Mervyn Singer

Summary

Affiliation: University College London
Country: UK

Publications

  1. doi request reprint Management of fluid balance: a European perspective
    Mervyn Singer
    University College London, London, UK
    Curr Opin Anaesthesiol 25:96-101. 2012
  2. pmc The role of mitochondrial dysfunction in sepsis-induced multi-organ failure
    Mervyn Singer
    Bloomsbury Institute of Intensive Care Medicine University College London London, UK
    Virulence 5:66-72. 2014
  3. pmc Short-term hypoxic vasodilation in vivo is mediated by bioactive nitric oxide metabolites, rather than free nitric oxide derived from haemoglobin-mediated nitrite reduction
    Michele Umbrello
    Bloomsbury Institute of Intensive Care Medicine, University College London, Cruciform Building, Gower Street, London WC1E 6BT, UK
    J Physiol 592:1061-75. 2014
  4. pmc Bench-to-bedside review: Immunoglobulin therapy for sepsis - biological plausibility from a critical care perspective
    Manu Shankar-Hari
    Department of Critical Care Medicine, Guy s and St Thomas NHS Foundation Trust, London SE1 7EH, UK
    Crit Care 16:206. 2012
  5. pmc Clinical review: Update on hemodynamic monitoring--a consensus of 16
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, Belgium
    Crit Care 15:229. 2011
  6. pmc Biomarkers in sepsis
    Mervyn Singer
    University College London, London, UK
    Curr Opin Pulm Med 19:305-9. 2013
  7. pmc Advancing critical care: time to kiss the right frog
    Mervyn Singer
    Department of Intensive Care Medicine, Bloomsbury Institute of Intensive Care Medicine, University College London, Cruciform Building, Gower Street, London WC1E 6BT, UK
    Crit Care 17:S3. 2013
  8. pmc Thirty years of critical care medicine
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Bruxelles, Belgium
    Crit Care 14:311. 2010
  9. pmc Clinical review: a systematic review of corticosteroid use in infections
    Jody Aberdein
    Department of Intensive Care Medicine, University College London Hospitals NHS Trust, Mortimer St, London W1T 3AA, UK
    Crit Care 10:203. 2006
  10. pmc Why aren't we practising homogenized medicine?
    Mervyn Singer
    Crit Care 11:157. 2007

Collaborators

Detail Information

Publications121 found, 100 shown here

  1. doi request reprint Management of fluid balance: a European perspective
    Mervyn Singer
    University College London, London, UK
    Curr Opin Anaesthesiol 25:96-101. 2012
    ....
  2. pmc The role of mitochondrial dysfunction in sepsis-induced multi-organ failure
    Mervyn Singer
    Bloomsbury Institute of Intensive Care Medicine University College London London, UK
    Virulence 5:66-72. 2014
    ..This overview will provide insights into mitochondrial biology, the relevance to sepsis, and therapeutic opportunities that possibly emerge. ..
  3. pmc Short-term hypoxic vasodilation in vivo is mediated by bioactive nitric oxide metabolites, rather than free nitric oxide derived from haemoglobin-mediated nitrite reduction
    Michele Umbrello
    Bloomsbury Institute of Intensive Care Medicine, University College London, Cruciform Building, Gower Street, London WC1E 6BT, UK
    J Physiol 592:1061-75. 2014
    ..In conclusion, acute hypoxic vasodilation is an adaptive NO-mediated response conferred through bioactive metabolites rather than free NO from haemoglobin-mediated reduction of nitrite...
  4. pmc Bench-to-bedside review: Immunoglobulin therapy for sepsis - biological plausibility from a critical care perspective
    Manu Shankar-Hari
    Department of Critical Care Medicine, Guy s and St Thomas NHS Foundation Trust, London SE1 7EH, UK
    Crit Care 16:206. 2012
    ....
  5. pmc Clinical review: Update on hemodynamic monitoring--a consensus of 16
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, 808 Route de Lennik, 1070 Brussels, Belgium
    Crit Care 15:229. 2011
    ....
  6. pmc Biomarkers in sepsis
    Mervyn Singer
    University College London, London, UK
    Curr Opin Pulm Med 19:305-9. 2013
    ..This review discusses the current developments in biomarkers for sepsis...
  7. pmc Advancing critical care: time to kiss the right frog
    Mervyn Singer
    Department of Intensive Care Medicine, Bloomsbury Institute of Intensive Care Medicine, University College London, Cruciform Building, Gower Street, London WC1E 6BT, UK
    Crit Care 17:S3. 2013
    ..Complacency, with an unfair apportion of blame on the patient for not getting better, is the biggest threat to continued improvement...
  8. pmc Thirty years of critical care medicine
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Route de Lennik 808, 1070 Bruxelles, Belgium
    Crit Care 14:311. 2010
    ..We then look at the process of care and realize that, here, huge progress has been made. Lastly, we suggest how critical care medicine will continue to evolve for the better over the next 30 years...
  9. pmc Clinical review: a systematic review of corticosteroid use in infections
    Jody Aberdein
    Department of Intensive Care Medicine, University College London Hospitals NHS Trust, Mortimer St, London W1T 3AA, UK
    Crit Care 10:203. 2006
    ..We therefore performed a systematic review of the literature to identify the current strength of evidence for the use of corticosteroids in specified infections, and to make appropriate graded recommendations...
