Steven P Sinkins

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. ncbi request reprint Gene drive systems for insect disease vectors
    Steven P Sinkins
    Department of Zoology, University of Oxford, Oxford OX1 3PS, UK
    Nat Rev Genet 7:427-35. 2006
  2. pmc Wolbachia stimulates immune gene expression and inhibits plasmodium development in Anopheles gambiae
    Zakaria Kambris
    Department of Zoology, University of Oxford, Peter Medawar Building for Pathogen Research, Oxford, United Kingdom
    PLoS Pathog 6:e1001143. 2010
  3. pmc Transcriptional profiling of Anopheles gambiae mosquitoes for adult age estimation
    P E Cook
    Department of Zoology, University of Oxford, Peter Medawar Building for Pathogen Research, Oxford, UK
    Insect Mol Biol 19:745-51. 2010
  4. pmc Invertebrate post-segregation distorters: a new embryo-killing gene
    Steven P Sinkins
    Department of Zoology, University of Oxford, United Kingdom
    PLoS Biol 9:e1001114. 2011
  5. ncbi request reprint Wolbachia variability and host effects on crossing type in Culex mosquitoes
    Steven P Sinkins
    Department of Zoology, University of Oxford, Peter Medawar Building, South Parks Road, Oxford OX1 3SY, UK
    Nature 436:257-60. 2005
  6. pmc Horizontal gene transfer between Wolbachia and the mosquito Aedes aegypti
    Lisa Klasson
    Department of Zoology, University of Oxford, Oxford, UK
    BMC Genomics 10:33. 2009
  7. pmc Genome evolution of Wolbachia strain wPip from the Culex pipiens group
    Lisa Klasson
    Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, Oxford, United Kingdom
    Mol Biol Evol 25:1877-87. 2008
  8. pmc A Wolbachia wMel transinfection in Aedes albopictus is not detrimental to host fitness and inhibits Chikungunya virus
    Marcus S C Blagrove
    University of Oxford, Peter Medawar Building for Pathogen Research and Departments of Medicine NDM Zoology, Oxford, United Kingdom
    PLoS Negl Trop Dis 7:e2152. 2013
  9. pmc Wolbachia strain wMel induces cytoplasmic incompatibility and blocks dengue transmission in Aedes albopictus
    Marcus S C Blagrove
    Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, United Kingdom
    Proc Natl Acad Sci U S A 109:255-60. 2012
  10. ncbi request reprint Population dynamic models of the spread of Wolbachia
    Penelope A Hancock
    Department of Zoology, University of Oxford, United Kingdom
    Am Nat 177:323-33. 2011

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Gene drive systems for insect disease vectors
    Steven P Sinkins
    Department of Zoology, University of Oxford, Oxford OX1 3PS, UK
    Nat Rev Genet 7:427-35. 2006
    ..Here we explore the potential of natural gene drive systems and discuss the artificial constructs that could be envisaged for this purpose...
  2. pmc Wolbachia stimulates immune gene expression and inhibits plasmodium development in Anopheles gambiae
    Zakaria Kambris
    Department of Zoology, University of Oxford, Peter Medawar Building for Pathogen Research, Oxford, United Kingdom
    PLoS Pathog 6:e1001143. 2010
    ..The data are discussed with respect to the comparative effects on malaria vectorial capacity of life shortening and direct inhibition of Plasmodium development that can be produced by Wolbachia...
  3. pmc Transcriptional profiling of Anopheles gambiae mosquitoes for adult age estimation
    P E Cook
    Department of Zoology, University of Oxford, Peter Medawar Building for Pathogen Research, Oxford, UK
    Insect Mol Biol 19:745-51. 2010
    ..The resulting age estimation assay was able to predict female age from lab-reared samples with sufficient accuracy to provide a potentially useful tool for studies of malaria epidemiology and control...
  4. pmc Invertebrate post-segregation distorters: a new embryo-killing gene
    Steven P Sinkins
    Department of Zoology, University of Oxford, United Kingdom
    PLoS Biol 9:e1001114. 2011
    ..elegans has produced an unusual distribution pattern for a selfish genetic element; further population and functional studies will shed light on its evolution. The element might also have potential for use in disease control...
  5. ncbi request reprint Wolbachia variability and host effects on crossing type in Culex mosquitoes
    Steven P Sinkins
    Department of Zoology, University of Oxford, Peter Medawar Building, South Parks Road, Oxford OX1 3SY, UK
    Nature 436:257-60. 2005
    ....
  6. pmc Horizontal gene transfer between Wolbachia and the mosquito Aedes aegypti
    Lisa Klasson
    Department of Zoology, University of Oxford, Oxford, UK
    BMC Genomics 10:33. 2009
    ..Recent transfers of genome fragments from Wolbachia into insect chromosomes have been reported, but it has been argued that these fragments may be on an evolutionary trajectory to degradation and loss...
  7. pmc Genome evolution of Wolbachia strain wPip from the Culex pipiens group
    Lisa Klasson
    Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, Oxford, United Kingdom
    Mol Biol Evol 25:1877-87. 2008
    ..This host-Wolbachia system, with its complex patterns of sterility induced between populations, now provides an excellent model for unraveling the molecular systems underlying host reproductive manipulation...
