Research Topics
| Atul SinghalSummaryAffiliation: University College London Country: UK Publications
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Detail Information
Publications
Clinical safety of iron-fortified formulasA Singhal
Medical Research Council Childhood Nutrition Research Centre, Institute of Child Health, London, United Kingdom
Pediatrics 105:E38. 2000..Iron could theoretically increase pro-oxidant stress, with potential adverse effects, including infection risk, and some clinicians suspect that iron-fortified formulas induce gastrointestinal disturbance...- Early nutrition and leptin concentrations in later lifeAtul Singhal
MRC Childhood Nutrition Research Center, Institute of Child Health, London, United Kingdom
Am J Clin Nutr 75:993-9. 2002..Because obesity is associated with high leptin concentrations relative to fat mass, programming of leptin concentrations may be one mechanism by which early nutrition influences later obesity... 
Early growth and later atherosclerosisAtul Singhal
Childhood Nutrition Research Centre, University College London, Institute of Child Health, London, UK
World Rev Nutr Diet 106:162-7. 2013..The present review considers this evidence, the underlying mechanisms involved, and its implications for public health...- Nutrition in infancy and long-term risk of obesity: evidence from 2 randomized controlled trialsAtul Singhal
Medical Research Council Childhood Nutrition Research Centre, University College London, Institute of Child Health, London, United Kingdom
Am J Clin Nutr 92:1133-44. 2010..Growth acceleration as a consequence of relative overnutrition in infancy has been suggested to increase the risk of later obesity. However, few studies have investigated this association by using an experimental study design... - Early origins of cardiovascular disease: is there a unifying hypothesis?Atul Singhal
MRC Childhood Nutrition Research Centre, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
Lancet 363:1642-5. 2004 - Endothelial dysfunction: role in obesity-related disorders and the early origins of CVDAtul Singhal
MRC Childhood Nutrition Research Centre, Institute of Child Health, London, UK
Proc Nutr Soc 64:15-22. 2005..It also considers the mechanisms by which obesity impairs endothelial function, understanding of which will be important to further scientific knowledge and to improve public health... - Adiponectin predicts insulin resistance but not endothelial function in young, healthy adolescentsAtul Singhal
Medical Research Council, Childhood Nutrition Research Centre, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, United Kingdom
J Clin Endocrinol Metab 90:4615-21. 2005..We tested this hypothesis in a healthy, nonobese population... - Early nutrition and long-term cardiovascular healthAtul Singhal
MRC Childhood Nutrition Research Centre, Institute of Child Health, London, United Kingdom
Nutr Rev 64:S44-9; discussion S72-91. 2006..The size of this effect is large and relevant for public health. The potential mechanisms involved include a benefit of slower weight gain in breast-fed compared with formula-fed babies... - Promotion of faster weight gain in infants born small for gestational age: is there an adverse effect on later blood pressure?Atul Singhal
Medical Research Council Childhood Nutrition Research Centre, Institute of Child Health, 30 Guilford St, London, UK
Circulation 115:213-20. 2007..We report the long-term impact of growth promotion in term infants born small for gestational age (birth weight <10th percentile)... - Infant nutrition and stereoacuity at age 4-6 yAtul Singhal
Medical Research Council Childhood Nutrition Research Center, Institute of Child Health, London, United Kingdom
Am J Clin Nutr 85:152-9. 2007.... - Breastfeeding, early growth and later obesityA Singhal
Childhood Nutrition Research Centre, Institute of Child Health, London, UK
Obes Rev 8:51-4. 2007 - Dietary nucleotides and fecal microbiota in formula-fed infants: a randomized controlled trialAtul Singhal
Childhood Nutrition Research Center, Institute of Child Health, London, United Kingdom
Am J Clin Nutr 87:1785-92. 2008..A higher nucleotide intake may also have favorable effects on the fecal microbial composition and incidence of diarrhea in infancy. However, few studies have tested this hypothesis with an experimental study design... - The early origins of atherosclerosisAtul Singhal
The MRC Childhood Nutrition Research Centre, Institute of Child Health, London, UK
Adv Exp Med Biol 646:51-8. 2009..The critical window for these effects is unknown, but evidence is accumulating for programming effects of growth from very early in infancy... - Dietary nucleotides and early growth in formula-fed infants: a randomized controlled trialAtul Singhal
Institute of Child Health, Medical Research Council Childhood Nutrition Research Center, 30 Guilford St, London WC1N 3EH, United Kingdom
Pediatrics 126:e946-53. 2010..However, relatively few large-scale randomized trials have tested this hypothesis in healthy infants... - Breastmilk feeding and lipoprotein profile in adolescents born preterm: follow-up of a prospective randomised studyAtul Singhal