  10. pmc Why aren't we practising homogenized medicine?
    Mervyn Singer
    Crit Care 11:157. 2007
    ..The need for further generalisable research, anonymised audit, external peer review and open access databases is discussed...
  11. pmc Bench-to-bedside review: potential strategies to protect or reverse mitochondrial dysfunction in sepsis-induced organ failure
    Alessandro Protti
    Bloomsbury Institute of Intensive Care Medicine, Wolfson Institute for Biomedical Research and Department of Medicine, University College London, London, UK
    Crit Care 10:228. 2006
    ..Repair of damaged organelles through stimulation of mitochondrial biogenesis and reactivation of cellular metabolism may accelerate resolution of the multiple organ failure syndrome...
  12. pmc In vivo killing of Staphylococcus aureus using a light-activated antimicrobial agent
    Parjam S Zolfaghari
    Bloomsbury Institute of Intensive Care Medicine, Wolfson Institute for Biomedical Research, University College London, London, UK
    BMC Microbiol 9:27. 2009
    ..In this study we report for the first time the use of a light-activated antimicrobial agent, methylene blue, to kill an epidemic methicillin-resistant Staphylococcus aureus (EMRSA-16) strain in two mouse wound models...
  13. ncbi request reprint Mitochondrial function in sepsis: acute phase versus multiple organ failure
    Mervyn Singer
    Intensive Care Medicine, Bloomsbury Institute of Intensive Care Medicine, Department of Medicine, University College London, London, UK
    Crit Care Med 35:S441-8. 2007
    ..To describe temporal changes in mitochondrial function during the septic process, including the recovery phase...
  14. ncbi request reprint The Surviving Sepsis guidelines: evidence-based ... or evidence-biased?
    Mervyn Singer
    Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK
    Crit Care Resusc 8:244-5. 2006
  15. pmc The key advance in the treatment of sepsis in the last 10 years...doing less
    Mervyn Singer
    University College London, Gower St, London WC1E 6BT, UK
    Crit Care 10:122. 2006
    ..Although certainly not qualifying as a 'brave new world' in terms of daring and exciting innovation, the importance of (often covert) iatrogenic complications should not be underestimated...
  16. pmc Treating critical illness: the importance of first doing no harm
    Mervyn Singer
    Bloomsbury Institute of Intensive Care Medicine, University College London, United Kingdom
    PLoS Med 2:e167. 2005
  17. ncbi request reprint Catecholamine treatment for shock--equally good or bad?
    Mervyn Singer
    Bloomsbury Institute of Intensive Care Medicine, Wolfson Institute for Biomedical Research and Department of Medicine, University College London, London WC1E 6BT, UK
    Lancet 370:636-7. 2007
  18. ncbi request reprint Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation
    Mervyn Singer
    Bloomsbury Institute of Intensive Care Medicine, Wolfson Institute of Biomedical Research and Department of Medicine, University College London, London, UK
    Lancet 364:545-8. 2004
    ..Third, this effect on mitochondria might be the consequence of acute-phase changes in hormones and inflammatory mediators...
  19. ncbi request reprint Arginine vasopressin vs. terlipressin in the treatment of shock states
    Mervyn Singer
    Bloomsbury Institute of Intensive Care Medicine, University College London, Cruciform Building, Gower Street, London WC1E 6BT, United Kingdom
    Best Pract Res Clin Anaesthesiol 22:359-68. 2008
    ..This review analyses the published literature and makes comparisons, where possible, between vasopressin and terlipressin...
  20. ncbi request reprint Cellular dysfunction in sepsis
    Mervyn Singer
    University College London, Cruciform Building, Gower Street, London WC1E 6BT, UK
    Clin Chest Med 29:655-60, viii-ix. 2008
    ..This may well represent an adaptive mechanism analogous to hibernation that prevents a massive degree of cell death and thus enables eventual recovery in survivors...
  21. doi request reprint Oesophageal Doppler
    Mervyn Singer
    Intensive Care Medicine, Department of Medicine and Wolfson Institute of Biomedical Research, University College London, Cruciform Building, Gower Street, London WC1E 6BT, UK
    Curr Opin Crit Care 15:244-8. 2009
    ....
  22. pmc Bench-to-bedside review: the role of C1-esterase inhibitor in sepsis and other critical illnesses
    Mervyn Singer
    Bloomsbury Institute of Intensive Care Medicine, University College London, Cruciform Building, Gower Street, London, WC1E 6BT, UK
    Crit Care 15:203. 2011
    ..The purpose of this bench-to-bedside review is to summarize the literature relating to complement activation in sepsis and other critical illnesses and the role of C1-esterase inhibitor (C1 INH) as a potential therapy...
  23. pmc Another nail in the hammer's coffin?
    Mervyn Singer
    Bloomsbury Institute of Intensive Care Medicine, University College London, Cruciform Building, Gower Street, London WC1E 6BT, UK
    Crit Care 15:179. 2011
    ..Their use requires re-evaluation in the light of a wide range of deleterious actions and retrospective studies suggesting harm...
