Alan J Silman

Summary

Affiliation: University of Manchester
Country: UK

Publications

  1. pmc Contraceptives, pregnancy, and RA
    A J Silman
    ARC Epidemiology Unit, School of Epidemiology and Health Sciences, University of Manchester, Manchester M13 9PT, UK
    Ann Rheum Dis 61:383. 2002
  2. pmc British Society for Rheumatology Biologics Register
    A Silman
    ARC Epidemiology Unit, University of Manchester, UK
    Ann Rheum Dis 62:ii28-9. 2003
  3. pmc Epidemiology and genetics of rheumatoid arthritis
    Alan J Silman
    ARC Epidemiology Unit, School of Epidemiology and Health Sciences, University of Manchester, UK
    Arthritis Res 4:S265-72. 2002
  4. ncbi request reprint Risk factors for Colles' fracture in men and women: results from the European Prospective Osteoporosis Study
    A J Silman
    ARC Epidemiology Unit, Manchester University Medical School, Manchester, UK
    Osteoporos Int 14:213-8. 2003
  5. ncbi request reprint Musculoskeletal pain is associated with very low levels of vitamin D in men: results from the European Male Ageing Study
    John McBeth
    ARC Epidemiology Unit, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Ann Rheum Dis 69:1448-52. 2010
  6. pmc Elevated levels of gonadotrophins but not sex steroids are associated with musculoskeletal pain in middle-aged and older European men
    Abdelouahid Tajar
    Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Stopford Building, Oxford Road, Manchester, M13 9PT, UK
    Pain 152:1495-501. 2011
  7. pmc Influence of arthritis and non-arthritis related factors on areal bone mineral density (BMDa) in women with longstanding inflammatory polyarthritis: a primary care based inception cohort
    Stephen R Pye
    Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    BMC Musculoskelet Disord 11:106. 2010
  8. doi request reprint No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain
    Barbara I Nicholl
    Manchester Academic Health Science Centre, University of Manchester, UK
    Ann Rheum Dis 69:2009-12. 2010
  9. doi request reprint Perturbed insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 are not associated with chronic widespread pain in men: results from the European Male Ageing Study
    John McBeth
    ARC Epidemiology Unit, The University of Manchester, Manchester, UK
    J Rheumatol 36:2523-30. 2009
  10. pmc Influence of inflammatory polyarthritis on quantitative heel ultrasound measurements
    Stephen R Pye
    Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    BMC Musculoskelet Disord 13:133. 2012

Detail Information

Publications93

  1. pmc Contraceptives, pregnancy, and RA
    A J Silman
    ARC Epidemiology Unit, School of Epidemiology and Health Sciences, University of Manchester, Manchester M13 9PT, UK
    Ann Rheum Dis 61:383. 2002
  2. pmc British Society for Rheumatology Biologics Register
    A Silman
    ARC Epidemiology Unit, University of Manchester, UK
    Ann Rheum Dis 62:ii28-9. 2003
    ....
  3. pmc Epidemiology and genetics of rheumatoid arthritis
    Alan J Silman
    ARC Epidemiology Unit, School of Epidemiology and Health Sciences, University of Manchester, UK
    Arthritis Res 4:S265-72. 2002
    ..However, the epidemiological data so far are inconclusive. There has recently been renewed interest in the link between cigarette smoking and RA, and the data presented so far are consistent with and suggestive of an increased risk...
  4. ncbi request reprint Risk factors for Colles' fracture in men and women: results from the European Prospective Osteoporosis Study
    A J Silman
    ARC Epidemiology Unit, Manchester University Medical School, Manchester, UK
    Osteoporos Int 14:213-8. 2003
    ..The results are broadly in line with the few other published prospective studies suggesting only a modest role for these factors in influencing susceptibility to fracture...
  5. ncbi request reprint Musculoskeletal pain is associated with very low levels of vitamin D in men: results from the European Male Ageing Study
    John McBeth
    ARC Epidemiology Unit, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Ann Rheum Dis 69:1448-52. 2010
    ..A study was undertaken to test the hypothesis that musculoskeletal pain is associated with low vitamin D levels but the relationship is explained by physical inactivity and/or other putative confounding factors...
  6. pmc Elevated levels of gonadotrophins but not sex steroids are associated with musculoskeletal pain in middle-aged and older European men
    Abdelouahid Tajar
    Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Stopford Building, Oxford Road, Manchester, M13 9PT, UK
    Pain 152:1495-501. 2011
    ..28; 95% CI 1.09 to 1.50) and also CWP (vs no pain, RRR=1.51; 95% CI 1.10 to 2.07). Similar results were found for FSH. Gonadotrophins, but not sex steroid hormone levels, are associated with musculoskeletal pain in men...
