D J Skene

Summary

Affiliation: University of Surrey
Country: UK

Publications

  1. ncbi request reprint Circadian rhythm sleep disorders in the blind and their treatment with melatonin
    Debra J Skene
    Centre for Chronobiology, School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, UK
    Sleep Med 8:651-5. 2007
  2. ncbi request reprint Human circadian rhythms: physiological and therapeutic relevance of light and melatonin
    Debra J Skene
    Centre for Chronobiology, School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, UK
    Ann Clin Biochem 43:344-53. 2006
  3. ncbi request reprint Melatonin as a chronobiotic
    Josephine Arendt
    School of Biomedical and Molecular Sciences, Centre for Chronobiology, University of Surrey, Guildford, Surrey GU2 7XH, UK
    Sleep Med Rev 9:25-39. 2005
  4. ncbi request reprint Optimization of light and melatonin to phase-shift human circadian rhythms
    D J Skene
    Centre for Chronobiology, School of Biomedical and Life Sciences, University of Surrey, Guildford GU2 7XH, UK
    J Neuroendocrinol 15:438-41. 2003
  5. ncbi request reprint Melatonin rhythmicity: effect of age and Alzheimer's disease
    Debra J Skene
    School of Biomedical and Life Sciences, University of Surrey, Guildford GU2 7XH, UK
    Exp Gerontol 38:199-206. 2003
  6. ncbi request reprint Use of melatonin in the treatment of phase shift and sleep disorders
    D J Skene
    School of Biological Sciences, University of Surrey, Guildford, U K
    Adv Exp Med Biol 467:79-84. 1999
  7. ncbi request reprint Melatonin in circadian sleep disorders in the blind
    D J Skene
    School of Biological Sciences, University of Surrey, Guildford, UK
    Biol Signals Recept 8:90-5. 1999
  8. ncbi request reprint Use of melatonin in circadian rhythm disorders and following phase shifts
    D J Skene
    School of Biological Sciences, University of Surrey, Guildford, UK
    Acta Neurobiol Exp (Wars) 56:359-62. 1996
  9. ncbi request reprint Effects of light on human circadian rhythms
    D J Skene
    School of Biological Sciences, University of Surrey, Guildford, UK
    Reprod Nutr Dev 39:295-304. 1999
  10. ncbi request reprint Relationship between melatonin rhythms and visual loss in the blind
    S W Lockley
    Chronobiology Laboratory, School of Biological Sciences, University of Surrey, United Kingdom
    J Clin Endocrinol Metab 82:3763-70. 1997