  24. pmc Clinical review: Thinking outside the box--an iconoclastic view of current practice
    Mervyn Singer
    Bloomsbury Institute of Intensive Care Medicine, Department of Medicine, University College London, London WC1E 6BT, UK
    Crit Care 15:225. 2011
    ..This article is a synopsis of a roundtable meeting held in Brussels in March 2010 designed specifically to confront doctrine with reasoned scientific argument, and to propose new ideas for advancing critical care practices and outcomes...
  25. ncbi request reprint Reversal of life-threatening, drug-related potassium-channel syndrome by glibenclamide
    Mervyn Singer
    Bloomsbury Institute of Intensive Care Medicine, Department of Medicine, University College London, Middlesex Hospital, London W1T 3AA, UK
    Lancet 365:1873-5. 2005
    ..Over the past 3 years, we have seen this syndrome and response in five patients taking nicorandil, ciclosporin, or isoflurane, which suggests that this disorder arises more frequently than is currently realised...
  26. ncbi request reprint Management of multiple organ failure: guidelines but no hard-and-fast rules
    M Singer
    Bloomsbury Institute of Intensive Care Medicine, UCL Medical School, Rayne Institute, London, UK
    J Antimicrob Chemother 41:103-12. 1998
    ..An increasing emphasis is being placed on prevention of organ dysfunction, including maintenance of tissue oxygenation, nutrition and infection control...
  27. ncbi request reprint Post hoc insights from PAC-Man--the U.K. pulmonary artery catheter trial
    Sheila E Harvey
    Medical Statistics Unit, London School of Hygiene and Tropical Medicine, London, UK
    Crit Care Med 36:1714-21. 2008
    ..K. intensive care units and to generate hypotheses to guide future research by examining subsets of patients included in the PAC-Man Study...
  28. pmc Resistance to endotoxic shock in mice lacking natriuretic peptide receptor-A
    Catherine M Panayiotou
    Pharmacology NPP, University College London, Medical Sciences Building, London, UK
    Br J Pharmacol 160:2045-54. 2010
    ....
  29. ncbi request reprint An integrated approach to assessing nitroso-redox balance in systemic inflammation
    Alex Dyson
    Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK
    Free Radic Biol Med 51:1137-45. 2011
    ....
  30. doi request reprint Inhibition of vascular adenosine triphosphate-sensitive potassium channels by sympathetic tone during sepsis
    Yi Ling Chan
    Bloomsbury Institute of Intensive Care Medicine, Centre for Clinical Pharmacology and Therapeutics, Division of Medicine, University College London, UK
    Crit Care Med 40:1261-8. 2012
    ..Temporal changes in ex-vivo channel activity and subunit gene expression were also investigated...
  31. ncbi request reprint Succinate recovers mitochondrial oxygen consumption in septic rat skeletal muscle
    Alessandro Protti
    Bloomsbury Institute of Intensive Care Medicine, Wolfson Institute for Biomedical Research, and Department of Medicine, University College London, London, UK
    Crit Care Med 35:2150-5. 2007
    ..Increasing electron flow through complex II by addition of succinate may improve mitochondrial oxygen utilization and thus adenosine triphosphate production...
  32. ncbi request reprint Cellular energetic metabolism in sepsis: the need for a systems approach
    Jane E Carré
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Biochim Biophys Acta 1777:763-71. 2008
    ..A modular framework is proposed that can be used to assess the control hierarchy of cellular energetics in this complex pathophysiological condition...
  33. ncbi request reprint Differential effects of vasopressin and norepinephrine on vascular reactivity in a long-term rodent model of sepsis
    Lucinda K Barrett
    Wolfson Institute for Biomedical Research, and the Department of Medicine, University College London, London, UK
    Crit Care Med 35:2337-43. 2007
    ..We investigated whether a long-term rodent model of sepsis would produce changes in endogenous levels and pressor reactivity to exogenous norepinephrine and vasopressin comparable with those seen in septic patients...
  34. ncbi request reprint Low-molecular-weight polyethylene glycol improves survival in experimental sepsis
    Gareth L Ackland
    Centre for Anaesthesia, Critical Care and Pain Management, University College London, London, UK
    Crit Care Med 38:629-36. 2010
    ..We hypothesized that part of the beneficial action of PEGylated drugs may be derived from the anti-inflammatory properties of polyethylene glycol (PEG) itself...
  35. pmc BK large conductance Ca²+-activated K+ channel-deficient mice are not resistant to hypotension and display reduced survival benefit following polymicrobial sepsis
    Alastair J O'Brien
    Institute of Hepatology and Department of Medicine, University College, London, UK
    Shock 35:485-91. 2011
    ..In conclusion, the BK channel does not appear to be integral to sepsis-induced hypotension but does affect survival through other mechanisms. The pressor effect of TEA may be related to effects on other potassium channels...
  36. doi request reprint Bladder tissue oxygen tension monitoring in pigs subjected to a range of cardiorespiratory and pharmacological challenges
    Alex Dyson
    Bloomsbury Institute of Intensive Care Medicine, Division of Medicine, University College London, Cruciform Building, Gower St, London, WC1E 6BT, UK
    Intensive Care Med 38:1868-76. 2012
    ..As a prelude to clinical testing, we aimed to provide further validation of bladder tPO(2) monitoring in a large animal model undergoing a range of cardiorespiratory insults and vasoactive drug interventions...
