Benjamin D Simons
Affiliation: University of Cambridge
Greulich P, Simons B. Dynamic heterogeneity as a strategy of stem cell self-renewal. Proc Natl Acad Sci U S A. 2016;113:7509-14 pubmed publisher
..In particular, in 2D epithelial layers, we show that the mechanism of dynamic heterogeneity avoids some pathological dependencies that undermine models based on a hierarchical stem/progenitor organization. ..
Basak O, Krieger T, Muraro M, Wiebrands K, Stange D, Frias Aldeguer J, et al
. Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy. Proc Natl Acad Sci U S A. 2018;115:E610-E619 pubmed publisher
..Our findings suggest a niche-based mechanism for the regulation of NSC fate and number. ..
Kitadate Y, Jörg D, Tokue M, Maruyama A, Ichikawa R, Tsuchiya S, et al
. Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche. Cell Stem Cell. 2019;24:79-92.e6 pubmed publisher
..We propose that this model provides a generic and robust mechanism to support stem cell homeostasis in open, or facultative, niche environments. ..
Hara K, Nakagawa T, Enomoto H, Suzuki M, Yamamoto M, Simons B, et al
. Mouse spermatogenic stem cells continually interconvert between equipotent singly isolated and syncytial states. Cell Stem Cell. 2014;14:658-72 pubmed publisher
..Thus, our results define an alternative and dynamic model for spermatogenic stem cell function in the mouse testis. ..
Krieger T, Simons B. Dynamic stem cell heterogeneity. Development. 2015;142:1396-406 pubmed publisher
..With a focus on mammalian spermatogenesis, intestinal maintenance and the hair cycle, we review the role of dynamic heterogeneity in the regulation of adult stem cell populations. ..
Rulands S, Lee H, Clark S, Angermueller C, Smallwood S, Krueger F, et al
. Genome-Scale Oscillations in DNA Methylation during Exit from Pluripotency. Cell Syst. 2018;7:63-76.e12 pubmed publisher
..These observations provide insights into the emergence of epigenetic heterogeneity during early embryo development, indicating that dynamic changes in DNA methylation might influence early cell fate decisions. ..
Sznurkowska M, Hannezo E, Azzarelli R, Rulands S, Nestorowa S, Hindley C, et al
. Defining Lineage Potential and Fate Behavior of Precursors during Pancreas Development. Dev Cell. 2018;46:360-375.e5 pubmed publisher
..These findings define quantitatively how the functional behavior and lineage progression of precursor pools determine the large-scale patterning of pancreatic sub-compartments. ..
Simons B. Deep sequencing as a probe of normal stem cell fate and preneoplasia in human epidermis. Proc Natl Acad Sci U S A. 2016;113:128-33 pubmed publisher
Rulands S, Simons B. Tracing cellular dynamics in tissue development, maintenance and disease. Curr Opin Cell Biol. 2016;43:38-45 pubmed publisher
..Here, we review how quantitative lineage tracing strategies are shaping our understanding of the cellular mechanisms of tissue development, maintenance and disease. ..