A Simpson

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. pmc Effect of household pet ownership on infant immune response and subsequent sensitization
    Angela Simpson
    Manchester Academic Health Science Centre, NIHR Translational Research Facility in Respiratory Medicine, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK
    J Asthma Allergy 3:131-7. 2010
  2. pmc Quantification of atopy, lung function and airway hypersensitivity in adults
    Susana Marinho
    The University of Manchester, Manchester Academic Health Science Centre, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK
    Clin Transl Allergy 1:16. 2011
  3. pmc Genetic variation in vascular endothelial growth factor-a and lung function
    Angela Simpson
    University of Manchester, Wythenshawe Hospital, Manchester, UK
    Am J Respir Crit Care Med 185:1197-204. 2012
  4. ncbi request reprint Prevention of allergic sensitization by environmental control
    Angela Simpson
    University of Manchester, University Hospital of South Manchester National Health Service Foundation Trust, Second Floor, Education and Research Centre, Manchester, United Kingdom
    Curr Allergy Asthma Rep 9:363-9. 2009
  5. doi request reprint The role of lipopolysaccharide in the development of atopy in humans
    A Simpson
    Manchester Academic Health Science Centre, NIHR Translational Research Facility in Respiratory Medicine, University Hospital of South Manchester NHS Foundation Trust, The University of Manchester, Manchester, UK
    Clin Exp Allergy 40:209-23. 2010
  6. ncbi request reprint Beyond atopy: multiple patterns of sensitization in relation to asthma in a birth cohort study
    Angela Simpson
    The University of Manchester, Manchester Academic Health Science Centre, NIHR Translational Research Facility in Respiratory Medicine, University Hospital of South Manchester NHS Foundation Trust, Manchester, United Kingdom
    Am J Respir Crit Care Med 181:1200-6. 2010
  7. ncbi request reprint Rhinoconjunctivitis in 5-year-old children: a population-based birth cohort study
    S Marinho
    University of Manchester, Academic Division of Medicine and Surgery, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK
    Allergy 62:385-93. 2007
  8. ncbi request reprint Stringent environmental control in pregnancy and early life: the long-term effects on mite, cat and dog allergen
    A Simpson
    North West Lung Research Centre, Wythenshawe Hospital, Manchester, UK
    Clin Exp Allergy 33:1183-9. 2003
  9. ncbi request reprint Household characteristics and allergen and endotoxin levels in Aleppo, Syrian Arab Republic
    W Al Ali
    North West Lung Research Centre, Wythenshawe Hospital, Manchester, United Kingdom
    East Mediterr Health J 16:717-24. 2010
  10. ncbi request reprint NAC Manchester Asthma and Allergy Study (NACMAAS): risk factors for asthma and allergic disorders in adults
    B M Simpson
    North-west Lung Centre, Wythenshawe Hospital, Southmoor Road, Manchester M23 9LT, UK
    Clin Exp Allergy 31:391-9. 2001

