David H Skuse

Summary

Affiliation: University College London
Country: UK

Publications

  1. ncbi request reprint Evidence from Turner's syndrome of an imprinted X-linked locus affecting cognitive function
    D H Skuse
    Behavioural Sciences Unit, Institute of Child Health, London, UK
    Nature 387:705-8. 1997
  2. ncbi request reprint Rethinking the nature of genetic vulnerability to autistic spectrum disorders
    David H Skuse
    Behavioural and Brain Sciences Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Trends Genet 23:387-95. 2007
  3. doi request reprint Genetic influences on social cognition
    David H Skuse
    Department of Behavioural and Brain Sciences, Institute of Child Health, University College London, London WC1N 1EH, United Kingdom
    Pediatr Res 69:85R-91R. 2011
  4. doi request reprint Social communication competence and functional adaptation in a general population of children: preliminary evidence for sex-by-verbal IQ differential risk
    David H Skuse
    Behavioural and Brain Sciences Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    J Am Acad Child Adolesc Psychiatry 48:128-37. 2009
  5. doi request reprint Dopaminergic-neuropeptide interactions in the social brain
    David H Skuse
    Behavioural and Brain Sciences Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Trends Cogn Sci 13:27-35. 2009
  6. doi request reprint Is autism really a coherent syndrome in boys, or girls?
    David H Skuse
    Behavioural and Brain Sciences Unit, Institute of Child Health, London, UK
    Br J Psychol 100:33-7. 2009
  7. ncbi request reprint Measuring autistic traits: heritability, reliability and validity of the Social and Communication Disorders Checklist
    David H Skuse
    Behavioural and Brain Sciences Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Br J Psychiatry 187:568-72. 2005
  8. ncbi request reprint Functional dissociation of amygdala-modulated arousal and cognitive appraisal, in Turner syndrome
    D H Skuse
    Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Brain 128:2084-96. 2005
  9. ncbi request reprint X-linked genes and mental functioning
    David H Skuse
    Behavioural and Brain Sciences Unit, Institute of Child Health, London, UK
    Hum Mol Genet 14:R27-32. 2005
  10. ncbi request reprint The amygdala and development of the social brain
    David Skuse
    Behavioural and Brain Sciences Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, United Kingdom
    Ann N Y Acad Sci 1008:91-101. 2003

