R B Sim

Summary

Affiliation: University of Oxford
Country: UK

Publications

  1. doi request reprint Complement factor H in its alternative identity as adrenomedullin-binding protein 1
    Robert B Sim
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK Department of Infection, Immunity and Inflammation, University of Leicester, University Rd, Leicester, LE1 9HN, UK Electronic address
    Mol Immunol 68:45-8. 2015
  2. pmc The complement system of the goat: haemolytic assays and isolation of major proteins
    Isabel Moreno-Indias
    Animal Science Department, Universidad de Las Palmas de Gran Canaria, Arucas, Las Palmas, 35413, Spain
    BMC Vet Res 8:91. 2012
  3. ncbi request reprint C1q binding and complement activation by prions and amyloids
    Robert B Sim
    MRC Immunochemistry Unit, Department of Biochemistry, Oxford University, South Parks Road, Oxford OX1 3QU, UK
    Immunobiology 212:355-62. 2007
  4. ncbi request reprint Proteases of the complement system
    R B Sim
    MRC Immunochemistry Unit, Department of Biochemistry, Oxford University, South Parks Road, Oxford OX1 3QU, UK
    Biochem Soc Trans 32:21-7. 2004
  5. pmc Human leukocyte C1q receptor binds other soluble proteins with collagen domains
    R Malhotra
    Department of Biochemistry, University of Oxford, United Kingdom
    J Exp Med 172:955-9. 1990
  6. pmc Chemical and hydrodynamic characterization of the human leucocyte receptor for complement subcomponent C1q
    R Malhotra
    Department of Biochemistry, University of Oxford, U K
    Biochem J 262:625-31. 1989
  7. ncbi request reprint The C1q and collectin binding site within C1q receptor (cell surface calreticulin)
    G R Stuart
    Department of Biochemistry, University of Oxford, UK
    Immunopharmacology 38:73-80. 1997
  8. pmc Severe fibrosis in hepatitis C virus-infected patients is associated with increased activity of the mannan-binding lectin (MBL)/MBL-associated serine protease 1 (MASP-1) complex
    K S Brown
    Institute of Infection, Immunity and Inflammation, School of Molecular Medical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham, UK
    Clin Exp Immunol 147:90-8. 2007
  9. ncbi request reprint Collectins and host defence
    R B Sim
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Rd, Oxford OX1 3QU, UK
    Novartis Found Symp 279:170-81; discussion 181-6, 216-9. 2006
  10. ncbi request reprint Interaction of C1q and the collectins with the potential receptors calreticulin (cC1qR/collectin receptor) and megalin
    R B Sim
    Department of Biochemistry, University of Oxford, UK
    Immunobiology 199:208-24. 1998

