Colette J Smith

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint The problems faced when assessing the prevalence and incidence of antiretroviral-related toxicities
    Colette J Smith
    Department of Primary Care and Population Sciences and Royal Free Centre for HIV Medicine, Royal Free and University College Medical School, London, UK
    Antivir Ther 9:865-78. 2004
  2. ncbi request reprint The potential for CD4 cell increases in HIV-positive individuals who control viraemia with highly active antiretroviral therapy
    Colette J Smith
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Royal Free Campus, London, UK
    AIDS 17:963-9. 2003
  3. ncbi request reprint Response to efavirenz-containing regimens in previously antiretroviral-naive HIV-positive patients: the role of gender
    Colette J Smith
    HIV Biostatistics and Epidemiology Group and Department of Primary Care and Population Science, Royal Free and University College Medical School, London, United Kingdom
    J Acquir Immune Defic Syndr 46:62-7. 2007
  4. doi request reprint Factors associated with viral rebound among highly treatment-experienced HIV-positive patients who have achieved viral suppression
    C J Smith
    Research Department of Infection and Population Health, Royal Free and University College Medical School, London, UK
    HIV Med 10:19-27. 2009
  5. ncbi request reprint The rate of viral rebound after attainment of an HIV load <50 copies/mL according to specific antiretroviral drugs in use: results from a multicenter cohort study
    Colette J Smith
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, United Kingdom
    J Infect Dis 192:1387-97. 2005
  6. ncbi request reprint The role of antiretroviral therapy in the incidence of pancreatitis in HIV-positive individuals in the EuroSIDA study
    Colette J Smith
    Royal Free and University College Medical School, London, UK
    AIDS 22:47-56. 2008
  7. ncbi request reprint The relationship between CD4 cell count nadirs and the toxicity profiles of antiretroviral regimens
    J Smith Colette
    Centre for HIV Medicine, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Royal Free Hospital, London, UK
    Antivir Ther 10:459-67. 2005
  8. ncbi request reprint Factors influencing increases in CD4 cell counts of HIV-positive persons receiving long-term highly active antiretroviral therapy
    Colette J Smith
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Royal Free Campus, London, United Kingdom
    J Infect Dis 190:1860-8. 2004
  9. ncbi request reprint Use of viral load measured after 4 weeks of highly active antiretroviral therapy to predict virologic outcome at 24 weeks for HIV-1-positive individuals
    Colette J Smith
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Royal Free Campus, London, United Kingdom
    J Acquir Immune Defic Syndr 37:1155-9. 2004
  10. ncbi request reprint Cardiovascular disease risk factors and antiretroviral therapy in an HIV-positive UK population
    C J Smith
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    HIV Med 5:88-92. 2004

Detail Information

Publications45

  1. ncbi request reprint The problems faced when assessing the prevalence and incidence of antiretroviral-related toxicities
    Colette J Smith
    Department of Primary Care and Population Sciences and Royal Free Centre for HIV Medicine, Royal Free and University College Medical School, London, UK
    Antivir Ther 9:865-78. 2004
    ..We investigated the possible explanations for the differences in the incidence and prevalence rates of HAART-related toxicities between studies, focussing on metabolic and hepatotoxic disorders...
  2. ncbi request reprint The potential for CD4 cell increases in HIV-positive individuals who control viraemia with highly active antiretroviral therapy
    Colette J Smith
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Royal Free Campus, London, UK
    AIDS 17:963-9. 2003
    ..To study the long-term CD4 cell responses to highly active antiretroviral therapy (HAART) in treatment-naive patients whose viral loads remained below 500 copies/ml for prolonged periods...
  3. ncbi request reprint Response to efavirenz-containing regimens in previously antiretroviral-naive HIV-positive patients: the role of gender
    Colette J Smith
    HIV Biostatistics and Epidemiology Group and Department of Primary Care and Population Science, Royal Free and University College Medical School, London, United Kingdom
    J Acquir Immune Defic Syndr 46:62-7. 2007
    ..We investigated the role of gender on response to efavirenz (EFV)-containing regimens in previously antiretroviral-naive patients...