  37. doi request reprint Early functional and transcriptomic changes in the myocardium predict outcome in a long-term rat model of sepsis
    Alain Rudiger
    Bloomsbury Institute of Intensive Care Medicine, Division of Medicine, University College London, Gower Street, London WC1E 6BT, UK
    Clin Sci (Lond) 124:391-401. 2013
    ..Transcriptomic analysis in heart tissue identified changes in signalling pathways that correlated with clinical dysfunction. These pathways merit further study to both better understand and potentially modify the disease process...
  38. doi request reprint Temporal changes in tissue cardiorespiratory function during faecal peritonitis
    Alex Dyson
    Bloomsbury Institute of Intensive Care Medicine, Department of Medicine and Wolfson Institute for Biomedical Research, University College London, Cruciform Building, Gower St, London, WC1E 6BT, UK
    Intensive Care Med 37:1192-200. 2011
    ..We also examined the utility of a dynamic oxygen challenge test to assess the microcirculation...
  39. ncbi request reprint Cardioprotection, attenuated systemic inflammation, and survival benefit of beta1-adrenoceptor blockade in severe sepsis in rats
    Gareth L Ackland
    Centre for Anaesthesia, Critical Care and Pain Medicine, University College London, UK
    Crit Care Med 38:388-94. 2010
    ..To explore the hypothesis that beta-1 adrenoreceptor blockade may be protective through the attenuation of sympathetic hyperactivity and catecholaminergic inflammatory effects on cardiac and hepatic function...
  40. doi request reprint Variable effects of inhibiting iNOS and closing the vascular ATP-sensitive potassium channel (via its pore-forming and sulfonylurea receptor subunits) in endotoxic shock
    Alastair O'Brien
    Department of Medicine, University College London, United Kingdom
    Shock 31:535-41. 2009
    ..It therefore remains uncertain whether the iNOS pathway or the K(ATP) channel represents a potential target for drug development in the treatment of endotoxic shock...
  41. pmc Survival in critical illness is associated with early activation of mitochondrial biogenesis
    Jane E Carré
    Bloomsbury Institute for Intensive Care Medicine, Department of Medicine and Wolfson Institute of Biomedical Research, University College London, London, United Kingdom
    Am J Respir Crit Care Med 182:745-51. 2010
    ..We postulate that survivors have a greater ability to maintain or recover normal mitochondrial functionality...
  42. ncbi request reprint The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching
    Michele Umbrello
    1 Department of Medicine, Bloomsbury Institute of Intensive Care Medicine, University College London, London, United Kingdom
    Antioxid Redox Signal 19:1690-710. 2013
    ....
  43. ncbi request reprint Tissue oxygen monitoring in rodent models of shock
    Alex Dyson
    Bloomsbury Institute of Intensive Care Medicine, University College London, Gower Street, London, UK
    Am J Physiol Heart Circ Physiol 293:H526-33. 2007
    ..Whole body monitoring is not generally reflective of these changes...
  44. ncbi request reprint Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure
    David Brealey
    Bloomsbury Institute of Intensive Care Medicine, Wolfson Institute of Biomedical Research, Department of Medicine, University College London, London WC1E 6BT, United Kingdom
    Am J Physiol Regul Integr Comp Physiol 286:R491-7. 2004
    ..Despite the well-recognized limitations of laboratory models, we found clear parallels between this long-term model and human disease characteristics that will facilitate future translational research...
  45. doi request reprint Monitoring tissue perfusion, oxygenation, and metabolism in critically ill patients
    Nasirul J Ekbal
    Bloomsbury Institute of Intensive Care Medicine, Division of Medicine, University College London, London, England
    Chest 143:1799-808. 2013
    ..This review describes techniques available for real-time monitoring of tissue perfusion and metabolism and highlights novel developments that may complement or even supersede current tools...
  46. doi request reprint Animal models of sepsis: why does preclinical efficacy fail to translate to the clinical setting?
    Alex Dyson
    Bloomsbury Institute of Intensive Care Medicine, Department of Medicine, University College London, London, United Kingdom
    Crit Care Med 37:S30-7. 2009
    ..To postulate reasons as to why the benefits seen with novel therapies in animal models of sepsis fail to translate to the clinical setting...
  47. pmc Peripheral neural detection of danger-associated and pathogen-associated molecular patterns
    Gareth L Ackland
    Department of Medicine, Division of Medicine, Bloomsbury Institute of Intensive Care Medicine, University College London, London, United Kingdom
    Crit Care Med 41:e85-92. 2013
    ....
  48. ncbi request reprint Tissue oxygen and hemodynamics in renal medulla, cortex, and corticomedullary junction during hemorrhage-reperfusion
    Tony Whitehouse
    Bloomsbury Institute of Intensive Care Medicine, University College London, Gower St, London WC1E 6BT, UK
    Am J Physiol Renal Physiol 291:F647-53. 2006
    ..To our knowledge, this is the first quantitative demonstration of a markedly heterogeneous intrarenal cardiorespiratory response to a hemodynamic insult, with effects most marked at the corticomedullary junction...