  7. pmc Influence of arthritis and non-arthritis related factors on areal bone mineral density (BMDa) in women with longstanding inflammatory polyarthritis: a primary care based inception cohort
    Stephen R Pye
    Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    BMC Musculoskelet Disord 11:106. 2010
    ..The aim of this analysis was to determine the relative influence of disease and non-disease factors on areal bone mineral density (BMDa) in a primary care based cohort of women with inflammatory polyarthritis...
  8. doi request reprint No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain
    Barbara I Nicholl
    Manchester Academic Health Science Centre, University of Manchester, UK
    Ann Rheum Dis 69:2009-12. 2010
    ..The aim of this study was to investigate the association between the catechol-O-methyltransferase (COMT) 'pain sensitivity' haplotypes and chronic widespread pain (CWP) in two distinct cohorts...
  9. doi request reprint Perturbed insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 are not associated with chronic widespread pain in men: results from the European Male Ageing Study
    John McBeth
    ARC Epidemiology Unit, The University of Manchester, Manchester, UK
    J Rheumatol 36:2523-30. 2009
    ..To determine whether perturbations of insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 (IGFBP-3) were associated with the presence of chronic widespread pain (CWP) in men...
  10. pmc Influence of inflammatory polyarthritis on quantitative heel ultrasound measurements
    Stephen R Pye
    Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    BMC Musculoskelet Disord 13:133. 2012
    ..The aims of this analysis were i) to determine the influence of IP on QUS measurements at the heel and, ii) among those with IP to determine the influence of disease related factors on these measurements...
  11. doi request reprint Lower vitamin D levels are associated with depression among community-dwelling European men
    David M Lee
    Arthritis Research UK Epidemiology Unit, University of Manchester, UK
    J Psychopharmacol 25:1320-8. 2011
    ..Further studies are required to determine whether higher levels of vitamin D have an antidepressant effect in older adults...
  12. doi request reprint Vitamin D, parathyroid hormone and the metabolic syndrome in middle-aged and older European men
    David M Lee
    ARC Epidemiology Unit, The University of Manchester, Manchester M13 9PT, UK
    Eur J Endocrinol 161:947-54. 2009
    ..The aim of our analysis was to examine the association of 25(OH)D and PTH with Adult Treatment Panel III-defined MetS in middle-aged and older European men...
  13. pmc Influence of lifestyle factors on quantitative heel ultrasound measurements in middle-aged and elderly men
    Stephen R Pye
    ARC Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Calcif Tissue Int 86:211-9. 2010
    ..Modification of lifestyle, including increasing physical activity and stopping smoking, may help optimize bone strength and reduce the risk of fracture in middle-aged and elderly European men...
  14. pmc Association of the HLA-DRB1 gene with premature death, particularly from cardiovascular disease, in patients with rheumatoid arthritis and inflammatory polyarthritis
    Tracey M Farragher
    Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester, UK
    Arthritis Rheum 58:359-69. 2008
    ..To examine the role of the variants of the PTPN22 and HLA-DRB1 genes as predictors of mortality in inflammatory polyarthritis (IP) and rheumatoid arthritis (RA)...
  15. doi request reprint Cohort profile: the European Male Ageing Study
    David M Lee
    Arthritis Research UK Epidemiology Unit, University of Manchester, Manchester, UK
    Int J Epidemiol 42:391-401. 2013
    ..EMAS actively encourages new collaborations, data sharing for validation studies and participation in genetic study consortia. Potential collaborators should contact the principal investigator (F.C.W.W.) in the first instance...
  16. ncbi request reprint Prevalence and associated factors for falls in women with established inflammatory polyarthritis
    Anna E Oswald
    ARC Epidemiology Unit, The University of Manchester, UK
    J Rheumatol 33:690-4. 2006
    ..To determine the one-year period prevalence and factors associated with falls in a community based cohort of women with established inflammatory polyarthritis (IP)...
  17. doi request reprint Association of HTR2A polymorphisms with chronic widespread pain and the extent of musculoskeletal pain: results from two population-based cohorts
    Barbara I Nicholl
    University of Manchester, Manchester, UK
    Arthritis Rheum 63:810-8. 2011
    ..The aim of the current study was to investigate whether genetic variation in genes across the serotoninergic system is associated with chronic widespread pain (CWP) and the number of pain sites reported...
  18. pmc A validation of the first genome-wide association study of calcaneus ultrasound parameters in the European Male Ageing Study
    Delnaz Roshandel
    Arthritis Research UK Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    BMC Med Genet 12:19. 2011
    ..The association between these SNPs and bone mineral density (BMD) measured using dual-energy X-ray absorptiometry (DXA) was also tested...