  4. doi request reprint Factors associated with viral rebound among highly treatment-experienced HIV-positive patients who have achieved viral suppression
    C J Smith
    Research Department of Infection and Population Health, Royal Free and University College Medical School, London, UK
    HIV Med 10:19-27. 2009
    ..More and more highly treatment-experienced patients are achieving viral suppression. However, the durability of suppression remains unclear...
  5. ncbi request reprint The rate of viral rebound after attainment of an HIV load <50 copies/mL according to specific antiretroviral drugs in use: results from a multicenter cohort study
    Colette J Smith
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, United Kingdom
    J Infect Dis 192:1387-97. 2005
    ....
  6. ncbi request reprint The role of antiretroviral therapy in the incidence of pancreatitis in HIV-positive individuals in the EuroSIDA study
    Colette J Smith
    Royal Free and University College Medical School, London, UK
    AIDS 22:47-56. 2008
    ..This study investigated the incidence of pancreatitis and its association with antiretroviral therapy (ART), focussing on stavudine and didanosine...
  7. ncbi request reprint The relationship between CD4 cell count nadirs and the toxicity profiles of antiretroviral regimens
    J Smith Colette
    Centre for HIV Medicine, Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Royal Free Hospital, London, UK
    Antivir Ther 10:459-67. 2005
    ..We investigated the relationship between the pre-HAART CD4 count nadir, HAART and the occurrence of laboratory-defined toxicities...
  8. ncbi request reprint Factors influencing increases in CD4 cell counts of HIV-positive persons receiving long-term highly active antiretroviral therapy
    Colette J Smith
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Royal Free Campus, London, United Kingdom
    J Infect Dis 190:1860-8. 2004
    ..We sought to investigate the factors associated with increases in CD4 cell count among human immunodeficiency virus (HIV)-positive antiretroviral-naive patients starting HAART...
  9. ncbi request reprint Use of viral load measured after 4 weeks of highly active antiretroviral therapy to predict virologic outcome at 24 weeks for HIV-1-positive individuals
    Colette J Smith
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Royal Free Campus, London, United Kingdom
    J Acquir Immune Defic Syndr 37:1155-9. 2004
    ..We suggest that this group of patients should be particularly closely monitored...
  10. ncbi request reprint Cardiovascular disease risk factors and antiretroviral therapy in an HIV-positive UK population
    C J Smith
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    HIV Med 5:88-92. 2004
    ..We sought to characterize the risk factors for cardiovascular disease present in an HIV-positive population...
  11. doi request reprint Stability of antiretroviral regimens in patients with viral suppression
    Rebecca K Lodwick
    Research Department of Infection and Population Health, Division of Population Health, Royal Free and University College Medical School, London, UK
    AIDS 22:1039-46. 2008
    ..To study the rate of treatment change due to toxicities in patients who achieved viral suppression within 6 months of starting antiretroviral therapy and who have never experienced virological failure...
  12. ncbi request reprint Deaths in the era of HAART: contribution of late presentation, treatment exposure, resistance and abnormal laboratory markers
    Caroline A Sabin
    Department of Primary Care and Population Sciences, Royal Free and UC Medical School, Pond St, London, UK
    AIDS 20:67-71. 2006
    ..To describe the characteristics of deaths that occur among HIV-positive individuals in the HAART era...
  13. ncbi request reprint Low-frequency K103N strengthens the impact of transmitted drug resistance on virologic responses to first-line efavirenz or nevirapine-based highly active antiretroviral therapy
    Anna Maria Geretti
    Department of Virology, Royal Free Hampstead NHS Trust, London, UK
    J Acquir Immune Defic Syndr 52:569-73. 2009
    ..There are conflicting data on the impact of low-frequency transmitted drug-resistant mutants on responses to first-line highly active antiretroviral therapy (HAART)...
  14. ncbi request reprint Success of clinical care for human immunodeficiency virus infection according to demographic group among sexually infected patients in a routine clinic population, 1999 to 2004
    Fiona C Lampe
    Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Royal Free Hospital, Rowland Hill Street, London, England
    Arch Intern Med 167:692-700. 2007
    ..The success of clinical care for human immunodeficiency virus infection may vary across demographic groups, because of patient- and health care-related factors...
  15. ncbi request reprint Late presenters in the era of highly active antiretroviral therapy: uptake of and responses to antiretroviral therapy
    Caroline A Sabin
    Royal Free and University College Medical School, Royal Free NHS Trust, London, UK
    AIDS 18:2145-51. 2004
    ..To investigate the characteristics and clinical, immunological and virological outcomes for individuals presenting for care with low CD4 cell counts...
