Research Topics
Genomes and GenesSpecies | Pat SimpsonSummaryAffiliation: University of Cambridge Country: UK Publications
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Publications
Conservation of upstream regulators of scute on the notum of cyclorraphous DipteraPat Simpson
Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
Dev Genes Evol 216:363-71. 2006..We discuss the possibility that independently acting cis-regulatory sequences at the scute locus may have arisen in the lineage giving rise to cyclorraphous flies...- Development and phylogeny of arthropodsPat Simpson
Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ UK
Bioessays 28:223-4. 2006 - The origin and evolution of stereotyped patterns of macrochaetes on the nota of cyclorraphous DipteraP Simpson
Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
Heredity (Edinb) 97:148-56. 2006..Other species of flies have different bristle patterns and so comparisons between them provide a good paradigm for the study of changes in gene regulation. Here, we review the current state of understanding of these changes... - The stars and stripes of animal bodies: evolution of regulatory elements mediating pigment and bristle patterns in DrosophilaPat Simpson
Department of Zoology, University of Cambridge, Cambridge, UK
Trends Genet 23:350-8. 2007..They show that ancestral regulatory modules have evolved to mediate different transcriptional outputs and suggest that evolution of cis-regulatory sequences might reflect a general mechanism driving evolutionary change... - Evolution of development in closely related species of flies and wormsPat Simpson
Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
Nat Rev Genet 3:907-17. 2002..Extending this approach to the study of development of closely related species promises to enrich this debate... - A major bristle QTL from a selected population of Drosophila uncovers the zinc-finger transcription factor poils-au-dos, a repressor of achaete-scuteJean Michel Gibert
Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
Dev Biol 288:194-205. 2005..In addition, we show that pad interacts synergistically with the repressor hairy and with Dpp signaling in posterior and anterior regions of the notum, respectively... 
Redundant mechanisms mediate bristle patterning on the Drosophila thoraxKazuya Usui
Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
Proc Natl Acad Sci U S A 105:20112-7. 2008..The redundant mechanisms might contribute to the robustness of the pattern. We discuss the possibility that patterning in trans by antagonism is ancestral and that the positional cis-regulatory sequences might be of recent origin...- achaete, but not scute, is dispensable for the peripheral nervous system of DrosophilaSylvain Marcellini
Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
Dev Biol 285:545-53. 2005..The difference between achaete and scute null flies is surprising and raises the question of the retention of both genes during the course of evolution... - An arthropod cis-regulatory element functioning in sensory organ precursor development dates back to the CambrianSavita Ayyar
Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
BMC Biol 8:127. 2010..First identified in Drosophila, the SOPE contains discrete binding sites for four regulatory factors. The SOPE of the Drosophila asense gene is situated in the 5' UTR... - Two or four bristles: functional evolution of an enhancer of scute in DrosophilidaeSylvain Marcellini
Department of Zoology, University of Cambridge, Cambridge, United Kingdom
PLoS Biol 4:e386. 2006..This work illustrates how, in the context of a conserved trans-regulatory landscape, evolutionary tinkering of pre-existing enhancers can modify gene expression patterns and contribute to morphological diversification... 
