C R Slater
Affiliation: University of Newcastle
- Structural determinants of the reliability of synaptic transmission at the vertebrate neuromuscular junctionClarke R Slater
School of Neurology, Neurobiology and Psychiatry, Faculty of Medical Sciences, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
J Neurocytol 32:505-22. 2003..A better understanding of how the structural features that influence the reliability of the neuromuscular transmission are controlled should be of general interest to neuroscientists and of use to clinicians...
- Structural factors influencing the efficacy of neuromuscular transmissionClarke R Slater
Institute of Neuroscience, Faculty of Medical Sciences, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
Ann N Y Acad Sci 1132:1-12. 2008..This condition emphasizes the importance of structural features in achieving reliability of neuromuscular transmission...
- Pre- and post-synaptic abnormalities associated with impaired neuromuscular transmission in a group of patients with 'limb-girdle myasthenia'C R Slater
School of Neurology, Neurobiology and Psychiatry, University of Newcastle upon Tyne, Bath, Newcastle upon Tyne, UK
Brain 129:2061-76. 2006....
- Structure and function of the neuromuscular junction in young adult mdx miceP R Lyons
Muscular Dystrophy Group Laboratories, Newcastle General Hospital, Newcastle upon Tyne, UK
J Neurocytol 20:969-81. 1991....
- Sodium channel mRNAs at the neuromuscular junction: distinct patterns of accumulation and effects of muscle activityS S Awad
Department of Neuroscience, University of Newcastle upon Tyne, NE2 4HH, Newcastle upon Tyne, United Kingdom
J Neurosci 21:8456-63. 2001..We conclude that factors, probably derived from the nerve, lead to the increased concentration of VGSC mRNAs at the NMJ. In addition, the expression of Na(V)1.5 mRNA is downregulated by muscle activity, both at the NMJ and away from it...
- The contribution of postsynaptic folds to the safety factor for neuromuscular transmission in rat fast- and slow-twitch musclesS J Wood
School of Neurosciences, The Medical School, University of Newcastle, Newcastle upon Tyne, UK
J Physiol 500:165-76. 1997..At normal frequencies of nerve impulse activity in vivo, this effect is likely to be crucial for ensuring effective neuromuscular transmission...
- Loss of motor neurons from the median nerve motor nucleus of the mutant mouse 'wobbler'M M Pollin
Division of Neurobiology, School of Neuroscience, Medical School, Newcastle upon Tyne, UK
J Neurocytol 19:29-38. 1990..By 6 weeks this figure has fallen to 10%, and to less than 4% in adult wobblers. We conclude that the most active period in the expression of the wobbler phenotype is from 3 to 6 weeks of age...
- Voltage-gated sodium channels and ankyrinG occupy a different postsynaptic domain from acetylcholine receptors from an early stage of neuromuscular junction maturation in ratsSarah J Bailey
School of Neurology, Neurobiology Psychiatry, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne NE2 4HH, United Kingdom
J Neurosci 23:2102-11. 2003....
- Accumulation of Nav1 mRNAs at differentiating postsynaptic sites in rat soleus musclesMark A Stocksley
School of Neurology, Neurobiology and Psychiatry, The Medical School, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
Mol Cell Neurosci 28:694-702. 2005..This suggests that factors other than local mRNA upregulation determine the timing of clustering of these two important postsynaptic ion channels...
- Congenital myasthenic syndromes and the formation of the neuromuscular junctionDavid Beeson
Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
Ann N Y Acad Sci 1132:99-103. 2008....