  16. ncbi request reprint Ongoing changes in HIV RNA levels during untreated HIV infection: implications for CD4 cell count depletion
    Andrew N Phillips
    HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, Royal Free Campus, UCL Royal Free Campus, London, UK
    AIDS 24:1561-7. 2010
    ..Understanding of the interplay between plasma HIV RNA level and CD4 cell count depletion in untreated infection remains incomplete...
  17. ncbi request reprint Physical and psychological symptoms and risk of virologic rebound among patients with virologic suppression on antiretroviral therapy
    Fiona C Lampe
    Department of Infection and Population Health, University College London Medical School, London, UK
    J Acquir Immune Defic Syndr 54:500-5. 2010
    ..We examined the association of self-reported physical and psychological symptoms with subsequent virologic rebound among patients with viral suppression on combination antiretroviral therapy (cART)...
  18. doi request reprint Long-term trends in adherence to antiretroviral therapy from start of HAART
    Valentina Cambiano
    HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, UCL Medical School, Royal Free Campus, London, UK
    AIDS 24:1153-62. 2010
    ..We aimed to investigate long-term trends in highly active antiretroviral therapy (HAART) adherence to identify the main predictors and to evaluate whether participants experience periods of low adherence (<or=60%)...
  19. doi request reprint No impact of rifamycin selection on tuberculosis treatment outcome in HIV coinfected patients
    Richa Singh
    Centre for Respiratory Medicine bDepartment of Infectious Diseases, Royal Free Hospital, London, UK
    AIDS 27:481-4. 2013
    ..Our data support the wider use of rifabutin in TB/HIV coinfection...
  20. doi request reprint Projected life expectancy of people with HIV according to timing of diagnosis
    Fumiyo Nakagawa
    HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, University College London, UK
    AIDS 26:335-43. 2012
    ..Our aims were to estimate the life expectancy of an HIV-infected MSM living in a developed country with extensive access to ART and healthcare, and to assess the effect of late diagnosis on life expectancy...
  21. ncbi request reprint Does immune reconstitution syndrome promote active tuberculosis in patients receiving highly active antiretroviral therapy?
    Ronan A M Breen
    Department of Thoracic and HIV Medicine, Royal Free Hospital, London, UK
    AIDS 19:1201-6. 2005
    ..To assess whether highly active anti-retroviral therapy (HAART) contributes to the presentation of active tuberculosis (TB)...
  22. ncbi request reprint How good are systemic symptoms and blood inflammatory markers at detecting individuals with tuberculosis?
    R A M Breen
    Department of Thoracic Medicine, Royal Free Hospital, London, UK
    Int J Tuberc Lung Dis 12:44-9. 2008
    ..The diagnosis of tuberculosis (TB) may be rejected in the absence of symptoms such as fever, sweats or weight loss...
  23. doi request reprint Effect of specific ART drugs on lipid changes and the need for lipid management in children with HIV
    Margaret P Rhoads
    Imperial College London, London, United Kingdom
    J Acquir Immune Defic Syndr 57:404-12. 2011
    ..We investigated the effects of individual antiretrovirals on lipids in HIV-infected children and the proportion potentially eligible for dietary or pharmacologic intervention...
  24. pmc Rapid diagnosis of smear-negative tuberculosis using immunology and microbiology with induced sputum in HIV-infected and uninfected individuals
    Ronan A M Breen
    Department of Immunology, Royal Free and University College Medical School, London, United Kingdom
    PLoS ONE 2:e1335. 2007
    ..Until now this has only been possible using the expensive and invasive technique of broncho-alveolar lavage. We sought to evaluate an immunoassay using non-invasive induced-sputum to diagnose active tuberculosis...
  25. pmc Paradoxical reactions during tuberculosis treatment in patients with and without HIV co-infection
    R A M Breen
    Department of Thoracic and HIV Medicine, Royal Free Hospital, London NW3 2QG, UK
    Thorax 59:704-7. 2004
    ..It has been suggested that deterioration of tuberculosis (TB) during appropriate treatment, termed a paradoxical reaction (PR), is more common and severe in HIV positive individuals on highly active antiretroviral therapy (HAART)...