Evolution of the achaete-scute complex in insects: convergent duplication of proneural genesBarbara Negre
Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
Trends Genet 25:147-52. 2009..We document independent evolution of multiple copies of achaete-scute homologues and argue that this might have contributed to morphological diversity in Diptera and Lepidoptera...- Mutual exclusion of sensory bristles and tendons on the notum of dipteran fliesKazuya Usui
Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, United Kingdom
Curr Biol 14:1047-55. 2004..This pattern appears to date back to the origin of cyclorraphous flies about 100-140 million years ago. The origin of the four-row bauplan, which is independent of body size, and the reasons for its conservation, are not known... - Evolution of cis-regulatory sequences in DrosophilaPat Simpson
Department of Zoology, University of Cambridge, United Kingdom
Adv Genet 61:67-106. 2008..Although the number of such studies is still small, they suggest that changes in gene regulation might be an important factor in the evolution of animal morphology... - NF-kappaB/Rel-mediated regulation of the neural fate in DrosophilaSavita Ayyar
Department of Zoology, University of Cambridge, Cambridge, United Kingdom
PLoS ONE 2:e1178. 2007..We propose that this buffering of gene expression levels serves to keep the neuro-epithelium constantly poised for neurogenesis... - A conserved trans-regulatory landscape for scute expression on the notum of cyclorraphous DipteraJoanna Richardson
Department of Zoology, University of Cambridge, Downing Street, Cambridge, CB2 3EJ, UK
Dev Genes Evol 216:29-38. 2006..This suggests that the function of a trans-regulatory network of genes is relatively unchanged in derived Diptera and that many differences are likely to be due to changes in cis-regulatory sequences of scute... - Gene duplication at the achaete-scute complex and morphological complexity of the peripheral nervous system in DipteraNick Skaer
Dept of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
Trends Genet 18:399-405. 2002..This probably coincided in time with gene duplication events, raising the possibility that an increase in gene copy number might have provided the flexibility necessary for more complex transcriptional regulation... - scute expression in Calliphora vicina reveals an ancestral pattern of longitudinal stripes on the thorax of higher DipteraDaniela Pistillo
Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
Development 129:563-72. 2002..The implications for the evolution of the cis-regulatory elements responsible for sc expression in the proneural clusters of Drosophila, and function of Pnr are discussed... - Transcriptional heterochrony of scute and changes in bristle pattern between two closely related species of blowflyNick Skaer
Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, United Kingdom
Dev Biol 252:31-45. 2002..These observations illustrate the power of developmental heterochrony in bringing about rapid morphological change... - Evolution of cis-regulation of the proneural genesJean-Michel Gibert
Department of Zoology, University of Cambridge, UK
Int J Dev Biol 47:643-51. 2003..We suggest that this enhancer may have arisen during the evolution of the cyclorraphous flies and present a hypothesis for its possible function... - Differences in sensory projections between macro- and microchaetes in Drosophilid fliesAkiko Usui-Ishihara
Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, United Kingdom
Dev Biol 277:170-83. 2005..We discuss the possibility that macro- and microchaetes may have different functions and that these have implications for evolutionary constraints on bristle patterns... - Movement of bristle precursors contributes to the spacing pattern in DrosophilaOlivier Renaud
Department of Zoology, Downing Street, University of Cambridge, CB2 3EJ Cambridge, UK
Mech Dev 119:201-11. 2002..We suggest that, by altering the properties of epithelial cells in a graded fashion, Scabrous may provide cues that allow the precursors to remain evenly spaced after they have segregated... - Evolution of early development of the nervous system: a comparison between arthropodsAngelika Stollewerk
Department of Zoology, University of Cambridge, Cambridge, UK
Bioessays 27:874-83. 2005..We hypothesize that an evolutionary trend towards reduced cell numbers and possibly rapid embryogenesis in insects has culminated in the appearance of stereotyped neuroblast lineages... - The kinase Sgg modulates temporal development of macrochaetes in Drosophila by phosphorylation of Scute and PannierMingyao Yang
Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK
Development 139:325-34. 2012..We suggest that temporal control of ac-sc activity in cyclorraphous flies is likely to be regulated by permissive factors and might therefore not be encoded at the level of ac-sc gene sequences... - Diversity of transposable elements and repeats in a 600 kb region of the fly Calliphora vicinaBarbara Negre
Department of Zoology, University of Cambridge, Downing Street, Cambridge, CB2 3EJ, UK
Mob DNA 4:13. 2013..g., in evolution) and applications (e.g., as transgenic tools). They also represent a major challenge for the assembly and annotation of genomic sequences. However, they are still largely unknown in non-model species... - The expression of pannier and achaete-scute homologues in a mosquito suggests an ancient role of pannier as a selector gene in the regulation of the dorsal body patternCorinna Wülbeck
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, BP 163, 67404 Illkirch Cedex, CU de Strasbourg, France
Development 129:3861-71. 2002..This points to the existence of specific positional information along the borders, and suggests that Ag-pnr specifies pattern in the medial, dorsal notum, as in Drosophila, but via a different mechanism... - How to pattern an epithelium: lessons from achaete-scute regulation on the notum of DrosophilaManuel Calleja
Centro de Biologia Molecular, Universidad Autonoma de Madrid, 28049 Madrid, Spain
Gene 292:1-12. 2002..Thus there may be a common prepattern for the entire structure...