  19. ncbi request reprint Identification of late-onset hypogonadism in middle-aged and elderly men
    Frederick C W Wu
    Andrology Research Unit, Developmental and Regenerative Biomedicine Research Group, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom
    N Engl J Med 363:123-35. 2010
    ..We sought evidence-based criteria for identifying late-onset hypogonadism in the general population on the basis of an association between symptoms and a low testosterone level...
  20. pmc Rheumatoid arthritis association at 6q23
    Wendy Thomson
    Arthritis Research Campaign ARC Epidemiology Unit, Stopford Building, The University of Manchester, Manchester M13 9PT, UK
    Nat Genet 39:1431-3. 2007
    ..1 x 10(-8)) in a validation study, as described here. This SNP maps to 6q23, between the genes oligodendrocyte lineage transcription factor 3 (OLIG3) and tumor necrosis factor-alpha-induced protein 3 (TNFAIP3)...
  21. ncbi request reprint Outcomes after switching from one anti-tumor necrosis factor alpha agent to a second anti-tumor necrosis factor alpha agent in patients with rheumatoid arthritis: results from a large UK national cohort study
    Kimme L Hyrich
    University of Manchester, Manchester, UK
    Arthritis Rheum 56:13-20. 2007
    ..The present study was undertaken to compare drug continuation rates between the first course and second course of anti-TNF therapy...
  22. pmc Re-evaluation of putative rheumatoid arthritis susceptibility genes in the post-genome wide association study era and hypothesis of a key pathway underlying susceptibility
    Anne Barton
    ARC Epidemiology Unit, Stopford Building, The University of Manchester, Manchester, UK
    Hum Mol Genet 17:2274-9. 2008
    ..The effect sizes are less than those reported previously but are likely to be a more accurate reflection of the true effect size given the larger size of the cohort investigated in the current study...
  23. pmc Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13
    Anne Barton
    Arthritis Research Campaign, Epidemiology Unit, The University of Manchester, Manchester, UK
    Nat Genet 40:1156-9. 2008
    ....
  24. doi request reprint The association between different cognitive domains and age in a multi-centre study of middle-aged and older European men
    David M Lee
    ARC Epidemiology Unit, The University of Manchester, Manchester, UK
    Int J Geriatr Psychiatry 24:1257-66. 2009
    ....
  25. doi request reprint The European Male Ageing Study (EMAS): design, methods and recruitment
    David M Lee
    ARC Epidemiology Unit, The University of Manchester, Manchester, UK
    Int J Androl 32:11-24. 2009
    ..Such information is an important prerequisite to develop effective strategies to reduce age-related disabilities and optimise health and well-being into old-age...
  26. doi request reprint Endogenous hormones, androgen receptor CAG repeat length and fluid cognition in middle-aged and older men: results from the European Male Ageing Study
    David M Lee
    ARC Epidemiology Unit, Department of Medicine, Manchester Academic and Health Sciences Centre, Manchester Royal Infirmary, The University of Manchester, Grafton Street, Manchester, UK
    Eur J Endocrinol 162:1155-64. 2010
    ..Data remain divergent regarding the activational effects of endogenous hormones on adult cognitive function. We examined the association between cognition, hormones and androgen receptor (AR) CAG repeat length in a large cohort of men...
  27. ncbi request reprint Baseline levels of C-reactive protein and prediction of death from cardiovascular disease in patients with inflammatory polyarthritis: a ten-year followup study of a primary care-based inception cohort
    Nicola J Goodson
    University of Manchester, UK
    Arthritis Rheum 52:2293-9. 2005
    ..To test the hypothesis that the C-reactive protein (CRP) concentration at baseline is an independent predictor of death from cardiovascular disease (CVD) in newly diagnosed patients with inflammatory polyarthritis (IP)...
  28. pmc The association between neighbourhood socio-economic status and the onset of chronic widespread pain: results from the EPIFUND study
    Kelly A Davies
    Arthritis Research Campaign ARC, Epidemiology Unit, Research School of Translational Medicine, Stopford Building, University of Manchester, Manchester, United Kingdom
    Eur J Pain 13:635-40. 2009
    ..The aim of this study was to examine the hypothesis that socio-economic status predicts the onset of CWP but that this relationship would be explained by psychological factors...
  29. ncbi request reprint Predictors of low back pain in British schoolchildren: a population-based prospective cohort study
    Gareth T Jones
    Arthritis Research Campaign Epidemiology Unit, School of Epidemiology and Health Sciences, University of Manchester, United Kingdom
    Pediatrics 111:822-8. 2003
    ..To determine the onset of low back pain (LBP) in schoolchildren and to investigate the role of mechanical and psychosocial factors as risk factors for its onset...
