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Genomes and Genes | A David SmithSummaryAffiliation: University of Oxford Country: UK Publications
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Publications
Prevention of dementia: a role for B vitamins?A David Smith
Oxford Project to Investigate Memory and Aging OPTIMA, University of Oxford, UK
Nutr Health 18:225-6. 2006..Large-scale randomised trials of homocysteine-lowering B vitamins are needed to see if a proportion of dementia in the world can be prevented...
Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's diseaseOnofre Combarros
Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Marqués de Valdecilla University Hospital University of Cantabria, 39008 Santander, Spain
J Neuroinflammation 6:22. 2009....- The synergy factor: a statistic to measure interactions in complex diseasesMario Cortina Borja
, Sevilla, Spain
BMC Res Notes 2:105. 2009..It can be applied to primary or summarised data, e.g. published data. It can be used with any type of susceptibility factor, provided the data are dichotomised. Novel features include power estimation and meta-analysis... - The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis ProjectOnofre Combarros
Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Marqués de Valdecilla University Hospital University of Cantabria, 39008 Santander, Spain
BMC Med Genet 11:162. 2010..We therefore examined the associations with AD of the DBH -1021T allele and of the above interactions in the Epistasis Project, with 1757 cases of AD and 6294 elderly controls... - The worldwide challenge of the dementias: a role for B vitamins and homocysteine?A David Smith
Oxford Project to Investigate Memory and Aging, University of Oxford, UK
Food Nutr Bull 29:S143-72. 2008..Large-scale randomized trials of homocysteine-lowering vitamins are needed to see if a proportion of dementia in the world can be prevented... 
Vitamin B-12 and cognition in the elderlyA David Smith
Oxford Project to Investigate Memory and Ageing, The Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
Am J Clin Nutr 89:707S-11S. 2009..Pending the outcome of better trials, it is suggested that the elderly in particular should be encouraged to maintain a good, rather than just an adequate, vitamin B-12 status by dietary means...- Is folic acid good for everyone?A David Smith
Oxford Project to Investigate Memory and Ageing, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
Am J Clin Nutr 87:517-33. 2008..Only then can authorities develop the right strategies for the population as a whole... - Imaging the progression of Alzheimer pathology through the brainA David Smith
Oxford Project to Investigate Memory and Ageing, University Department of Pharmacology, Oxford OX1 3QT, United Kingdom
Proc Natl Acad Sci U S A 99:4135-7. 2002 - Homocysteine-lowering by B vitamins slows the rate of accelerated brain atrophy in mild cognitive impairment: a randomized controlled trialA David Smith
Oxford Project to Investigate Memory and Ageing, University of Oxford, Oxford, United Kingdom
PLoS ONE 5:e12244. 2010..Homocysteine is a risk factor for brain atrophy, cognitive impairment and dementia. Plasma concentrations of homocysteine can be lowered by dietary administration of B vitamins... - Determinants of plasma methylmalonic acid in a large population: implications for assessment of vitamin B12 statusAnna Vogiatzoglou
OPTIMA, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
Clin Chem 55:2198-206. 2009..However, data are sparse regarding factors, besides renal function, that may influence MMA concentrations. We searched for important determinants of plasma MMA in the general population... - Dietary sources of vitamin B-12 and their association with plasma vitamin B-12 concentrations in the general population: the Hordaland Homocysteine StudyAnna Vogiatzoglou
OPTIMA, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
Am J Clin Nutr 89:1078-87. 2009..Limited information is available on the association between vitamin B-12 status and intake from different dietary sources... - Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trialCeleste A de Jager
OPTIMA, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
Int J Geriatr Psychiatry 27:592-600. 2012..Here we report the effect of B vitamins on cognitive and clinical decline (secondary outcomes) in the same study... - Sulfur amino acids in methionine-restricted rats: hyperhomocysteinemiaAmany K Elshorbagy
Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
