Paul Skehel

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. doi request reprint VAPB interacts with and modulates the activity of ATF6
    Christos Gkogkas
    The Centre for Neuroscience Research, The University of Edinburgh, The Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Hum Mol Genet 17:1517-26. 2008
  2. doi request reprint The ALS8-associated mutant VAPB(P56S) is resistant to proteolysis in neurons
    Christos Gkogkas
    Centre for Integrative Physiology, The University of Edinburgh, Edinburgh, UK
    J Neurochem 117:286-94. 2011
  3. pmc A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis
    Agnes L Nishimura
    Human Genome Research Center, Department of Biology, Biosciences Institute, Sao Paulo University, Sao Paulo, Brazil
    Am J Hum Genet 75:822-31. 2004

Collaborators

  • Thomas H Gillingwater
  • Christos Gkogkas
  • Caroline Wardrope
  • Matthew Hannah
  • Susan Middleton
  • Agnes L Nishimura
  • Anna M Kremer
  • Miguel Mitne-Neto
  • Duilio Cascio
  • João R M Oliveira
  • Antonio Richieri-Costa
  • Fernando Kok
  • Jeanette Webb
  • Mayana Zatz
  • Helga C A Silva

Detail Information

Publications3

  1. doi request reprint VAPB interacts with and modulates the activity of ATF6
    Christos Gkogkas
    The Centre for Neuroscience Research, The University of Edinburgh, The Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    Hum Mol Genet 17:1517-26. 2008
    ..The mis-function of such regulatory systems may contribute to the pathological mechanisms of degenerative motor neuron disease...
  2. doi request reprint The ALS8-associated mutant VAPB(P56S) is resistant to proteolysis in neurons
    Christos Gkogkas
    Centre for Integrative Physiology, The University of Edinburgh, Edinburgh, UK
    J Neurochem 117:286-94. 2011
    ..These data suggest that neuronal cells have a particular requirement for VAPB proteolysis and that reduced levels of processed polypeptides may contribute to the neurodegeneration associated with amyotrophic lateral sclerosis type 8...
  3. pmc A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis
    Agnes L Nishimura
    Human Genome Research Center, Department of Biology, Biosciences Institute, Sao Paulo University, Sao Paulo, Brazil
    Am J Hum Genet 75:822-31. 2004
    ..These data suggest that clinically variable MNDs may be caused by a dysfunction in intracellular membrane trafficking...