Detail Information

Publications22

  1. ncbi request reprint Evidence from Turner's syndrome of an imprinted X-linked locus affecting cognitive function
    D H Skuse
    Behavioural Sciences Unit, Institute of Child Health, London, UK
    Nature 387:705-8. 1997
    ....
  2. ncbi request reprint Rethinking the nature of genetic vulnerability to autistic spectrum disorders
    David H Skuse
    Behavioural and Brain Sciences Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Trends Genet 23:387-95. 2007
    ....
  3. doi request reprint Genetic influences on social cognition
    David H Skuse
    Department of Behavioural and Brain Sciences, Institute of Child Health, University College London, London WC1N 1EH, United Kingdom
    Pediatr Res 69:85R-91R. 2011
    ..Genetic variation in the receptors associated with OT, AVP, dopamine, and serotonin has been intensively studied in humans and animal models. Recent findings are building an increasingly coherent picture of regulatory mechanisms...
  4. doi request reprint Social communication competence and functional adaptation in a general population of children: preliminary evidence for sex-by-verbal IQ differential risk
    David H Skuse
    Behavioural and Brain Sciences Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    J Am Acad Child Adolesc Psychiatry 48:128-37. 2009
    ..We aimed to ascertain both the population distribution of such deficits and their association with functional adaptation and cognitive ability in middle childhood...
  5. doi request reprint Dopaminergic-neuropeptide interactions in the social brain
    David H Skuse
    Behavioural and Brain Sciences Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Trends Cogn Sci 13:27-35. 2009
    ..We also examine the putative role of allelic variation in candidate genes on individual differences in social cognitive processing and associated social behaviour...
  6. doi request reprint Is autism really a coherent syndrome in boys, or girls?
    David H Skuse
    Behavioural and Brain Sciences Unit, Institute of Child Health, London, UK
    Br J Psychol 100:33-7. 2009
    ..This article is a commentary on 'Fetal testosterone and autistic traits' (Auyeung et al., 2009)...
  7. ncbi request reprint Measuring autistic traits: heritability, reliability and validity of the Social and Communication Disorders Checklist
    David H Skuse
    Behavioural and Brain Sciences Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Br J Psychiatry 187:568-72. 2005
    ..Whole-population surveys of unselected samples of children are hampered by the lack of appropriate screening instruments...
  8. ncbi request reprint Functional dissociation of amygdala-modulated arousal and cognitive appraisal, in Turner syndrome
    D H Skuse
    Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
    Brain 128:2084-96. 2005
    ..These findings imply X-linked genes are essential for binding somatic responses to the cognitive appraisal of emotional stimuli...
  9. ncbi request reprint X-linked genes and mental functioning
    David H Skuse
    Behavioural and Brain Sciences Unit, Institute of Child Health, London, UK
    Hum Mol Genet 14:R27-32. 2005
    ..Surprising specificity of effects has been described in both species, and identification of candidate genes cannot now be far off...
  10. ncbi request reprint The amygdala and development of the social brain
    David Skuse
    Behavioural and Brain Sciences Unit, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, United Kingdom
    Ann N Y Acad Sci 1008:91-101. 2003
    ..These, in turn, have direct or indirect consequences for social behavior...
  11. ncbi request reprint The developmental, dimensional and diagnostic interview (3di): a novel computerized assessment for autism spectrum disorders
    David Skuse
    Institute of Child Health, University College London
    J Am Acad Child Adolesc Psychiatry 43:548-58. 2004
    ....
  12. pmc Risk factors for development of sexually abusive behaviour in sexually victimised adolescent boys: cross sectional study
    D Skuse
    Behavioural Sciences Unit, Institute of Child Health, London WC1N 1EH
    BMJ 317:175-9. 1998
    ..To identify factors that may increase the risk of a sexually victimised adolescent boy developing sexually abusive behaviour...
  13. ncbi request reprint Behavioural neuroscience and child psychopathology: insights from model systems
    D H Skuse
    Behavioural Sciences Unit, Institute of Child Health, London, UK
    J Child Psychol Psychiatry 41:3-31. 2000
    ..This review draws out the parallels, and introduces recent findings from behavioural studies of C. elegans, D. melanogaster, and the laboratory mouse, as well as humans, to illustrate the point...
  14. ncbi request reprint Dosage-sensitive X-linked locus influences the development of amygdala and orbitofrontal cortex, and fear recognition in humans
    Catriona D Good
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, Institute of Child Health, London, UK
    Brain 126:2431-46. 2003
    ..We show that the thrombocytic activity of MAOB is proportionate to the number of X-chromosomes, and hypothesize that haploinsufficiency of this enzyme in 45,X females predisposes to their deficits in social cognition...
  15. ncbi request reprint Brief report: perception of genuine and posed smiles by individuals with autism
    Zillah L Boraston
    Behavioural and Brain Sciences Unit, Institute of Child Health, University College London, London WC1N 1EH, UK
    J Autism Dev Disord 38:574-80. 2008
    ..We conclude that reduced eye contact in autism leads to reduced ability to discriminate genuine from posed smiles with downstream effects on social interaction...
  16. ncbi request reprint Social communication deficits in conduct disorder: a clinical and community survey
    J Gilmour
    Sub Department of Clinical Health Psychology, University College London, UK
    J Child Psychol Psychiatry 45:967-78. 2004
    ..We hypothesised that pragmatic difficulties may underlie the antisocial behaviour in a proportion of children who are labelled as conduct disordered...
  17. doi request reprint Testing the construct validity of proposed criteria for DSM-5 autism spectrum disorder
    William P L Mandy
    Research Department of Clinical, Health and Educational Psychology, University College London, London, UK
    J Am Acad Child Adolesc Psychiatry 51:41-50. 2012
    ..To use confirmatory factor analysis to test the construct validity of the proposed DSM-5 symptom model of autism spectrum disorder (ASD), in comparison to alternative models, including that described in DSM-IV-TR...
  18. ncbi request reprint Adolescents and young adults with 22q11 deletion syndrome: psychopathology in an at-risk group
    Kate D Baker
    Behavioural and Brain Sciences Unit, Institute of Child Health, University College London, London WC1N 1EH, UK
    Br J Psychiatry 186:115-20. 2005
    ..If common neurodevelopmental trajectories characterise 22q11 deletion syndrome and idiopathic schizophrenia, then similar'premorbid'features would be predicted...
  19. doi request reprint Research review: What is the association between the social-communication element of autism and repetitive interests, behaviours and activities?
    William P L Mandy
    Sub Department of Clinical Health Psychology, University College London, London, UK
    J Child Psychol Psychiatry 49:795-808. 2008
    ..Some clinical and research implications are discussed...
  20. doi request reprint Social communication deficits in disruptive primary-school children
    R Donno
    Behavioural and Brain Sciences Unit, Institute of Child Health, University College London WC1N 1EH, UK
    Br J Psychiatry 196:282-9. 2010
    ..Parent and teacher data, from questionnaire surveys, suggest that school-identified disruptive children often have pragmatic language deficits of an autistic type...
  21. doi request reprint Common polymorphism in the oxytocin receptor gene (OXTR) is associated with human social recognition skills
    David H Skuse
    Institute of Child Health, University College London, London WC1N 1EH, United Kingdom
    Proc Natl Acad Sci U S A 111:1987-92. 2014
    ..Our findings imply that a critical role for the oxytocin system in social recognition has been conserved across perceptual boundaries through evolution, from olfaction in rodents to visual memory in humans. ..
  22. ncbi request reprint Influence of X chromosome and hormones on human brain development: a magnetic resonance imaging and proton magnetic resonance spectroscopy study of Turner syndrome
    William J Cutter
    Section of Brain Maturation, Department of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK
    Biol Psychiatry 59:273-83. 2006
    ..Hence, they allow us an opportunity to investigate genetic and endocrine influences on brain development...