  49. ncbi request reprint Association between mitochondrial dysfunction and severity and outcome of septic shock
    David Brealey
    Bloomsbury Institute of Intensive Care Medicine, Wolfson Institute of Biomedical Research and Department of Medicine, University College London, London W1T 3AA, UK
    Lancet 360:219-23. 2002
    ....
  50. ncbi request reprint Antibiotic use and impact on outcome from bacteraemic critical illness: the BActeraemia Study in Intensive Care (BASIC)
    Alberto Corona
    Bloomsbury Institute of Intensive Care Medicine, Department of Medicine and Wolfson Institute of Biomedical Research, University College London, and Department of Microbiology, University College London Hospitals NHS Foundation Trust, Gower Street, London WC1E 6BT, UK
    J Antimicrob Chemother 65:1276-85. 2010
    ..We therefore prospectively investigated the epidemiology of bacteraemia and fungaemia in intensive care units (ICUs); and the impact of timing, type and appropriateness of antibiotic intervention...
  51. ncbi request reprint Vasopressin: mechanisms of action on the vasculature in health and in septic shock
    Lucinda K Barrett
    Department of Medicine and Wolfson Institute for Biomedical Research, University College London, London, UK
    Crit Care Med 35:33-40. 2007
    ..However, despite considerable research attention, the mechanisms for vasopressin deficiency and hypersensitivity in vasodilatory shock remain unclear...
  52. doi request reprint Organ failure in the ICU: cellular alterations
    James N Fullerton
    Division of Medicine, Centre for Clinical Pharmacology, Rayne Institute, London, United Kingdom
    Semin Respir Crit Care Med 32:581-6. 2011
    ..This review discusses data demonstrating temporal changes in oxygen utilization through the septic process, evidence for mitochondrial derangements, and recovery of mitochondrial function preceding clinical recovery...
  53. doi request reprint The impact of inspired oxygen concentration on tissue oxygenation during progressive haemorrhage
    Alex Dyson
    Bloomsbury Institute of Intensive Care Medicine, Department of Medicine and Wolfson Institute for Biomedical Research, University College London, Gower Street, London, UK
    Intensive Care Med 35:1783-91. 2009
    ..However, this may induce microvascular constriction and potentially impair regional oxygen delivery. We thus investigated the impact of varying inspired oxygen concentrations in a rat model of progressive haemorrhage...
  54. pmc Is MOF an outcome parameter or a transient, adaptive state in critical illness?
    Nicolas Mongardon
    Bloomsbury Institute of Intensive Care Medicine, Department of Medicine, University College London, London, UK
    Curr Opin Crit Care 15:431-6. 2009
    ..However, this traditional paradigm may not be necessarily accurate. This review will investigate the rationale for no longer considering MOF to be simply a 'failed' pathophysiological state...
  55. ncbi request reprint Inflammation and endothelial function: direct vascular effects of human C-reactive protein on nitric oxide bioavailability
    Brian R Clapp
    Centre for Clinical Pharmacology and Therapeutics, BHF Laboratories, University College London, London, United Kingdom
    Circulation 111:1530-6. 2005
    ..We therefore investigated the direct effect of CRP on vascular reactivity...
  56. doi request reprint Tissue oxygen tension monitoring: will it fill the void?
    Alex Dyson
    Bloomsbury Institute of Intensive Care Medicine, Department of Medicine, University College London, London, UK
    Curr Opin Crit Care 17:281-9. 2011
    ..This article examines the different technologies available and reviews the current literature regarding its utility as a monitor...
  57. ncbi request reprint Importance of the environment for patient acquisition of methicillin-resistant Staphylococcus aureus in the intensive care unit: a baseline study
    Andrew P Wilson
    Department of Clinical Microbiology, University College London Hospitals, London, UK
    Crit Care Med 35:2275-9. 2007
    ..To assess the degree of environmental contamination with methicillin-resistant Staphylococcus aureus (MRSA) in critical care and the likelihood of subsequent new patient acquisition if carriers were or were not moved to single rooms...
  58. doi request reprint Oesophageal Doppler monitoring: should it be routine for high-risk surgical patients?
    Mervyn Singer
    Department of Medicine, University College London, London, UK
    Curr Opin Anaesthesiol 24:171-6. 2011
    ..To determine whether sufficient evidence exists to justify routine use of oesophageal Doppler monitoring to guide perioperative haemodynamic management in high-risk surgery...
  59. doi request reprint Prevalence and outcome of cirrhosis patients admitted to UK intensive care: a comparison against dialysis-dependent chronic renal failure patients
    Alastair J O'Brien
    Department of Clinical Pharmacology, University College London, 5 University Street, London WC1E 6JF, UK
    Intensive Care Med 38:991-1000. 2012
    ..Patients with decompensated liver cirrhosis who are admitted to intensive care units (ICU) are perceived, within the UK, as having a particularly poor prognosis...