  30. doi request reprint Patients waiting for a hip or knee joint replacement: is there any prioritization for surgery?
    Gretl A McHugh
    School of Nursing, Midwifery and Social Work, The University of Manchester, Manchester, UK
    J Eval Clin Pract 14:361-7. 2008
    ..To investigate whether patients are prioritized for joint replacement surgery on the basis of severity of osteoarthritis, pain and physical functioning...
  31. doi request reprint Genetic variation in the RANKL/RANK/OPG signaling pathway is associated with bone turnover and bone mineral density in men
    Delnaz Roshandel
    Arthritis Research UK, Epidemiology Unit, The University of Manchester, Manchester Academic Health Science Centre, Manchester, UK
    J Bone Miner Res 25:1830-8. 2010
    ..02, p = 6.06 x 10(-8)) and higher ultrasound BMD at the calcaneus (beta = 0.01, p = .037). Our findings suggest that genetic variation in the RANKL/RANK/OPG signaling pathway influences bone turnover and BMD in European men...
  32. doi request reprint Frailty in relation to variations in hormone levels of the hypothalamic-pituitary-testicular axis in older men: results from the European male aging study
    Abdelouahid Tajar
    Arthritis Research United Kingdom Epidemiology Unit, University of Manchester, Manchester, UK
    J Am Geriatr Soc 59:814-21. 2011
    ..To explore the associations between frailty and reproductive axis hormones (as an important regulatory system) in middle aged and older men...
  33. ncbi request reprint Pregnancy outcome in women who were exposed to anti-tumor necrosis factor agents: results from a national population register
    Kimme L Hyrich
    University of Manchester, Manchester, UK
    Arthritis Rheum 54:2701-2. 2006
  34. ncbi request reprint Childhood fractures do not predict future fractures: results from the European Prospective Osteoporosis Study
    Stephen R Pye
    ARC Epidemiology Unit, The University of Manchester, Manchester, United Kingdom
    J Bone Miner Res 24:1314-8. 2009
    ..Our data suggest that self-reported previous childhood fracture is not associated with an increased risk of future fracture in men or women...
  35. pmc Early functional disability predicts both all-cause and cardiovascular mortality in people with inflammatory polyarthritis: results from the Norfolk Arthritis Register
    Tracey M Farragher
    ARC Epidemiology Unit, The University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, and Norfolk Arthritis Register, Norfolk and Norwich University Hospital, UK
    Ann Rheum Dis 66:486-92. 2007
    ..To investigate the predictive value of early functional disability in patients with inflammatory polyarthritis (IP), for all-cause and cardiovascular disease (CVD) mortality...
  36. ncbi request reprint Mechanical injury and psychosocial factors in the work place predict the onset of widespread body pain: a two-year prospective study among cohorts of newly employed workers
    Elaine F Harkness
    ARC Epidemiology Unit, Medical School, University of Manchester, Manchester M13 9PT, UK
    Arthritis Rheum 50:1655-64. 2004
    ....
  37. pmc Lumbar disc degeneration: association between osteophytes, end-plate sclerosis and disc space narrowing
    Stephen R Pye
    ARC Epidemiology Unit, The University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Ann Rheum Dis 66:330-3. 2007
    ..Lumbar disc degeneration is characterised radiologically by the presence of osteophytes, end-plate sclerosis and disc space narrowing...
  38. doi request reprint Pain, physical functioning and quality of life of individuals awaiting total joint replacement: a longitudinal study
    Gretl A McHugh
    School of Nursing, Midwifery and Social Work, The University of Manchester, Manchester, UK
    J Eval Clin Pract 14:19-26. 2008
    ..To investigate if pain, physical function and the quality of life changed among adults with osteoarthritis while on the waiting list for hip or knee joint replacement...
  39. pmc Aspects of early arthritis. What determines the evolution of early undifferentiated arthritis and rheumatoid arthritis? An update from the Norfolk Arthritis Register
    Deborah P M Symmons
    ARC Epidemiology Unit, University of Manchester, UK
    Arthritis Res Ther 8:214. 2006
    ..New statistical techniques offer exciting possibilities for using longitudinal datasets such as NOAR to explore the long-term effects of treatment in IP and RA...
  40. pmc HLA-Cw6 and HLA-DRB1*07 together are associated with less severe joint disease in psoriatic arthritis
    Pauline Y P C Ho
    ARC EU, Stopford Building, University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Ann Rheum Dis 66:807-11. 2007
    ..Human leucocyte antigen (HLA) genes predict disease severity in psoriasis (HLA-Cw6) and rheumatoid arthritis (shared epitope (SE)), but the situation is unclear for psoriatic arthritis (PsA)...
