-90. 2002..However, no reliable data exist on the effect of a trial of labor on the risk of perinatal death in otherwise uncomplicated term pregnancies... - Early pregnancy levels of pregnancy-associated plasma protein a and the risk of intrauterine growth restriction, premature birth, preeclampsia, and stillbirthGordon C S Smith
Department of Obstetrics and Gynaecology, Cambridge University, CB2 2QQ, United Kingdom
J Clin Endocrinol Metab 87:1762-7. 2002..PAPP-A has been identified as a protease specific for IGF binding proteins. We conclude that control of the IGF system in the first and early second trimester trophoblast may have a key role in determining subsequent pregnancy outcome... - Predicting cesarean section and uterine rupture among women attempting vaginal birth after prior cesarean sectionGordon C S Smith
Department of Obstetrics and Gynaecology, Cambridge University, Cambridge, United Kingdom
PLoS Med 2:e252. 2005.... - First-trimester placentation and the risk of antepartum stillbirthGordon C S Smith
Department of Obstetrics and Gynaecology, Cambridge University and Rosie Hospital, Cambridge, England
JAMA 292:2249-54. 2004..Preterm birth and low birth weight are determined, at least in part, during the first trimester of pregnancy. However, it is unknown whether the risk of stillbirth is also determined during the first trimester... - The analysis of factors predicting antepartum stillbirthD Pasupathy
Department of Obstetrics and Gynaecology, Addenbrookes NHS Trust, Cambridge, UK
Minerva Ginecol 57:397-410. 2005..Future research in unexplained stillbirth should be directed towards developing better predictive tests to identify women at high risk and the evaluation of interventions in large scale trials... - Mode of delivery and the risk of delivery-related perinatal death among twins at term: a retrospective cohort study of 8073 birthsGordon C S Smith
Department of Obstetrics and Gynaecology, Cambridge University, UK
BJOG 112:1139-44. 2005..This is principally due to reducing the risk of death of the second twin due to intrapartum anoxia... - Time trend in the risk of delivery-related perinatal and neonatal death associated with breech presentation at termDharmintra Pasupathy
Department of Obstetrics and Gynaecology, Cambridge University, Cambridge CB2 2QQ, UK
Int J Epidemiol 38:490-8. 2009.... - Obstetric and neonatal outcomes in apparently isolated mild fetal ventriculomegalyAndrew C G Breeze
Fetal Medicine Service, Addenbrooke's Hospital, Cambridge, UK
J Perinat Med 33:236-40. 2005..Of the 11 infants with antenatal resolution of ventriculomegaly, 2 have delayed development. The infant with progressive ventriculomegaly has severe developmental problems... - Rates of and factors associated with delivery-related perinatal death among term infants in ScotlandDharmintra Pasupathy
Department of Obstetrics and Gynaecology, University of Cambridge, Cambridge CB2 2SW, England
JAMA 302:660-8. 2009..It is, however, unclear if this has been paralleled by decreased rates of perinatal and neonatal death associated with complications of labor at term... - Characterization of serotonin receptors in pregnant human myometriumYolande Cordeaux
University of Cambridge, Department of Obstetrics and Gynaecology, Level 2, The Rosie Hospital Addenbrooke s Box 223, Robinson Way, Cambridge CB22SW, UK
J Pharmacol Exp Ther 328:682-91. 2009..This study provides strong evidence for the expression of contractile 5-HT(2A) receptors in pregnant human myometrium, and this receptor is a potential target for novel uterotonic therapies... - Effects of medroxyprogesterone acetate on gene expression in myometrial explants from pregnant womenYolande Cordeaux
Department of Obstetrics and Gynaecology, University of Cambridge, Box 223, Cambridge CB2 0SW, United Kingdom
J Clin Endocrinol Metab 95:E437-47. 2010..Progesterone is important physiologically and therapeutically to maintain uterine quiescence during pregnancy, in part through controlling myometrial gene expression... - Time of birth and risk of neonatal death at term: retrospective cohort studyDharmintra Pasupathy
Department of Obstetrics and Gynaecology, University of Cambridge, and NIHR Cambridge Comprehensive Biomedical Research Centre, Cambridge CB2 2SW
BMJ 341:c3498. 2010..To determine the effect of time and day of birth on the risk of neonatal death at term... - Developmental control of the Nlrp6 inflammasome and a substrate, IL-18, in mammalian intestineSarah L Kempster
Dept of Obstetrics and Gynaecology, Univ of Cambridge, Box 223, Cambridge, CB2 0SW, United Kingdom
Am J Physiol Gastrointest Liver Physiol 300:G253-63. 2011.... - Stimulation of contractions in human myometrium by serotonin is unmasked by smooth muscle relaxantsYolande Cordeaux
Department of Obstetrics and Gynaecology, University of Cambridge, The Rosie Hospital, Cambridge, UK
Reprod Sci 15:727-34. 2008..The aim of this study was to investigate the ability of serotonin to increase contractions in human myometrium... - Postmortem fetal organ volumetry using magnetic resonance imaging and comparison to organ weights at conventional autopsyA C G Breeze