Nutrition 26:1201-4. 2010..We investigated the serum sulfur amino acid profile of male Fischer-344 rats fed a methionine-restricted diet for 3 mo... - Homocysteine as a predictor of cognitive decline in Alzheimer's diseaseAbderrahim Oulhaj
Oxford Project to Investigate Memory and Ageing OPTIMA, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
Int J Geriatr Psychiatry 25:82-90. 2010..We have tested whether baseline concentrations of homocysteine relate to the subsequent rate of cognitive decline in patients with established Alzheimer's disease (AD)... - Cysteine, homocysteine and bone mineral density: a role for body composition?Amany K Elshorbagy
Department of Physiology, Le Gros Clarke Building, Anatomy and Genetics, Oxford University, UK
Bone 44:954-8. 2009..Plasma total cysteine (tCys) and homocysteine (tHcy) are associated with body composition, which in turn affects bone mineral density (BMD)... - Association of the aromatase gene with Alzheimer's disease in womenHelen T Butler
Genomics Laboratory, Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
Neurosci Lett 468:202-6. 2010..In the hippocampus, it is upregulated in postmenopausal women and is lowered in AD. These sex-specific results are therefore plausible. However, our results now need to be replicated in a larger dataset... - Cognitive function in an elderly population: interaction between vitamin B12 status, depression, and apolipoprotein E ε4: the Hordaland Homocysteine StudyAnna Vogiatzoglou
OPTIMA, Department of Pharmacology, University of Oxford, Oxford, UK
Psychosom Med 75:20-9. 2013..To investigate the cross-sectional relation between metabolic markers of vitamin B(12) status and cognitive performance, and possible effect modification by the presence of depression and apolipoprotein E (ApoE) ε4... - The vitamin D receptor gene is associated with Alzheimer's diseaseDonald J Lehmann
Oxford Project to Investigate Memory and Ageing OPTIMA, University Department of Pharmacology, Oxford OX1 3QT, UK
Neurosci Lett 504:79-82. 2011..05. These associations are biologically plausible and are consistent with a role for vitamin D in AD. Nevertheless, we consider this to be a hypothesis-generating study, which needs to be replicated in a larger dataset... - Cognitive performance among the elderly and dietary fish intake: the Hordaland Health StudyEha Nurk
Department of Pharmacology, University of Oxford, UK
Am J Clin Nutr 86:1470-8. 2007..Increasing evidence suggests that cognitive impairment and dementia in older subjects might be influenced by a diet including seafood... - Dietary cystine level affects metabolic rate and glycaemic control in adult miceAmany K Elshorbagy
Department of Pharmacology, University of Oxford, UK
J Nutr Biochem 23:332-40. 2012..Overall, high cystine intake promotes adiposity and an adverse metabolic phenotype in mice, indicating that the positive association of plasma tCys with obesity in humans may be causal... - Transferrin and HFE genes interact in Alzheimer's disease risk: the Epistasis ProjectDonald J Lehmann
Oxford Project to Investigate Memory and Ageing, University Department of Physiology, Anatomy and Genetics, Oxford, UK
Neurobiol Aging 33:202.e1-13. 2012..We therefore suggest that iron overload may be a causative factor in the development of AD. Treatment for iron overload might thus be protective in some cases... - Plasma total homocysteine and memory in the elderly: the Hordaland Homocysteine StudyEha Nurk
Department of Pharmacology, Oxford Project to Investigate Memory and Ageing (OPTIMA, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom
Ann Neurol 58:847-57. 2005.... - Cysteine and obesity: consistency of the evidence across epidemiologic, animal and cellular studiesAmany K Elshorbagy
Department of Pharmacology, University of Oxford, Oxford, UK
Curr Opin Clin Nutr Metab Care 15:49-57. 2012..Animal and cellular experiments support the concept that cysteine may be obesogenic. Here we review experimental and epidemiologic findings linking cysteine and related compounds with fat regulation and obesity... - Serum levels of estradiol and testosterone and performance in different cognitive domains in healthy elderly men and womenEva Hogervorst
Oxford Project to Investigate Memory and Ageing and the Department of Pharmacology, University of Oxford and Radcliffe Infirmary Trust, Oxford, OX2 6HE, UK
