Research Topics
| David H SkuseSummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
Rethinking the nature of genetic vulnerability to autistic spectrum disordersDavid H Skuse
Behavioural and Brain Sciences Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
Trends Genet 23:387-95. 2007....
Genetic influences on social cognitionDavid H Skuse
Department of Behavioural and Brain Sciences, Institute of Child Health, University College London, London WC1N 1EH, United Kingdom
Pediatr Res 69:85R-91R. 2011..Genetic variation in the receptors associated with OT, AVP, dopamine, and serotonin has been intensively studied in humans and animal models. Recent findings are building an increasingly coherent picture of regulatory mechanisms...- Evidence from Turner's syndrome of an imprinted X-linked locus affecting cognitive functionD H Skuse
Behavioural Sciences Unit, Institute of Child Health, London, UK
Nature 387:705-8. 1997.... - Dopaminergic-neuropeptide interactions in the social brainDavid H Skuse
Behavioural and Brain Sciences Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
Trends Cogn Sci 13:27-35. 2009..We also examine the putative role of allelic variation in candidate genes on individual differences in social cognitive processing and associated social behaviour... - Measuring autistic traits: heritability, reliability and validity of the Social and Communication Disorders ChecklistDavid H Skuse
Behavioural and Brain Sciences Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
Br J Psychiatry 187:568-72. 2005..Whole-population surveys of unselected samples of children are hampered by the lack of appropriate screening instruments... - Social communication competence and functional adaptation in a general population of children: preliminary evidence for sex-by-verbal IQ differential riskDavid H Skuse
Behavioural and Brain Sciences Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
J Am Acad Child Adolesc Psychiatry 48:128-37. 2009..We aimed to ascertain both the population distribution of such deficits and their association with functional adaptation and cognitive ability in middle childhood... - Functional dissociation of amygdala-modulated arousal and cognitive appraisal, in Turner syndromeD H Skuse
Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
Brain 128:2084-96. 2005..These findings imply X-linked genes are essential for binding somatic responses to the cognitive appraisal of emotional stimuli... - X-linked genes and mental functioningDavid H Skuse
Behavioural and Brain Sciences Unit, Institute of Child Health, London, UK
Hum Mol Genet 14:R27-32. 2005..Surprising specificity of effects has been described in both species, and identification of candidate genes cannot now be far off... - The developmental, dimensional and diagnostic interview (3di): a novel computerized assessment for autism spectrum disordersDavid Skuse
Institute of Child Health, University College London
J Am Acad Child Adolesc Psychiatry 43:548-58. 2004.... - The amygdala and development of the social brainDavid Skuse
Behavioural and Brain Sciences Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, United Kingdom
Ann N Y Acad Sci 1008:91-101. 2003..These, in turn, have direct or indirect consequences for social behavior... - Behavioural neuroscience and child psychopathology: insights from model systemsD H Skuse
Behavioural Sciences Unit, Institute of Child Health, London, UK
J Child Psychol Psychiatry 41:3-31. 2000..This review draws out the parallels, and introduces recent findings from behavioural studies of C. elegans, D. melanogaster, and the laboratory mouse, as well as humans, to illustrate the point... 
Risk factors for development of sexually abusive behaviour in sexually victimised adolescent boys: cross sectional studyD Skuse
Behavioural Sciences Unit, Institute of Child Health, London WC1N 1EH
BMJ 317:175-9. 1998..To identify factors that may increase the risk of a sexually victimised adolescent boy developing sexually abusive behaviour...- Is autism really a coherent syndrome in boys, or girls?David H Skuse
Behavioural and Brain Sciences Unit, Institute of Child Health, London, UK
Br J Psychol 100:33-7. 2009..This article is a commentary on 'Fetal testosterone and autistic traits' (Auyeung et al., 2009)... - Dosage-sensitive X-linked locus influences the development of amygdala and orbitofrontal cortex, and fear recognition in humansCatriona D Good
Wellcome Department of Imaging Neuroscience, Institute of Neurology, Institute of Child Health, London, UK
Brain 126:2431-46. 2003..We show that the thrombocytic activity of MAOB is proportionate to the number of X-chromosomes, and hypothesize that haploinsufficiency of this enzyme in 45,X females predisposes to their deficits in social cognition... - Brief report: perception of genuine and posed smiles by individuals with autismZillah L Boraston
Behavioural and Brain Sciences Unit, Institute of Child Health, University College London, London WC1N 1EH, UK
J Autism Dev Disord 38:574-80. 2008..We conclude that reduced eye contact in autism leads to reduced ability to discriminate genuine from posed smiles with downstream effects on social interaction... - Social communication deficits in conduct disorder: a clinical and community surveyJ Gilmour
Sub Department of Clinical Health Psychology, University College London, UK
J Child Psychol Psychiatry 45:967-78. 2004..We hypothesised that pragmatic difficulties may underlie the antisocial behaviour in a proportion of children who are labelled as conduct disordered... - Testing the construct validity of proposed criteria for DSM-5 autism spectrum disorderWilliam P L Mandy
Research Department of Clinical, Health and Educational Psychology, University College London, London, UK
J Am Acad Child Adolesc Psychiatry 51:41-50. 2012..To use confirmatory factor analysis to test the construct validity of the proposed DSM-5 symptom model of autism spectrum disorder (ASD), in comparison to alternative models, including that described in DSM-IV-TR... - Research review: What is the association between the social-communication element of autism and repetitive interests, behaviours and activities?William P L Mandy
Sub Department of Clinical Health Psychology, University College London, London, UK
J Child Psychol Psychiatry 49:795-808. 2008..Some clinical and research implications are discussed... - Adolescents and young adults with 22q11 deletion syndrome: psychopathology in an at-risk groupKate D Baker
Behavioural and Brain Sciences Unit, Institute of Child Health, University College London, London WC1N 1EH, UK
Br J Psychiatry 186:115-20. 2005..If common neurodevelopmental trajectories characterise 22q11 deletion syndrome and idiopathic schizophrenia, then similar'premorbid'features would be predicted... - Social communication deficits in disruptive primary-school childrenR Donno
Behavioural and Brain Sciences Unit, Institute of Child Health, University College London WC1N 1EH, UK
Br J Psychiatry 196:282-9. 2010..Parent and teacher data, from questionnaire surveys, suggest that school-identified disruptive children often have pragmatic language deficits of an autistic type... - Influence of X chromosome and hormones on human brain development: a magnetic resonance imaging and proton magnetic resonance spectroscopy study of Turner syndromeWilliam J Cutter
Section of Brain Maturation, Department of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
Biol Psychiatry 59:273-83. 2006..Hence, they allow us an opportunity to investigate genetic and endocrine influences on brain development...