Collaborators

Detail Information

Publications25

  1. pmc Effect of household pet ownership on infant immune response and subsequent sensitization
    Angela Simpson
    Manchester Academic Health Science Centre, NIHR Translational Research Facility in Respiratory Medicine, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK
    J Asthma Allergy 3:131-7. 2010
    ..Further long-term follow-up of children in whom neonatal and infant immune responses have been measured is necessary to understand how these events occur and how they relate to subsequent disease...
  2. pmc Quantification of atopy, lung function and airway hypersensitivity in adults
    Susana Marinho
    The University of Manchester, Manchester Academic Health Science Centre, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK
    Clin Transl Allergy 1:16. 2011
    ..abstract:..
  3. pmc Genetic variation in vascular endothelial growth factor-a and lung function
    Angela Simpson
    University of Manchester, Wythenshawe Hospital, Manchester, UK
    Am J Respir Crit Care Med 185:1197-204. 2012
    ..Given the role of vascular endothelial growth factor (VEGF) in lung development, we hypothesized that polymorphisms in VEGF-A may be associated with lung function...
  4. ncbi request reprint Prevention of allergic sensitization by environmental control
    Angela Simpson
    University of Manchester, University Hospital of South Manchester National Health Service Foundation Trust, Second Floor, Education and Research Centre, Manchester, United Kingdom
    Curr Allergy Asthma Rep 9:363-9. 2009
    ....
  5. doi request reprint The role of lipopolysaccharide in the development of atopy in humans
    A Simpson
    Manchester Academic Health Science Centre, NIHR Translational Research Facility in Respiratory Medicine, University Hospital of South Manchester NHS Foundation Trust, The University of Manchester, Manchester, UK
    Clin Exp Allergy 40:209-23. 2010
    ....
  6. ncbi request reprint Beyond atopy: multiple patterns of sensitization in relation to asthma in a birth cohort study
    Angela Simpson
    The University of Manchester, Manchester Academic Health Science Centre, NIHR Translational Research Facility in Respiratory Medicine, University Hospital of South Manchester NHS Foundation Trust, Manchester, United Kingdom
    Am J Respir Crit Care Med 181:1200-6. 2010
    ..The pattern of IgE response (over time or to specific allergens) may reflect different atopic vulnerabilities which are related to the presence of asthma in a fundamentally different way from current definition of atopy...
  7. ncbi request reprint Rhinoconjunctivitis in 5-year-old children: a population-based birth cohort study
    S Marinho
    University of Manchester, Academic Division of Medicine and Surgery, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK
    Allergy 62:385-93. 2007
    ..There is a paucity of data on the prevalence, risk factors and natural history of rhinitis in early childhood...
  8. ncbi request reprint Stringent environmental control in pregnancy and early life: the long-term effects on mite, cat and dog allergen
    A Simpson
    North West Lung Research Centre, Wythenshawe Hospital, Manchester, UK
    Clin Exp Allergy 33:1183-9. 2003
    ..As part of a primary prevention of asthma study, we measured the effect of environmental control measures on Der p 1, Fel d 1 and Can f 1 over a 3.5-year period...
  9. ncbi request reprint Household characteristics and allergen and endotoxin levels in Aleppo, Syrian Arab Republic
    W Al Ali
    North West Lung Research Centre, Wythenshawe Hospital, Manchester, United Kingdom
    East Mediterr Health J 16:717-24. 2010
    ..6). Cockroach allergen Bla g 2 was significantly more likely to be detected in houses over 20 years old than newer houses. Endotoxin levels were significantly higher in wool/cotton mattresses and older houses...
  10. ncbi request reprint NAC Manchester Asthma and Allergy Study (NACMAAS): risk factors for asthma and allergic disorders in adults
    B M Simpson
    North-west Lung Centre, Wythenshawe Hospital, Southmoor Road, Manchester M23 9LT, UK
    Clin Exp Allergy 31:391-9. 2001
    ..3-16.3; P < 0.0001). The results of the current study emphasize the importance of sensitization to indoor allergens in asthma. However, evidence of a possible direct role of allergen exposure in asthma causation remains unclear...
  11. ncbi request reprint Dust mite allergens are carried on not only large particles
    A Custovic
    North West Lung Center, Wythenshawe Hospital, Manchester, UK
    Pediatr Allergy Immunol 10:258-60. 1999
    ..A small, but potentially significant proportion of this airborne allergen is associated with small particles which, when inhaled, may penetrate deep into the human respiratory tract...
  12. ncbi request reprint Effect of environmental manipulation in pregnancy and early life on respiratory symptoms and atopy during first year of life: a randomised trial
    A Custovic
    North West Lung Centre, Wythenshawe Hospital, M23 9LT, Manchester, UK
    Lancet 358:188-93. 2001
    ..Further follow up is needed, however, to ascertain whether living in a low-allergen environment reduces allergy and asthma in later life...
  13. ncbi request reprint Decreased prevalence of sensitization to cats with high exposure to cat allergen
    A Custovic
    North West Lung Centre, Wythenshawe Hospital, Manchester, United Kingdom
    J Allergy Clin Immunol 108:537-9. 2001
    ..0, P =.03; 5th centile, OR 2.2, 95% CI 1.2-4.3, P =.04, 6th centile, OR 2.5, 95% CI 1.3-4.9, P =.005). These results indicate that the prevalence of sensitization to cat is decreased in the lowest and highest cat allergen exposure groups...