Psychoneuroendocrinology 29:405-21. 2004..More research is required to investigate whether there is a window of time in which hormone therapy could be beneficial for middle-aged men... - Low thyroid-stimulating hormone as an independent risk factor for Alzheimer diseaseLiesbeth A D M van Osch
Oxford Project to Investigate Memory and Ageing, Department of Pharmacology, University of Oxford and Radcliffe Infirmary, UK
Neurology 62:1967-71. 2004..36, 95% CI = 1.19 to 4.67), independent of other risk factors. CONCLUSION: Lowered TSH within the normal range is a risk factor for AD, independent of several cerebrovascular risk factors and confounding variables... - Cysteine supplementation reverses methionine restriction effects on rat adiposity: significance of stearoyl-coenzyme A desaturaseAmany K Elshorbagy
Department of Pharmacology, University of Oxford, Oxford, UK
J Lipid Res 52:104-12. 2011..FM/BW% and serum leptin were modestly decreased. Our results indicate that anti-obesity effects of MR are caused by low cysteine and that dietary sulfur amino acid composition contributes to SCD1 regulation... - Facts and recommendations about total homocysteine determinations: an expert opinionHelga Refsum
Department of Pharmacology, University of Oxford, Oxford OX1 3QT, UK
Clin Chem 50:3-32. 2004.... - Polymorphisms in the catechol-O-methyltransferase (COMT) gene influence plasma total homocysteine levelsElizabeth M Tunbridge
Department of Psychiatry, University of Oxford, Oxford, United Kingdom
Am J Med Genet B Neuropsychiatr Genet 147:996-9. 2008..The results also indicate that COMT activity may influence a broader range of biochemical pathways than hitherto appreciated... - Total plasma homocysteine, age, systolic blood pressure, and cognitive performance in older peopleMarc M Budge
Department of Pharmacology, University of Oxford, and Radcliffe Infirmary, United Kingdom
J Am Geriatr Soc 50:2014-8. 2002..To investigate the relationship between total plasma homocysteine (tHcy) levels, blood pressure (BP) variables, renal function, and measures of cognitive performance in older people... - Human homologue of a gene mutated in the slow Wallerian degeneration (C57BL/Wld(s)) mouseF Shama Fernando
Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
Gene 284:23-9. 2002..We have also determined the intron/exon structure of the gene, which will facilitate the screening of these exons for mutations in human neurodegenerative disorders... - The Hordaland Homocysteine Study: a community-based study of homocysteine, its determinants, and associations with diseaseHelga Refsum
Norwegian Institute of Public Health, Oslo, Norway
J Nutr 136:1731S-1740S. 2006..Overall, the findings from HHS indicate that a raised tHcy level is associated with multiple clinical conditions, whereas a low tHcy level is associated with better physical and mental health... - Plasma homocysteine levels, cerebrovascular risk factors, and cerebral white matter changes (leukoaraiosis) in patients with Alzheimer diseaseEva Hogervorst
Oxford Project to Investigate Memory and Ageing, Department of Pharmacology, University of Oxford and Radcliffe Infirmary Trust, Oxford OX2 6HE, England
Arch Neurol 59:787-93. 2002..The pathogenesis of leukoaraiosis on computed tomographic (CT) scanning is unknown, but cerebrovascular risk factors for leukoaraiosis show overlap with those for Alzheimer disease (AD)... - The association of plasma cysteine and gamma-glutamyltransferase with BMI and obesityAmany K Elshorbagy
Department of Physiology, Anatomy and Genetics, Oxford University, Oxford, UK
Obesity (Silver Spring) 17:1435-40. 2009..We also suggest that the association of serum GGT with BMI and obesity is unrelated to the role of GGT in cysteine turnover. The potential link between cysteine and fat metabolism should be further evaluated... - Structural and functional bases of visuospatial associative memory in older adultsGiovanna Zamboni
Oxford Project to Investigate Memory and Ageing OPTIMA, Experimental Medicine Division of Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
Neurobiol Aging 34:961-72. 2013.... - Longitudinal quantitative proton magnetic resonance spectroscopy of the hippocampus in Alzheimer's diseaseRuth M Dixon
MRC Biochemical and Clinical Magnetic Resonance Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK
Brain 125:2332-41. 2002..In our cohort, the differences were more significant for the left hippocampus... - Large meta-analysis establishes the ACE insertion-deletion polymorphism as a marker of Alzheimer's diseaseDonald J Lehmann
