John Sinclair

Summary

Affiliation: University of Cambridge
Country: UK

Publications

  1. pmc Cell cycle arrest by human cytomegalovirus 86-kDa IE2 protein resembles premature senescence
    Emanuela Noris
    Department of Public Health and Microbiology, University of Turin, Italy
    J Virol 76:12135-48. 2002
  2. pmc The cellular protein MCM3AP is required for inhibition of cellular DNA synthesis by the IE86 protein of human cytomegalovirus
    Emma Poole
    Department of Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 7:e45686. 2012
  3. pmc Depletion of cellular pre-replication complex factors results in increased human cytomegalovirus DNA replication
    Tamara Evans Braun
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    PLoS ONE 7:e36057. 2012
  4. pmc A novel neuroprotective therapy for Parkinson's disease using a viral noncoding RNA that protects mitochondrial complex I activity
    Wei Li Kuan
    Department of Neurology, Addenbrooke s Hospital, England, UK
    J Exp Med 209:1-10. 2012
  5. ncbi request reprint Human cytomegalovirus mediates cell cycle progression through G(1) into early S phase in terminally differentiated cells
    J Sinclair
    Department of Medicine, University of Cambridge, Level 5, Addenbrookes Hospital, Hills Road, Cambridge CB2 2QQ, UK
    J Gen Virol 81:1553-65. 2000
  6. doi request reprint Chromatin structure regulates human cytomegalovirus gene expression during latency, reactivation and lytic infection
    John Sinclair
    Department of Medicine, Level 5, Addenbrooke s Hospital, University of Cambridge, Hills Rd, Cambridge CB22QQ, UK
    Biochim Biophys Acta 1799:286-95. 2010
  7. doi request reprint Manipulation of dendritic cell functions by human cytomegalovirus
    John Sinclair
    Department of Medicine, Level 5 Addenbrooke s Hospital, Hills Road, Cambridge CB22QQ, UK
    Expert Rev Mol Med 10:e35. 2008
  8. doi request reprint Human cytomegalovirus: Latency and reactivation in the myeloid lineage
    John Sinclair
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    J Clin Virol 41:180-5. 2008
  9. ncbi request reprint Latency and reactivation of human cytomegalovirus
    John Sinclair
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    J Gen Virol 87:1763-79. 2006
  10. ncbi request reprint Ets-2 Repressor Factor (ERF) mediates repression of the human cytomegalovirus major immediate-early promoter in undifferentiated non-permissive cells
    Mark Bain
    Department of Medicine, University of Cambridge, PO Box 157, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    J Gen Virol 84:41-9. 2003