  41. ncbi request reprint Predicting the onset of widespread body pain among children
    Gareth T Jones
    Unit of Chronic Disease Epidemiology, and Arthritis Research Campaign Epidemiology Unit, University of Manchester, Manchester, UK
    Arthritis Rheum 48:2615-21. 2003
    ..To determine factors associated with, and the predictors of, widespread body pain in children...
  42. doi request reprint Clinical features of childhood localized scleroderma in an incidence cohort
    Ariane L Herrick
    Arthritis Research UK Epidemiology Unit, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Rheumatology (Oxford) 50:1865-8. 2011
    ..Our aim was to describe clinical features and pattern of care in children with localized scleroderma presenting to secondary care during a 25-month incidence study...
  43. pmc Hypothalamic-pituitary-adrenal stress axis function and the relationship with chronic widespread pain and its antecedents
    John McBeth
    Arthritis Research Campaign ARC Epidemiology Unit, School of Epidemiology and Health Sciences, University of Manchester, Manchester, United Kingdom
    Arthritis Res Ther 7:R992-R1000. 2005
    ....
  44. ncbi request reprint Vitamin D status and bone mass in UK South Asian women
    Dipak K Roy
    Arthritis Research Campaign Epidemiology Unit, Stopford Building, The University of Manchester, Oxford Road, Manchester M13 9PT, UK
    Bone 40:200-4. 2007
    ..The aim of this study was to determine the association between serum PTH, 25OHD and bone mass in a population based sample of young UK South Asian women...
  45. ncbi request reprint Occurrence of Raynaud's phenomenon in children ages 12-15 years: prevalence and association with other common symptoms
    Gareth T Jones
    University of Manchester, Manchester, UK
    Arthritis Rheum 48:3518-21. 2003
    ..This study was undertaken to ascertain the prevalence of RP in children ages 12-15 years and to determine whether, as with other commonly reported symptoms, there were any associations with adverse psychosocial factors...
  46. doi request reprint Incidence of childhood linear scleroderma and systemic sclerosis in the UK and Ireland
    Ariane L Herrick
    University of Manchester, Manchester, UK, and Salford Royal Hospital, Salford, UK
    Arthritis Care Res (Hoboken) 62:213-8. 2010
    ..Our aim was to ascertain the incidence of childhood scleroderma in its different forms in the UK and Ireland, and to describe the age, sex, and ethnicity of the cases...
  47. ncbi request reprint Association of widespread body pain with an increased risk of cancer and reduced cancer survival: a prospective, population-based study
    John McBeth
    Unit of Epidemiology, The Medical School, University of Manchester, Manchester, UK
    Arthritis Rheum 48:1686-92. 2003
    ....
  48. doi request reprint Genetic variation in sex hormone genes influences heel ultrasound parameters in middle-aged and elderly men: results from the European Male Aging Study (EMAS)
    Kate L Limer
    ARC Epidemiology Unit, The University of Manchester, Manchester, United Kingdom
    J Bone Miner Res 24:314-23. 2009
    ....
  49. ncbi request reprint Predicting the onset of forearm pain: a prospective study across 12 occupational groups
    Elizabeth S Nahit
    University of Manchester, Manchester, United Kingdom
    Arthritis Rheum 49:519-25. 2003
    ..To determine, among workers free of forearm pain, the role of mechanical and psychosocial factors in predicting future onset...
  50. pmc Combined effects of three independent SNPs greatly increase the risk estimate for RA at 6q23
    Gisela Orozco
    ARC Epidemiology Unit, Stopford Building, The University of Manchester, Manchester M13 9PT, UK
    Hum Mol Genet 18:2693-9. 2009
    ..This is the first study to show that the confirmed loci from the GWA studies, that confer only a modest effect size, could harbour a significantly greater effect once the effect of additional risk variants are accounted for...
  51. ncbi request reprint Characteristics of a prevalent vertebral deformity predict subsequent vertebral fracture: results from the European Prospective Osteoporosis Study (EPOS)
    Mark Lunt
    ARC Epidemiology Unit, University of Manchester, Manchester, UK
    Bone 33:505-13. 2003
    ..0 (95% CI;2.6, 6.0)). In summary, the risk of a subsequent vertebral fracture in individuals with preexisting deformities is importantly influenced by the characteristics of these deformities...
  52. doi request reprint Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men
    David M Lee
    ARC Epidemiology Unit, The University of Manchester, Manchester M13 9PT, UK
    J Neurol Neurosurg Psychiatry 80:722-9. 2009
    ..The aim of this trial was to examine the association between 25-hydroxyvitamin D (25(OH)D) levels and cognitive performance in middle-aged and older European men...