  60. ncbi request reprint Give oxygen, get a blood pressure... but don't overdo it
    Mervyn Singer
    Bloomsbury Institute of Intensive Care Medicine, University College London, London WC1E 6BT
    Hosp Med 66:73-5. 2005
  61. ncbi request reprint Prospective audit of bacteraemia management in a university hospital ICU using a general strategy of short-course monotherapy
    Alberto Corona
    Bloomsbury Institute of Intensive Care Medicine, University College London, Jules Thorn Building, Middlesex Hospital, Mortimer Street, London W1N 3AA
    J Antimicrob Chemother 54:809-17. 2004
    ..g. endocarditis, osteomyelitis). We decided to assess this approach for treating community-, hospital-, and ICU-acquired bacteraemia by monitoring clinical response, relapse rate and patient outcome...
  62. doi request reprint Infection in the critically ill--questions we should be asking
    John R Prowle
    Intensive Care Unit, University College London Hospitals NHS Foundation Trust, Euston Road, London, UK
    J Antimicrob Chemother 66:ii3-10. 2011
    ..In this time of financial restraint, we need to identify true priorities from both health and economic perspectives, and to see what practices can safely and effectively be modified or abandoned...
  63. ncbi request reprint The evolutionary role of nutrition and metabolic support in critical illness
    Nicolas Mongardon
    Bloomsbury Institute of Intensive Care Medicine, Wolfson Institute for Biomedical Research, University College London, Cruciform Building, Gower Street, London WC1E 6BT, UK
    Crit Care Clin 26:443-50, vii-viii. 2010
    ..This approach fits a teleologic argument that enabled many sick people to survive well before the advent of modern medicine and explains why catabolism still occurs despite adequate feeding...
  64. pmc Hyperglycemia in critical illness: a review
    David Brealey
    Bloomsbury Institute of Intensive Care Medicine, University College London, London, United Kingdom
    J Diabetes Sci Technol 3:1250-60. 2009
    ..The net result is derangement of endothelial, immune and coagulation function and an association with neuropathy and myopathy. These changes can be prevented, at least in part, by the use of insulin to maintain normoglycemia...
  65. ncbi request reprint The Pancreatitis Outcome Prediction (POP) Score: a new prognostic index for patients with severe acute pancreatitis
    David A Harrison
    Intensive Care National Audit and Research Centre, Tavistock House, Tavistock Square, London, United Kingdom
    Crit Care Med 35:1703-8. 2007
    ..Some scores cannot be applied until several days into hospital admission. We thus sought to develop a new and more sensitive outcome prediction score--the Pancreatitis Outcome Prediction (POP) Score--for these high-risk patients...
  66. pmc The pore-forming subunit of the K(ATP) channel is an important molecular target for LPS-induced vascular hyporeactivity in vitro
    Alastair J O'Brien
    BHF Laboratories, Department of Medicine, Rayne Building, University College London, 5 University Street, London WC1E 6JF, UK
    Br J Pharmacol 144:367-75. 2005
    ..The effectiveness of pore inhibitors over SUR inhibitors of the K(ATP) channel suggests altered SUR function following LPS administration, which cannot be explained by thromboxane receptor inhibition...
  67. ncbi request reprint Mechanisms of sepsis-induced cardiac dysfunction
    Alain Rudiger
    Bloomsbury Institute of Intensive Care Medicine, Wolfson Institute for Biomedical Research and Department of Medicine, University College London, UK
    Crit Care Med 35:1599-608. 2007
    ..To review mechanisms underlying sepsis-induced cardiac dysfunction in general and intrinsic myocardial depression in particular...
  68. ncbi request reprint Fundamentals of oxygen delivery
    James Yassin
    Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK
    Contrib Nephrol 156:119-32. 2007
    ..Understanding this pathway, which still remains to be properly characterized, will greatly aid both diagnosis and management of the hypoxic patient...
  69. ncbi request reprint Metabolic failure
    Mervyn Singer
    Intensive Care Medicine, Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK
    Crit Care Med 33:S539-42. 2005
  70. ncbi request reprint Strategies to modulate cellular energetic metabolism during sepsis
    Alessandro Protti
    Bloomsbury Institute of Intensive Care Medicine, University College London, Gower Street, London WC1E 6BT, UK
    Novartis Found Symp 280:7-16; discussion 16-20, 160-4. 2007
    ..The aim of this review is to discuss putative interventions aimed at preventing or reversing mitochondrial dysfunction that may have possible clinical relevance, and to stress the importance of the correct timing of intervention...
  71. doi request reprint Microvascular and interstitial oxygen tension in the renal cortex and medulla studied in a 4-h rat model of LPS-induced endotoxemia
    Alex Dyson
    Department of Translational Physiology, Academic Medical Center, Amsterdam, The Netherlands
    Shock 36:83-9. 2011
    ..Taken in conjunction with the decrease in urine output, our results could represent either a functional renal impairment or an adaptive response...
  72. pmc Temporal variation in endotoxin-induced vascular hyporeactivity in a rat mesenteric artery organ culture model
    A J O'Brien
    The Centre for Clinical Pharmacology, Department of Medicine, University College London, Rayne Institute, University Street, London WC1E 6JJ, UK
    Br J Pharmacol 133:351-60. 2001
    ..Moreover, conventional doses of L-NAME and AMG became increasingly ineffective over time. Thus, the choice of inhibitor merits careful consideration in long-term models...
