P Simmonds

Summary

Affiliation: University of Edinburgh
Country: UK

Publications

  1. Simmonds P, McIntyre C, Savolainen Kopra C, Tapparel C, Mackay I, Hovi T. Proposals for the classification of human rhinovirus species C into genotypically assigned types. J Gen Virol. 2010;91:2409-19 pubmed publisher
    ....
  2. Witteveldt J, Martin Gans M, Simmonds P. Enhancement of the Replication of Hepatitis C Virus Replicons of Genotypes 1 to 4 by Manipulation of CpG and UpA Dinucleotide Frequencies and Use of Cell Lines Expressing SECL14L2 for Antiviral Resistance Testing. Antimicrob Agents Chemother. 2016;60:2981-92 pubmed publisher
    ..These methods of replication enhancement provide new tools for monitoring the susceptibility and resistance of a wide range of HCV genotypes to DAAs. ..
  3. Simmonds P. SSE: a nucleotide and amino acid sequence analysis platform. BMC Res Notes. 2012;5:50 pubmed publisher
    ..SSE combines sequence editor functions with analytical tools in a comprehensive and user-friendly package that assists considerably in bioinformatic and evolution research. ..
  4. request reprint
    Simmonds P. Transfusion virology: progress and challenges. Blood Rev. 1998;12:171-7 pubmed
    ..Establishing a framework for PCR-based screening would also enable the testing for others such as hepatitis A virus, parvovirus B19 and GBV-C/HGV for which serological detection methods cannot be or have not been developed...
  5. Simmonds P, Smith D. Structural constraints on RNA virus evolution. J Virol. 1999;73:5787-94 pubmed
    ..quot; This places a major restriction on the use of nucleotide or amino acid sequence comparisons to calculate times of divergence of other viruses evolving under the same structural constraints as GB viruses. ..
  6. Simmonds P. The origin of hepatitis C virus. Curr Top Microbiol Immunol. 2013;369:1-15 pubmed publisher
    ..Further research on a much wider range of mammals is needed to better understand the true genetic diversity of HCV-like viruses and their host ranges in the search for the ultimate origin of HCV in humans. ..
  7. Simmonds P, Xia W, Baillie J, McKinnon K. Modelling mutational and selection pressures on dinucleotides in eukaryotic phyla--selection against CpG and UpA in cytoplasmically expressed RNA and in RNA viruses. BMC Genomics. 2013;14:610 pubmed publisher
    ....
  8. Simmonds P, Karakasiliotis I, Bailey D, Chaudhry Y, Evans D, Goodfellow I. Bioinformatic and functional analysis of RNA secondary structure elements among different genera of human and animal caliciviruses. Nucleic Acids Res. 2008;36:2530-46 pubmed publisher
    ..This study provides comprehensive bioinformatic resources for future functional studies of MNV and other caliciviruses. ..
  9. Simmonds P, Douglas J, Bestetti G, Longhi E, Antinori S, Parravicini C, et al. A third genotype of the human parvovirus PARV4 in sub-Saharan Africa. J Gen Virol. 2008;89:2299-302 pubmed publisher
    ....

Detail Information

Publications9

  1. Simmonds P, McIntyre C, Savolainen Kopra C, Tapparel C, Mackay I, Hovi T. Proposals for the classification of human rhinovirus species C into genotypically assigned types. J Gen Virol. 2010;91:2409-19 pubmed publisher
    ....
  2. Witteveldt J, Martin Gans M, Simmonds P. Enhancement of the Replication of Hepatitis C Virus Replicons of Genotypes 1 to 4 by Manipulation of CpG and UpA Dinucleotide Frequencies and Use of Cell Lines Expressing SECL14L2 for Antiviral Resistance Testing. Antimicrob Agents Chemother. 2016;60:2981-92 pubmed publisher
    ..These methods of replication enhancement provide new tools for monitoring the susceptibility and resistance of a wide range of HCV genotypes to DAAs. ..
  3. Simmonds P. SSE: a nucleotide and amino acid sequence analysis platform. BMC Res Notes. 2012;5:50 pubmed publisher
    ..SSE combines sequence editor functions with analytical tools in a comprehensive and user-friendly package that assists considerably in bioinformatic and evolution research. ..
  4. request reprint
    Simmonds P. Transfusion virology: progress and challenges. Blood Rev. 1998;12:171-7 pubmed
    ..Establishing a framework for PCR-based screening would also enable the testing for others such as hepatitis A virus, parvovirus B19 and GBV-C/HGV for which serological detection methods cannot be or have not been developed...
  5. Simmonds P, Smith D. Structural constraints on RNA virus evolution. J Virol. 1999;73:5787-94 pubmed
    ..quot; This places a major restriction on the use of nucleotide or amino acid sequence comparisons to calculate times of divergence of other viruses evolving under the same structural constraints as GB viruses. ..
  6. Simmonds P. The origin of hepatitis C virus. Curr Top Microbiol Immunol. 2013;369:1-15 pubmed publisher
    ..Further research on a much wider range of mammals is needed to better understand the true genetic diversity of HCV-like viruses and their host ranges in the search for the ultimate origin of HCV in humans. ..
  7. Simmonds P, Xia W, Baillie J, McKinnon K. Modelling mutational and selection pressures on dinucleotides in eukaryotic phyla--selection against CpG and UpA in cytoplasmically expressed RNA and in RNA viruses. BMC Genomics. 2013;14:610 pubmed publisher
    ....
  8. Simmonds P, Karakasiliotis I, Bailey D, Chaudhry Y, Evans D, Goodfellow I. Bioinformatic and functional analysis of RNA secondary structure elements among different genera of human and animal caliciviruses. Nucleic Acids Res. 2008;36:2530-46 pubmed publisher
    ..This study provides comprehensive bioinformatic resources for future functional studies of MNV and other caliciviruses. ..
  9. Simmonds P, Douglas J, Bestetti G, Longhi E, Antinori S, Parravicini C, et al. A third genotype of the human parvovirus PARV4 in sub-Saharan Africa. J Gen Virol. 2008;89:2299-302 pubmed publisher
    ....