  26. ncbi request reprint Treatment outcomes amongst previously antiretroviral-naïve HIV-infected patients starting lopinavir/ritonavir-containing antiretroviral regimens at the Royal Free Hospital
    C J Smith
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, Rowland Hill Street, London, UK
    HIV Med 8:55-63. 2007
    ..To describe outcomes in patients starting first-line antiretroviral regimens including lopinavir/ritonavir (LPV/r) in a routine clinic setting...
  27. doi request reprint Failure to achieve a CD4+ cell count response on combination antiretroviral therapy despite consistent viral load suppression
    Jemma L O'Connor
    aResearch Department of Infection and Population Health, UCL, London bNorth Bristol NHS Trust, Bristol cSt George s Healthcare NHS Trust, London dSouth Tees Hospitals NHS Foundation Trust, Middlesbrough eBrighton and Sussex University Hospitals NHS Trust, Brighton fNorth Middlesex University Hospital NHS Trust gMortimer Market Centre, University College Medical School hImperial College Healthcare NHS Trust iHomerton University Hospital NHS Trust jBarts and The London NHS Trust kChelsea and Westminster Hospital NHS Foundation Trust lSouth London Healthcare NHS Trust, London mThe Lothian University Hospitals NHS Trust, Edinburgh nUniversity Hospitals of Leicester NHS Trust, Leicester oKings College Hospital NHS Foundation Trust, London, UK pRoyal Free Hampstead NHS Trust, London, UK
    AIDS 28:919-24. 2014
    ..To assess CD4 cell count recovery in people severely immunosuppressed at start of antiretroviral therapy (ART) who achieve and maintain viral load suppression...
  28. ncbi request reprint Virological response to highly active antiretroviral therapy is unaffected by antituberculosis therapy
    Ronan A M Breen
    Department of HIV Medicine, Royal Free Hospital, and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, United Kingdom
    J Infect Dis 193:1437-40. 2006
    ..Tuberculosis recurrence rates were similar to those found in an HIV-uninfected population of 156 subjects (3% and 1%, respectively). Treatment for HIV and tuberculosis does not compromise outcomes for either disease...
  29. pmc Adverse events and treatment interruption in tuberculosis patients with and without HIV co-infection
    R A M Breen
    Department of Thoracic and HIV Medicine, Royal Free Hospital, London, UK
    Thorax 61:791-4. 2006
    ..A study was undertaken to assess the frequency of serious (grade III/IV) adverse events and interruption of anti-TB treatment in the era of effective antiretroviral therapy...
  30. ncbi request reprint No association between HIV disease and its treatment and thyroid function
    S Madge
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and UC Medical School, Rowland Hill Street, London, UK
    HIV Med 8:22-7. 2007
    ....
  31. doi request reprint Use of a prescription-based measure of antiretroviral therapy adherence to predict viral rebound in HIV-infected individuals with viral suppression
    V Cambiano
    HIV Epidemiology and Biostatistics Group, Research Department of Infection and Population Health, UCL Medical School, London, UK
    HIV Med 11:216-24. 2010
    ..The aim of the study was to assess whether a simple, routinely available measure of antiretroviral therapy (ART) adherence predicts viral rebound at the next HIV viral load (VL) measurement in virally suppressed patients...
  32. ncbi request reprint Haemoglobin and albumin as markers of HIV disease progression in the highly active antiretroviral therapy era: relationships with gender
    S Shah
    Department of Thoracic Medicine, Royal Free Centre for HIV Medicine, Royal Free and University College Medical School and Royal Free Hospital, Rowland Hill Street, London, UK
    HIV Med 8:38-45. 2007
    ..The aims of the study were to describe gender differences in haemoglobin and albumin and to investigate the prognostic value of these measurements in relation to highly active antiretroviral therapy (HAART)...
  33. doi request reprint An audit of viral load in one clinical population to describe features of viraemic patients on antiretroviral therapy
    S Madge
    Royal Free Centre for HIV Medicine, Royal Free and University College London Medical School, London, UK
    HIV Med 9:208-13. 2008
    ..To assess the prevalence of an undetectable viral load (VL) (<50 HIV-1 RNA copies/mL) in a clinical population and to identify those viraemic and at risk of failing antiretroviral therapy (ART)...