  73. pmc Improved survival for HIV infected patients with severe Pneumocystis jirovecii pneumonia is independent of highly active antiretroviral therapy
    R F Miller
    Centre for Sexual Health and HIV Research, University College London, Mortimer Market Centre, London WC1E 6AU, UK
    Thorax 61:716-21. 2006
    ..A study was undertaken to examine the outcome from intensive care for patients with PCP and to identify prognostic factors...
  74. doi request reprint Mechanisms and functional consequences of liver failure substantially differ between endotoxaemia and faecal peritonitis in rats
    Peter Recknagel
    Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany
    Liver Int 33:283-93. 2013
    ..However, the biological significance of such models is questionable as the complexity of clinical sepsis and associated organ failure is only partially replicated...
  75. ncbi request reprint Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): a randomised controlled trial
    Sheila Harvey
    Intensive Care National Audit and Research Centre, London, UK
    Lancet 366:472-7. 2005
    ..Our aim was, therefore, to ascertain whether hospital mortality is reduced in critically ill patients when they are managed with a PAC...
  76. pmc Medication errors: a prospective cohort study of hand-written and computerised physician order entry in the intensive care unit
    Rob Shulman
    Pharmacy Department, University College London Hospitals, Middlesex Hospital, London, UK
    Crit Care 9:R516-21. 2005
    ..The study aimed to compare the impact of computerised physician order entry (CPOE) without decision support with hand-written prescribing (HWP) on the frequency, type and outcome of medication errors (MEs) in the intensive care unit...
  77. doi request reprint The impact of enhanced cleaning within the intensive care unit on contamination of the near-patient environment with hospital pathogens: a randomized crossover study in critical care units in two hospitals
    A Peter R Wilson
    Departments of Microbiology and Infection Control, University College London Hospitals, London, United Kingdom
    Crit Care Med 39:651-8. 2011
    ..To determine the effect of enhanced cleaning of the near-patient environment on the isolation of hospital pathogens from the bed area and staff hands...
  78. ncbi request reprint Hypoxia accelerates nitric oxide-dependent inhibition of mitochondrial complex I in activated macrophages
    Matthew T Frost
    Wolfson Institute for Biomedical Research, University College London, Gower St, London WC1E 6BT, UK
    Am J Physiol Regul Integr Comp Physiol 288:R394-400. 2005
    ..Our results suggest that hypoxia amplified the mitochondrial inhibition induced by NO generated during inflammatory disease states...
  79. ncbi request reprint The validity of trans-esophageal Doppler ultrasonography as a measure of cardiac output in critically ill adults
    Paul M Dark
    Department of Intensive Care Medicine, Injury, Repair and Rehabilitation Research Group, Hope Hospital, University of Manchester, Stott Lane, M6 8HD, Greater Manchester, UK
    Intensive Care Med 30:2060-6. 2004
    ..To determine the validity of the esophageal Doppler monitor (EDM) and echo-esophageal Doppler (Echo-ED) in measuring cardiac output in the critically ill...
  80. ncbi request reprint Pharmacokinetic studies of linezolid and teicoplanin in the critically ill
    Tony Whitehouse
    Bloomsbury Institute of Intensive Care Medicine, Department of Medicine, University College London, London, UK
    J Antimicrob Chemother 55:333-40. 2005
    ..To determine the pharmacokinetic characteristics of linezolid and teicoplanin in critically ill patients...
  81. ncbi request reprint Angiotensin II blockade augments renal cortical microvascular pO2 indicating a novel, potentially renoprotective action
    Jill T Norman
    Centre for Nephrology, Department of Medicine, Royal Free and University College Medical School, London, UK
    Nephron Physiol 94:p39-46. 2003
    ....
  82. ncbi request reprint System interactions
    Mervyn Singer
    Bloomsbury Institute of Intensive Care Medicine, Dept of Medicine and Wolfson Institute of Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Novartis Found Symp 280:252-62; discussion 262-5. 2007
    ....
  83. ncbi request reprint Large variation in MRSA policies, procedures and prevalence in English intensive care units: a questionnaire analysis
    Janeane Hails
    Bloomsbury Institute of Intensive Care Medicine, Jules Thorn Building, Middlesex Hospital, Mortimer St, London W1T 3AA, UK
    Intensive Care Med 29:481-3. 2003
    ..We thus sought to identify MRSA prevalence and the variation of infection control policy across intensive care units in England...
  84. doi request reprint Potential metabolic consequences of statins in sepsis
    David A Brealey
    University College Hospitals NHS Foundation Trust, University College London, London, United Kingdom
    Crit Care Med 39:1514-20. 2011
    ..Here we provide a narrative review of the function and roles of ubiquinone in cellular metabolism, the interactions with statins, and the potential consequences in the critically ill...
  85. pmc Randomised controlled trial assessing the impact of a nurse delivered, flow monitored protocol for optimisation of circulatory status after cardiac surgery
    Moira McKendry
    Bloomsbury Institute of Intensive Care Medicine, Department of Medicine and Wolfson Institute of Biomedical Research, University College London, Middlesex Hospital, London W1T 3AA
    BMJ 329:258. 2004
    ..To assess whether a nurse led, flow monitored protocol for optimising circulatory status in patients after cardiac surgery reduces complications and shortens stay in intensive care and hospital...