  14. doi request reprint Body mass index in young children and allergic disease: gender differences in a longitudinal study
    C S Murray
    Manchester Academic Health Science Centre, NIHR Translational Research Facility in Respiratory Medicine, University Hospital of South Manchester NHS Foundation Trust, The University of Manchester, Manchester, UK
    Clin Exp Allergy 41:78-85. 2011
    ..The increase in allergic diseases has occurred in parallel with the obesity epidemic, suggesting a possible association...
  15. ncbi request reprint Quantification of atopy and the probability of rhinitis in preschool children: a population-based birth cohort study
    S Marinho
    Academic Division of Medicine and Surgery, University of Manchester, Manchester, UK
    Allergy 62:1379-86. 2007
    ..Atopy quantification using IgE levels/skin test diameter (SPT-MWD) may better predict the expression of rhinitis than using atopy as a dichotomous variable...
  16. ncbi request reprint Synthetic pillows contain higher levels of cat and dog allergen than feather pillows
    A Custovic
    North West Lung Centre, Wythenshawe Hospital, Manchester, UK
    Pediatr Allergy Immunol 11:71-3. 2000
    ..01). We have therefore demonstrated that synthetic pillows contain significantly more pet allergens than feather pillows, supporting the view that tightly woven encasements surrounding feather pillows act as a barrier for allergens...
  17. doi request reprint Modelling air pollution for epidemiologic research--Part I: A novel approach combining land use regression and air dispersion
    A Molter
    Centre for Occupational and Environmental Health, School of Community Based Medicine, Manchester Academic Health Science Centre, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK
    Sci Total Environ 408:5862-9. 2010
    ..33, NO(2): R²=0.62; measured data: PM(10): R²=0.56, NO(2): R²=0.86). The validation further showed low mean prediction errors and root mean squared errors for both models...
  18. ncbi request reprint Skin test reactivity to natural and recombinant Blomia and Dermatophagoides spp. allergens among mite allergic patients in the UK
    A Simpson
    North West Lung Centre, Wythenshawe Hospital, Manchester, M23 9LT, UK
    Allergy 58:53-6. 2003
    ..pteronyssinus and to assess allergenic activity and cross-reactivity of recombinant (r) Group 5 allergens amongst these patients, who live in the UK and who are not exposed to B. tropicalis in their homes...
  19. ncbi request reprint Methylation of IL-2 promoter at birth alters the risk of asthma exacerbations during childhood
    J A Curtin
    The University of Manchester, Manchester Academic Health Science Centre, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK
    Clin Exp Allergy 43:304-11. 2013
    ..Epigenetic modifications may have a role in asthma susceptibility...
  20. ncbi request reprint The role of inhalant allergens in allergic airways disease
    A Custovic
    The University of Manchester, Manchester Academic Health Science Centre, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK
    J Investig Allergol Clin Immunol 22:393-401; qiuz follow 401. 2012
    ....
  21. pmc Reported versus confirmed wheeze and lung function in early life
    L Lowe
    North West Lung Research Centre, Wythenshawe Hospital, Southmoor Road, Manchester M23 9LT, UK
    Arch Dis Child 89:540-3. 2004
    ..To investigate the relation between parentally reported wheeze (unconfirmed), physician confirmed wheeze, and subsequent lung function...
  22. doi request reprint Dietary antioxidant intake, allergic sensitization and allergic diseases in young children
    S Patel
    School of Translational Medicine, University of Manchester and NIHR Translational Research Facility in Respiratory Medicine, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK
    Allergy 64:1766-72. 2009
    ..The aetiology remains unclear but is likely to be a result of changing lifestyle and/or environment. A reduction in antioxidant intake, consequent to reduced intake of fresh fruits and vegetables, has been suggested as a possible cause...
  23. ncbi request reprint Allergy and infection: understanding their relationship
    A Custovic
    Academic Division of Medicine and Surgery South, University of Manchester, North West Lung Centre, Wythenshawe Hospital, Manchester, UK
    Allergy 60:10-3. 2005
    ..Further investigation of this synergism could help to understand the mechanisms of asthma exacerbations and lead to the development of strategies for prevention...
  24. ncbi request reprint Household characteristics and mite allergen levels in Manchester,UK
    A Simpson
    North West Lung Centre, Wythenshawe Hospital, Manchester, UK
    Clin Exp Allergy 32:1413-9. 2002
    ..Mite allergen levels vary enormously between different homes in the same geographical area. No large scale studies of mite levels in Manchester homes has been conducted to identify factors associated with higher levels...
  25. doi request reprint Modelling air pollution for epidemiologic research--part II: predicting temporal variation through land use regression
    A Molter
    Centre for Occupational and Environmental Health, School of Community Based Medicine, Manchester Academic Health Science Centre, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK
    Sci Total Environ 409:211-7. 2010
    ..The advantage of this study is that it uses data from an air dispersion model, which provided concentrations for 2005 and 2010, and therefore allowed extrapolation over a longer time period...