MRC Childhood Nutrition Research Centre, Institute of Child Health, London, UK
Lancet 363:1571-8. 2004..We tested the hypothesis that breastmilk feeding benefits the lipoprotein profile in adolescents born preterm, in whom randomisation to different diets at birth is feasible... - Energy intake and resting metabolic rate in preschool Jamaican children with homozygous sickle cell diseaseAtul Singhal
MRC Childhood Nutrition Research Center, Institute of Child Health, London, United Kingdom
Am J Clin Nutr 75:1093-7. 2002..The growth deficit in SCD emerges at an early age, but few studies have addressed the adequacy of energy intake relative to RMR in young children... - Early nutrition in preterm infants and later blood pressure: two cohorts after randomised trialsA Singhal
Medical Research Council Childhood Nutrition Research Centre, Institute of Child Health, London, UK
Lancet 357:413-9. 2001..We undertook such a study to test the hypothesis that early diet programmes blood pressure in later life in children randomly assigned different diets at birth... - Influence of leptin on arterial distensibility: a novel link between obesity and cardiovascular disease?Atul Singhal
MRC Childhood Nutrition Research Center, Institute of Child Health, London, UK
Circulation 106:1919-24. 2002..Therefore, we tested the hypothesis that high leptin concentrations are associated with lower arterial distensibility, an index of circulatory function relevant to the atherosclerotic process... - Programming of lean body mass: a link between birth weight, obesity, and cardiovascular disease?Atul Singhal
MRC Childhood Nutrition Research Center, Institute of Child Health, London, UK
Am J Clin Nutr 77:726-30. 2003..Programming of more lean tissue rather than fat mass by a high birth weight might explain this paradox and also explain the association of birth weight with later body mass index. This concept has been inadequately tested... - Low nutrient intake and early growth for later insulin resistance in adolescents born pretermAtul Singhal
The MRC Childhood Nutrition Research Centre, Institute of Child Health, London, UK
Lancet 361:1089-97. 2003.... - Is slower early growth beneficial for long-term cardiovascular health?Atul Singhal
MRC Childhood Nutrition Research Center, Institute of Child Health, 30 Guilford St, London, UK, WC1N 1EH
Circulation 109:1108-13. 2004..To test this hypothesis in humans, we measured flow-mediated endothelium-dependent dilation (FMD) in a population subject to slower early growth and in healthy controls... - The 10-year follow-up of a randomised trial of long-chain polyunsaturated fatty acid supplementation in preterm infants: effects on growth and blood pressureKathy Kennedy
MRC Childhood Nutrition Research Centre, UCL Institute of Child Health, London, UK
Arch Dis Child 95:588-95. 2010..To test the hypothesis that consumption of infant formulas containing long-chain polyunsaturated fatty acids (LCPUFAs) by preterm infants would favourably influence growth, body composition and blood pressure (BP) at age 10 years... - Randomized, double-blind trial of long-chain polyunsaturated fatty acid supplementation with fish oil and borage oil in preterm infantsMary S Fewtrell
MRC Childhood Nutrition Research Centre, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
J Pediatr 144:471-9. 2004..To test the efficacy and safety of long-chain polyunsaturated fatty acid (LCPUFA) supplementation with gamma-linolenic acid, a precursor of arachidonic acid, and docosahexaenoic acid in preterm infants... - Early diet and peak bone mass: 20 year follow-up of a randomized trial of early diet in infants born pretermMary S Fewtrell
MRC Childhood Nutrition Research Centre, UCL Institute of Child Health, London, UK
Bone 45:142-9. 2009..Preterm infants are at risk of metabolic bone disease due to inadequate mineral intake with unknown consequences for later bone health... - Toddler diets in the UK: deficiencies and imbalances. 2. Relationship of toddler diet to later healthJulie Lanigan
MRC Childhood Nutrition Research Centre, Institute of Child Health, London
J Fam Health Care 17:197-200. 2007..Meals plans are included. This paper follows on from Part 1 (Journal of Family Health Care 2007; 17(5): 167-170) which reviewed the risks of micronutrient deficiencies... - Double-blind, randomized trial of long-chain polyunsaturated fatty acid supplementation in formula fed to preterm infantsMary S Fewtrell
MRC Childhood Nutrition Research Center, Institute of Child Health, London, United Kingdom
Pediatrics 110:73-82. 2002.... - Early nutrition and long-term health: a practical approachJulie Lanigan
The MRC Childhood Nutrition Research Centre, University College London, Institute of Child Health, London WC1N 1EH, UK
Proc Nutr Soc 68:422-9. 2009..The present review considers this evidence, the underlying mechanisms involved and its implications for public health... - The effect of intrauterine growth on verbal IQ scores in childhood: a study of monozygotic twinsCaroline J Edmonds
Medical Research Council, Childhood Nutrition Research Centre, Institute of Child Health, University College London, London, United Kingdom