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Circadian rhythm sleep disorders in the blind and their treatment with melatonin
    Debra J Skene
    Centre for Chronobiology, School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, UK
    Sleep Med 8:651-5. 2007
    ..If practicable, assessment of an individual's circadian phase (by measurement of the endogenous melatonin rhythm in plasma, saliva or urine) is recommended prior to commencing treatment to optimise melatonin's effectiveness...
  2. ncbi request reprint Human circadian rhythms: physiological and therapeutic relevance of light and melatonin
    Debra J Skene
    Centre for Chronobiology, School of Biomedical and Molecular Sciences, University of Surrey, Guildford GU2 7XH, UK
    Ann Clin Biochem 43:344-53. 2006
    ....
  3. ncbi request reprint Melatonin as a chronobiotic
    Josephine Arendt
    School of Biomedical and Molecular Sciences, Centre for Chronobiology, University of Surrey, Guildford, Surrey GU2 7XH, UK
    Sleep Med Rev 9:25-39. 2005
    ..No long-term safety data exist, and the optimum dose and formulation for any application remains to be clarified...
  4. ncbi request reprint Optimization of light and melatonin to phase-shift human circadian rhythms
    D J Skene
    Centre for Chronobiology, School of Biomedical and Life Sciences, University of Surrey, Guildford GU2 7XH, UK
    J Neuroendocrinol 15:438-41. 2003
    ..Whether other nonvisual light responses (e.g. circadian phase resetting) show a similar spectral sensitivity is currently being studied...
  5. ncbi request reprint Melatonin rhythmicity: effect of age and Alzheimer's disease
    Debra J Skene
    School of Biomedical and Life Sciences, University of Surrey, Guildford GU2 7XH, UK
    Exp Gerontol 38:199-206. 2003
    ..Future research needs to pinpoint the site(s) of age-related dysfunction so that therapies can be specifically tailored to correct the abnormality in addition to reinforcing any of the intact processes...
  6. ncbi request reprint Use of melatonin in the treatment of phase shift and sleep disorders
    D J Skene
    School of Biological Sciences, University of Surrey, Guildford, U K
    Adv Exp Med Biol 467:79-84. 1999
    ..Compared with placebo, melatonin advanced the sleep period in subjects with DSPS. Melatonin also improved a number of sleep parameters in blind subjects suffering from non-24-hour sleep wake disorder...
  7. ncbi request reprint Melatonin in circadian sleep disorders in the blind
    D J Skene
    School of Biological Sciences, University of Surrey, Guildford, UK
    Biol Signals Recept 8:90-5. 1999
    ..The results suggest that prior knowledge of the subject's type of circadian rhythm, and timing of treatment in relation to the individual's circadian phase, may improve the efficacy of melatonin...
  8. ncbi request reprint Use of melatonin in circadian rhythm disorders and following phase shifts
    D J Skene
    School of Biological Sciences, University of Surrey, Guildford, UK
    Acta Neurobiol Exp (Wars) 56:359-62. 1996
    ..Taken together these findings suggest that melatonin is of benefit in facilitating adaptation to forced phase shifts and in conditions of circadian rhythm disturbance...
  9. ncbi request reprint Effects of light on human circadian rhythms
    D J Skene
    School of Biological Sciences, University of Surrey, Guildford, UK
    Reprod Nutr Dev 39:295-304. 1999
    ..Thus, ocular light appears to be the predominant time cue and major determinant of circadian rhythm type. Optimisation of the light for entrainment (intensity, duration, wavelength, time of administration) requires further study...
  10. ncbi request reprint Relationship between melatonin rhythms and visual loss in the blind
    S W Lockley
    Chronobiology Laboratory, School of Biological Sciences, University of Surrey, United Kingdom
    J Clin Endocrinol Metab 82:3763-70. 1997
    ..6 +/- 0.4 and 0.5 +/- 0.3 microgram/h, respectively). These results indicate that a higher proportion of NPL subjects have abnormal melatonin rhythms compared to those with LP...
  11. ncbi request reprint Sleep and activity rhythms are related to circadian phase in the blind
    S W Lockley
    School of Biological Sciences, University of Surrey, Guildford, UK
    Sleep 22:616-23. 1999
    ..The aim of the study was to assess sleep with simultaneous measurement of an endogenous marker of the circadian clock, namely 6-sulphatoxymelatonin (aMT6s)...
  12. ncbi request reprint Comparison between subjective and actigraphic measurement of sleep and sleep rhythms
    S W Lockley
    School of Biological Sciences, University of Surrey, Guildford, UK
    J Sleep Res 8:175-83. 1999
    ..In particular, the methods agreed when assessing changes in sleep in relation to a circadian phase marker (the 6-sulphatoxymelatonin (aMT6s) rhythm) in both entrained (n = 30) and free-running (n = 4) subjects...
  13. pmc An action spectrum for melatonin suppression: evidence for a novel non-rod, non-cone photoreceptor system in humans
    K Thapan
    Centre for Chronobiology, School of Biomedical and Life Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK
    J Physiol 535:261-7. 2001
    ..74). 5. Our data strongly support a primary role for a novel short-wavelength photopigment in light-induced melatonin suppression and provide the first direct evidence of a non-rod, non-cone photoreceptive system in humans...
  14. ncbi request reprint Use of a newly developed technique to isolate rat pinealocytes and study the effects of adenosine agonists on melatonin production
    J Nicholls
    School of Biological Sciences, University of Surrey, Guildford, United Kingdom
    J Pineal Res 23:164-8. 1997
    ..These results are consistent with activation by NECA of an A2b adenosine receptor...
  15. ncbi request reprint Suppression of nocturnal plasma melatonin and 6-sulphatoxymelatonin by bright and dim light in man
    C J Bojkowski
    Department of Biochemistry, University of Surrey, Guildford, England
    Horm Metab Res 19:437-40. 1987
    ..05, P less than 0.01), 0130 h (P less than 0.01, P less than 0.01) and 0200 h (P less than 0.01, P less than 0.001) respectively.(ABSTRACT TRUNCATED AT 250 WORDS)..
  16. ncbi request reprint Effect of menopause on melatonin and alertness rhythms investigated in constant routine conditions
    J F Walters
    Neuroendocrinology Group, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, Surrey, England
    Chronobiol Int 22:859-72. 2005
    ..In conclusion, under controlled experimental conditions the timing of the melatonin rhythm was advanced in postmenopausal women altering its phase relationship to subjective alertness and sleepiness...
  17. ncbi request reprint Contribution of CYP1A2 in the hepatic metabolism of melatonin: studies with isolated microsomal preparations and liver slices
    D J Skene
    School of Biological Sciences, University of Surrey, Guildford, Surrey, GU2 5XH, UK
    J Pineal Res 31:333-42. 2001
    ..Collectively, all the above data provide strong experimental evidence that CYP1A2 is an important catalyst of the 6-hydroxylation of melatonin...