Division of Maternal Fetal Medicine, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke s Hospital, Hills Road, Cambridge, UK
Ultrasound Obstet Gynecol 31:187-93. 2008..We examined the feasibility of using postmortem MRI to provide estimates of organ size and weight... - Localization and control of expression of VEGF-A and the VEGFR-2 receptor in fetal sheep intestinesKatrina Holmes
Department of Obstetrics and Gynecology, University of Cambridge, Cambridge, CB2 2QQ, UK
Pediatr Res 63:143-8. 2008..These data show that intestinal VEGF-A is up-regulated with advancing gestation in a glucocorticoid-dependent manner--novel findings consistent with a role for VEGF-A stimulated angiogenesis in preparing the fetal gut for birth... - Paraoxonase-3, a putative circulating antioxidant, is systemically up-regulated in late gestation in the fetal rat, sheep, and humanGusztav Belteki
Department of Obstetrics and Gynaecology, University of Cambridge, and Neonatal Intensive Care Unit, Addenbrooke s Hospital, Box 223, Cambridge CB2 0SW, United Kingdom
J Clin Endocrinol Metab 95:3798-805. 2010..Although prematurity is associated with oxidative stress, no effective antioxidant therapy has yet been identified... - Advanced maternal age and the risk of perinatal death due to intrapartum anoxia at termDharmintra Pasupathy
Department of Obstetrics and Gynaecology, University of Cambridge, Cambridge, UK
J Epidemiol Community Health 65:241-5. 2011..However, the effect of maternal age on the risk of perinatal death due to these complications is unclear. The aim of the present study was to determine the association between maternal age and delivery-related perinatal death at term... - Doppler flow velocimetry in the superior mesenteric artery on the first day of life in preterm infants and the risk of neonatal necrotizing enterocolitisEdile M Murdoch
Neonatal Intensive Care Unit, Addenbrooke s Hospital, Cambridge, United Kingdom
Pediatrics 118:1999-2003. 2006..The purpose of this work was to relate Doppler indices of splanchnic perfusion and vascular resistance to the risk of developing necrotizing enterocolitis... - An integrated model for the prediction of pre-eclampsia using maternal factors and uterine artery Doppler velocimetry in unselected low-risk womenChristina K H Yu
Am J Obstet Gynecol 195:330. 2006 - An integrated model for the prediction of preeclampsia using maternal factors and uterine artery Doppler velocimetry in unselected low-risk womenChristina K H Yu
Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, Denmark Hill, London, UK
Am J Obstet Gynecol 193:429-36. 2005..The purpose of this study was to develop a predictive model for preeclampsia... - Outcomes associated with a trial of labor after prior cesarean deliveryGordon C S Smith
N Engl J Med 352:1718-20; author reply 1718-20. 2005 - Fetal growth in early pregnancy and risk of delivering low birth weight infant: prospective cohort studyRadek Bukowski
Department of Obstetrics and Gynecology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA
BMJ 334:836. 2007..To determine if first trimester fetal growth is associated with birth weight, duration of pregnancy, and the risk of delivering a small for gestational age infant... - Individualized norms of optimal fetal growth: fetal growth potentialRadek Bukowski
Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas 77555, USA
Obstet Gynecol 111:1065-76. 2008..To demonstrate that individualized optimal fetal growth norms, accounting for physiologic and pathologic determinants of fetal growth, better identify normal and abnormal outcomes of pregnancy than existing methods... - Re: "A proportional hazards model with time-dependent covariates and time-varying effects for analysis of fetal and infant death"Gordon C S Smith
Am J Epidemiol 161:100; author reply 100-1. 2005 - Pregnancy complications and subsequent maternal cerebrovascular events: a retrospective cohort study of 119,668 birthsJill P Pell
Greater Glasgow National Health Service Board, Department of Public Health, Glasgow, United Kingdom
Am J Epidemiol 159:336-42. 2004.... - Parachute use to prevent death and major trauma related to gravitational challenge: systematic review of [randomized] controlled trialsGordon C S Smith
J Int Assoc Physicians AIDS Care (Chic Ill) 3:108-9. 2004 - Perinatal death in twins. Author's reply on absolute riskGordon C S Smith
BMJ 334:762. 2007 - Congenital anomalies after treatment for infertilitySoo-Mi Park
BMJ 333:665-6. 2006 - Estimating human fetal blood volume on the basis of gestational age and fetal abdominal circumferenceGordon C S Smith
Fetal Medicine Unit, The Queen Mother's Hospital, Yorkhill, Glasgow, UK
BJOG 109:721-2. 2002 - Human sexual size dimorphism in early pregnancyRadek Bukowski
Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX 77555 1062, USA
Am J Epidemiol 165:1216-8. 2007..009; spontaneous conception = 120 g, 95% CI: 107, 132, p < 0.00001). These data demonstrate that human fetuses exhibit sexual size dimorphism in the first trimester of pregnancy...