Pediatrics 126:e1095-101. 2010.... - Randomized controlled trial of the MEND program: a family-based community intervention for childhood obesityPaul M Sacher
MRC Childhood Nutrition Research Centre, UCL Institute of Child Health, London, UK
Obesity (Silver Spring) 18:S62-8. 2010..High-attendance rates suggest that families found this intensive community-based intervention acceptable. Further larger controlled trials are currently underway to confirm the promising findings of this initial trial... - Does early growth affect long-term risk factors for cardiovascular disease?Atul Singhal
MRC Childhood Nutrition Research Centre, Institute of Child Health, University College London, London, UK
Nestle Nutr Workshop Ser Pediatr Program 65:55-64; discussion 64-9. 2010..The present review considers this evidence, the underlying mechanisms involved and its implications for public health... - A simplified approach to analysing bio-electrical impedance data in epidemiological surveysJ C K Wells
MRC Childhood Nutrition Research Centre, Institute of Child Health, London, UK
Int J Obes (Lond) 31:507-14. 2007..It is simple, quick and cheap, but less accurate than other methods. It has potential epidemiological value, but has conventionally required validation before application... - Fetal, infant and childhood growth: relationships with body composition in Brazilian boys aged 9 yearsJ C K Wells
MRC Childhood Nutrition Research Centre, Institute of Child Health, London UK
Int J Obes (Lond) 29:1192-8. 2005..Early growth rate has been linked to later obesity categorised by body mass index (BMI), but the development of body composition has rarely been studied... - Catch-up growth in small-for-gestational-age term infants: a randomized trialM S Fewtrell
MRC Childhood Nutrition Research Centre, Institute of Child Health, London, England
Am J Clin Nutr 74:516-23. 2001..Small-for-gestational-age (SGA) term infants are at risk of long-term growth deficits... - Body composition in early onset eating disordersD Nicholls
Brain and Behavioural Sciences Unit, Institute of Child Health, London, UK
Eur J Clin Nutr 56:857-65. 2002..Although of value as screening instruments the limitation in disease states is their inability to discriminate fat and fat-free components of body weight... - Randomized trial comparing the efficacy of a novel manual breast pump with a standard electric breast pump in mothers who delivered preterm infantsM S Fewtrell
MRC Childhood Nutrition Research Centre, Institute of Child Health, London
Pediatrics 107:1291-7. 2001.... - Toddler diets in the U.K.: deficiencies and imbalances. 1. Risk of micronutrient deficienciesBianca Turnbull
MRC Childhood Nutrition Research Centre, Institute of Child Health, University College, London
J Fam Health Care 17:167-70. 2007..In Part 2 (to be published in Journal of Family Health Care 2007; 17[6]), the authors will consider effects on health of nutritional imbalance resulting from overconsumption of energy and nutrients... - Does breastfeeding protect from growth acceleration and later obesity?Atul Singhal
The MRC Childhood Nutrition Research Centre, Institute of Child Health, London, UK
Nestle Nutr Workshop Ser Pediatr Program 60:15-25; discussion 25-9. 2007..The present review considers the evidence for a role of early growth and breastfeeding in the programming of obesity and the underlying mechanisms involved... - How much loss to follow-up is acceptable in long-term randomised trials and prospective studies?Mary S Fewtrell
Childhood Nutrition Research Centre, UCL Institute of Child Health, London, UK
Arch Dis Child 93:458-61. 2008 - Prevention of obesity in preschool childrenJulie Lanigan
The MRC Childhood Nutrition Research Centre, University College London, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK
Proc Nutr Soc 69:204-10. 2010..However, few of these studies have been successful and there is an urgent need, therefore, for the development of evidence-based interventions aimed at the prevention of preschool obesity... - Randomized trial of nutrient-enriched formula versus standard formula for postdischarge preterm infantsA Lucas
MRC Childhood Nutrition Research Centre, Institute of Child Health, London, England
Pediatrics 108:703-11. 2001..3) Our data raise the possibility that breastfed postdischarge preterm infants may require nutritional supplementation, currently under investigation... - Nutritional interventions in infancy and childhood for prevention of atherosclerosis and the metabolic syndromeAtul Singhal
MRC Childhood Nutrition Research Centre, Institute of Child Health, London, UK
Nestle Nutr Workshop Ser Pediatr Program 57:15-25; discussion 25-30. 2006 - The circulating calcification inhibitors, fetuin-A and osteoprotegerin, but not matrix Gla protein, are associated with vascular stiffness and calcification in children on dialysisRukshana C Shroff
Nephrourology Unit, Great Ormond Street Hospital and UCL Institute of Child Health, London WC1N 1EH, UK
Nephrol Dial Transplant 23:3263-71. 2008.... - Circulating human heat shock protein 60 in the blood of healthy teenagers: a novel determinant of endothelial dysfunction and early vascular injury?Julian P J Halcox
Arterioscler Thromb Vasc Biol 25:e141-2. 2005