  34. doi request reprint The associations between age and the development of laboratory abnormalities and treatment discontinuation for reasons other than virological failure in the first year of highly active antiretroviral therapy
    C A Sabin
    Department of Primary Care and Population Science, Royal Free and UC Medical School, London, UK
    HIV Med 10:35-43. 2009
    ....
  35. ncbi request reprint Cervical intraepithelial neoplasia treatment in Human Immunodeficiency Virus-positive women
    S Shah
    Department of Primary Care, Royal Free and University College Medical Schools, London, UK
    J Obstet Gynaecol 28:327-32. 2008
    ..Additionally, there is often incomplete clearance of CIN at the resection margins emphasing the need for close follow-up after surgery...
  36. doi request reprint Systemic amyloidosis in England: an epidemiological study
    Jennifer H Pinney
    Department of Medicine, UK National Amyloidosis Centre, Royal Free and University College Medical School, London, UK
    Br J Haematol 161:525-32. 2013
    ..Although there are various limitations to this study, the available data suggest the incidence of systemic amyloidosis in England exceeds 0·8/100 000 of the population...
  37. doi request reprint Clinical experience with bosentan and sitaxentan in connective tissue disease-associated pulmonary arterial hypertension
    Christopher J Valerio
    The National Pulmonary Hypertension Unit, Royal Free Hospital, London, UK
    Rheumatology (Oxford) 49:2147-53. 2010
    ....
  38. ncbi request reprint Trends in underlying causes of death in people with HIV from 1999 to 2011 (D:A:D): a multicohort collaboration
    Colette J Smith
    Research Department of Infection and Population Health, University College London, London, UK Electronic address
    Lancet 384:241-8. 2014
    ..Consequently, the relative importance of other traditionally non-AIDS-related morbidities has increased. We investigated trends over time in all-cause mortality and for specific causes of death in people with HIV from 1999 to 2011...
  39. doi request reprint The relationships of ABCB1 3435C>T and CYP2B6 516G>T with high-density lipoprotein cholesterol in HIV-infected patients receiving Efavirenz
    T W Mahungu
    Department of HIV Medicine, Royal Free NHS Trust, London, UK
    Clin Pharmacol Ther 86:204-11. 2009
    ..20 mmol/l, group 1 +0.47 mmol/l, group 2 +1.00 mmol/l; P(ANOVA) < 0.0001). These findings need to be validated in independent cohorts...
  40. ncbi request reprint Role of N-terminal brain natriuretic peptide (N-TproBNP) in scleroderma-associated pulmonary arterial hypertension
    Mark H Williams
    Department of Cardiology, Royal Free Hospital, London, UK
    Eur Heart J 27:1485-94. 2006
    ....
  41. pmc Systemic sclerosis associated pulmonary hypertension: improved survival in the current era
    M H Williams
    Department of Cardiology, Royal Free Hospital, London, UK
    Heart 92:926-32. 2006
    ..To measure survival, haemodynamic function and functional class in patients with systemic sclerosis associated pulmonary arterial hypertension (SSc-PAH) in two treatment eras...
  42. ncbi request reprint The use and abuse of hypothesis tests: how to present P values
    C J Smith
    Research Department of Infection and Population Health, UCL Medical School, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK
    Phlebology 25:107-12. 2010
    ....
  43. ncbi request reprint Clinical application of a rapid lung-orientated immunoassay in individuals with possible tuberculosis
    R A M Breen
    Department of Immunology, Royal Free and University College Medical School, London, UK
    Thorax 63:67-71. 2008
    ..Lung sampling enables combined microbiological and immunological testing and uses higher frequency antigen-specific responses than in blood...
  44. doi request reprint Incidence of pancreatitis in HIV-infected patients, and the association with antiretroviral therapy
    Colette J Smith
    AIDS 22:997-8. 2008
  45. doi request reprint HIV-1 drug resistance in HIV-1-infected children in the United Kingdom from 1998 to 2004
    Rana Chakraborty
    Paediatric Infectious Diseases Unit, St George s Hospital, London
    Pediatr Infect Dis J 27:457-9. 2008
    ..Three-class resistance was noted in 42 samples (14.1%). Our study also highlighted underutilization of testing and the need for prompt genotyping after drug discontinuation which may have lead to an underestimation of HIV-1 resistance...