  53. ncbi request reprint Dietary risk factors for the development of inflammatory polyarthritis: evidence for a role of high level of red meat consumption
    Dorothy J Pattison
    University of Manchester, Manchester, UK
    Arthritis Rheum 50:3804-12. 2004
    ..To investigate the association of red meat and other specific dietary components in predicting the development of inflammatory polyarthritis...
  54. ncbi request reprint Genetic epidemiology of rheumatoid arthritis
    Jacqueline E Oliver
    ARC Epidemiology Unit, Manchester University, School of Epidemiology and Health Sciences, Manchester, UK
    Curr Opin Rheumatol 18:141-6. 2006
    ..This review aims to summarize articles published between October 2004 and November 2005 that have investigated the genetic epidemiology of rheumatoid arthritis...
  55. ncbi request reprint Onset of neck pain after a motor vehicle accident: a case-control study
    Nicola J Wiles
    ARC Epidemiology Unit and The Unit of Chronic Disease Epidemiology, Division of Epidemiology and Health Sciences, University of Manchester, UK
    J Rheumatol 32:1576-83. 2005
    ....
  56. ncbi request reprint Comparison of the response to infliximab or etanercept monotherapy with the response to cotherapy with methotrexate or another disease-modifying antirheumatic drug in patients with rheumatoid arthritis: results from the British Society for Rheumatology Bi
    Kimme L Hyrich
    University of Manchester, Manchester, UK
    Arthritis Rheum 54:1786-94. 2006
    ....
  57. pmc Why are women predisposed to autoimmune rheumatic diseases?
    Jacqueline E Oliver
    University of Manchester, Oxford Road, Manchester, M13 9PL, UK
    Arthritis Res Ther 11:252. 2009
    ..These will all be reviewed, focusing on the major autoimmune connective tissue disorders: rheumatoid arthritis, systemic lupus erythematosus and scleroderma...
  58. pmc Psychological stress and fibromyalgia: a review of the evidence suggesting a neuroendocrine link
    Anindya Gupta
    ARC Epidemiology Unit, School of Epidemiology and Health Sciences, Manchester, UK
    Arthritis Res Ther 6:98-106. 2004
    ..Whether such abnormalities have an aetiologic role remains uncertain but should be testable by well-designed prospective studies...
  59. ncbi request reprint Does chronic pain predict future psychological distress?
    John McBeth
    Arthritis Research Campaign ARC Epidemiology Unit, School of Epidemiology and Health Sciences, Stopford Building, University of Manchester, Oxford Road, M13 9PT, Manchester, UK
    Pain 96:239-45. 2002
    ..These findings indicate that it is those persons with chronic widespread pain in the presence of other physical and psychosocial factors who will become distressed...
  60. ncbi request reprint Mortality in early inflammatory polyarthritis: cardiovascular mortality is increased in seropositive patients
    Nicola J Goodson
    ARC Epidemiology Unit, University of Manchester Medical School, Manchester, UK
    Arthritis Rheum 46:2010-9. 2002
    ..To determine the degree and causes of any excess mortality observed during the early years of inflammatory polyarthritis (IP)...
  61. pmc Predictors of hip joint replacement in new attenders in primary care with hip pain
    Fraser Birrell
    ARC Epidemiology Unit, University of Manchester
    Br J Gen Pract 53:26-30. 2003
    ..Studies investigating the factors associated with need for total hip replacement should ideally be based on prospective investigation of new attenders in primary care...
  62. ncbi request reprint Evidence for a novel rheumatoid arthritis susceptibility locus on chromosome 6p
    William Brintnell
    University of Manchester, Manchester, UK
    Arthritis Rheum 50:3823-30. 2004
    ..To investigate whether the large linkage peak on chromosome 6p harbors rheumatoid arthritis (RA) susceptibility loci in addition to the well-characterized HLA-DRB1 gene...
  63. ncbi request reprint Reconciling subject differences in recruitment to clinical trials and clinical practice
    Kimme L Hyrich
    University of Manchester, Manchester, UK
    J Rheumatol 32:2475-6. 2005
    ....
  64. ncbi request reprint Quality of care for people with osteoarthritis: a qualitative study
    Gretl A McHugh
    School of Nursing, Midwifery and Social Work, The University of Manchester, Oxford Road, Manchester, UK
    J Clin Nurs 16:168-76. 2007
    ..The overall aim of this qualitative study was to explore within primary care the experiences of management and care of individuals with end-stage lower limb osteoarthritis who are on the waiting list for joint replacement...
  65. ncbi request reprint Whole-genome screening for susceptibility genes in multicase families with Behçet's disease
    Jumana Karasneh
    University of Manchester, Manchester, UK
    Arthritis Rheum 52:1836-42. 2005
    ..The aim of this study was to perform a whole-genome linkage analysis for identification of other susceptibility loci for Behçet's disease in multicase families...