  86. pmc Survival of HIV-infected patients in the intensive care unit in the era of highly active antiretroviral therapy
    S J Dickson
    University College London Hospitals, London, UK
    Thorax 62:964-8. 2007
    ..A study was undertaken to examine the outcome from the ICU for HIV-infected patients and to identify prognostic factors...
  87. ncbi request reprint Treatment of pulmonary hypertension in the general adult intensive care unit: a role for oral sildenafil?
    J Ng
    Department of Critical Care, University College London Hospitals, Mortimer Street, London W1T 3AA, UK
    Br J Anaesth 94:774-7. 2005
    ..The relative pulmonary vascular specificity of oral sildenafil, and its low cost, makes it an attractive therapeutic alternative to inhaled nitric oxide, and warrants further study...
  88. ncbi request reprint Endothelial dysfunction in critically ill patients: the effect of haemofiltration
    R Cardigan
    Department of Haematology, University College London, UK
    Intensive Care Med 24:1264-71. 1998
    ..To examine the effect of a single episode of continuous venovenous haemofiltration (CVVH) on indicators of endothelial injury and the protein C/S system in critically ill patients...
  89. ncbi request reprint Italy versus the United Kingdom: differing styles for treating bacteremia in the critically ill patient, but who's right?
    A Corona
    Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK
    Minerva Anestesiol 74:155-61; quiz 162-3. 2008
    ..A multi-centre, multi-national questionnaire survey was used to assess variations in antibiotic strategy between ICUs in the United Kingdom (UK) and Italy...
  90. ncbi request reprint Short-course monotherapy strategy for treating bacteremia in the critically ill
    A Corona
    Bloomsbury Institute of Intensive Care Medicine, University College, London, UK
    Minerva Anestesiol 72:841-57. 2006
    ..g. endocarditis, osteomyelitis). The aim of this study is to assess our policy by monitoring the clinical response, relapse rate and patient outcome...
  91. pmc Pharmacological optimization of tissue perfusion
    N Mongardon
    Bloomsbury Institute of Intensive Care Medicine, Wolfson Institute for Biomedical Research and Department of Medicine, University College London, London, UK
    Br J Anaesth 103:82-8. 2009
    ..This review highlights these areas and some new pharmacological agents that broaden our therapeutic options...
  92. ncbi request reprint An evaluation of the clinical and cost-effectiveness of pulmonary artery catheters in patient management in intensive care: a systematic review and a randomised controlled trial
    S Harvey
    Intensive Care National Audit and Research Centre, London, UK
    Health Technol Assess 10:iii-iv, ix-xi, 1-133. 2006
    ..To evaluate the clinical and cost-effectiveness of managing critically ill patients in adult, general intensive care with or without pulmonary artery catheters (PACs)...
  93. ncbi request reprint Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Crit Care Med 36:1937-49. 2008
    ..To develop consensus statements for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients...
  94. ncbi request reprint Terlipressin for norepinephrine-resistant septic shock
    Alastair O'Brien
    Lancet 359:1209-10. 2002
    ..Terlipressin seems to be an effective rescue therapy, which is able to restore blood pressure in patients with catecholamine-resistant septic shock, without obvious complication...
  95. ncbi request reprint Linezolid versus teicoplanin in the treatment of Gram-positive infections in the critically ill: a randomized, double-blind, multicentre study
    Jorge A Cepeda
    Department of Clinical Microbiology, Pharmacy Department, University College London Hospitals, Grafton Way, London WC1E 6DB, UK
    J Antimicrob Chemother 53:345-55. 2004
    ..A randomized, prospective study was therefore performed to compare linezolid with the glycopeptide antibiotic, teicoplanin, for the treatment of suspected or proven Gram-positive infections in an intensive care population...
  96. ncbi request reprint Adrenal function in sepsis: the retrospective Corticus cohort study
    Diane Lipiner-Friedman
    Service de Reanimation, Hôpital Raymond Poincaré APHP, Faculté de Médecine Paris Ile de France Ouest UVSQ, Garches, France
    Crit Care Med 35:1012-8. 2007
    ..To refine the value of baseline and adrenocorticotropin hormone (ACTH)-stimulated cortisol levels in relation to mortality from severe sepsis or septic shock...
  97. ncbi request reprint Oxygen consumption of human peripheral blood mononuclear cells in severe human sepsis
    Ioulia Belikova
    Department of Anesthesiology and Critical Care, Lariboisiere University Hospital, Paris, France
    Crit Care Med 35:2702-8. 2007
    ..Because the mechanisms of such down-regulation are unclear, we investigated the hypothesis of an energetic failure of immune cells to participate in immune dysfunction...
  98. ncbi request reprint Role of KATP channels in sepsis
    James F Buckley
    British Heart Foundation Laboratories and Bloomsbury Institute for Intensive Care Medicine, UK
    Cardiovasc Res 72:220-30. 2006
    ..In this review we critically examine the role of the K(ATP) channel in sepsis...
  99. ncbi request reprint Powering up failed organs
    Mervyn Singer
    Am J Respir Crit Care Med 176:733-4. 2007