M G Smirnova

Summary

Affiliation: University of Newcastle
Country: UK

Publications

  1. ncbi TNF-alpha in the regulation of MUC5AC secretion: some aspects of cytokine-induced mucin hypersecretion on the in vitro model
    M G Smirnova
    Department of Physiological Sciences, Medical School, University of Newcastle, Newcastle upon Tyne, UK
    Cytokine 12:1732-6. 2000
  2. ncbi Up-regulation of mucin secretion in HT29-MTX cells by the pro-inflammatory cytokines tumor necrosis factor-alpha and interleukin-6
    M G Smirnova
    Department of Physiological Sciences, University of Newcastle, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Eur Cytokine Netw 12:119-25. 2001
  3. ncbi In vitro study of IL-8 and goblet cells: possible role of IL-8 in the aetiology of otitis media with effusion
    Marina G Smirnova
    Department of Physiological Sciences, Medical School, University of Newcastle, Newcastle upon Tyne, UK
    Acta Otolaryngol 122:146-52. 2002
  4. ncbi Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion
    Marina G Smirnova
    Department of Physiological Sciences, University of Newcastle, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Eur Cytokine Netw 13:161-72. 2002
  5. ncbi LPS up-regulates mucin and cytokine mRNA expression and stimulates mucin and cytokine secretion in goblet cells
    Marina G Smirnova
    School of Cell and Molecular Biosciences, The Medical School, University of Newcastle, Framlington Place, UK
    Cell Immunol 221:42-9. 2003
  6. pmc The immunoregulatory and allergy-associated cytokines in the aetiology of the otitis media with effusion
    Marina G Smirnova
    School of Cell and Molecular Biosciences, University of Newcastle, The Medical School, Framlington Place Newcastle upon Tyne, NE2 4HH, Nottingham, UK
    Mediators Inflamm 13:75-88. 2004
  7. ncbi Evidence of T-helper cell 2 cytokine regulation of chronic otitis media with effusion
    Marina G Smirnova
    Institute for Cell and Molecular Biosciences and School of Biomedical Sciences, Medical Faculty, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Acta Otolaryngol 125:1043-50. 2005

Collaborators

Detail Information

Publications7

  1. ncbi TNF-alpha in the regulation of MUC5AC secretion: some aspects of cytokine-induced mucin hypersecretion on the in vitro model
    M G Smirnova
    Department of Physiological Sciences, Medical School, University of Newcastle, Newcastle upon Tyne, UK
    Cytokine 12:1732-6. 2000
    ..This hypersecretion of mucin could then lead to the failure of the mucociliary clearance system, resulting in the accumulation of a mucin-rich effusion in the middle ear and the movement to a more chronic phase of the disease...
  2. ncbi Up-regulation of mucin secretion in HT29-MTX cells by the pro-inflammatory cytokines tumor necrosis factor-alpha and interleukin-6
    M G Smirnova
    Department of Physiological Sciences, University of Newcastle, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Eur Cytokine Netw 12:119-25. 2001
    ..The results presented here suggest that IL-6 and TNF-alpha generate a differential up-regulation of mucin secretion and thus contribute to the expression of mucin genes in inflammatory responses...
  3. ncbi In vitro study of IL-8 and goblet cells: possible role of IL-8 in the aetiology of otitis media with effusion
    Marina G Smirnova
    Department of Physiological Sciences, Medical School, University of Newcastle, Newcastle upon Tyne, UK
    Acta Otolaryngol 122:146-52. 2002
    ....
  4. ncbi Role of the pro-inflammatory cytokines tumor necrosis factor-alpha, interleukin-1 beta, interleukin-6 and interleukin-8 in the pathogenesis of the otitis media with effusion
    Marina G Smirnova
    Department of Physiological Sciences, University of Newcastle, Medical School, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK
    Eur Cytokine Netw 13:161-72. 2002
    ..In this article, we aim to present an overview of current research developments in the pro-inflammatory cytokine involvement in the aetiology of otitis media with effusion...
  5. ncbi LPS up-regulates mucin and cytokine mRNA expression and stimulates mucin and cytokine secretion in goblet cells
    Marina G Smirnova
    School of Cell and Molecular Biosciences, The Medical School, University of Newcastle, Framlington Place, UK
    Cell Immunol 221:42-9. 2003
    ....
  6. pmc The immunoregulatory and allergy-associated cytokines in the aetiology of the otitis media with effusion
    Marina G Smirnova
    School of Cell and Molecular Biosciences, University of Newcastle, The Medical School, Framlington Place Newcastle upon Tyne, NE2 4HH, Nottingham, UK
    Mediators Inflamm 13:75-88. 2004
    ....
  7. ncbi Evidence of T-helper cell 2 cytokine regulation of chronic otitis media with effusion
    Marina G Smirnova
    Institute for Cell and Molecular Biosciences and School of Biomedical Sciences, Medical Faculty, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
    Acta Otolaryngol 125:1043-50. 2005
    ..The mucin content of effusions correlated with the concentrations of IL-4 (>10 pg/ml) and -13, suggesting involvement of IL-4 and -13 in upregulation of the middle ear mucin metabolism...