  66. ncbi request reprint Commentary: Do genes or environment influence development of rheumatoid arthritis?
    Alan J Silman
    ARC Epidemiology Unit, Manchester University Medical School, Manchester M13 9PT
    BMJ 324:264. 2002
  67. ncbi request reprint Low back pain in schoolchildren: occurrence and characteristics
    Kath D Watson
    Arthritis Research Campaign ARC Epidemiology Unit, School of Epidemiology and Health Sciences, Stopford Building, University of Manchester, Oxford Road, M13 9PT, UK
    Pain 97:87-92. 2002
    ..Adolescent low back pain is common although medical attention is rarely sought. Such symptoms in childhood, particularly as they are so common, may have important consequences for chronic low back pain in adulthood...
  68. ncbi request reprint Cigarette smoking as a significant risk factor for digital vascular disease in patients with systemic sclerosis
    Beverley J Harrison
    North Manchester General Hospital and ARC Epidemiology Unit, Manchester, UK
    Arthritis Rheum 46:3312-6. 2002
    ..Cigarette smoking is an important risk factor for vascular disease in the general population. We investigated the influence of cigarette smoking on digital ischemia in patients with SSc...
  69. ncbi request reprint The changing face of rheumatoid arthritis: why the decline in incidence?
    Alan J Silman
    Arthritis Rheum 46:579-81. 2002
  70. pmc Common variants near MC4R are associated with fat mass, weight and risk of obesity
    Ruth J F Loos
    MRC Epidemiology Unit, Addenbrooke s Hospital, Cambridge CB2 0QQ, UK
    Nat Genet 40:768-75. 2008
    ....
  71. ncbi request reprint The Cheshire Foot Pain and Disability Survey: a population survey assessing prevalence and associations
    Adam P Garrow
    Diabetes Foot Clinic, Disablement Services Centre, Withington Hospital, Cavendish Road, Manchester M20 1LB, UK
    Pain 110:378-84. 2004
    ..Further work is necessary to understand more about the extent and type of unmet need and on how patients presenting with symptoms of disabling foot pain should best be managed...
  72. ncbi request reprint When should the doctor order a spine X-ray? Identifying vertebral fractures for osteoporosis care: results from the European Prospective Osteoporosis Study (EPOS)
    Stephen Kaptoge
    Department of Medicine, Institute of Public Health, University of Cambridge, Cambridge, UK
    J Bone Miner Res 19:1982-93. 2004
    ..Use of X-rays can be optimized by selecting patients at high risk using a short screening procedure...
  73. ncbi request reprint An evaluation of the decision tree format of the American College of Rheumatology 1987 classification criteria for rheumatoid arthritis: performance over five years in a primary care-based prospective study
    Mark Lunt
    University of Manchester Medical School, UK
    Arthritis Rheum 52:2277-83. 2005
    ..Moreover, the use of clinical surrogates to substitute for missing rheumatoid factor (RF) and radiologic erosion data was assessed for validity and for its influence on the resulting RA prevalence estimates...
  74. ncbi request reprint Psychosocial risk factors for the onset of abdominal pain. Results from a large prospective population-based study
    Smita L S Halder
    Department of GI Sciences, Hope Hospital, Salford M6 8HD, UK
    Int J Epidemiol 31:1219-25; discussion 1225-6. 2002
    ..To determine the psychosocial risk factors for the development of abdominal pain and to determine whether, in those people who consulted, symptoms had been attributed to an organic cause...
  75. ncbi request reprint Predicting new onset of widespread pain following a motor vehicle collision
    Gwenllian Wynne-Jones
    Primary Care Sciences Research Centre, Keele University, Keele, United Kingdom
    J Rheumatol 33:968-74. 2006
    ....
  76. ncbi request reprint Anti-tumor necrosis factor-alpha agents for rheumatoid arthritis: assessing longterm safety
    Kimme L Hyrich
    J Rheumatol 33:831-3. 2006
  77. pmc Predicting the onset of knee pain: results from a 2-year prospective study of new workers
    Gareth T Jones
    Aberdeen Pain Research Collaboration, Epidemiology Group, University of Aberdeen, School of Medicine, Polwarth Building, Foresterhill, Aberdeen AB25 2ZD, UK
    Ann Rheum Dis 66:400-6. 2007
    ..To determine the relative contribution of work-related mechanical (injury) factors and psychosocial factors to the onset of a new episode of knee pain, in a cohort of newly employed workers...
  78. ncbi request reprint Are common symptoms in childhood associated with chronic widespread body pain in adulthood? Results from the 1958 British Birth Cohort Study
    Gareth T Jones
    University of Aberdeen, Aberdeen, UK
    Arthritis Rheum 56:1669-75. 2007
    ..However, it is unknown whether this association persists into adulthood. The aim of the current study was to examine, prospectively, whether children with common symptoms experience an increased risk of chronic widespread pain as adults...