Collaborators

Detail Information

Publications20

  1. doi request reprint Complement factor H in its alternative identity as adrenomedullin-binding protein 1
    Robert B Sim
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK Department of Infection, Immunity and Inflammation, University of Leicester, University Rd, Leicester, LE1 9HN, UK Electronic address
    Mol Immunol 68:45-8. 2015
    ..Adrenomedullin has potential therapeutic uses in diseases affecting the vasculature, and factor H has been administered with adrenomedullin in some animal models of disease. ..
  2. pmc The complement system of the goat: haemolytic assays and isolation of major proteins
    Isabel Moreno-Indias
    Animal Science Department, Universidad de Las Palmas de Gran Canaria, Arucas, Las Palmas, 35413, Spain
    BMC Vet Res 8:91. 2012
    ..The aim of the present study was to develop a haemolytic assay for the study of the complement system in dairy goats (Capra aegagrus hircus) and to characterize the major goat complement system proteins...
  3. ncbi request reprint C1q binding and complement activation by prions and amyloids
    Robert B Sim
    MRC Immunochemistry Unit, Department of Biochemistry, Oxford University, South Parks Road, Oxford OX1 3QU, UK
    Immunobiology 212:355-62. 2007
    ..Bound complement proteins may then influence the uptake and transport of prion particles by dendritic cells (DCs) and their subsequent proliferation at sites such as follicular DCs...
  4. ncbi request reprint Proteases of the complement system
    R B Sim
    MRC Immunochemistry Unit, Department of Biochemistry, Oxford University, South Parks Road, Oxford OX1 3QU, UK
    Biochem Soc Trans 32:21-7. 2004
    ..Much attention has been focused on controlling the formation or activity of the protease complexes C3bBb and C4b2a (containing activated factor B and C2 respectively), as these generate the inflammatory peptides C3a and C5a...
  5. pmc Human leukocyte C1q receptor binds other soluble proteins with collagen domains
    R Malhotra
    Department of Biochemistry, University of Oxford, United Kingdom
    J Exp Med 172:955-9. 1990
    ..One of the possible roles for ligand-receptor binding may be initiation of phagocytosis...
  6. pmc Chemical and hydrodynamic characterization of the human leucocyte receptor for complement subcomponent C1q
    R Malhotra
    Department of Biochemistry, University of Oxford, U K
    Biochem J 262:625-31. 1989
    ..8), and does not bind a significant weight of detergent. The radioiodinated isolated receptor binds specifically and saturably to solid-phase Clq, but not to collagen, IgG, bovine serum albumin or complement component C3...
  7. ncbi request reprint The C1q and collectin binding site within C1q receptor (cell surface calreticulin)
    G R Stuart
    Department of Biochemistry, University of Oxford, UK
    Immunopharmacology 38:73-80. 1997
    ..The C1q and collection binding site on C1qR/CRT has therefore been localised to the S-domain...
  8. pmc Severe fibrosis in hepatitis C virus-infected patients is associated with increased activity of the mannan-binding lectin (MBL)/MBL-associated serine protease 1 (MASP-1) complex
    K S Brown
    Institute of Infection, Immunity and Inflammation, School of Molecular Medical Sciences, University of Nottingham, Queen s Medical Centre, Nottingham, UK
    Clin Exp Immunol 147:90-8. 2007
    ..The potential role of MBL/MASP-1 complex activity in disease progression is worthy of further study to investigate possible mechanistic links...
  9. ncbi request reprint Collectins and host defence
    R B Sim
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Rd, Oxford OX1 3QU, UK
    Novartis Found Symp 279:170-81; discussion 181-6, 216-9. 2006
    ..Mice deficient in SP-A or SP-D are susceptible to lung infections, and SP-D-deficient mice develop an emphysema-like condition...
  10. ncbi request reprint Interaction of C1q and the collectins with the potential receptors calreticulin (cC1qR/collectin receptor) and megalin
    R B Sim
    Department of Biochemistry, University of Oxford, UK
    Immunobiology 199:208-24. 1998
    ..Two such candidate receptors, cell-surface calreticulin (also referred to as cC1qR or collectin receptor) and megalin are discussed in this review...
  11. ncbi request reprint Complement C4bC2 complex formation: an investigation by surface plasmon resonance
    A Laich
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, OX1 3QU, Oxford, UK
    Biochim Biophys Acta 1544:96-112. 2001
    ..Weak interaction was observed at FB concentrations in the physiological range (500-1000 nM). Kd was 1.2x10(-6) M, indicating possible cross-reactivity between classical and alternative pathways of the activation of the complement system...
  12. ncbi request reprint The mannose-binding lectin (MBL) route for activation of complement
    M Kojima
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Adv Exp Med Biol 535:229-50. 2003
  13. pmc Expression of the proteinase specialized in bone resorption, cathepsin K, in granulomatous inflammation
    A Diaz
    Department of Biochemistry, University of Oxford, UK
    Mol Med 6:648-59. 2000
    ..We came across cathepsin K while working on Echinococcus granulosus, a persistent tissue-dwelling, cyst-forming parasite that elicits a granulomatous response...
  14. ncbi request reprint Serine proteases of the complement system
    R B Sim
    MRC Immunochemistry Unit, Department of Biochemistry, South Parks Road, Oxford, OX1 3QU, UK
    Biochem Soc Trans 28:545-50. 2000
    ....
  15. ncbi request reprint Discrete MBL-MASP complexes show wide inter-individual variability in concentration: data from UK vs Armenian populations
    K R Mayilyan
    MRC Immunochemistry Unit, Department of Biochemistry, Oxford University, Oxford, UK
    Int J Immunopathol Pharmacol 19:567-80. 2006
    ..It is likely that in individuals with high MBL concentration there is excess free MBL not occupied by MASPs, particularly not by MASP-2...
  16. ncbi request reprint Collectins and their role in lung immunity
    T P Hickling
    MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Rd, Oxford OX1 3QU, UK
    J Leukoc Biol 75:27-33. 2004
    ..Recent work has shown that collectins have roles in resistance to allergy and in the control of apoptosis and clearance of apoptotic macrophage in the lung...
  17. ncbi request reprint Functional analysis of the classical, alternative, and MBL pathways of the complement system: standardization and validation of a simple ELISA
    M A Seelen
    Department of Nephrology, C3P 29, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    J Immunol Methods 296:187-98. 2005
    ..The results demonstrate the value of these ELISA-based procedures for the functional assessment of complement deficiencies in clinical practice. The assay is now available commercially in kit form...
  18. pmc Characterization of primary amino acid sequence of human complement control protein factor I from an analysis of cDNA clones
    C F Catterall
    Biochem J 242:849-56. 1987
    ....
  19. ncbi request reprint Distinct pathways of mannan-binding lectin (MBL)- and C1-complex autoactivation revealed by reconstitution of MBL with recombinant MBL-associated serine protease-2
    T Vorup-Jensen
    Department of Medical Microbiology and Immunology, University of Aarhus, Aarhus, Denmark
    J Immunol 165:2093-100. 2000
    ..The results suggest that the catalytic activities of MASP-2 split between the two proteases of the C1 complex during the course of vertebrate complement evolution...
  20. pmc Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients
    G J Cooper
    Department of Biochemistry, University of Oxford, United Kingdom
    Proc Natl Acad Sci U S A 84:8628-32. 1987
    ..The accumulation of amyloid, including diabetes-associated peptide, in islets may impair islet function in type 2 diabetes mellitus...