The Oxford Project to Investigate Memory and Ageing OPTIMA, Department of Pharmacology, University of Oxford, Oxford, United Kingdom
Am J Epidemiol 162:305-17. 2005..This interaction warrants further investigation... - Non-linear relationships of cerebrospinal fluid biomarker levels with cognitive function: an observational studyJonathan H Williams
OPTIMA, University of Oxford, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK
Alzheimers Res Ther 3:5. 2011..Levels of cerebrospinal fluid (CSF) β-amyloid (Aβ) and Tau proteins change in Alzheimer's disease (AD). We tested if the relationships of these biomarkers with cognitive impairment are linear or non-linear... - The interaction of serum folate and estradiol levels in Alzheimer's diseaseEva Hogervorst
Oxford Project to Investigate Memory and Ageing, University Department of Pharmacology, Radcliffe Infirmary, Oxford, United Kingdom
Neuro Endocrinol Lett 23:155-60. 2002..Because estradiol (TE2) after the menopause is largely derived from estrone (TE1), we computed the ratio TE2/(TE1+TE2) and a total steroid index (TT+TE2+TE1)... - Homocysteine, B vitamins, and cognitive deficit in the elderlyA David Smith
Am J Clin Nutr 75:785-6. 2002 - Association between subcortical vascular disease on CT and neuropathological findingsRoberta Rossi
Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio-FBF, Brescia, Italy
Int J Geriatr Psychiatry 19:690-5. 2004..05). CONCLUSION: The standardized assessment of svCVD on CT films at the time of the diagnosis correlates with small vessel disease on pathology at death... - Hippocampal atrophy in Alzheimer disease: age mattersA David Smith
Neurology 67:728; author reply 728. 2006 - Folic acid fortification: the good, the bad, and the puzzle of vitamin B-12A David Smith
Am J Clin Nutr 85:3-5. 2007 - Relations of glutamate carboxypeptidase II (GCPII) polymorphisms to folate and homocysteine concentrations and to scores of cognition, anxiety, and depression in a homogeneous Norwegian population: the Hordaland Homocysteine StudyCharles H Halsted
Genome and Biomedical Sciences Facility, University of California Davis, Davis, CA 95616, USA
Am J Clin Nutr 86:514-21. 2007..Previous studies provided conflicting results on the effect of the GCPII 1561C-->T polymorphism on folate and total homocysteine (tHcy) concentrations... - Plasma folate concentration and cognitive performance: Rotterdam Scan StudyLonneke M L de Lau
Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, Netherlands
Am J Clin Nutr 86:728-34. 2007..Evidence is increasing for beneficial and independent effects of folate on cognitive function, but the underlying biologic mechanism is as yet unknown... - Homocysteine, B vitamins, and cardiovascular diseaseHelga Refsum
N Engl J Med 355:207; author reply 209-11. 2006 - Are we ready for mandatory fortification with vitamin B-12?Helga Refsum
Am J Clin Nutr 88:253-4. 2008 - The association between depression, anxiety, and cognitive function in the elderly general population--the Hordaland Health StudyEva Biringer
Institute of Clinical Medicine, University of Bergen, Norway
Int J Geriatr Psychiatry 20:989-97. 2005..To examine the association between depression and/or anxiety and cognitive function in the elderly general population... - Medial temporal lobe atrophy, apolipoprotein genotype, and plasma homocysteine in Sri Lankan patients with Alzheimer's diseaseH Asita de Silva
Department of Pharmacology, Faculty of Medicine, University of Kelaniya, Sri Lanka
Exp Aging Res 31:345-54. 2005..001). This first report of apoE4, plasma tHcy, MTL thickness, and AD from Sri Lanka shows that high plasma tHcy, the presence of apoE4 allele, and MTL atrophy are associated with AD... - Pathological validation of a CT-based scale for subcortical vascular disease. The OPTIMA StudyRoberta Rossi
Laboratory of Epidemiology and Neuroimaging, IRCCS San Giovanni di Dio-FBF, Brescia, Italy
Dement Geriatr Cogn Disord 19:61-6. 2005..This supports the validity of the CT-based visual rating scale as a valid tool to detect subcortical vascular changes in elderly persons... - Butyrylcholinesterase K variant associated with higher enzyme activity in the temporal cortex of elderly patientsAndrea Tasker
Institute for Ageing and Health, Wolfson Research Centre, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne NE4 6BE, UK
Neurosci Lett 442:297-9. 2008..Linear regression analysis, controlling for gender, diagnosis, age at death and study centre, showed that the number of BCHE-K alleles was associated with increasing BuChE activity (p=0.009)...