Affiliation: University of Edinburgh
- VAPB interacts with and modulates the activity of ATF6Christos Gkogkas
The Centre for Neuroscience Research, The University of Edinburgh, The Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
Hum Mol Genet 17:1517-26. 2008..The mis-function of such regulatory systems may contribute to the pathological mechanisms of degenerative motor neuron disease...
- The ALS8-associated mutant VAPB(P56S) is resistant to proteolysis in neuronsChristos Gkogkas
Centre for Integrative Physiology, The University of Edinburgh, Edinburgh, UK
J Neurochem 117:286-94. 2011..These data suggest that neuronal cells have a particular requirement for VAPB proteolysis and that reduced levels of processed polypeptides may contribute to the neurodegeneration associated with amyotrophic lateral sclerosis type 8...
- A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosisAgnes L Nishimura
Human Genome Research Center, Department of Biology, Biosciences Institute, Sao Paulo University, Sao Paulo, Brazil
Am J Hum Genet 75:822-31. 2004..These data suggest that clinically variable MNDs may be caused by a dysfunction in intracellular membrane trafficking...