  8. pmc A Wolbachia wMel transinfection in Aedes albopictus is not detrimental to host fitness and inhibits Chikungunya virus
    Marcus S C Blagrove
    University of Oxford, Peter Medawar Building for Pathogen Research and Departments of Medicine NDM Zoology, Oxford, United Kingdom
    PLoS Negl Trop Dis 7:e2152. 2013
    ..Wolbachia strains also vary in their relative fitness effects on their hosts and this is a particularly important consideration with respect to the potential of newly created transinfections for use in disease control...
  9. pmc Wolbachia strain wMel induces cytoplasmic incompatibility and blocks dengue transmission in Aedes albopictus
    Marcus S C Blagrove
    Peter Medawar Building for Pathogen Research, University of Oxford, Oxford OX1 3SY, United Kingdom
    Proc Natl Acad Sci U S A 109:255-60. 2012
    ..Complete bidirectional cytoplasmic incompatibility was observed with WT strains infected with the naturally occurring Ae. albopictus Wolbachia, and this provides a mechanism for introducing wMel into natural populations of this species...
  10. ncbi request reprint Population dynamic models of the spread of Wolbachia
    Penelope A Hancock
    Department of Zoology, University of Oxford, United Kingdom
    Am Nat 177:323-33. 2011
    ..The results help understand the natural dynamics of Wolbachia infections and aid the design of programs to introduce Wolbachia to control insects that are disease vectors or pests...
  11. pmc Ankyrin repeat domain-encoding genes in the wPip strain of Wolbachia from the Culex pipiens group
    Thomas Walker
    Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    BMC Biol 5:39. 2007
    ..Species in the Culex pipiens complex display an unusually high number of Wolbachia-induced crossing types, and based on present data, only the wPip strain is present...
  12. pmc Immune activation by life-shortening Wolbachia and reduced filarial competence in mosquitoes
    Zakaria Kambris
    Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    Science 326:134-6. 2009
    ..The cost of constitutive immune up-regulation may contribute to the life-shortening phenotype...
  13. pmc Wolbachia in the Culex pipiens group mosquitoes: introgression and superinfection
    Thomas Walker
    Peter Medawar Building for Pathogen Research and Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
    J Hered 100:192-6. 2009
    ..The Wolbachia density was also shown to be lower in the parental Mol strain males compared with Col strain males, and no inverse relationship between WO phage and Wolbachia density could be detected...
  14. pmc Strategies for introducing Wolbachia to reduce transmission of mosquito-borne diseases
    Penelope A Hancock
    Department of Zoology, University of Oxford, Oxford, United Kingdom
    PLoS Negl Trop Dis 5:e1024. 2011
    ..The results show the importance of including mosquito population dynamics in studying Wolbachia spread and that male-biased releases can be an effective and safe way of rapidly establishing the symbiont in mosquito populations...
  15. doi request reprint Wolbachia and arbovirus inhibition in mosquitoes
    Steven P Sinkins
    Biomedical and Life Sciences, Lancaster University, Lancaster LA1 4YQ, UK and University of Oxford, Peter Medawar Building for Pathogen Research, NDM Experimental Medicine, South Parks Road, Oxford OX1 3SY, UK
    Future Microbiol 8:1249-56. 2013
    ..aegypti populations. ..
  16. pmc Transcriptional regulation of Culex pipiens mosquitoes by Wolbachia influences cytoplasmic incompatibility
    Sofia B Pinto
    Peter Medawar Building for Pathogen Research and Nuffield Department of Medicine NDM, University of Oxford, Oxford, United Kingdom Department of Zoology, University of Oxford, Oxford, United Kingdom
    PLoS Pathog 9:e1003647. 2013
    ..These data suggest that Wolbachia-mediated regulation of host gene expression is a component of the mechanism of cytoplasmic incompatibility. ..
  17. ncbi request reprint Male-specific insecticide resistance and mosquito transgene dispersal
    Steven P Sinkins
    Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK
    Trends Parasitol 20:413-6. 2004
    ..It should be possible to produce constructs where any potential risk of loss of male-specific expression would be negligible...
  18. pmc Use of Wolbachia to drive nuclear transgenes through insect populations
    Steven P Sinkins
    Vector Research Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Proc Biol Sci 271:1421-6. 2004
    ..The results provide a potentially powerful addition to the few insect transgene drive mechanisms that are available...
  19. ncbi request reprint Wolbachia and cytoplasmic incompatibility in mosquitoes
    Steven P Sinkins
    Vector Research Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Insect Biochem Mol Biol 34:723-9. 2004
    ....
  20. pmc Genome sequence of Aedes aegypti, a major arbovirus vector
    Vishvanath Nene
    Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA
    Science 316:1718-23. 2007
    ..An increase in genes encoding odorant binding, cytochrome P450, and cuticle domains relative to An. gambiae suggests that members of these protein families underpin some of the biological differences between the two mosquito species...