Collaborators

Detail Information

Publications24

  1. pmc Cell cycle arrest by human cytomegalovirus 86-kDa IE2 protein resembles premature senescence
    Emanuela Noris
    Department of Public Health and Microbiology, University of Turin, Italy
    J Virol 76:12135-48. 2002
    ..Altogether our results demonstrate for the first time that HCMV, after arresting the cell cycle and inhibiting apoptosis, triggers the cellular senescence program, probably through the p16(INK4a) and p53 pathways...
  2. pmc The cellular protein MCM3AP is required for inhibition of cellular DNA synthesis by the IE86 protein of human cytomegalovirus
    Emma Poole
    Department of Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge, United Kingdom
    PLoS ONE 7:e45686. 2012
    ....
  3. pmc Depletion of cellular pre-replication complex factors results in increased human cytomegalovirus DNA replication
    Tamara Evans Braun
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    PLoS ONE 7:e36057. 2012
    ....
  4. pmc A novel neuroprotective therapy for Parkinson's disease using a viral noncoding RNA that protects mitochondrial complex I activity
    Wei Li Kuan
    Department of Neurology, Addenbrooke s Hospital, England, UK
    J Exp Med 209:1-10. 2012
    ....
  5. ncbi request reprint Human cytomegalovirus mediates cell cycle progression through G(1) into early S phase in terminally differentiated cells
    J Sinclair
    Department of Medicine, University of Cambridge, Level 5, Addenbrookes Hospital, Hills Road, Cambridge CB2 2QQ, UK
    J Gen Virol 81:1553-65. 2000
    ..This progression is correlated with a direct physical and functional interaction between the HCMV 86 kDa major immediate-early protein (IE86) and the cyclin-dependent kinase inhibitor p21(Cip1)...
  6. doi request reprint Chromatin structure regulates human cytomegalovirus gene expression during latency, reactivation and lytic infection
    John Sinclair
    Department of Medicine, Level 5, Addenbrooke s Hospital, University of Cambridge, Hills Rd, Cambridge CB22QQ, UK
    Biochim Biophys Acta 1799:286-95. 2010
    ....
  7. doi request reprint Manipulation of dendritic cell functions by human cytomegalovirus
    John Sinclair
    Department of Medicine, Level 5 Addenbrooke s Hospital, Hills Road, Cambridge CB22QQ, UK
    Expert Rev Mol Med 10:e35. 2008
    ....
  8. doi request reprint Human cytomegalovirus: Latency and reactivation in the myeloid lineage
    John Sinclair
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    J Clin Virol 41:180-5. 2008
    ..Thus there is a crucial link between the differentiation of myeloid cells and transcriptional reactivation of latent virus which is likely to play a key role in viral pathogenesis...
  9. ncbi request reprint Latency and reactivation of human cytomegalovirus
    John Sinclair
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    J Gen Virol 87:1763-79. 2006
    ....
  10. ncbi request reprint Ets-2 Repressor Factor (ERF) mediates repression of the human cytomegalovirus major immediate-early promoter in undifferentiated non-permissive cells
    Mark Bain
    Department of Medicine, University of Cambridge, PO Box 157, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    J Gen Virol 84:41-9. 2003
    ..Finally, we show that following differentiation to a permissive phenotype ERF's repressive effects are severely abrogated...
  11. pmc Autorepression of the human cytomegalovirus major immediate-early promoter/enhancer at late times of infection is mediated by the recruitment of chromatin remodeling enzymes by IE86
    Matthew Reeves
    Department of Medicine, Box 157, Level 5, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, United Kingdom
    J Virol 80:9998-10009. 2006
    ....
  12. pmc Human cytomegalovirus latency-associated proteins elicit immune-suppressive IL-10 producing CD4⁺ T cells
    Gavin M Mason
    University of Cambridge, Department of Medicine, Cambridge, Cambridgeshire, United Kingdom
    PLoS Pathog 9:e1003635. 2013
    ..This suggests that HCMV skews the T cell responses to latency-associated antigens to one that is overall suppressive in order to sustain latent carriage in vivo...
  13. pmc Identification of TRIM23 as a cofactor involved in the regulation of NF-kappaB by human cytomegalovirus
    Emma Poole
    Department of Medicine, University of Cambridge, Box 157, Level 5, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, United Kingdom
    J Virol 83:3581-90. 2009
    ..Therefore, we present a novel role for TRIM23 that is specific to UL144-mediated activation of NF-kappaB during the course of virus infection...
  14. pmc NF-kappaB-mediated activation of the chemokine CCL22 by the product of the human cytomegalovirus gene UL144 escapes regulation by viral IE86
    Emma Poole
    Department of Medicine, Box 157, University of Cambridge, Level 5 Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, United Kingdom
    J Virol 82:4250-6. 2008
    ....
  15. ncbi request reprint Ets-2 repressor factor recruits histone deacetylase to silence human cytomegalovirus immediate-early gene expression in non-permissive cells
    Edward Wright
    Department of Medicine, University of Cambridge, PO Box 157, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    J Gen Virol 86:535-44. 2005
    ....
  16. pmc Human cytomegalovirus IE72 protein interacts with the transcriptional repressor hDaxx to regulate LUNA gene expression during lytic infection
    Matthew Reeves
    Department of Medicine, Level 5, Box 157, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
    J Virol 84:7185-94. 2010
    ..It also suggests that the targeting of cellular factors by IE72 is important throughout the different phases of HCMV gene expression during productive infection...
  17. ncbi request reprint The S phase of the cell cycle and its perturbation by human cytomegalovirus
    Mark Bain
    Department of Medicine, University of Cambridge Clinical School, Level 5, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    Rev Med Virol 17:423-34. 2007
    ....
  18. pmc The myeloid transcription factor GATA-2 regulates the viral UL144 gene during human cytomegalovirus latency in an isolate-specific manner
    Emma Poole
    University of Cambridge, Department of Medicine, Cambridge, United Kingdom
    J Virol 87:4261-71. 2013
    ..Taken together, these data suggest that the HCMV latency-associated transcriptome may be virus isolate specific and dependent on the repertoire of transcription factor binding sites in the promoters of latency-associated genes...
  19. ncbi request reprint Human cytomegalovirus encodes an MHC class I-like molecule (UL142) that functions to inhibit NK cell lysis
    Mark R Wills
    Department of Medicine, School of Clinical Medicine, University of Cambridge, United Kingdom
    J Immunol 175:7457-65. 2005
    ..From these data we conclude that UL142 is a novel HCMV-encoded MHC class I-related molecule which inhibits NK cell killing in a clonally dependent manner...
  20. pmc Regulation of human cytomegalovirus transcription in latency: beyond the major immediate-early promoter
    Matthew Reeves
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Hills Road, Cambridge CB2 0QQ, UK
    Viruses 5:1395-413. 2013
    ....
  21. doi request reprint Virally induced changes in cellular microRNAs maintain latency of human cytomegalovirus in CD34⁺ progenitors
    Emma Poole
    University of Cambridge, Department of Medicine, Box 157, Level 5 Laboratories Block, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    J Gen Virol 92:1539-49. 2011
    ....
  22. doi request reprint Cytomegalovirus beta2.7 RNA transcript protects endothelial cells against apoptosis during ischemia/reperfusion injury
    Jing Zhao
    Department of Medicine, Addenbrooke s Hospital, University of Cambridge, Cambridge, CB2 OQQ, UK
    J Heart Lung Transplant 29:342-5. 2010
    ..In this study, we investigated whether stabilizing Complex I in EC in an in vitro model of ischemia could prevent apoptosis...
  23. ncbi request reprint Targeted inhibition of the transcription factor YY1 in an embryonal carcinoma cell line results in retarded cell growth, elevated levels of p53 but no increase in apoptotic cell death
    Mark Bain
    Department of Medicine, University of Cambridge, PO Box 157, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Eur J Cell Biol 84:543-53. 2005
    ..However, the cells do not undergo apoptosis, are not induced to differentiate, do not exhibit excessive levels of DNA damage, and synthesise DNA normally...
  24. pmc Human cytomegalovirus sequences expressed in latently infected individuals promote a latent infection in vitro
    Felicia Goodrum
    Department of Immunobiology, BIO5 Institute, University of Arizona, Tucson, AZ 85711, USA
    Blood 110:937-45. 2007
    ..Importantly, UL138 RNA was expressed in CD34(+) cells and monocytes from HCMV-seropositive, healthy individuals. UL138 might be a target for antivirals against latent virus...