  79. doi request reprint Hypothalamic-pituitary-testicular axis disruptions in older men are differentially linked to age and modifiable risk factors: the European Male Aging Study
    Frederick C W Wu
    Department of Endocrinology, Manchester Royal Infirmary, Oxford Road, Manchester, United Kingdom
    J Clin Endocrinol Metab 93:2737-45. 2008
    ..The cause of declining testosterone (T) in aging men and their relationships with risk factors are unclear...
  80. ncbi request reprint Determining aspects of ethnicity amongst persons of South Asian origin: the use of a surname-classification programme (Nam Pehchan)
    Gary J Macfarlane
    Aberdeen Pain Research Collaboration, Epidemiology Group, Department of Public Health, University of Aberdeen, Polwarth Building, Foresterhill, Aberdeen, AB25 2ZD, UK
    Public Health 121:231-6. 2007
    ..The aim of the current study was to assess the validity of the Nam Pehchan name classification programme of religion and language against subject self-report...
  81. ncbi request reprint Should infection still be considered as the most likely triggering factor for rheumatoid arthritis?
    Sara M Carty
    J Rheumatol 30:425-9. 2003
  82. ncbi request reprint Cases of early inflammatory polyarthritis should not be classified as having rheumatoid arthritis
    Deborah P M Symmons
    J Rheumatol 30:902-4. 2003
  83. ncbi request reprint Anti-tumor necrosis factor alpha therapy and the risk of lymphoma in rheumatoid arthritis: no clear answer
    Deborah P M Symmons
    Arthritis Rheum 50:1703-6. 2004
  84. pmc Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
    Sheila A Fisher
    Department of Medical and Molecular Genetics, King s College London School of Medicine, 8th Floor Guy s Tower, Guy s Hospital, London SE1 9RT, UK
    Nat Genet 40:710-2. 2008
    ..These data provide the first detailed illustration of the genetic relationship between these common inflammatory bowel diseases...
  85. ncbi request reprint Assessment of sexual health in aging men in Europe: development and validation of the European Male Ageing Study sexual function questionnaire
    Daryl B O'Connor
    Institute of Psychological Sciences, University of Leeds, Leeds, UK
    J Sex Med 5:1374-85. 2008
    ..Assessment of male sexual dysfunction has been the focus of substantial scientific effort. Less research has focused on the development of instruments for the measurement of sexual functioning in aging men...
  86. ncbi request reprint Defining response to disease modifying antirheumatic drugs in patients with rheumatoid arthritis
    Samantha L Hider
    J Rheumatol 32:6-10. 2005
  87. ncbi request reprint Factors influencing response to disease modifying antirheumatic drugs in patients with rheumatoid arthritis
    Samantha L Hider
    J Rheumatol 32:11-16. 2005
  88. ncbi request reprint Minimal disease activity for rheumatoid arthritis: a preliminary definition
    George A Wells
    Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    J Rheumatol 32:2016-24. 2005
    ..This set of 2 definitions gained approval of 73% of the attendees. These (and other) definitions will now be subject to further validation in other databases...
  89. ncbi request reprint Scleroderma--developing measures of response
    Daniel E Furst
    University of California at Los Angeles, CA 90025, USA
    J Rheumatol 32:2477-80. 2005
    ..Deliberations focused on progress in the assessment of gastrointestinal disease, renal physiology, vascular damage, and the unique challenges inherent in studying pediatric patients with scleroderma...
  90. ncbi request reprint Comment on Hendriks et al.: prognostic factors for poor recovery in acute whiplash patients. Pain 2005;114:408-416
    Gwenllian Wynne-Jones
    Pain 119:247-8; author reply 248-9. 2005
  91. pmc Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    Eleftheria Zeggini
    Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, OX3 7LJ, UK
    Science 316:1336-41. 2007
    ..The regions identified underscore the importance of pathways influencing pancreatic beta cell development and function in the etiology of type 2 diabetes...
  92. pmc Influence of weight, body mass index and lifestyle factors on radiographic features of lumbar disc degeneration
    Stephen R Pye
    Ann Rheum Dis 66:426-7. 2007
  93. pmc In adult onset myositis, the presence of interstitial lung disease and myositis specific/associated antibodies are governed by HLA class II haplotype, rather than by myositis subtype
    Hector Chinoy
    Rheumatic Diseases Centre, Hope Hospital, Salford, UK
    Arthritis Res Ther 8:R13. 2006
    ..In conclusion, these findings support the notion that myositis patients with differing myositis serology have different immunogenetic profiles, and that these profiles may define specific myositis subtypes...